Patents by Inventor Ulrich Werner

Ulrich Werner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMBINATION OF AN INSULIN AND A GLP-1-AGONIST
    Publication number: 20120021978
    Abstract: The invention relates to a drug comprising at least one insulin and at least one GLP-1 receptor agonist.
    Type: Application
    Filed: October 9, 2009
    Publication date: January 26, 2012
    Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Ulrich Werner, Barbel Rotthauser, Christopher James Smith
  • LONG-ACTING FORMULATIONS OF INSULINS
    Publication number: 20110301081
    Abstract: The application relates to an aqueous pharmaceutical formulation comprising 200-1000 U/mL [equimolar to 200-1000 IU human insulin] of insulin glargine.
    Type: Application
    Filed: May 18, 2011
    Publication date: December 8, 2011
    Applicant: SANOFI
    Inventors: Reinhard Becker, Annke Frick, Peter Boderke, Christiane Fürst, Werner Müller, Katrin Tertsch, Ulrich Werner, Petra Loos, Isabell Schöttle
  • Amino-substituted 8-N-benzimidazoles and methods for their use in blood sugar disorders
    Patent number: 8003668
    Abstract: The present invention comprises the use of amino-substituted 8-N-benzimidazoles compounds of formula I wherein R3, R4-R5, R11 and R20-R21 are hereinafter defined which display a therapeutically utilizable blood sugar-lowering action. These compounds are intended to be particularly suitable in the treatment of diabetes.
    Type: Grant
    Filed: September 14, 2007
    Date of Patent: August 23, 2011
    Assignee: Sanofi-Aventis
    Inventors: Elisabeth Defossa, Karl Schoenafinger, Gerhard Jaehne, Christian Buning, Georg Tschank, Ulrich Werner
  • NOVEL INSULIN DERIVATIVES HAVING AN EXTREMELY DELAYED TIME-ACTION PROFILE
    Publication number: 20110173722
    Abstract: The invention relates to novel insulin analogs having a basal time-action profile, which are characterized by the addition and/or substitution of negatively and positively charged amino acid residues and by an amidation of the C-terminal carboxy group of the B chain and histidine in position 8 of the insulin A chain. The invention also relates to the production and use thereof.
    Type: Application
    Filed: June 22, 2010
    Publication date: July 14, 2011
    Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Paul HABERMANN, Gerhard SEIPKE, Roland KURRLE, Gunter MULLER, Mark SOMMERFELD, Norbert TENNAGELS, Georg TSCHANK, Ulrich WERNER
  • NOVEL INSULIN DERIVATIVES HAVING AN EXTREMELY DELAYED TIME-ACTION PROFILE
    Publication number: 20110077197
    Abstract: The invention relates to novel insulin analogs having a basal time-action profile, which are characterized by the following features: a) the B chain end consists of an amidated basic amino acid residue such as lysine or arginine amide; b) the N-terminal amino acid residue of the insulin A chain is a lysine or arginine radical; c) the amino acid position A8 is occupied by a histidine radical; d) the amino acid position A21 is occupied by a glycine radical; and e) one or more substitutions and/or additions of negatively charged amino acid residues are carried out in the positions A5, A15, A18, B-1, B0, B1, B2, B3 and B4.
    Type: Application
    Filed: June 22, 2010
    Publication date: March 31, 2011
    Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Paul HABERMANN, Gerhard SEIPKE, Roland KURRLE, Gunter MULLER, Mark SOMMERFELD, Norbert TENNAGELS, Georg TSCHANK, Ulrich WERNER
  • Substituted, bicyclic 8-pyrrolidinoxanthines, and methods for their use as inhibitors of dipeptidyl peptidase
    Patent number: 7888343
    Abstract: The present invention involves substituted bicyclic 8-pyrrolidinoxanthines and their derivatives of formula I: wherein the various R groups are defined herein. The present invention also comprises pharmaceutical compositions comprising them as well as processes for the preparation of these compounds and methods for the treatment of metabolic disorders such as type-2 diabetes, insulin resistance, hyperglycemia, arteriosclerosis diseases and the like through the administration of said compositions.
    Type: Grant
    Filed: January 18, 2007
    Date of Patent: February 15, 2011
    Assignee: Sanofi-A Ventis Deutschland GmbH
    Inventors: Karl Schoenafinger, Gerhard Jaehne, Elisabeth Defossa, Lothar Schwink, Holger Wagner, Christian Buning, Georg Tschank, Ulrich Werner
  • Substituted 8-aminoalkoxy-xanthine compounds and compositions useful in the treatment of hyperlipidemia and diabetes
    Patent number: 7879864
    Abstract: Compounds for the treatment of elevated blood glucose levels and the physiological and metabolic disorders arising therefrom are disclosed which are inhibitors of the enzyme dipeptidyl peptidase IV (DDP-IV) and comprise novel substituted bicyclic 8-pyrrolidinoxanthines of formula I and their derivatives: wherein the various R-groups are defined herein. These compounds may be combined with other secondary active compounds which also are effective in the treatment of said disorders and the disease states or physiological manifestations arising therefrom.
    Type: Grant
    Filed: February 13, 2007
    Date of Patent: February 1, 2011
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Karl Schoenafinger, Gerhard Jaehne, Elisabeth Defossa, Christian Buning, Georg Tschank, Ulrich Werner
  • Substituted bicyclic 8-pyrrolidinoxanthines, methods for their production, pharmaceutical formulations and their use
    Patent number: 7838528
    Abstract: Compounds for the treatment of elevated blood glucose levels and the physiological and metabolic disorders arising therefrom are disclosed and comprise novel substituted bicyclic 8-pyrrolidinoxanthines and their derivatives of formula I: wherein the various R groups are hereinafter defined. The present invention also comprises pharmaceutical compositions comprising them as well as processes for the preparation of these compounds. Particular blood glucose disorders treatable thereby include type-2 diabetes, insulin resistance, hyperglycemia, arteriosclerotic diseases and the like.
    Type: Grant
    Filed: January 17, 2007
    Date of Patent: November 23, 2010
    Assignee: sanofi-aventis Deutschland GmbH
    Inventors: Karl Schoenafinger, Gerhard Jaehne, Elisabeth Defossa, Lothar Schwink, Holger Wagner, Christian Buning, Georg Tschank, Ulrich Werner
  • Substituted 2-aminoalkylthiobenzimidazole compounds, pharmaceutical compositions thereof and methods for their use
    Patent number: 7795445
    Abstract: The present invention comprises the substituted 2-aminoalkylthiobenzimidazoles of formula I wherein R1-R5 and R11-R16 are hereinafter defined. These compounds, their derivatives and the pharmaceutically acceptable salts thereof are useful in the reduction of elevated blood sugar levels and are therefore useful in the treatment of hyperglycemia, diabetes, atherosclerosis and other blood sugar disorders. These compounds are particularly suitable in the treatment of type-2 diabetes.
    Type: Grant
    Filed: September 14, 2007
    Date of Patent: September 14, 2010
    Assignee: sanofi-aventis
    Inventors: Elisabeth Defossa, Karl Schoenafinger, Gerhard Jaehne, Christian Buning, Georg Tschank, Ulrich Werner
  • Substituted, bicyclic 8-pyrrolidinobenzimidazoles, methods for their production and their use as medicaments
    Patent number: 7569700
    Abstract: The present invention relates to carboxamide derivative compounds of formula I in which R1-R6 and R12 are hereinafter defined and together comprise carboximide derivatives for the therapeutic treatment of diabetes, hyperglycemia, lipid and carbohydrate metabolism disorders, arteriosclerotic manifestations and disorders and other blood sugar related disorders through a metabolic blood sugar-lowering action.
    Type: Grant
    Filed: September 14, 2007
    Date of Patent: August 4, 2009
    Assignee: sanofi - aventis
    Inventors: Elisabeth Defossa, Karl Schoenafinger, Gerhard Jaehne, Christian Buning, Georg Tschank, Ulrich Werner
  • AMINOCARBONYL-SUBSTITUTED 8-N-BENZIMIDAZOLES, METHODS FOR THEIR PREPARATION AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS
    Publication number: 20080090869
    Abstract: The present invention comprises the use of amino-carbonyl-substituted 8-N-benzimidazoles compounds of formula I wherein R3, R4-R5, R11 and R20-R21 are hereinafter defined which display a therapeutically utilizable blood sugar-lowering action. These compounds are intended to be particularly suitable in the treatment of diabetes, carbohydrate and lipid metabolic disorders and other blood sugar complications.
    Type: Application
    Filed: September 14, 2007
    Publication date: April 17, 2008
    Applicant: SANOFI-AVENTIS
    Inventors: Elisabeth DEFOSSA, Karl SCHOENAFINGER, Gerhard JAEHNE, Christian BUNING, Georg TSCHANK, Ulrich WERNER
  • SUBSTITUTED, BICYCLIC 8-PYRROLIDINOBENZIMIDAZOLES, METHODS FOR THEIR PRODUCTION AND THEIR USE AS MEDICAMENTS
    Publication number: 20080090890
    Abstract: The present invention relates to carboxamide derivative compounds of formula I in which R1-R6 and R12 are hereinafter defined and together comprise carboximide derivatives for the therapeutic treatment of diabetes, hyperglycemia, lipid and carbohydrate metabolism disorders, arteriosclerotic manifestations and disorders and other blood sugar related disorders through a metabolic blood sugar-lowering action.
    Type: Application
    Filed: September 14, 2007
    Publication date: April 17, 2008
    Applicant: SANOFI-AVENTIS
    Inventors: Elisabeth DEFOSSA, Karl SCHOENAFINGER, Gerhard JAEHNE, Christian BUNING, Georg TSCHANK, Ulrich WERNER
  • AMIDE-SUBSTITUTED 8 N BENZIMIDAZOLES, METHOD FOR THE PRODUCTION THEREOF, AND USE OF THE SAME AS MEDICAMENTS
    Publication number: 20080090868
    Abstract: The present invention comprises the use of amino-substituted 8-N-benzimidazoles compounds of formula I wherein R3, R4-R5, R11 and R20-R21 are hereinafter defined which display a therapeutically utilizable blood sugar-lowering action. These compounds are intended to be particularly suitable in the treatment of diabetes.
    Type: Application
    Filed: September 13, 2007
    Publication date: April 17, 2008
    Applicant: SANOFI-AVENTIS
    Inventors: Elisabeth DEFOSSA, Karl SCHOENAFINGER, Gerhard JAEHNE, Christian BUNING, Georg TSCHANK, Ulrich WERNER
  • AMINO-SUBSTITUTED 8-N-BENZIMIDAZOLES AND METHODS FOR THEIR USE IN BLOOD SUGAR DISORDERS
    Publication number: 20080090870
    Abstract: The present invention comprises the use of amino-substituted 8-N-benzimidazoles compounds of formula I wherein R3, R4-R5, R11 and R20-R21 are hereinafter defined which display a therapeutically utilizable blood sugar-lowering action. These compounds are intended to be particularly suitable in the treatment of diabetes.
    Type: Application
    Filed: September 14, 2007
    Publication date: April 17, 2008
    Applicant: SANOFI-AVENTIS
    Inventors: Elisabeth DEFOSSA, Karl SCHOENAFINGER, Gerhard JAEHNE, Christian BUNING, Georg TSCHANK, Ulrich WERNER
  • SUBSTITUTED 2-AMINOALKYLTHIOBENZIMIDAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF AND METHODS FOR THEIR USE
    Publication number: 20080090889
    Abstract: The present invention comprises the substituted 2-aminoalkylthiobenzimidazoles of formula I wherein R1-R5 and R11-R16 are hereinafter defined. These compounds, their derivatives and the pharmaceutically acceptable salts thereof are useful in the reduction of elevated blood sugar levels and are therefore useful in the treatment of hyperglycemia, diabetes, atherosclerosis and other blood sugar disorders. These compounds are particularly suitable in the treatment of type-2 diabetes.
    Type: Application
    Filed: September 14, 2007
    Publication date: April 17, 2008
    Applicant: SANOFI-AVENTIS
    Inventors: Elisabeth DEFOSSA, Karl SCHOENAFINGER, Gerhard JAEHNE, Christian BUNING, Georg TSCHANK, Ulrich WERNER
  • SUBSTITUTED 8-AMINOALKOXY-XANTHINE COMPOUNDS AND COMPOSITIONS USEFUL IN THE TREATMENT OF HYPERLIPIDEMIA AND DIABETES
    Publication number: 20070299090
    Abstract: Compounds for the treatment of elevated blood glucose levels and the physiological and metabolic disorders arising therefrom are disclosed which are inhibitors of the enzyme dipeptidyl peptidase IV (DDP-IV) and comprise novel substituted bicyclic 8-pyrrolidinoxanthines of formula I and their derivatives: wherein the various R-groups are defined herein. These compounds may be combined with other secondary active compounds which also are effective in the treatment of said disorders and the disease states or physiological manifestations arising therefrom.
    Type: Application
    Filed: February 13, 2007
    Publication date: December 27, 2007
    Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Karl Schoenafinger, Gerhard Jaehne, Elisabeth Defossa, Christian Buning, Georg Tschank, Ulrich Werner
  • SUBSTITUTED 8-AMINOALKYLTHIOXANTHINES, AND THEIR USE AS INHIBITORS OF DIPEPTIDYL PEPTIDASE IV
    Publication number: 20070265284
    Abstract: The invention 8-aminothioxanthines and the derivatives of formula I wherein the various R groups and substituents are comprised of a number of different (C1-C10)-alkyl, cycloalkyl, aryl, alkene, alkyne, etc.
    Type: Application
    Filed: January 11, 2007
    Publication date: November 15, 2007
    Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Karl Schoenafinger, Gerhard Jaehne, Elisabeth Defossa, Guenter Billen, Christian Buning, Georg Tschank, Ulrich Werner
  • SUBSTITUTED, BICYCLIC 8-PYRROLIDINOXANTHINES, AND METHODS FOR THEIR USE AS INHIBITORS OF DIPEPTIDYL PEPTIDASE
    Publication number: 20070197563
    Abstract: The present invention involves substituted bicyclic 8-pyrrolidinoxanthines and their derivatives of formula I: wherein the various R groups are defined herein. The present invention also comprises pharmaceutical compositions comprising them as well as processes for the preparation of these compounds and methods for the treatment of metabolic disorders such as type-2 diabetes, insulin resistance, hyperglycemia, arteriosclerosis diseases and the like through the administration of said compositions.
    Type: Application
    Filed: January 18, 2007
    Publication date: August 23, 2007
    Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Karl SCHOENAFINGER, Gerhard JAEHNE, Elisabeth DEFOSSA, Lothar SCHWINK, Holger WAGNER, Christian BUNING, Georg TSCHANK, Ulrich WERNER
  • Method and device for altering the vibration characteristic of a motor system
    Publication number: 20070170788
    Abstract: The invention relates to a method for operation of a motor system (1), or a motor system (1), comprising an electrical motor (2) and an add-on module (3), whereby the add-on module (3) is mounted on the electrical motor (1), by means of a fixing system (11). A first fixing system (11) may be exchanged for a second fixing system (12) of a different type and is exchanged to alter the vibration characteristics of the motor system (1). A motor system (1) is furthermore provided with different fixing positions (13, 15, 17, 19) for the fitting of the add-on module (3) to the electrical motor (2) by means of fixing systems (11).
    Type: Application
    Filed: September 23, 2004
    Publication date: July 26, 2007
    Inventor: Ulrich Werner
  • SUBSTITUTED BICYCLIC 8-PYRR0LIDINOXANTHINES, METHODS FOR THEIR PRODUCTION, PHARMACEUTICAL FORMULATIONS AND THEIR USE
    Publication number: 20070167468
    Abstract: Compounds for the treatment of elevated blood glucose levels and the physiological and metabolic disorders arising therefrom are disclosed and comprise novel substituted bicyclic 8-pyrrolidinoxanthines and their derivatives of formula l: wherein the various R groups are hereinafter defined. The present invention also comprises pharmaceutical compositions comprising them as well as processes for the preparation of these compounds. Particular blood glucose disorders treatable thereby include type-2 diabetes, insulin resistance, hyperglycemia, arteriosclerotic diseases and the like.
    Type: Application
    Filed: January 17, 2007
    Publication date: July 19, 2007
    Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Karl SCHOENAFINGER, Gerhard JAEHNE, Elisabeth DEFOSSA, Lothar SCHWINK, Holger WAGNER, Christian BUNING, Georg TSCHANK, Ulrich WERNER