Abstract: The invention relates to a drug comprising at least one insulin and at least one GLP-1 receptor agonist.

Abstract: A lift system for a rotor blade of a wind turbine includes a lifting device having a structural frame body having a root end and a tip end. The root end supports a root cradle and the tip end supports a tip cradle. The root and tip cradles each have a profile that corresponds to at least one exterior surface of the rotor blade so as to receive and support at least a portion of the rotor blade. Due to a shape of the rotor blade, when the rotor blade is installed in the lifting device and lifted uptower, the rotor blade can experience an asymmetric loading. Accordingly, the lift system also includes a variable airflow assembly coupled to tip end of the lifting device. The variable airflow assembly includes at least one surface moveable between a plurality of positions having varying resistances so as to counteract the asymmetric loading.

Abstract: A machine assembly includes a load machine secured to a frame construction. An electrical machine is coupled to the load machine and drives the load machine. The electrical machine is secured to the frame construction via multiple intermediate elements. Frame-side main parts of the intermediate elements are secured to the frame construction and machine-side main parts of the intermediate elements are secured to the electric machine. Spring assemblies are respectively arranged between the machine-side main parts and the frame-side main parts for transferring a weight force of the electric machine from the machine-side main parts to the frame-side main parts.

Abstract: A method and system are provided for cooling a heat-exchanger in a wind turbine that has an electric generator with a cooling air flow directed therethrough. Effluent cooling air flow from the electric generator is directed into an air ejector pump and acts as motive air through the air ejector pump. Cold air is drawn into the air ejector pump by the vacuum generated by the motive air moving through the air ejector pump. The heat exchanger is disposed in-line with the cold air flow so that the cold air is drawn through the heat-exchanger, removes heat from the fluid circulated through the heat-exchanger, and becomes heated air that is combined with the motive air and discharged from the nacelle.

Abstract: A method and system are provided for cooling a heat-exchanger in a wind turbine that has an electric generator with a cooling air flow directed therethrough. Effluent cooling air flow from the electric generator is directed into an air ejector pump and acts as motive air through the air ejector pump. Cold air is drawn into the air ejector pump by the vacuum generated by the motive air moving through the air ejector pump. The heat exchanger is disposed in-line with the cold air flow so that the cold air is drawn through the heat-exchanger, removes heat from the fluid circulated through the heat-exchanger, and becomes heated air that is combined with the motive air and discharged from the nacelle.

Abstract: The present invention relates to a conjugate comprising a sulfonamide of formula (I) and an active pharmaceutical ingredient such as an insulin analog comprising at least one mutation relative to the parent insulin, wherein the insulin analog comprises a mutation at position B16 which is substituted with a hydrophobic amino acid and/or a mutation at position B25 which is substituted with a hydrophobic amino acid. The present invention further relates to a sulfonamide of formula (A). Moreover, the present invention relates to an insulin analog comprising at least one mutation relative to the parent insulin.

Abstract: A lift system for a rotor blade of a wind turbine includes a lifting device having a structural frame body having a root end and a tip end. The root end supports a root cradle and the tip end supports a tip cradle. The root and tip cradles each have a profile that corresponds to at least one exterior surface of the rotor blade so as to receive and support at least a portion of the rotor blade. Due to a shape of the rotor blade, when the rotor blade is installed in the lifting device and lifted uptower, the rotor blade can experience an asymmetric loading. Accordingly, the lift system also includes a variable airflow assembly coupled to tip end of the lifting device. The variable airflow assembly includes at least one surface moveable between a plurality of positions having varying resistances so as to counteract the asymmetric loading.

Abstract: The invention relates to a drug comprising at least one insulin and at least one GLP-1 receptor agonist.

Abstract: The invention describes novel conjugates of formula (I) of a pharmaceutical agent and a moiety capable of binding to a glucose sensing protein allowing a reversible release of the pharmaceutical agent depending on the glucose concentration.

Abstract: The invention describes novel conjugates of formula (I) of a pharmaceutical agent and a moiety capable of binding to a glucose sensing protein allowing a reversible release of the pharmaceutical agent depending on the glucose concentration.

Abstract: The application relates to an aqueous pharmaceutical formulation comprising 200-1000 U/mL [equimolar to 200-1000 IU human insulin] of insulin glargine.

Abstract: The present invention relates to a conjugate comprising a sulfonamide of formula (I) and an active pharmaceutical ingredient such as an insulin analog comprising at least one mutation relative to the parent insulin, wherein the insulin analog comprises a mutation at position B16 which is substituted with a hydrophobic amino acid and/or a mutation at position B25 which is substituted with a hydrophobic amino acid. The present invention further relates to a sulfonamide of formula (A). Moreover, the present invention relates to an insulin analog comprising at least one mutation relative to the parent insulin.

Abstract: The invention describes novel conjugates of formula (I) of a pharmaceutical agent and a moiety capable of binding to a glucose sensing protein allowing a reversible release of the pharmaceutical agent depending on the glucose concentration.

Abstract: The invention relates to an electrical machine (1) comprising a rotor (4) which is rotatably mounted around a rotation axis (5) extending in the axial direction (3) in bearing devices (16, 17), a stator (7) having two axial ends, an air gap between rotor and stator, an interior chamber (10) encompassing the stator (7) and rotor (4), a sleeve (11) encompassing a first part (111) which encloses the interior chamber (10), a frame (12) having a first (123) and a second (121) longitudinal support (123), a first (122) and a second (124) cross-support, and a dividing device (2) on the frame (12). The stator (7) comprises a fastening device (15) for connection to the frame (12) and the dividing device (2) can make the interior chamber accessible from the outside in a plane parallel to the frame (12). The invention further relates to a collection, to a frame (12), to a sleeve (11), or to a service or production method of such an electrical machine (1).

Abstract: A rotor turning device for balancing a rotor secured atop a tower of a wind turbine during installation and/or repair of one or more rotor blades of the wind turbine includes a hydraulic drive mechanism for operably engaging with a brake disc of the wind turbine. The brake disc is positioned adjacent to a gearbox of the wind turbine. The rotor turning device also includes a mounting device for securing the rotor turning device adjacent to the brake disc of the wind turbine. Thus, when the hydraulic drive mechanism engages the brake disc, the rotor is rotated to a desired position so as to position one or more rotor blades of the wind turbine in a balanced configuration.

Abstract: A system for enabling servicing of a rotor of a wind turbine has a rotor blade sling with at least one strap configured to be placed over the top of a rotor blade in a ten o'clock position or a two o'clock position. One or more rigid bars extend from the hub and out away from the hub, and the one or more rigid bars are coupled to the at least one strap. One or more support straps are coupled to the at least one strap, and the one or more support straps are configured to couple and support a rotor blade in a six o'clock position.

Abstract: The application relates to an aqueous pharmaceutical formulation comprising 200-1000 U/mL [equimolar to 200-1000 IU human insulin] of insulin glargine.

Abstract: A counterweight system for mounting a rotor blade on a balanced rotatable hub of a wind turbine is disclosed. The rotatable hub can have at least one blade root region configured to receive a blade root of the rotor blade, and also have a pitch system configured to rotate the rotor blade around a pitch axis. The counterweight system can have at least one support structure having a proximal end spaced apart from a distal end with the proximal end mountable to at least one blade root region of the rotatable hub. The at least one counterweight mass can be at least partially filled with fluid and coupled to the distal end of the at least one support structure. The at least one support structure can be arranged substantially parallel to the pitch axis such that the pitch system rotates the counterweight mass about the pitch axis.

Abstract: The present disclosure is directed to systems and methods for manufacturing a wind turbine rotor blade that can be easily lifted and lowered to and from a rotor installed atop a tower. The method includes providing a plurality of root inserts for a blade root of the blade and securing at least one cylindrical member to one of the root inserts such that the cylindrical member is substantially perpendicular with the root insert. The method also includes arranging the root inserts in a blade mold of the blade and forming a blade shell with the plurality of root inserts laminated therein. The method may further include securing at least one attachment component within each of the cylindrical members so as to provide an attachment location for a pulley cable used to lift and lower the rotor blade to and from the rotor installed atop the tower.

Abstract: A rotor turning device for balancing a rotor secured atop a tower of a wind turbine during installation and/or repair of one or more rotor blades of the wind turbine includes a hydraulic drive mechanism for operably engaging with a brake disc of the wind turbine. The brake disc is positioned adjacent to a gearbox of the wind turbine. The rotor turning device also includes a mounting device for securing the rotor turning device adjacent to the brake disc of the wind turbine. Thus, when the hydraulic drive mechanism engages the brake disc, the rotor is rotated to a desired position so as to position one or more rotor blades of the wind turbine in a balanced configuration.