Patents by Inventor Uwe Marx

Uwe Marx has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9856458
    Abstract: A 3D in vitro bi-phasic cartilage-bone organoid includes a layer of an artificial cartilage tissue, and a layer of an artificial bone tissue comprising a structure-giving scaffold and a bone marrow structure. The layer of the artificial cartilage tissue contacts at least one surface of the layer of the artificial bone tissue.
    Type: Grant
    Filed: February 28, 2013
    Date of Patent: January 2, 2018
    Assignee: TISSUSE GMBH
    Inventors: Mark Rosowski, Shirin Kadler, Roland Lauster, Uwe Marx
  • Patent number: 9791433
    Abstract: The present invention is directed to a multi-organ-chip device comprising a base layer; an organ layer arranged on the base layer; an antra layer arranged on the organ layer; and an actuator layer; wherein the base layer is configured to provide a solid support for the further layers; the organ layer is configured to comprise a multiplicity of individual organ equivalents, each organ equivalent comprising one or more organ growth sections, each of the organ growth sections being configured to comprise an organoid cavity for housing at least one organoid of an organ and to comprise a micro-inlet and a micro-outlet for fluid communication between the organoid cavity of the organ growth section and a self-contained circulation system, wherein the organ layer comprises at least one organ equivalent configured to represent the organs lung, small intestine, spleen, pancreas, liver, kidney and bone marrow, respectively, and a self-contained circulation system configured to be in direct fluid communication with the o
    Type: Grant
    Filed: August 15, 2013
    Date of Patent: October 17, 2017
    Assignee: TISSUSE GMBH
    Inventor: Uwe Marx
  • Patent number: 9780345
    Abstract: A device for electrical interconnection of cells of a battery pack through cell connectors, and a battery pack having the device and the cell connectors are provided. A plurality of cell connectors for connection of at least two cell poles are fitted on a mounting plate, electrically isolated from one another. Each cell connector has at least one flexible bracket which extends away from a connection area. The flexible brackets are coupled to the connection area through a resilient structure having a meandering shape.
    Type: Grant
    Filed: September 30, 2010
    Date of Patent: October 3, 2017
    Assignees: DIEHL STIFTUNG & CO. KG, BAYERISCHE MOTOREN WERKE AG
    Inventors: Harald Heck, Andreas Volek, Ralf Hojda, Uwe Marx, Harald Wich, Rolf Pechloff, Frank Warmuth, Dirk Hopsch, Jörg Seybold, Hubertus Goesmann, Philipp Petz, Axelle Hauck
  • Patent number: 9506024
    Abstract: A self-contained circulation system, which supports the formation of capillaries in capillary growth sections and allows the formation of micro organoids and/or micro tissue sections for monitoring the effect of one or more test compounds and determining efficacy, side-effects, biosafety, metabolites, mode of action or organ regeneration as well as methods of establishing such micro organoids and/or micro tissue in the self-contained circulation system.
    Type: Grant
    Filed: August 5, 2011
    Date of Patent: November 29, 2016
    Assignee: TISSUSE GMBH
    Inventors: Uwe Marx, Gerd Lindner, Reyk Horland, Silke Hoffmann, Roland Lauster
  • Publication number: 20150253309
    Abstract: The present invention is directed to a multi-organ-chip device comprising a base layer; an organ layer arranged on the base layer; an antra layer arranged on the organ layer; and an actuator layer; wherein the base layer is configured to provide a solid support for the further layers; the organ layer is configured to comprise a multiplicity of individual organ equivalents, each organ equivalent comprising one or more organ growth sections, each of the organ growth sections being configured to comprise an organoid cavity for housing at least one organoid of an organ and to comprise a micro-inlet and a micro-outlet for fluid communication between the organoid cavity of the organ growth section and a self-contained circulation system, wherein the organ layer comprises at least one organ equivalent configured to represent the organs lung, small intestine, spleen, pancreas, liver, kidney and bone marrow, respectively, and a self-contained circulation system configured to be in direct fluid communication with the o
    Type: Application
    Filed: August 15, 2013
    Publication date: September 10, 2015
    Applicant: TISSUSE GMBH
    Inventor: Uwe Marx
  • Publication number: 20150093428
    Abstract: A 3D in vitro bi-phasic cartilage-bone organoid includes a layer of an artificial cartilage tissue, and a layer of an artificial bone tissue comprising a structure-giving scaffold and a bone marrow structure. The layer of the artificial cartilage tissue contacts at least one surface of the layer of the artificial bone tissue.
    Type: Application
    Filed: February 28, 2013
    Publication date: April 2, 2015
    Applicant: TISSUSE GMBH
    Inventors: Mark Rosowski, Shirin Fatehi-Varkani, Roland Lauster, Uwe Marx
  • Publication number: 20150093777
    Abstract: A method for at least one of determining and monitoring at least one condition of/in a three dimensional cell culture system comprising at least one growth section, the at least one condition being selected from the group consisting of a physiological condition, a vitality, and a metabolism status, the method includes determining the physiological condition using erythrocytes as detectors, determining and/or monitoring the vitality by measuring living cell fluorescent dyes, and determining and/or monitoring the metabolism status by at least one of measuring an autofluorescence of NADH and/or FAD, by determining a NADH/NAD+ ratio, and by determining a NADH/FAD ratio.
    Type: Application
    Filed: April 26, 2013
    Publication date: April 2, 2015
    Applicant: TISSUSE GMBH
    Inventors: Uwe Marx, Lutz Kloke, Reyk Horland, Silke Hoffman, Alexandra Lorenz, Sven Brincker, Katharina Schimek
  • Publication number: 20140377233
    Abstract: The present invention is directed to a method of preparing an artificial tooth primordium in vitro, comprising the steps: a) providing isolated mesenchymal dental pulp cells; and b) culturing the mesenchymal dental pulp cells under non-adherent conditions to form a cell aggregate representing an artificial tooth primordium; as well as to an artificial tooth primordium derived therefrom.
    Type: Application
    Filed: February 20, 2013
    Publication date: December 25, 2014
    Inventors: Roland Lauster, Uwe Marx, Jennifer Binder, Mark Rosowski
  • Patent number: 8911995
    Abstract: The invention provides a culture device comprising a plurality of culture units, wherein each unit comprises a culture chamber, an inlet port for liquid supply of the culture and an outlet port for discharging liquid from the unit, wherein the inlet port is in fluid communication with the culture chamber and the culture chamber is in fluid communication with the outlet port for allowing a liquid flow through the culture chamber. The culture device is particularly suitable for testing immune cells and immunofunction in vitro. Aspects of the invention include a culture device and associated methods for cultivating immune cells and an in vitro method of analysing the effect of a test compound on immune cells.
    Type: Grant
    Filed: August 21, 2008
    Date of Patent: December 16, 2014
    Assignee: ProBioGen AG
    Inventors: Richard Ammer, Christian Demmler, Uwe Marx, Annika Lubitz, Michael Sacharjat, Christoph Giese
  • Publication number: 20140302549
    Abstract: A self-contained organ-on-a-chip device includes at least one organ growth section comprising at least two organ cavities and a degradable matrix or a micro-channel arranged between the at least two organ cavities. The degradable matrix or the micro-channel is configured to allow for a formation of a capillary network between the at least two organ cavities within the at least one organ growth section.
    Type: Application
    Filed: June 20, 2014
    Publication date: October 9, 2014
    Inventor: UWE MARX
  • Publication number: 20130295598
    Abstract: A self-contained circulation system, which supports the formation of capillaries in capillary growth sections and allows the formation of micro organoids and/or micro tissue sections for monitoring the effect of one or more test compounds and determining efficacy, side-effects, biosafety, metabolites, mode of action or organ regeneration as well as methods of establishing such micro organoids and/or micro tissue in the self-contained circulation system.
    Type: Application
    Filed: August 5, 2011
    Publication date: November 7, 2013
    Applicant: TECHNISCHE UNIVERSITAET BERLIN
    Inventors: Uwe Marx, Gerd Lindner, Reyk Horland, Silke Hoffman, Roland Lauster
  • Publication number: 20120231320
    Abstract: A device for electrical interconnection of cells (12) of a battery pack (11) by means of cell connectors (15) and a battery pack (11) having such cell connectors (15) are distinguished as being convenient for assembly and functionally reliable in that at least one mounting plate (16), which can be latched on the battery pack (11) in a mounting frame (17), is fitted with cell connectors (15) which are electrically isolated from one another, on the basis of the geometric requirement of cell poles (13) to be interconnected to one another, which cell connectors (15) each have flexible brackets (19) for their apex areas (23) to make elastic contact with the end surfaces (26) of cell poles (13). The brackets (19), which are supported by one flank in the form of a flexible spring on the mounting plate (16), are part of a stamped grid, which also comprises conductor tracks (32) which are integrally connected thereto, for example for connection of a battery management means.
    Type: Application
    Filed: September 30, 2010
    Publication date: September 13, 2012
    Applicants: BAYERISCHE MOTOREN WERKE AG, DIEHL STIFTUNG & CO. KG
    Inventors: Harald Heck, Andreas Volek, Ralf Hojda, Uwe Marx, Harald Wich, Rolf Pechloff, Frank Warmuth, Dirk Hopsch, Jörg Seybold, Hubertus Goesmann, Philipp Petz, Axelle Hauck
  • Publication number: 20110312512
    Abstract: The invention provides a culture device comprising a plurality of culture units, wherein each unit comprises a culture chamber, an inlet port for liquid supply of the culture and an outlet port for discharging liquid from the unit, wherein the inlet port is in fluid communication with the culture chamber and the culture chamber is in fluid communication with the outlet port for allowing a liquid flow through the culture chamber. The culture device is particularly suitable for testing immune cells and immunofunction in vitro. Aspects of the invention include a culture device and associated methods for cultivating immune cells and an in vitro method of analysing the effect of a test compound on immune cells.
    Type: Application
    Filed: August 21, 2008
    Publication date: December 22, 2011
    Inventors: Richard Ammer, Christian Demmler, Uwe Marx, Annika Lubitz, Michael Sacharjat, Christoph Giese
  • Publication number: 20110144202
    Abstract: The present invention relates to a pharmaceutically stable and highly concentrated aqueous oxaliplatin solution. The present invention also concerns a method for preparing said solution.
    Type: Application
    Filed: June 9, 2009
    Publication date: June 16, 2011
    Inventors: Uwe Marx, Julien Thorens, Stephane Bernard
  • Publication number: 20110086382
    Abstract: A self-contained organ-on-a-chip device includes at least one medium feed reservoir and at least one organ growth section including at least one organ cavity. The at least one medium feed reservoir is configured to connect to the at least one organ growth section by a microfluidic feed channel and the at least one organ cavity.
    Type: Application
    Filed: June 4, 2009
    Publication date: April 14, 2011
    Inventor: Uwe Marx
  • Publication number: 20090286317
    Abstract: The invention provides a culture system, which combines a device for undifferentiated proliferation of the cells with a device for cell differentiation and proliferation. Aspects of the invention include a modular culture system, a kit and an associated method for combining undifferentiated proliferation of cells with differentiation and proliferation of cells in a single, integrated device. The culture system has a first compartment comprising a plurality of miniaturized culture cavities that are sealed on one end by a surface that may be perforated, and a second compartment which defines one or more, larger culture chambers, and wherein said first and second compartment can be sterilely connected and living cell material can be transferred directly and in a controlled manner from the first compartment into the second compartment.
    Type: Application
    Filed: September 13, 2007
    Publication date: November 19, 2009
    Inventors: Christian Demmler, Christoph Giese, Richard Ammer, Uwe Marx
  • Publication number: 20090155895
    Abstract: Initiation of growth and cultivation of cells can be performed by introducing the cells into culture compartments of a liquid-gas-phase exposure bioreactor containing a supply chamber in which there are disposed hollow-filament membranes having an inside diameter of no larger than 5 mm, wherein an inner volume of said hollow-filament membranes forms the culture compartments. Approximately one half of the supply chamber is filled with a nutrient medium and a remainder is filled with a gas mixture. Perfusion of medium and gas is turned on simultaneously or separately. The hollow-filament membranes and the cells contained therein are cyclically exposed to the gas or liquid phase.
    Type: Application
    Filed: December 18, 2008
    Publication date: June 18, 2009
    Applicant: ProBioGen AG
    Inventors: Uwe Marx, Marco Riedel, Hikmat Bushnaq-Josting
  • Patent number: 7531351
    Abstract: Initiation of growth and cultivation of cells can be performed by introducing the cells into culture compartments of a liquid-gas-phase exposure bioreactor containing a supply chamber in which there are disposed hollow-filament membranes having an inside diameter of no larger than 5 mm, wherein an inner volume of said hollow-filament membranes forms the culture compartments. Approximately one half of the supply chamber is filled with a nutrient medium and a remainder is filled with a gas mixture. Perfusion of medium and gas is turned on simultaneously or separately. The hollow-filament membranes and the cells contained therein are cyclically exposed to the gas or liquid phase.
    Type: Grant
    Filed: June 14, 2005
    Date of Patent: May 12, 2009
    Assignee: ProBioGen AG
    Inventors: Uwe Marx, Marco Riedel, Hikmat Bushnaq-Josting
  • Patent number: 7501232
    Abstract: The invention relates to a method for the non-invasive selection of single living cells under gentle conditions from mixtures of cells or cell cultures with respect to a specific production performance. To this end, the concentration of substances produced by the individual cells which become enriched at the cell membrane, such as reporter gene products (GFP) or specifically secreted products, such as antibodies, is determined by fluorescence-microscopic detection methods.
    Type: Grant
    Filed: May 12, 2004
    Date of Patent: March 10, 2009
    Assignee: Probiogen AG
    Inventors: Uwe Marx, Christian D. Demmler, Christoph Giese
  • Publication number: 20060194320
    Abstract: The invention relates to methods and devises for the faithful modeling of organ functions in vitro.
    Type: Application
    Filed: May 19, 2004
    Publication date: August 31, 2006
    Applicant: PROBIOGEN
    Inventors: Hikmat Bushnaq-Josting, Marco Riedel, Uwe Marx, Christoph Giese