Abstract: A Portable communications device (1), particularly as an additional functional unit in a radiotelephone (100), comprising an input, output radio interface (2) for local data exchange between two adjacent communications devices (1; 100) or between a communications device (1; 100) and a data processing device (12) adapted to the,local data exchange, or a data-reproducing device (13), or an adapted data source (50). The range (r) of the input/output radio interface (2) is short compared with the range of a conventional radio interface for data :transfer, and corresponds essentially to a talking distance. The communications device (1, 100) further includes a memory device (6) and a data processing device (5). Different data sequences are identified and selectively retrievable in the memory device (6). The activation of the input/output radio interface (2) can be initiated manually.

Abstract: A method is provided for measuring a state variable of a biological cell (3) located in a nutrient medium (2) and supported on and adhering to a support area (5). Within the support area (5) for the cell (3) and at a distance from the support area edge, an opening is made in the membrane of the cell (3). The edge of the cell membrane that surrounds the opening and adheres to the support area (5) seals off the liquid found inside the cell (3) from the nutrient medium (2). Through the opening the state variable (2) is measured. An apparatus for performing the method is also provided.

Abstract: The invention relates to a method for producing an optical transmitting and receiving device (1, 1a) comprising a light emitting transmission element (3, 3a) and a receiving element (4, 4a) which converts this light into an electrical magnitude. The transmission and receiving elements are inserted into a silicon substrate. The optical transmitting and receiving device (1) is preferably inserted in a monolithic manner into a common substrate, comprising a sequence of superimposed layers for the light emitting transmission element (3) and the light receiving element (4). An electrically insulating intermediate layer (9, 9a) is incorporated between the transmission and receiving element.

Abstract: A process is provided for the intracellular manipulation of a biological cell (3) which is positioned adhering to a support area (5) in a culture medium (2). Inside the support area (5) for the cell (3) an opening into the membrane of the cell (3) is created spaced from its support edge. The edge of the cell membrane surrounding the opening, adhering to the support area (5), thus seals off the cell fluid situated in the interior of the cell (3) from the culture medium (2) and insulates the cell fluid against the culture medium (2). The interior of the cell (3) is manipulated through the opening. An apparatus for implementing the process is also provided, including an object carrier (4) with a support area (5) for adhering the cell and a poration tool (6) for creating the opening in the cell membrane. The poration tool (6) may be any of various chemical, mechanical and/or electrical devices.

Abstract: A process is provided for the intracellular manipulation of a biological cell (3) which is positioned adhering to a support area (5) in a culture medium (2). Inside the support area (5) for the cell (3) an opening into the membrane of the cell (3) is created spaced from its support edge. The edge of the cell membrane surrounding the opening, adhering to the support area (5), thus seals off the cell fluid situated in the interior of the cell (3) from the culture medium (2) and insulates the cell fluid against the culture medium (2). The interior of the cell (3) is manipulated through the opening. An apparatus for implementing the process is also provided, including an object carrier (4) with a support area (5) for adhering the cell and a poration tool (6) for creating the opening in the cell membrane. The poration tool (6) may be any of various chemical, mechanical and/or electrical devices.

Abstract: A method is provided for measuring a state variable of a biological cell (3) located in a nutrient medium (2) and supported on and adhering to a support area (5). Within the support area (5) for the cell (3) and at a distance from the support area edge, an opening is made in the membrane of the cell (3). The edge of the cell membrane that surrounds the opening and adheres to the support area (5) seals off the liquid found inside the cell (3) from the nutrient medium (2). Through the opening the state variable (2) is measured. An apparatus for performing the method is also provided.

Abstract: A capacitive sensor is described which includes a first electrode remote from a second electrode, wherein the first electrode and the second electrode form a measurement capacitance. The first electrode is arranged on a first substrate member and the second electrode is arranged on a second substrate member. At least one of the electrodes has a spatially resolved structure which allows a spatially resolved measurement of the capacitance. The spatial structure of the electrode may be implemented in form of several mutually parallel stripe-shaped elements or in form of a plurality of spaced-apart elements that are arranged in a two-dimensional pattern. Associated with the electrodes are electronic processing units integrated in the substrate members.

Abstract: A measuring device (1) has a semiconductor arrangement, which includes a semiconductor chip (2) connected to a carrier (4) having at least one through-hole (3). The semiconductor chip (2) has at least one sensor (6) with an active sensor surface (5) facing the through-hole (3). The semiconductor chip (2) has electrical terminal points (9), which are connected using flip-chip connections (10) to terminal contacts (11) facing the terminal points (9) and located on the carrier (4). The carrier (4) has electrical strip conductors (12), which connect the terminal contacts (11) to contact elements (13) located on the carrier. To the rear side of the carrier (4) having the contact elements (13) a strip conductor carrier (16) is provided, which has strip conductors (12) connected to opposing contacts (14). The opposing contacts (14) are each electrically connected using flip-chip connections (17), to a contact element (13), which are allocated to each of them.

Abstract: A device (1) serves for conducting investigations on cell specimens, wherein the device has a microtiter plate or similar receiving device with a plurality of individual containers for the cell specimens. Furthermore, a measuring facility for recording changes in individual specimens is provided. On the underside the microtiter plate or similar receiving device has a measuring structure which carries at least one sensor allocated to each receiving vessel. The measuring structure can either be combined with a bottomless upper part of a conventional microtiter plate, or instead it is a semiconductor substrate plate (2) with a plurality of bowl-shaped receptacle depressions (3) situated therein and provided as containers. At least one sensor is allocated to each depression.

Abstract: A capacitive sensor including a first electrode and a second electrode which are disposed opposite each other in spaced-apart relationship to form a capacitor, the first electrode being disposed on a first substrate and the second electrode on a second substrate, the substrates being joined together at the sides of the electrodes, and the second substrate forming, in the area of the second electrode, a diaphragm deformable by pressure. An electronic signal processing device for processing the measurement signals is incorporated in one of the substrates below the electrode disposed thereon.

Abstract: A method is provided for measuring a state variable of a biological cell (3) located in a nutrient medium (2) and supported on and adhering to a support area (5). Within the support area (5) for the cell (3) and at a distance from the support area edge, an opening is made in the membrane of the cell (3). The edge of the cell membrane that surrounds the opening and adheres to the support area (5) seals off the liquid found inside the cell (3) from the nutrient medium (2). Through the opening the state variable (2) is measured. An apparatus for performing the method is also provided.

Abstract: A chip arrangement (1) has a substrate board (2) with an opening (3), into which a carrier chip (4) is inserted, which has an electrical or electronic structural component (5). At least one conductor path (7) is integrated into the carrier chip (4), which connects the structural component (5) to the electrical connection contact (8). The carrier chip (4) is inserted into the opening (3) in such a way that its ends project beyond the opposite-facing, flat-sided surfaces (9, 9′) of the substrate board (2), and thereby form overhangs (10, 10′). Here, the structural component is arranged on the overhang (10) projecting beyond the one surface (9), and the connection contact (8) is arranged on the overhang (10′) projecting beyond the other surface (9′), and the conductor path (7) connecting the structural component (5) and the connection contact (8) passes through the opening (3). A seal is arranged between the substrate board (2) and the carrier chip (4).

Abstract: A measuring device (1) for measuring or investigating physiological parameters using biological cells or chemical and biologically active substances contained in an analyte (2). The measuring device comprises a sensor (4) with an electronic measurement structure (6) located on a substrate (5). Function-specific receptor cells and/or target cells (7) form part of the sensor (4) and are in direct contact with the measurement structure (6). For measurement, the medium under investigation can be brought into contact with the target cells or receptor cells (7). The measuring device (1) is especially compact in its design and facilitates largely feedback-free investigation of biological or chemical components contained in the analyte.

Abstract: An apparatus (1) for measuring physiological parameters has a test chamber (2) having boundaries defined by a first semiconductor chip (3) and a second semiconductor chip (4), between which chips a seal (7) bordering the test chamber (2) is arranged as a distance spacer. The first semiconductor chip (3) has an active side, which faces the test chamber (2) and has planar sensors, on which biological cells (6) located in a nutrient medium can be adherently deposited in order to measure physiological parameters directly on the cells (6). The second semiconductor chip (4) has on an active side, facing the test chamber (2), at least one additional sensor to measure global physiological parameters. The semiconductor chips (3, 4) are held in the sealing position using a mounting (8) that grasps over them on the outer side. Outside of the test chamber (2) the semiconductor chips (3, 4) each have electric connection contacts, which contact with opposing contacts of the mounting.

Abstract: A device (1) functions for treating malignant, tumorous tissue areas. The device has at least one measuring sensor for determining chemical or physical signal patterns in the immediate vicinity of the tumor cells or similar tissue part, a control unit and at least one treatment assembly, which has as an active agent release element for chemically influencing and/or treatment electrodes for physically influencing the tumorous tissue area to be treated. The sensor(s), the active agent release element, and the treatment electrodes are connected to the control unit for a physical and/or chemical treatment of the tumorous tissue area, controlled as a function of the measured values of the tumor cells. The device is constructed in the form of a swallowable capsule or dragée, and a sensor is provided for detecting release parameters. The control unit is designed with a threshold value switch for activating the active agent release element and/or the electrodes when a predetermined target value is exceeded.

Abstract: A measuring device for measuring or examining physiological parameters on biocomponents includes an FET sensor 5 whose electrical protective layer 12 is roughened or has a structured coating 15. The structuring of the active sensor contact surface 12 is adapted to the outer contour and topography of the biocomponent in question, so that a better possibility is available for anchoring the biocomponents to the contact surface 24 forming the FET protective layer of the sensor 5.

Abstract: A measuring apparatus (1) for measuring physiological and/or chemical and/or physical properties of at least one living cell (3) contains, in addition to further sensors (4.1, 4.2), a plurality of optical sensors (4) on a support (2), particularly a support made of semiconductor material. By means of a controller (6) and a switching facility (8) which are integrated on the same support (2), the individual optical sensors (4) and the further sensors (4.1, 4.2) can be selectively interrogated. An external signal-analyzing facility (7) with a screen represents a sort of near-field microscope.

Abstract: A measuring device for measuring or examining physiological parameters on biocomponents includes an FET sensor 5 whose electrical protective layer 12 is roughened or has a structured coating 15. The structuring of the active sensor contact surface 12 is adapted to the outer contour and topography of the biocomponent in question, so that a better possibility is available for anchoring the biocomponents to the contact surface 24 forming the FET protective layer of the sensor 5.

Abstract: A specimen slide (1) for a microscope, camera or other such observation device has a receiving area (2) for cell or tissue samples or other such organic material and a smaller observation area (3) for the organic material. The specimen slide (1) at least in the observation area is made of transparent material. Within the receiving area (2) the specimen slide (1) is provided with thin-film sensors (6 to 12) adjacent to the observation area (3) for measuring physiological parameters of the organic material. The chemical and physical characteristics of the organic material under observation can be picked up by the sensors while it is observed, for example under a microscope. Sensors of differing types can be provided, such as interdigital capacitors (6), NO sensors (8), O.sub.2 sensors (9) or temperature sensors (11), thereby making available important physiological measurement and/or control parameters.

Abstract: A virtual reality system permanently connected with a device to be worn by a user is disclosed which has an optical position-sensing facility that contains at least one radiation source defining a fixed reference point in space and an optical receiving system permanently connected with the device. The optical receiving system includes three radiation detectors, whose optical axes are parallel to each other. The first radiation detector has a reception pattern which shows a rising/falling sensitivity characteristic in a first angular range. The second radiation detector has a reception pattern which shows a rising/falling sensitivity characteristic in a second angular range. The third radiation detector has a reception pattern which shows a slowly varying sensitivity characteristic within at least the first and second angular ranges.