Abstract: A household appliance includes a compartment, a door for closing the compartment, a non-movable part, and a door monitoring apparatus including a contact pair which has two contact parts. One of the two contact parts is arranged on the door and the other one of the two contact parts is arranged on the non-movable part of the household appliance.

Abstract: A household PEF cooking device includes a cooking product container which can be filled with liquid and includes PEF electrodes which lie opposite one another and between which a cooking product can be introduced. A PEF signal generator applies PEF signals to the PEF electrodes, and a control device control the PEF signal generator. An IR sensor which measures contactlessly is disposed at a distance from the PEF electrodes and connected to the control device. A measuring dot of the IR sensor encompasses an outer face of an electrically conductive region of a wall of the cooking product container, which electrically conductive region can be contacted on an inner face by the liquid when the cooking product container is full.

Abstract: A removable container for a product to be cooked for use in a PEF cooking appliance has a treatment chamber including at least two PEF electrodes between which a product to be cooked can be introduced and to which PEF signals pulsed with alternating polarity can be applied. Further provided are a sensor and a sensor circuit which includes an energy supply device configured without battery and DC-isolated from the PEF cooking appliance, an evaluation circuit connected to the sensor and the energy supply device, and a data transmission device connected to the evaluation circuit and the energy supply device. The data transmission device is configured to transmit data received from the evaluation circuit to the PEF cooking appliance in a non-electrical manner.

Abstract: A household PEF cooking appliance includes a container for food to be cooked, opposing outer PEF electrodes disposed in the container, and a partition variably disposed in the container between the outer PEF electrodes and oriented parallel to the outer PEF electrodes.

Abstract: The invention relates to an anti-CD16A antigen binding protein for use in NK cell-based immunotherapy, wherein the anti-CD16A antigen binding protein is to be administered intermittently and in combination with a cytokine. In certain embodiments the antigen binding protein is a tetravalent and bispecific CD30/CD16A tandem diabody.

Abstract: A machine arrangement sequentially processes sheet-like substrates with multiple different processing stations each having a substrate-guiding unit and a substrate-processing unit. At least one of the processing stations has, as a substrate-processing unit, at least one non-impact printing device which prints on the substrate. The processing station with the at least one non-impact printing device has a printing cylinder. Each non-impact printing device is arranged at the circumference of the printing cylinder. The printing cylinder is triple-sized or quadruple-sized. A double-sized or a triple-sized transfer drum, or a corresponding feed cylinder, is arranged directly upstream of this printing cylinder. Alternatively, a double-sized or a triple-sized transfer drum, or a corresponding transfer cylinder, is arranged directly downstream of this printing cylinder.

Abstract: The present invention relates to pyrazolo[1,5-a][1,3,5]triazine and pyrazolo[1,5-a]pyrimidine derivatives and/or pharmaceutically acceptable salts thereof, the use of these derivatives as pharmaceutically active agents, especially for the prophylaxis and/or treatment of cell proliferative diseases, inflammatory diseases, immunological diseases, cardiovascular diseases and infectious diseases. Furthermore, the present invention is directed towards pharmaceutical compositions containing at least one of the pyrazolo[1,5-a][1,3,5]triazine and pyrazolo[1,5-a]pyrimidine derivatives and/or pharmaceutically acceptable salts thereof.

Abstract: The invention provides novel coumarin derivatives as specific mitochondrial RNA polymerase inhibitors for the treatment of cancer.

Abstract: The present invention relates to pyrazolo [1,5-a] [1,3,5]triazine and pyrazolo[1,5-a] pyrimidine derivatives and/or pharmaceutically acceptable salts thereof, the use of these derivatives as pharmaceutically active agents, especially for the prophylaxis and/or treatment of cell proliferative diseases, inflammatory diseases, immunological diseases, cardiovascular diseases and infectious diseases. Furthermore, the present invention is directed towards pharmaceutical compositions containing at least one of the pyrazolo [1,5-a][1,3,5]triazine and pyrazolo [1,5-a]pyrimidine derivatives and/or pharmaceutically acceptable salts thereof.

Abstract: The invention provides novel coumarin derivatives as specific mitochondrial RNA polymerase inhibitors for the treatment of cancer.

Abstract: The invention provides novel 4-phenyl-coumarin derivatives, processes for their preparation and uses thereof as specific mitochondrial RNA polymerase inhibitors for the treatment of cancer.

Abstract: The invention provides novel 4-phenyl-coumarin derivatives, processes for their preparation and uses thereof as specific mitochondrial RNA polymerase inhibitors for the treatment of cancer.

Abstract: A radial shaft seal is provided for sealing between high and low pressure sides in an annular space between a shaft and a static structural receiving part, wherein the shaft seal is rotationally symmetric and arranged coaxially to the shaft. A first sealing ring has an inner periphery bulging toward the low pressure side and forms a first sealing lip abutting the shaft. A spacer ring has first and second faces directed towards the high and low pressure sides, respectively. An elastic shaped part has an outer periphery abutting the second face of the spacer ring and an inner periphery bulging toward the high pressure side and abutting the first sealing lip. At least the spacer ring and elastic shaped part define a cavity subjected to the high pressure side or a control pressure which presses the first sealing lip against the shaft via the elastic shaped part.

Abstract: The invention relates to a fan unit (1) for mobile use for ventilating an area in which it is deployed, in particular for circulating fresh air in areas contaminated by smoke or gases, which comprises a main frame (2), having a lifting frame (4) mounted thereon and an axial fan (3). A first pivot arrangement (8) for the lifting frame (4) is disposed on the one hand in the region of a frame part (7) extending up from a base frame (6) and on the other hand in a first end region (14) of the lifting frame (4) facing the frame part (7). The lifting frame (4) can be adjusted in terms of its vertical distance from the base frame (6) from a non-operating position lying closer thereto into a raised deployment position. A second pivot arrangement (17) is disposed on the lifting frame (4) about which a support frame (19) is mounted so as to be pivotable in terms of its relative position with respect to the base frame (6).

Abstract: The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

Abstract: The present invention relates to pyrazolo[1,5-a][1,3,5]triazine derivatives and/or pharmaceutically acceptable salts thereof, the use of these derivatives as pharmaceutically active agents, especially for the prophylaxis and/or treatment of infectious diseases, including opportunistic diseases, immunological diseases, autoimmune diseases, cardiovascular diseases, cell proliferative diseases, inflammation, erectile dysfunction and stroke, and pharmaceutical compositions containing at least one of said pyrazolo[1,5-a][1,3,5]triazine derivatives and/or pharmaceutically acceptable salts thereof. Furthermore, the present invention relates to the use of said pyrazolo[1,5-a][1,3,5]triazine derivatives as inhibitors for a protein kinase.

Abstract: The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

Abstract: The invention relates to a fan unit (1) for mobile use for ventilating an area in which it is deployed, in particular for circulating fresh air in areas contaminated by smoke or gases, which comprises a main frame (2), having a lifting frame (4) mounted thereon and an axial fan (3). A first pivot arrangement (8) for the lifting frame (4) is disposed on the one hand in the region of a frame part (7) extending up from a base frame (6) and on the other hand in a first end region (14) of the lifting frame (4) facing the frame part (7). The lifting frame (4) can be adjusted in terms of its vertical distance from the base frame (6) from a non-operating position lying closer thereto into a raised deployment position. A second pivot arrangement (17) is disposed on the lifting frame (4) about which a support frame (19) is mounted so as to be pivotable in terms of its relative position with respect to the base frame (6).

Abstract: The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

Abstract: The present invention relates to disubstituted triazine derivatives and/or pharmaceutically acceptable salts thereof, the use of these derivatives as pharmaceutically active agents, especially for the prophylaxis and/or treatment of infectious diseases, including opportunistic diseases, immunological diseases, autoimmune diseases, cardiovascular diseases, cell proliferative diseases, inflammation, erectile dysfunction and stroke, and pharmaceutical compositions containing at least one of said disubstituted triazine derivatives and/or pharmaceutically acceptable salts thereof. Furthermore, the present invention relates to the use of said disubstituted triazine derivatives as inhibitors for a protein kinase.