Abstract: Bi-specific fusion proteins with therapeutic uses are provided, as well as pharmaceutical compositions comprising such fusion proteins, and methods for using such fusion proteins to repair or regenerate damaged or diseased tissue. The bi-specific fusion proteins generally comprise: (a) a targeting polypeptide domain that binds to a target molecule; and (b) an activator domain that detectably modulates tissue regeneration.

Abstract: Provided are ionizable cationic lipids and lipid nanoparticles for the delivery of nucleic acids to cells (e.g., immune cells), and methods of making and using such lipids and targeted lipid nanoparticles.

Abstract: Bi-specific fusion proteins with therapeutic uses are provided, as well as pharmaceutical compositions comprising such fusion proteins, and methods for using such fusion proteins to repair or regenerate damaged or diseased tissue. The bi-specific fusion proteins generally comprise: (a) a targeting polypeptide domain that binds to a target molecule; and (b) an activator domain that detectably modulates tissue regeneration.

Abstract: The tube has a first lumen with a proximal end and an open distal end to be placed inside a body cavity. An outer wall encloses the first lumen and a camera lumen. A camera module (10) is arranged in the camera lumen at a distal end thereof so that the camera module is positioned adjacent the distal end of the first lumen. An image transmission cable (13) attached to the camera module extends through the camera lumen to connect to an image display device. The camera module is fixed in the camera lumen by means of a camera housing (14) including a tubular housing part (17) surrounding the camera module and a distal end wall (18). The tubular housing part and the distal end wall are integrally moulded and form one single housing element (19). The tubular housing part fits tightly into the camera lumen of the tube.

Abstract: Nanoparticle systems that genetically modify monocytes/macrophages in vivo to (1) recruit additional immune cells to a treatment site; (2) remain activated at the treatment site providing an on-going stimulatory signal to other immune cells; and (3) secrete bispecific immune-cell engaging antibodies that bind antigens on cells of interest at the treatment site and also bind and activate the recruited immune cells to destroy the bound cell. The systems can also inhibit the activity of transforming growth factor beta (TGF?).

Abstract: The present invention relates to methods for treating disease, in particular cancer and autoimmune and inflammatory diseases, using engineered cells.

Abstract: A medical device including a main tube having an outer wall, a first lumen, and a camera lumen; a tip housing separately manufactured from the main tube and including a tubular housing part extending from a proximal end to a distal end, a first lumen extension, a camera lumen extension, the tubular housing part enclosing the first lumen extension and the camera lumen extension, and the proximal end of the tip housing mounted at the distal end of the main tube; a camera module; a camera housing positioned in the camera lumen extension and affixing the camera module to the tip housing, the camera housing having a tubular housing part having an inner face; and a support structure including a tubular end part having an outer face adhesively bonded to the inner face of the tubular housing part to secure the camera module to the camera housing.

Abstract: The present disclosure features, at least in part, methods for conserving cell function, e.g., immune cell function, e.g., after one or more cycles of freezing and/or thawing the nucleated cell. In embodiments, the methods comprise contacting an immune cell with a protein nanoparticle comprising an IL-15 complex.

Abstract: A tissue collection device (1) for collection of one or more exposed tissue samples (2) from a biopsy needle or biopsy device, which tissue collection device comprises one or more pieces of a carrier medium (6) and is arranged to temporarily bring a piece of carrier medium into physical contact with the tissue sample, while the tissue sample is still positioned in the biopsy needle or biopsy device, so that the tissue sample (2) adheres to the carrier medium (6) and is removed from the biopsy needle (3) or biopsy device (4) with the carrier medium (6), when the carrier medium (6) is removed from the biopsy needle or biopsy device again. Furthermore, a biopsy device comprising such a tissue collection device is disclosed.

Abstract: Provided are ionizable cationic lipids and lipid nanoparticles for the delivery of nucleic acids to cells (e.g., immune cells), and methods of making and using such lipids and targeted lipid nanoparticles.

Abstract: A catheter having a distal end for insertion into a patient and including: a catheter tube enclosing at least a first catheter lumen and a vision lumen separated from the first catheter lumen, the first catheter lumen having a first distal opening at the distal end of the catheter; a window closing off a distal end of the vision lumen and having a planar interior window surface facing the vision lumen and a planar exterior window surface; and a vision device positioned in the vision lumen and having a vision module, such as a camera with an image sensor or an optical fibre, having an optical axis extending through the window; wherein the interior window surface and/or the exterior window surface is/are non-orthogonal with respect to the optical axis of the vision module, and the window surfaces are non-parallel.

Abstract: Bi-specific fusion proteins with therapeutic uses are provided, as well as pharmaceutical compositions comprising such fusion proteins, and methods for using such fusion proteins to repair or regenerate damaged or diseased tissue. The bi-specific fusion proteins generally comprise: (a) a targeting polypeptide domain that binds to a target molecule; and (b) an activator domain that detectably modulates tissue regeneration.

Abstract: Bi-specific fusion proteins with therapeutic uses are provided, as well as pharmaceutical compositions comprising such fusion proteins, and methods for using such fusion proteins to repair or regenerate damaged or diseased tissue. The bi-specific fusion proteins generally comprise: (a) a targeting polypeptide domain that binds to a target molecule; and (b) an activator domain that detectably modulates tissue regeneration.

Abstract: The present invention relates to a foldable propeller (1) for a boat, e.g. for a sailboat or a multihull yacht, where the foldable propeller (1) comprises a hub (2) with a plurality of blades, each blade comprising a blade root arranged to pivot around a separate pivot pin in order to be either in a first operative orientation, where the blade (4) is pointing mainly in a radial direction, or in a second inoperative orientation, where the blade is pointing mainly in an axial direction. The hub (2) comprises a number of hub flanges (28) for holding the pivot pins (9). The pivot pin (9) comprises at its second end (21) a head (26) with a recess (24) that accommodates the first end (20) of another of the pivot pins (9) inside the head (26).

Abstract: The present disclosure relates to a method for attaching, detecting and retrieving a single cell on a manipulation medium comprising the steps of: attaching the single cell onto the manipulation medium by applying a carrier liquid; partially drying out the carrier liquid; detecting a property of the single cell by rotating the manipulation medium and scanning a light beam over the manipulation medium; loosening the single cell from the manipulation medium without damaging the single cell by manipulating the single cell with an instrument; and retrieving the single cell from the manipulation medium by aspirating the single cell into a tube, wherein the carrier liquid is dried out to a degree corresponding to that the single cell does not move during the rotation of the manipulation medium and that the single cell can be loosened by the instrument without damaging the single cell.

Abstract: A tissue collection device (1) for collection of one or more exposed tissue samples (2) from a biopsy needle or biopsy device, which tissue collection device comprises one or more pieces of a carrier medium (6) and is arranged to temporarily bring a piece of carrier medium into physical contact with the tissue sample, while the tissue sample is still positioned in the biopsy needle or biopsy device, so that the tissue sample (2) adheres to the carrier medium (6) and is removed from the biopsy needle (3) or biopsy device (4) with the carrier medium (6), when the carrier medium (6) is removed from the biopsy needle or biopsy device again. Furthermore, a biopsy device comprising such a tissue collection device is disclosed.

Abstract: The present disclosure relates to a method for attaching, detecting and retrieving a single cell on a manipulation medium comprising the steps of: attaching the single cell onto the manipulation medium by applying a carrier liquid; partially drying out the carrier liquid; detecting a property of the single cell by rotating the manipulation medium and scanning a light beam over the manipulation medium; loosening the single cell from the manipulation medium without damaging the single cell by manipulating the single cell with an instrument; and retrieving the single cell from the manipulation medium by aspirating the single cell into a tube, wherein the carrier liquid is dried out to a degree corresponding to that the single cell does not move during the rotation of the manipulation medium and that the single cell can be loosened by the instrument without damaging the single cell. The disclosure further relates to an apparatus for detection and manipulation of one or more object(s).

Abstract: The present disclosure features, at least in part, methods for conserving cell function, e.g., immune cell function, e.g., after one or more cycles of freezing and/or thawing the nucleated cell. In embodiments, the methods comprise contacting an immune cell with a protein nanoparticle comprising an IL-15 complex.

Abstract: Bi-specific fusion proteins with therapeutic uses are provided, as well as pharmaceutical compositions comprising such fusion proteins, and methods for using such fusion proteins to repair or regenerate damaged or diseased tissue. The bi-specific fusion proteins generally comprise: (a) a targeting polypeptide domain that binds to a target molecule; and (b) an activator domain that detectably modulates tissue regeneration.

Abstract: The present invention relates to an apparatus for optical inspection of the opened abdominal cavity (10) of gutted fish (11), comprising a conveying device (12) configured for conveying the fish (11) along a processing line in the longitudinal direction, pivotable ventral flaps holding elements (17) configured for holding open the abdominal cavity (10) of the fish, at least one optical imaging system (21, 22, 23) arranged along the processing line, said optical imaging system being designed and configured to take at least one sequence of images of abdominal cavity regions of one of the fish (11) in each case, said sequence comprising a plurality of single images, at least one illumination device (24, 25) configured for illuminating the abdominal cavity regions in each case with light of a predetermined spectral composition, in each case at the times the single images are taken, an evaluation unit (26) configured to evaluate the image sequence according to prescribed quality parameters, said evaluation unit be