Abstract: The invention relates to polymerizates that can be obtained by a) reacting at least one polyisocyanate with at least one polyol and optionally at least one radically curable monomer A with groups reactive toward isocyanate in at least one radically curable monomer B to form polyurethane particles having an average diameter of less than 40 nm, preferably less than 20 nm, and especially preferably less than 10 nm and an average number of radically curable functionalities in a range of 2 to 4, preferably 2 to 3, and b) emulsion polymerizing the product obtained under a). By means of the emulsion polymerization, larger cross-linked polyurethane/polymer hybrid dispersions are produced, in which the nanoparticles act as a connecting member between the polymer areas and the polyurethane components.

Abstract: The present invention relates to pyrazolo[1,5-a][1,3,5]triazine derivatives and/or pharmaceutically acceptable salts thereof, the use of these derivatives as pharmaceutically active agents, especially for the prophylaxis and/or treatment of infectious diseases, including opportunistic diseases, immunological diseases, autoimmune diseases, cardiovascular diseases, cell proliferative diseases, inflammation, erectile dysfunction and stroke, and pharmaceutical compositions containing at least one of said pyrazolo[1,5-a][1,3,5]triazine derivatives and/or pharmaceutically acceptable salts thereof. Furthermore, the present invention relates to the use of said pyrazolo[1,5-a][1,3,5]triazine derivatives as inhibitors for a protein kinase.

Abstract: The invention relates to a non-aqueous dispersion of organic polymer particles in a reactive diluent. Said non-aqueous dispersion can be obtained in that at least one monomer is polymerized in the reactive diluent, forming the organic polymer particles, wherein the reactive diluent does not participate in said polymerization due to the orthogonal reactivity thereof relative to the monomers, but comprises a functionality allowing later targeted polymerization. Depending on the organic polymer particles or reactive diluents used, the non-aqueous dispersion can be used in multifaceted applications having a wide range of application profiles. In order to produce said non-aqueous dispersion, polymerization of at least one monomer in a stirred tank reactor in the presence of a reactive diluent is particularly suitable, wherein the conversion is performed at a stirring speed of at least 2 m/s, wherein the ratio of the stirrer diameter to the vessel diameter is set to 0.3-0.

Abstract: The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

Abstract: The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

Abstract: The present invention relates to disubstituted triazine derivatives and/or pharmaceutically acceptable salts thereof, the use of these derivatives as pharmaceutically active agents, especially for the prophylaxis and/or treatment of infectious diseases, including opportunistic diseases, immunological diseases, autoimmune diseases, cardiovascular diseases, cell proliferative diseases, inflammation, erectile dysfunction and stroke, and pharmaceutical compositions containing at least one of said disubstituted triazine derivatives and/or pharmaceutically acceptable salts thereof. Furthermore, the present invention relates to the use of said disubstituted triazine derivatives as inhibitors for a protein kinase.

Abstract: The present invention relates to 1-nitrogen-heterocyclic-2-carboxamides and/or pharmaceutically acceptable salts thereof, the use of these derivatives as pharmaceutically active agents, especially for the treatment and/or prevention of Axl receptor tyrosine kinase subfamily induced disorders, including cancer and primary tumor metastases, and pharmaceutical compositions containing at least one of said 1-nitrogen-heterocyclic-2-carboxamide derivatives and/or pharmaceutically acceptable salts thereof.

Abstract: In a method for producing a control arm for arrangement on an automobile axle formed as one-piece part from a light-metal extruded profile, a semi-finished product made from a light-metal extruded profile having a Pi-shaped cross-sectional configuration with a bottom web, side webs extending from the bottom web, and legs projecting from the webs is processed by cutting, whereafter bearing seat openings are introduced and sections of the processed semi-finished product are expanded. A control arm produced with the method of the invention for arrangement on an automobile axle is also disclosed.

Abstract: A sealing element for a rotary piston machine for sealing a lever is provided which is guided in an annular gap and is rotatable around a rotational axis, wherein the sealing element is rotationally symmetrical relative to the rotational axis, characterized in that the sealing element comprises a dynamic region and a static region, wherein the dynamic region has an axial sealing face being directed towards the annular gap, and a radial sealing face being directed towards the interior of an annular channel of the rotary piston machine, which annular channel surrounds the annular gap; and wherein the static region serves to fix the sealing element to the rotary piston machine, and wherein there is formed in the static region a channel, to which a fluid can be supplied.

Abstract: The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of poly(ADP-ribose)polymerase (PARP) and thus useful for the treatment of cancer, inflammatory diseases, reperfusion injuries, ischaemic conditions, stroke, renal failure, cardiovascular diseases, vascular diseases other than cardiovascular diseases, diabetes mellitus, neurodegenerative diseases, retroviral infections, retinal damage, skin senescence and UV-induced skin damage, and as chemo- or radiosensitizers for cancer treatment.

Abstract: Disclosed are compounds of formula (I) that are used as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

Abstract: A radial shaft seal is provided for sealing between high and low pressure sides in an annular space between a shaft and a static structural receiving part, wherein the shaft seal is rotationally symmetric and arranged coaxially to the shaft. A first sealing ring has an inner periphery bulging toward the low pressure side and forms a first sealing lip abutting the shaft. A spacer ring has first and second faces directed towards the high and low pressure sides, respectively. An elastic shaped part has an outer periphery abutting the second face of the spacer ring and an inner periphery bulging toward the high pressure side and abutting the first sealing lip. At least the spacer ring and elastic shaped part define a cavity subjected to the high pressure side or a control pressure which presses the first sealing lip against the shaft via the elastic shaped part.

Abstract: In a method for producing a control arm for arrangement on an automobile axle formed as one-piece part from a light-metal extruded profile, a semi-finished product made from a light-metal extruded profile having a Pi-shaped cross-sectional configuration with a bottom web, side webs extending from the bottom web, and legs projecting from the webs is processed by cutting, whereafter bearing seat openings are introduced and sections of the processed semi-finished product are expanded. A control arm produced with the method of the invention for arrangement on an automobile axle is also disclosed.

Abstract: The present invention relates to macrocyclic compounds of formula (I): wherein W, n, m, R1, R2, R3, R4, R5, Ra, M, Z and ring B are defined herein, and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising them, and their use for the treatment or prevention of infection by hepatitis C virus.

Abstract: Disclosed are anhydrous transparent dispersions of polyurethane(meth)acrylate particles in a reactive diluent, which can be obtained by reacting a polyisocyanate with at least one polyol and a nucleophilically functionalized (meth)acrylic acid ester in the reactive diluent. The inventive dispersions are characterized in that the polyurethane(meth)acrylate particles have an average diamert of less than 40 nm. The invention further relates to a method for producing such dispersions, the use thereof as an adhesive, cut glass, or impact resistance modifier, and a molded article made from said dispersion.

Abstract: The invention relates to a non-aqueous dispersion of organic polymer particles in a reactive diluent. Said non-aqueous dispersion can be obtained in that at least one monomer is polymerized in the reactive diluent, forming the organic polymer particles, wherein the reactive diluent does not participate in said polymerization due to the orthogonal reactivity thereof relative to the monomers, but comprises a functionality allowing later targeted polymerization. Depending on the organic polymer particles or reactive diluents used, the non-aqueous dispersion can be used in multifaceted applications having a wide range of application profiles. In order to produce said non-aqueous dispersion, polymerization of at least one monomer in a stirred tank reactor in the presence of a reactive diluent is particularly suitable, wherein the conversion is performed at a stirring speed of at least 2 m/s, wherein the ratio of the stirrer diameter to the vessel diameter is set to 0.3-0.

Abstract: In the case of a system for marking a region within an image of a road map detail displayed on a vehicle video screen, a regional location can first be selected by a control element. The region, which represents one of several administrative levels, can be constantly fixed via an enter function of the control element. The administrative level and thereby the size of the region can be changed by a rotational movement of the control element, which can be rotated about a longitudinal axis.