Abstract: The present invention relates to compounds of formula (I) wherein R1, R2, R3, R5, W, X, X1, Y, Y1, Z and Z1 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit PDE10A and can be used in the treatment of CNS disorders such as schizophrenia, Alzheimer's disease, and Parkinson's disease.

Abstract: The invention relates to a compound of formula (I) wherein A and R1 to R7 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.

Abstract: The invention is concerned with novel nitrogen-containing heteroaryl compounds of formula (I) wherein A1, A2, R1, R2, R3, R4, R5 and R6 are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit PDE10A and can be used as therapeutics.

Abstract: A method of programming control of a forming machine which has a plurality of controllable machine axes includes displaying an axis selection menu with graphical symbols for machine axes of the forming machine; receiving an input for selection of a machine axis to be programmed; displaying an axial movement menu containing options for the input of movement parameters for definition of a course of movement of the axial movement of the selected machine axis; receiving inputs for definition of movement parameters; displaying an axial movement coordination menu containing options for input of coordination parameters for definition of a coordination of courses of movement of the axial movements of machine axes; receiving inputs for definition of values for coordination parameters.

Abstract: A method for forming an auxiliary stack when a sheet stack is changed in a sheet delivery of a sheet-processing machine includes providing an auxiliary stack support for supporting the auxiliary stack during a non-stop stack change and multiple stop and separator elements disposed outside a stacking area in front of edges of the sheet stack to form a gap in a stream of sheets conveyed by a conveying system and released to fall onto the sheet stack. The sheet stack is lowered to form a gap for the auxiliary stack support, the stop elements for the front edge and the rear edge of the sheet stack are moved into a disengaged stand-by position before the main stack is lowered. For this purpose, the stop elements are equipped with remote-controllable actuating devices that are connected to a control unit. A device for forming an auxiliary stack is also provided.

Abstract: The invention is concerned with novel nitrogen-containing heteroaryl compounds of formula (I) wherein A1, A2, R1, R2, R3, R4, R5 and R6 are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit PDE10A and can be used as therapeutics.

Abstract: An apparatus for feeding wire to wire-processing machines, in which the wire is drawn off from a pay-off reel holding a wire coil and rotatable about a spindle and fed to a wire feeder upstream of the wire-processing machine, wherein at least one wire-deflecting device, via which the wire drawn off from the pay-off reel is guided and released towards the wire feeder, is connected downstream of the pay-off reel in the wire draw-off direction, and wherein a wire-storage device is provided upstream of the wire feeder, this apparatus presents a guide path, forming a closed circuit, on which the wire runs and the diameter of which can be altered between a smaller value corresponding to an inner radial position of the guide path and a larger value corresponding to an outer radial position of the guide path, wherein the guide path is spring-pretensioned towards the outer radial position.

Abstract: A pressing device (50) for pressing cutting means onto circumferential surfaces (12) of substantially cylindrical workpiece portions (13) during a finishing operation is provided for pressing the cutting means onto a circumferential surface with a pressing force over a contact angle. The pressing device is steplessly adaptable for the machining of workpiece portions of differing diameters that have a diameter difference of at least 0.1 mm.

Abstract: According to a method for the fine machining of internal surfaces of bore holes in tools by fine boring and subsequent honing, the following steps are executed: Fine boring of at least one bore hole (131) in a tool (130) by means of a fine boring tool (128) of a fine boring device (120) for the creation of a fine bored hole; Transfer of the tool to a machining position of a honing device (140) for the machining of the fine bored bore hole by means of a honing tool (148A) of the honing device; Measurement of the fine bored bore hole with one of the measurement devices (160) allocated to the honing device in the machining position for the creation of at least one bore hole measurement signal representing the properties of the fine bored bore hole. The fine boring device is controlled subject to the bore hole measuring signal.

Abstract: The invention is concerned with novel nitrogen-containing heteroaryl derivatives of formula (I) wherein R1, R2, R3, R4, R5, A1, A2, and Y are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit PDE10A and can be used as medicaments.

Abstract: The invention is concerned with novel imidazopyrimidine derivatives of formula (I) wherein R1, R2 and R8 are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit PDE10A and can be used as pharmaceuticals.

Abstract: The present invention provides a method for the treatment of schizophrenia which comprises administering a compound of formula wherein the substituents are as described herein or a pharmaceutically active acid-addition salt thereof. In particular, the invention provides methods for treating both positive and negative symptoms of schizophrenia through dual inhibition of NK1 and NK3 receptors. The invention also provides novel compounds with formula I and methods for preparing compounds of the invention.

Abstract: The present invention relates to compounds of formula (I) wherein R1, R2, R3, R5, W, X, X1, Y, Y1, Z and Z1 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit PDE10A and can be used in the treatment of CNS disorders such as schizophrenia, Alzheimer's disease, and Parkinson's disease.

Abstract: The present invention relates to compounds of formula I wherein A, n, R1a to R1e and R2 to R5 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are glucocorticoid receptor antagonists useful for the treatment and/or prevention of diseases such as diabetes, dyslipidemia, obesity, hypertension, cardiovascular diseases, adrenal imbalance or depression.

Abstract: The invention is concerned with triazolopyridine compounds of formula (I) wherein R1, R2, R3 and R4 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit PDE10A and can be used as pharmaceuticals.

Abstract: The invention relates to an external device (100) having at least one memory, which device can be connected with a computer (24) or computer network by way of a serial bus system. In order to make available an external device (100) that can be used to provide increased protection against access by unauthorized persons to security-relevant regions and sensitive data in computers (24) and computer networks, the invention provides that the external device (100) has a processor (14) as well as a USB drive (15) and a biometric means (12b) for identification of a person, wherein processor (14), USB drive (15), and biometric means (12b) are coupled with one another.

Abstract: The invention is concerned with novel imidazopyridine derivatives of formula (I) wherein R1, R2, R3, R4, R5 and A are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit PDE10A and can be used for the treatment of various diseases, including central nervous system disorders such as Alzheimer's disease, Parkinson's disease, and schizophrenia.

Abstract: The invention is concerned with triazolopyridine compounds of formula (I) wherein R1, R2, R3 and R4 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit PDE10A and can be used as pharmaceuticals.

Abstract: The present invention is concerned with novel pyridazinones of formula (I) wherein R1, R2, R3 and R4 are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit PDE10A and can be used for the treatment of CNS disorders.

Abstract: The present invention relates to compounds of formula I wherein A, n, R1a to R1e and R2 to R5 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are glucocorticoid receptor antagonists useful for the treatment and/or prevention of diseases such as diabetes, dyslipidemia, obesity, hypertension, cardiovascular diseases, adrenal imbalance or depression.