Patents by Inventor Ulrich von Andrian
Ulrich von Andrian has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20200215179Abstract: Provided herein are new compositions including an inactivated pathogen and one or more adjuvant-loaded polymeric nanoparticles, wherein the adjuvant-loaded nanoparticles are bound to the inactivated pathogen. These compositions are useful for preventing and/or treating diseases caused by the specific pathogens, especially when administered to a subject's mucosal membranes.Type: ApplicationFiled: November 11, 2019Publication date: July 9, 2020Inventors: Georg Stary, Aleksandar Filip Radovic-Moreno, Pamela A. Basto, Michael N. Starnbach, Robert S. Langer, Omid C. Farokhzad, Ulrich Von Andrian
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Publication number: 20200206145Abstract: This invention relates to amphiphile-polymer particles, compositions, methods of making, and methods of use thereof.Type: ApplicationFiled: March 9, 2020Publication date: July 2, 2020Inventors: Jinjun Shi, Xi Zhu, Omid C. Farokhzad, Xiaoding Xu, Yanlan Liu, Aude Thiriot, Ulrich Von Andrian
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Patent number: 10583091Abstract: This invention relates to amphiphile-polymer particles comprising obtaining a first solution comprising a water-insoluble polymer, a payload and a first amphiphile in a water-miscible solvent; mixing the first solution with an aqueous second solution to form an aqueous composition comprising a particle comprising a water-insoluble polymeric core comprising the water-insoluble polymer; the payload; and the first amphiphile.Type: GrantFiled: October 23, 2015Date of Patent: March 10, 2020Assignees: The Brigham and Women's Hospital, Inc., President and Fellows of Harvard CollegeInventors: Jinjun Shi, Xi Zhu, Omid C. Farokhzad, Xiaoding Xu, Yanlan Liu, Aude Thiriot, Ulrich Von Andrian
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Patent number: 10485861Abstract: Provided herein are new compositions including an inactivated pathogen and one or more adjuvant-loaded polymeric nanoparticles, wherein the adjuvant-loaded nanoparticles are bound to the inactivated pathogen. These compositions are useful for preventing and/or treating diseases caused by the specific pathogens, especially when administered to a subject's mucosal membranes.Type: GrantFiled: March 14, 2014Date of Patent: November 26, 2019Assignees: President and Fellows of Harvard College, Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.Inventors: Georg Stary, Aleksandar Filip Radovic-Moreno, Pamela A. Basto, Michael N. Starnbach, Robert S. Langer, Omid C. Farokhzad, Ulrich Von Andrian
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Patent number: 10272050Abstract: This disclosure relates to nanoparticles, compositions, methods of making, and methods of use thereof.Type: GrantFiled: October 14, 2015Date of Patent: April 30, 2019Assignees: The Brigham and Women's Hospital, Inc., President and Fellows of Harvard CollegeInventors: Omid C. Farokhzad, Won Il Choi, Ulrich von Andrian, Nazila Kamaly
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Publication number: 20180142017Abstract: Provided herein are methods for reducing corneal inflammation, reducing inflammatory cell (e.g., dendritic cell) recruitment to the cornea, and treating an corneal inflammatory disorder in a subject that include administering to the subject one or more of a MadCAM-1 antagonist, an ?4?7 integrin antagonist, a L-selectin antagonist, and an E-selectin antagonist. Also provided are compositions containing one or more of a MadCAM-1 antagonist, an ?4?7 integrin antagonist, a L-selectin antagonist, and an E-selectin antagonist, and kits containing these compositions.Type: ApplicationFiled: August 4, 2017Publication date: May 24, 2018Inventors: Pedram Hamrah, Ulrich von Andrian, Aslihan Turhan
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Patent number: 9872905Abstract: The instant invention is based, at least in part, on the discovery that CXCR6 plays a critical role in antigen-specific effector function of NK cells. Accordingly, the invention provides, among other things, methods for modulation of antigen-specific NK cell effector function, methods for identifying modulators of antigen-specific NK cell effector function.Type: GrantFiled: December 1, 2010Date of Patent: January 23, 2018Assignee: President and Fellows of Harvard CollegeInventors: Ulrich Von Andrian, Silke Paust
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Publication number: 20170304213Abstract: This invention relates to amphiphile-polymer particles comprising obtaining a first solution comprising a water-insoluble polymer, a payload and a first amphiphile in a water-miscible solvent; mixing the first solution with an aqueous second solution to form an aqueous composition comprising a particle comprising a water-insoluble polymeric core comprising the water-insoluble polymer; the payload; and the first amphiphile.Type: ApplicationFiled: October 23, 2015Publication date: October 26, 2017Inventors: Jinjun Shi, Xi Zhu, Omid C. Farokhzad, Xiaoding Xu, Yanlan Liu, Aude Thiriot, Ulrich Von Andrian
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Publication number: 20170216218Abstract: This disclosure relates to nanoparticles, compositions, methods of making, and methods of use thereof.Type: ApplicationFiled: October 14, 2015Publication date: August 3, 2017Inventors: Omid C. Farokhzad, Won Il Choi, Ulrich von Andrian, Nazila Kamaly
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Patent number: 9439859Abstract: The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface and an immunostimulatory moiety. In some embodiments, the immunostimulatory moiety is adjuvant. The invention provides pharmaceutical compositions comprising inventive nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive nanocarriers and pharmaceutical compositions thereof.Type: GrantFiled: November 19, 2013Date of Patent: September 13, 2016Assignees: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc., Presidents and Fellows of Harvard CollegeInventors: Frank Alexis, Matteo Iannacone, Jinjun Shi, Pamela Basto, Elliott Ashley Moseman, Ulrich von Andrian, Robert S. Langer, Omid C. Farokhzad, Elena Tonti
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Publication number: 20160008451Abstract: Provided herein are new compositions including an inactivated pathogen and one or more adjuvant-loaded polymeric nanoparticles, wherein the adjuvant-loaded nanoparticles are bound to the inactivated pathogen. These compositions are useful for preventing and/or treating diseases caused by the specific pathogens, especially when administered to a subject's mucosal membranes.Type: ApplicationFiled: March 14, 2014Publication date: January 14, 2016Inventors: Georg STARY, Aleksandar Filip RADOVIC-MORENO, Pamela A. BASTO, Michael N. STARNBACH, Robert S. LANGER, Omid C. FAROKHZAD, Ulrich Von ANDRIAN
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Patent number: 9233072Abstract: The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface and an immunostimulatory moiety. In some embodiments, the immunostimulatory moiety is an adjuvant. The invention provides pharmaceutical compositions comprising inventive nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive nanocarriers and pharmaceutical compositions thereof.Type: GrantFiled: October 12, 2012Date of Patent: January 12, 2016Assignees: Massachusetts Institute of Technology, The Brigham and Women's Hosptial, Inc., President and Fellows of Harvard CollegeInventors: Frank Alexis, Matteo Iannacone, Jinjun Shi, Pamela Basto, Elliott Ashley Moseman, Ulrich von Andrian, Robert S. Langer, Omid C. Farokhzad, Elena Tonti
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Patent number: 8932595Abstract: The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface having a plurality of nicotine moieties. The invention provides pharmaceutical compositions comprising nanocarriers. The present invention provides methods of designing, manufacturing, and using nanocarriers and pharmaceutical compositions thereof. For example, the present invention describes nanocarriers capable of eliciting an immune response and the production of anti-nicotine antibodies.Type: GrantFiled: October 9, 2009Date of Patent: January 13, 2015Assignees: Massachusetts Institute of Technology, President and Fellows of Harvard College, The Brigham and Women's Hospital, Inc.Inventors: Matteo Iannacone, Ulrich von Andrian, Omid C. Farokhzad, Frank Alexis, Pamela Basto, Jinjun Shi, Elliott Ashley Moseman, Robert S. Langer, Elena Tonti
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Publication number: 20150010563Abstract: Provided herein are methods for reducing corneal inflammation, reducing inflammatory cell (e.g., dendritic cell) recruitment to the cornea, and treating an corneal inflammatory disorder in a subject that include administering to the subject one or more of a MadC AM-1 antagonist, an ?4?7 integrin antagonist, a L-selectin antagonist, and an E-selectin antagonist. Also provided are compositions containing one or more of a MadC AM-1 antagonist, an ?4?7 integrin antagonist, a L-selectin antagonist, and an E-selectin antagonist, and kits containing these compositions.Type: ApplicationFiled: February 21, 2013Publication date: January 8, 2015Applicant: Massachusetts Eye & Ear InfirmaryInventors: Pedram Hamrah, Ulrich von Andrian, Aslihan Turhan
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Patent number: 8906381Abstract: The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides synthetic nanocarriers capable of eliciting an immune system response in the form of antibody production, wherein the nanocarriers lack any T cell antigens. In some embodiments, the invention provides nanocarriers that comprise an immunofeature surface, which provides high avidity binding of the nanocarriers to antigen presenting cells. The invention provides pharmaceutical compositions comprising such nanocarriers. The present invention provides methods of designing, manufacturing, and using such nanocarriers and pharmaceutical compositions thereof.Type: GrantFiled: October 9, 2009Date of Patent: December 9, 2014Assignees: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc., President and Fellows of Harvard CollegeInventors: Matteo Iannacone, Frank Alexis, Pamela Basto, Elliott Ashley Moseman, Jinjun Shi, Robert S. Langer, Omid C. Farokhzad, Ulrich von Andrian, Elena Tonti
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Publication number: 20140127301Abstract: The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface and an immunostimulatory moiety. In some embodiments, the immunostimulatory moiety is adjuvant. The invention provides pharmaceutical compositions comprising inventive nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive nanocarriers and pharmaceutical compositions thereof.Type: ApplicationFiled: November 19, 2013Publication date: May 8, 2014Applicants: Massachusetts Institute of Technology, President and Fellows of Harvard College, The Brigham and Women's Hospital, Inc.Inventors: Frank Alexis, Matteo Iannacone, Jinjun Shi, Pamela Basto, Elliott Ashley Moseman, Ulrich von Andrian, Robert S. Langer, Omid C. Farokhzad, Elena Tonti
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Patent number: 8637028Abstract: The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface and an immunostimulatory moiety. In some embodiments, the immunostimulatory moiety is an adjuvant. The invention provides pharmaceutical compositions comprising inventive nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive nanocarriers and pharmaceutical compositions thereof.Type: GrantFiled: October 9, 2009Date of Patent: January 28, 2014Assignees: President and Fellows of Harvard College, Massachusetts Institute of Technology, The Brigham and Women's HospitalInventors: Frank Alexis, Matteo Iannacone, Jinjun Shi, Pamela Basto, Elliott Ashley Moseman, Ulrich von Andrian, Robert S. Langer, Omid C. Farokhzad, Elena Tonti
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Patent number: 8591905Abstract: The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface having a plurality of nicotine moieties. The invention provides pharmaceutical compositions comprising inventive nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive nanocarriers and pharmaceutical compositions thereof. For example, the present invention nanocarriers capable of eliciting an immune response and the production of anti-nicotine antibodies.Type: GrantFiled: April 22, 2009Date of Patent: November 26, 2013Assignees: The Brigham and Women's Hospital, Inc., President and Fellows of Harvard College, Massachusetts Institute of TechnologyInventors: Ulrich von Andrian, Omid C. Farokhzad, Frank Alexis, Matteo Iannacone, Pamela Basto, Jinjun Shi, Elliott Ashley Moseman, Robert S. Langer, Elena Tonti
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Patent number: 8562998Abstract: The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface. The nanocarriers are capable of targeting antigen presenting cells when administered to a subject. The invention provides pharmaceutical compositions comprising nanocarriers. The present invention provides methods of designing, manufacturing, and using nanocarriers and pharmaceutical compositions thereof.Type: GrantFiled: October 9, 2009Date of Patent: October 22, 2013Assignees: President and Fellows of Harvard College, Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.Inventors: Jinjun Shi, Frank Alexis, Matteo Iannacone, Elliott Ashley Moseman, Pamela Basto, Robert S. Langer, Omid C. Farokhzad, Ulrich von Andrian, Elena Tonti
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Publication number: 20130195919Abstract: The invention provides, for example, compositions comprising induced tolerogenic dendritic cells which are capable of suppressing an antigen specific T cell-mediated immune response, and to methods of making and using the same. The invention also provides compositions comprising induced immunogenic dendritic cells and methods of making and using them.Type: ApplicationFiled: March 7, 2011Publication date: August 1, 2013Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Ulrich Von Andrian, Roberto Maldonado, Fulvia Vascotto