Abstract: The present invention lies in the field of food ingredients and concerns a method for the production of dihydrochalcones from various educts as well as the corresponding enzymes, which are used for the production of dihydrochalcones. Furthermore, the present invention concerns transgenic microorganisms and vectors for expressing the enzymes according to the invention.

Abstract: A rotor (1) of an electrical machine is already known, comprising a rotor body (3) which can be rotated about a rotor axis (2) and comprising several cooling ducts (5) which have a cooling duct opening (8.1, 8.2) at each of its ends, wherein one cooling duct opening (8.1) of one of the cooling ducts (5) is arranged radially further outside than the other cooling duct opening (8.2) of the same cooling duct (5). The driving force for generating an airflow through the cooling ducts (5) is generated by a radial offset between a channel of a hollow shaft of the rotor and one of the cooling duct openings of the rotor. In the rotor (1) according to the invention, the driving force for generating the airflow is generated solely in the cooling duct (5) in question of the rotor (1). According to the invention: the first cover element (10) covers the radially innermost partial cross-section of the cooling duct opening (8.

Abstract: The present invention relates to a nucleic acid molecule encoding a chain myeloid capable of specifically binding to CD33, CD16 and CD123, wherein said nucleic molecule comprises: (a) a nucleic add molecule encoding a protein represented by SEQ ID NO:1; (b) a nucleic acid molecule represented by SEQ ID NO:2; (c) the nucleic add molecule of (b), wherein each thymine is replaced by urea; (d) a nucleic acid molecule encoding a protein having at least 98% sequence identity to the protein of (a); or (e) a nucleic add molecule that is degenerate with respect to the nucleic acid molecule of (b) or (c). The present invention further relates to a vector comprising the nucleic acid molecule of the invention, a host cell transformed or transfected with the nucleic acid molecule or the vector of the invention, as well as to a method for the production of a single chain myeloid capable of specifically binding to CD33, CD16 and CD123.

Abstract: The present invention relates to reagents which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said reagents.

Abstract: A bending machine that produces complex bent parts from straight wire rods includes computer-numerical control unit; a transport system that transports successive wire rods along a transport path, wherein the transport system has a plurality of workpiece-receiving devices each for receiving a single wire rod; a plurality of workstations arranged along the transport path, wherein at least two of the workstations are configured as bending stations, wherein at least one bending station comprises a bending unit configured as a rotary draw bending unit.

Abstract: The invention relates to compounds of Formula (I) wherein X1, X2, X3, L, RX4, R1, R2A, R2B, R3, R4, R5, and R6 are as described in the description; to their preparation, to pharmaceutically acceptable salts thereof, to pharmaceutical compositions containing one or more compounds of Formula (I), and to the use of such compounds as medicaments, especially as Kv7 openers.

Abstract: The invention relates to a bending device (2) for bending a rod-like or tubular workpiece (4), comprising a bending machine (6), which has a bending head (8), which is designed for bending the workpiece (4) in a forming process, and a control means (24), which controls the operation of the bending machine (6), a robot (10), which comprises a multi-joint arm (11) which can be adjusted by motors, having a gripper end (12), which is designed for gripping and holding the workpiece (4), and a control unit (22), which is designed to control the operation of the robot (10), wherein the control means (24) is designed to control the bending machine (6) and the robot (10) during the bending process.

Abstract: The invention relates to compounds of Formula (I) wherein X1, X2, X3, Y, R1, R2A, R2B, R3, and R4 are as described in the description; to their preparation, to pharmaceutically acceptable salts thereof, to pharmaceutical compositions containing one or more compounds of Formula (I), and to the use of such compounds as medicaments, especially as Kv7 openers.

Abstract: The present invention provides a compound of formula I, having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.

Abstract: The invention relates to a bending device (2) for bending a rod-like or tubular workpiece (4), comprising a bending machine (6), which has a bending head (8), which is designed for bending the workpiece (4) in a forming process, and a control means (24), which controls the operation of the bending machine (6), a robot (10), which comprises a multi-joint arm (11) which can be adjusted by motors, having a gripper end (12), which is designed for gripping and holding the workpiece (4), and a control unit (22), which is designed to control the operation of the robot (10), wherein the control means (24) is designed to control the bending machine (6) and the robot (10) during the bending process.

Abstract: The present invention provides a compound of formula I having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.

Abstract: The present invention provides a compound of formula I, having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.

Abstract: The present invention provides a compound of formula I, having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.

Abstract: The invention relates to a compound of formula (I) wherein R1 and R2 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.

Abstract: In a method for noncontact, radiation thermometric temperature measurement, a short-circuit photocurrent that is proportional to a received radiant power is produced in a photodiode radiation detector that is operating photovoltaically without bias voltage. The photocurrent is processed in a current to voltage converter. Subsequently, a temperature signal corresponding to the radiant power is generated. A corrective current, dependent on a temperature of the photodiode radiation detector, is added to the short-circuit photocurrent to compensate a fault current, wherein the fault current is based on an input bias current and an input offset voltage of the current to voltage converter across a temperature-dependent shunt resistance of the photodiode radiation detector. A device with a corrective current source controlled by a microcontroller is provided that can be used to perform the method.

Abstract: The present invention provides a compound of formula I having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.

Abstract: The present invention provides a compound of formula I, having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.

Abstract: The present invention provides a compound of formula I having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.

Abstract: The present invention provides a compound of formula I, having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.

Abstract: The invention relates to a compound of formula (I) wherein R1 and R2 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.