Abstract: The application relates to an aqueous pharmaceutical formulation comprising 200-1000 U/mL [equimolar to 200-1000 IU human insulin] of insulin glargine.

Abstract: The present invention relates to a conjugate comprising a sulfonamide of formula (I) and an active pharmaceutical ingredient such as an insulin analog comprising at least one mutation relative to the parent insulin, wherein the insulin analog comprises a mutation at position B16 which is substituted with a hydrophobic amino acid and/or a mutation at position B25 which is substituted with a hydrophobic amino acid. The present invention further relates to a sulfonamide of formula (A). Moreover, the present invention relates to an insulin analog comprising at least one mutation relative to the parent insulin.

Abstract: A method for detaching or installing a rotor blade from or to a hub of a wind turbine includes positioning the rotor blade toward a ground location between a three o'clock position and a nine o'clock position. The method also includes mounting a mechanical arm to an uptower location of the wind turbine. Further, the mechanical arm includes a torqueing tool at a distal end thereof. Thus, the method also includes removing or installing, via the torqueing tool, each of the plurality of hub fasteners so as to detach or attach the rotor blade from or to the hub.

Abstract: A method for installing a plurality of rotor blades to a rotatable hub secured atop a tower of a wind turbine includes providing a counterweight assembly having, at least, an arm member and a counterweight mass secured at a distal end of the mounting assembly. The method also includes securing the arm member of the counterweight assembly to the hub of the wind turbine. Further, the method includes consecutively installing the plurality of rotor blades onto the hub of the wind turbine. Moreover, the method includes rotating the arm member about a rotation axis of the hub to continuously adjust a position of the counterweight mass between each consecutive installation of the plurality of rotor blades to change a center of gravity of the hub and maintain a balanced rotor of the wind turbine during installation of the plurality of rotor blades.

Abstract: The present disclosure is directed to a fastener retention assembly for a wind turbine rotor. The fastener retention assembly includes a rotor hub and a pitch bearing race coupled to the rotor hub. One of the pitch bearing race or the rotor hub defines an annular slot. The pitch bearing race and the rotor hub further defines a plurality of passages extending from the slot through the pitch bearing race and the rotor hub. The fastener retention assembly also includes a plurality of fasteners coupling the rotor hub and the pitch bearing race. Each of the plurality of fasteners is at least partially positioned within the slot and one of the plurality of passages. The fastener retention assembly further includes a retaining ring partially positioned within the slot to retain the plurality of fasteners within the plurality of passages.

Abstract: The application relates to an aqueous pharmaceutical formulation comprising 200-1000 U/mL [equimolar to 200-1000 IU human insulin] of insulin glargine.

Abstract: A base unit for use in forming a molecular model has a polyhedral body having a first set of faces defining a plurality of first attachment surfaces, and a second set of faces defining a plurality of second attachment surfaces. A first set of the plurality of second attachment surfaces has a North magnetic polarity, and a second set of the plurality of second attachment surfaces has a South magnetic polarity. The base unit is magnetically coupleable to another base unit in a first configuration in which rotation of the base unit relative to the another unit is inhibited, and in a second configuration in which rotation of the base unit relative to the another unit is not inhibited.

Abstract: A method for removing a rotor blade from a wind turbine may generally include installing a blade sock around an outer perimeter of the rotor blade, coupling a support cable to the blade root, lowering the rotor blade relative to the hub using the support cable, coupling at least one pulley cable between the rotor blade and a winch using at least one pulley, moving the pulley cable relative to the pulley to lower the rotor blade relative to the hub, applying a force through the blade sock as the pulley cable is moved relative to the pulley in order to control an orientation of the rotor blade and further lowering the rotor blade to a location on or adjacent to the support surface.

Abstract: The invention describes novel conjugates of formula (I) of a pharmaceutical agent and a moiety capable of binding to a glucose sensing protein allowing a reversible release of the pharmaceutical agent depending on the glucose concentration.

Abstract: The invention relates to a drug comprising at least one insulin and at least one GLP-1 receptor agonist.

Abstract: A counterweight system for mounting a rotor blade on a balanced rotatable hub of a wind turbine is disclosed. The rotatable hub can have at least one blade root region configured to receive a blade root of the rotor blade, and also have a pitch system configured to rotate the rotor blade around a pitch axis. The counterweight system can have at least one support structure having a proximal end spaced apart from a distal end with the proximal end mountable to at least one blade root region of the rotatable hub. The at least one counterweight mass can be at least partially filled with fluid and coupled to the distal end of the at least one support structure. The at least one support structure can be arranged substantially parallel to the pitch axis such that the pitch system rotates the counterweight mass about the pitch axis.

Abstract: The present disclosure is directed to a fastener retention assembly for a wind turbine rotor. The fastener retention assembly includes a rotor hub and a pitch bearing race coupled to the rotor hub. One of the pitch bearing race or the rotor hub defines an annular slot. The pitch bearing race and the rotor hub further defines a plurality of passages extending from the slot through the pitch bearing race and the rotor hub. The fastener retention assembly also includes a plurality of fasteners coupling the rotor hub and the pitch bearing race. Each of the plurality of fasteners is at least partially positioned within the slot and one of the plurality of passages. The fastener retention assembly further includes a retaining ring partially positioned within the slot to retain the plurality of fasteners within the plurality of passages.

Abstract: The application relates to an aqueous pharmaceutical formulation comprising 200-1000 U/mL [equimolar to 200-1000 IU human insulin] of insulin glargine.

Abstract: A method for detaching or installing a rotor blade from or to a hub of a wind turbine includes positioning the rotor blade toward a ground location between a three o'clock position and a nine o'clock position. The method also includes mounting a mechanical arm to an uptower location of the wind turbine. Further, the mechanical arm includes a torqueing tool at a distal end thereof. Thus, the method also includes removing or installing, via the torqueing tool, each of the plurality of hub fasteners so as to detach or attach the rotor blade from or to the hub.

Abstract: The present disclosure is directed to systems and methods for manufacturing a wind turbine rotor blade that can be easily lifted and lowered to and from a rotor installed atop a tower. The method includes providing a plurality of root inserts for a blade root of the blade and securing at least one cylindrical member to one of the root inserts such that the cylindrical member is substantially perpendicular with the root insert. The method also includes arranging the root inserts in a blade mold of the blade and forming a blade shell with the plurality of root inserts laminated therein. The method may further include securing at least one attachment component within each of the cylindrical members so as to provide an attachment location for a pulley cable used to lift and lower the rotor blade to and from the rotor installed atop the tower.

Abstract: The invention relates to a drug comprising at least one insulin and at least one GLP-1 receptor agonist.

Abstract: In one aspect, a method for installing a blade sock onto a rotor blade of a wind turbine may generally include positioning the blade sock adjacent to a blade tip of the rotor blade, wherein the blade sock comprises a sock strap forming a closed-shape. In addition, the method may include moving the blade sock relative to the rotor blade such that the blade tip is received within the closed-shape formed by the sock strap and moving the blade sock spanwise along the rotor blade towards a blade root of the rotor blade until the blade sock is positioned at an intermediate location defined between the blade root and the blade tip, wherein the sock strap is configured to fit tightly around an outer perimeter of the rotor blade at the intermediate location.

Abstract: A wye ring centering system is provided. The system includes a plurality of rollers configured for contacting a wye ring, and a plurality of mounting fasteners configured for supporting the plurality of rollers. Each of the mounting fasteners is configured to pass through a fan hub. The plurality of rollers and the plurality of mounting fasteners are distributed at substantially equal intervals around the fan hub. The wye ring is placed over the plurality of rollers to center the wye ring around a shaft.

Abstract: The present disclosure is directed to systems and methods for manufacturing a wind turbine rotor blade that can be easily lifted and lowered to and from a rotor installed atop a tower. The method includes providing a plurality of root inserts for a blade root of the blade and securing at least one cylindrical member to one of the root inserts such that the cylindrical member is substantially perpendicular with the root insert. The method also includes arranging the root inserts in a blade mold of the blade and forming a blade shell with the plurality of root inserts laminated therein. The method may further include securing at least one attachment component within each of the cylindrical members so as to provide an attachment location for a pulley cable used to lift and lower the rotor blade to and from the rotor installed atop the tower.

Abstract: A method for repairing or servicing a wye ring of a generator includes the steps of, dismantling the generator to gain access to the wye ring, determining a fault location in the wye ring; and attaching a patch to the wye ring in an area of the fault location. The patch provides an electrical path around the fault location so that the generator is repaired.