Patents by Inventor Utkan Demirci
Utkan Demirci has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11946846Abstract: A system and method for sorting sperm is provided. The system includes a housing and a microfluidic system supported by the housing. The system also includes an inlet providing access to the microfluidic system to deliver sperm to the microfluidic system and an outlet providing access to the microfluidic system to harvest sorted sperm from the microfluidic system. The microfluidic system provides a flow path for sperm from the inlet to the outlet and includes at least one channel extending from the inlet to the outlet to allow sperm delivered to the microfluidic system through the inlet to progress along the flow path toward the outlet. The microfluidic system also includes a filter including a first plurality of micropores arranged in the flow path between the inlet and the outlet to cause sperm traveling along the flow path to move against through the filter and gravity to reach the outlet.Type: GrantFiled: September 13, 2023Date of Patent: April 2, 2024Assignee: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.Inventors: Utkan Demirci, Waseem Asghar
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Publication number: 20240027320Abstract: A system and method for sorting sperm is provided. The system includes a housing and a microfluidic system supported by the housing. The system also includes an inlet providing access to the microfluidic system to deliver sperm to the microfluidic system and an outlet providing access to the microfluidic system to harvest sorted sperm from the microfluidic system. The microfluidic system provides a flow path for sperm from the inlet to the outlet and includes at least one channel extending from the inlet to the outlet to allow sperm delivered to the microfluidic system through the inlet to progress along the flow path toward the outlet. The microfluidic system also includes a filter including a first plurality of micropores arranged in the flow path between the inlet and the outlet to cause sperm traveling along the flow path to move against through the filter and gravity to reach the outlet.Type: ApplicationFiled: September 22, 2023Publication date: January 25, 2024Inventors: Utkan Demirci, Waseem Asghar
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Publication number: 20230417647Abstract: A system and method for sorting sperm is provided. The system includes a housing and a microfluidic system supported by the housing. The system also includes an inlet providing access to the microfluidic system to deliver sperm to the microfluidic system and an outlet providing access to the microfluidic system to harvest sorted sperm from the microfluidic system. The microfluidic system provides a flow path for sperm from the inlet to the outlet and includes at least one channel extending from the inlet to the outlet to allow sperm delivered to the microfluidic system through the inlet to progress along the flow path toward the outlet. The microfluidic system also includes a filter including a first plurality of micropores arranged in the flow path between the inlet and the outlet to cause sperm traveling along the flow path to move against through the filter and gravity to reach the outlet.Type: ApplicationFiled: September 13, 2023Publication date: December 28, 2023Inventors: Utkan Demirci, Waseem Asghar
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Patent number: 11841309Abstract: A system and method for sorting sperm is provided. The system includes a housing and a microfluidic system supported by the housing. The system also includes an inlet providing access to the microfluidic system to deliver sperm to the microfluidic system and an outlet providing access to the microfluidic system to harvest sorted sperm from the microfluidic system. The microfluidic system provides a flow path for sperm from the inlet to the outlet and includes at least one channel extending from the inlet to the outlet to allow sperm delivered to the microfluidic system through the inlet to progress along the flow path toward the outlet. The microfluidic system also includes a filter including a first plurality of micropores arranged in the flow path between the inlet and the outlet to cause sperm traveling along the flow path to move against through the filter and gravity to reach the outlet.Type: GrantFiled: June 23, 2023Date of Patent: December 12, 2023Assignee: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.Inventors: Utkan Demirci, Waseem Asghar
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Publication number: 20230332996Abstract: A system and method for sorting sperm is provided. The system includes a housing and a microfluidic system supported by the housing. The system also includes an inlet providing access to the microfluidic system to deliver sperm to the microfluidic system and an outlet providing access to the microfluidic system to harvest sorted sperm from the microfluidic system. The microfluidic system provides a flow path for sperm from the inlet to the outlet and includes at least one channel extending from the inlet to the outlet to allow sperm delivered to the microfluidic system through the inlet to progress along the flow path toward the outlet. The microfluidic system also includes a filter including a first plurality of micropores arranged in the flow path between the inlet and the outlet to cause sperm traveling along the flow path to move against through the filter and gravity to reach the outlet.Type: ApplicationFiled: June 23, 2023Publication date: October 19, 2023Inventors: Utkan Demirci, Waseem Asghar
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Patent number: 11788943Abstract: A system and method for sorting sperm is provided. The system includes a housing and a microfluidic system supported by the housing. The system also includes an inlet providing access to the microfluidic system to deliver sperm to the microfluidic system and an outlet providing access to the microfluidic system to harvest sorted sperm from the microfluidic system. The microfluidic system provides a flow path for sperm from the inlet to the outlet and includes at least one channel extending from the inlet to the outlet to allow sperm delivered to the microfluidic system through the inlet to progress along the flow path toward the outlet. The microfluidic system also includes a filter including a first plurality of micropores arranged in the flow path between the inlet and the outlet to cause sperm traveling along the flow path to move against through the filter and gravity to reach the outlet.Type: GrantFiled: July 25, 2022Date of Patent: October 17, 2023Assignee: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.Inventors: Utkan Demirci, Waseem Asghar
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Patent number: 11761952Abstract: A device (“the ExoTIC device”) for the isolation of extracellular vesicles from an extracellular vesicle-containing sample in which the sample is flowed through a membrane in a flow chamber to capture and purify the extracellular vesicles on the membrane. The extracellular vesicles may be washed and collected and utilized in any one of a number of ways including, but not limited to, identifying biomarkers of a disease, identifying the presence of a biomarker in a patient to determine whether a patient has a disease, and therapeutically treating existing diseases by re-introducing the extracellular vesicles, potentially modified, back into a body.Type: GrantFiled: June 11, 2021Date of Patent: September 19, 2023Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Fei Liu, Utkan Demirci, Sanjiv Sam Gambhir, Viswam S. Nair
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Patent number: 11717821Abstract: A diagnostic method for a detection of a nuclear deformation based a cellular differentiation includes the following steps: preparing nano/micropatterned surfaces; performing a cell seeding on the nano/micropatterned surfaces; imaging; analyzing nuclear deformations of a single cell and a cell population with an algorithm method.Type: GrantFiled: October 6, 2017Date of Patent: August 8, 2023Inventors: Vasif Nejat Hasirci, Utkan Demirci
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Publication number: 20230242872Abstract: A microfluidic chip is provided for self-sorting highly motile, morphologically normal sperm cell with high DNA integrity from a fresh semen sample. The sperm self-sorting microfluidic chip has one or more inlet chambers, and sperm collection outlet chamber(s), and the middle of the channel features various micro-fabricated structures in different geometrical shapes and orientations, with varying periodicities and patterns, such as an array of micro-fabricated pillars that facilitate the transport of the active and healthy sperm into the outlet chamber.Type: ApplicationFiled: February 24, 2023Publication date: August 3, 2023Inventors: Utkan Demirci, Erkan Tüzel, James Leonard Kingsley, Thiruppathiraja Chinnasamy
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Patent number: 11709122Abstract: A system and method for sorting sperm is provided. The system includes a housing and a microfluidic system supported by the housing. The system also includes an inlet providing access to the microfluidic system to deliver sperm to the microfluidic system and an outlet providing access to the microfluidic system to harvest sorted sperm from the microfluidic system. The microfluidic system provides a flow path for sperm from the inlet to the outlet and includes at least one channel extending from the inlet to the outlet to allow sperm delivered to the microfluidic system through the inlet to progress along the flow path toward the outlet. The microfluidic system also includes a filter including a first plurality of micropores arranged in the flow path between the inlet and the outlet to cause sperm traveling along the flow path to move against through the filter and gravity to reach the outlet.Type: GrantFiled: May 17, 2021Date of Patent: July 25, 2023Assignee: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.Inventors: Utkan Demirci, Waseem Asghar
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Patent number: 11618882Abstract: A microfluidic chip is provided for self-sorting highly motile, morphologically normal sperm cell with high DNA integrity from a fresh semen sample. The sperm self-sorting microfluidic chip has one or more inlet chambers, and sperm collection outlet chamber(s), and the middle of the channel features various micro-fabricated structures in different geometrical shapes and orientations, with varying periodicities and patterns, such as an array of micro-fabricated pillars that facilitate the transport of the active and healthy sperm into the outlet chamber.Type: GrantFiled: January 22, 2017Date of Patent: April 4, 2023Assignees: The Board of Trustees of the Leland Stanford Junior University, Worcester Polytechnic InstituteInventors: Utkan Demirci, Erkan Tüzel, James Leonard Kingsley, Thiruppathiraja Chinnasamy
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Publication number: 20220364975Abstract: A system and method for sorting sperm is provided. The system includes a housing and a microfluidic system supported by the housing. The system also includes an inlet providing access to the microfluidic system to deliver sperm to the microfluidic system and an outlet providing access to the microfluidic system to harvest sorted sperm from the microfluidic system. The microfluidic system provides a flow path for sperm from the inlet to the outlet and includes at least one channel extending from the inlet to the outlet to allow sperm delivered to the microfluidic system through the inlet to progress along the flow path toward the outlet. The microfluidic system also includes a filter including a first plurality of micropores arranged in the flow path between the inlet and the outlet to cause sperm traveling along the flow path to move against through the filter and gravity to reach the outlet.Type: ApplicationFiled: July 25, 2022Publication date: November 17, 2022Inventors: Utkan Demirci, Waseem Asghar
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Publication number: 20220323960Abstract: A heterogeneous population of cells are separated and collected according to a method. The heterogeneous population of cells in a paramagnetic medium are placed in a fluidic channel in which the fluidic channel comprises two or more outlets. The heterogeneous population of cells in the fluidic channel are separated based on differences in magnetic susceptibility and density of the heterogeneous population of cells. Fluid comprising the separated cells is withdrawn from the two or more outlets using variable flow rates by fluidic pumps at respective ones of the two or more outlets simultaneously to fractionalize the fluid comprising the separated cells across the two or more outlets by manipulation of the variable flow rates relative to one another.Type: ApplicationFiled: April 20, 2022Publication date: October 13, 2022Inventors: Murat Baday, Naside Gozde Durmus, Semih Calamak, Utkan Demirci, Ronald W. Davis, Lars Steinmetz, Jaeyoung Yang, Thiruppathiraja Chinnasamy, Alessandro Tocchio
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Patent number: 11338290Abstract: Systems and methods for levitating populations of moieties, cells, or other such units using one or more magnets in a microfluidic environment are provided. These systems and methods may be used to, for example, separate or sort heterogeneous populations of the units from one another, to assembly a multi-unit assembly during the levitating of the units, and to evaluate samples at the point of care in real-time. These systems and methods may also utilize a frame that enables an imaging device, such as a smartphone, to capture the units in real time as they are manipulated in the system.Type: GrantFiled: September 30, 2016Date of Patent: May 24, 2022Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Murat Baday, Naside Gozde Durmus, Semih Calamak, Utkan Demirci, Ronald W. Davis, Lars Steinmetz, Jaeyoung Yang, Thiruppathiraja Chinnasamy, Alessandro Tocchio
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Publication number: 20220118452Abstract: An extracellular vesicle-containing sample can be processed using a device for isolating one or more subpopulations of the extracellular vesicles. The extracellular vesicle-containing sample is flowed through a flow chamber of the device under an applied fluid pressure, in which the device has one or more inlets and two or more outlets in fluid communication with one another via the flow chamber. The device has one or more filters in the flow chamber between the inlet(s) and at least one of the outlet(s). The extracellular vesicle-containing sample is flowed through the filter(s) in the flow chamber to sort the extracellular vesicles of extracellular vesicle-containing sample by size into two or more subpopulations of the extracellular vesicles. At least one of the subpopulations that has been sorted flows out of a corresponding one of the outlets. Surface marker-based exosome sorting using magnetic beads may be used after the size-based exosome isolation.Type: ApplicationFiled: October 19, 2021Publication date: April 21, 2022Inventors: Utkan Demirci, Mehmet Ozgun Ozen, Naside Gozde Durmus, Rakhi Gupta, Sharon Pitteri, Fernando Jose Garcia Marques
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Publication number: 20220073872Abstract: A method for sorting motile cells includes introducing an initial population of motile cells into an inlet port of a microfluidic channel, the initial population of motile cells having a first average motility; incubating the population of motile cells in the microfluidic channel; and collecting a sorted population of motile cells at an outlet port of the microfluidic channel. The sorted population of motile cells has a second average motility higher than the first average motility.Type: ApplicationFiled: August 20, 2021Publication date: March 10, 2022Inventors: Utkan Demirci, Xiaohui Zhang, Emre Kayaalp, Hooman Safaee, Savas Tasoglu, Paolo Nicolas Catalano
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Publication number: 20210373037Abstract: Magnetic cell levitation and cell monitoring systems and methods are disclosed. A method for separating a heterogeneous population of cells is performed by placing a microcapillary channel containing the heterogeneous population of cells in a magnetically-responsive medium in the disclosed levitation system and separating the cells by balancing magnetic and corrected gravitational forces on the individual cells. A levitation system is also disclosed, having a microscope on which the microcapillary channel is placed and a set of two magnets between which the microcapillary channel is placed. Additionally, a method for monitoring cellular processes in real-time using the levitation system is disclosed.Type: ApplicationFiled: February 8, 2021Publication date: December 2, 2021Inventors: Utkan Demirci, Ionita Ghiran, Savas Tasoglu, Ronald W. Davis, Lars Steinmetz, Naside Gozde Durmus, Huseyin Cumhur Tekin
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Publication number: 20210339253Abstract: Embodiments of the present disclosure relate to a magnetic bead platform for isolating sperm cells from biological samples. In some embodiments, such magnetic bead platforms integrate recognition reagents to its surface to bind target cells, such as sperm cells. Such embodiments provide the ability to at least one of rapidly isolate and quantitate sperm cells from biological samples as occur in sexual assault evidence, for example, thereby enhancing identification of suspects in these cases and contributing to the safety of society.Type: ApplicationFiled: July 7, 2021Publication date: November 4, 2021Inventors: Leonard KLEVAN, Fatih INCI, Utkan DEMIRCI
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Publication number: 20210311025Abstract: A device (“the ExoTIC device”) for the isolation of extracellular vesicles from an extracellular vesicle-containing sample in which the sample is flowed through a membrane in a flow chamber to capture and purify the extracellular vesicles on the membrane. The extracellular vesicles may be washed and collected and utilized in any one of a number of ways including, but not limited to, identifying biomarkers of a disease, identifying the presence of a biomarker in a patient to determine whether a patient has a disease, and therapeutically treating existing diseases by re-introducing the extracellular vesicles, potentially modified, back into a body.Type: ApplicationFiled: June 11, 2021Publication date: October 7, 2021Inventors: Fei Liu, Utkan Demirci, Sanjiv Sam Gambhir, Viswam S. Nair
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Publication number: 20210270715Abstract: A system and method for sorting sperm is provided. The system includes a housing and a microfluidic system supported by the housing. The system also includes an inlet providing access to the microfluidic system to deliver sperm to the microfluidic system and an outlet providing access to the microfluidic system to harvest sorted sperm from the microfluidic system. The microfluidic system provides a flow path for sperm from the inlet to the outlet and includes at least one channel extending from the inlet to the outlet to allow sperm delivered to the microfluidic system through the inlet to progress along the flow path toward the outlet. The microfluidic system also includes a filter including a first plurality of micropores arranged in the flow path between the inlet and the outlet to cause sperm traveling along the flow path to move against through the filter and gravity to reach the outlet.Type: ApplicationFiled: May 17, 2021Publication date: September 2, 2021Inventors: Utkan Demirci, Waseem Asghar