Abstract: The present invention relates to Orally Inhaled and Nasal Drug Product (OINDP) comprising a benzodiazepine, in particular remimazolam.

Abstract: A sealing bellows for a ball joint having a housing-side sealing area, a stud-side sealing area, and an outlet opening arranged between the sealing areas and which penetrates a wall of the sealing bellows. The outlet opening is open in the unassembled state of the sealing bellows. The outlet opening is closed in the assembled state of a ball joint. The sealing bellows and/or the ball joint can be used for a multi-point link, particularly a two-point link.

Abstract: A sealing element for a ball joint has a sealing area on the housing side and a sealing area a distance away therefrom in an axial direction of the sealing element on the stud side. Arranged between the housing-side sealing area and the stud-side sealing area is an outlet opening which extends through the sealing element to allow the passage of spent lubricant. The outlet opening extends in the axial direction of the sealing element, passing all the way through the sealing element in the axial direction. Further, the sealing element is incorporated in a ball joint which is incorporated in a two-point control arm.

Abstract: A ball joint for a chassis component in the form of a two-point linkage. The ball joint includes a housing and a ball stud fitted and able to be deflected in the housing, as well as a sealing element arranged between the housing and the ball stud, which surrounds the ball stud all round. Deflection movement of the ball stud, relative to the housing, is restricted at least in some areas by the sealing element. The sealing element is attached to the housing by an interlocked connection. The sealing element of the ball joint is attached to the housing by a snap-on connection. A two-point linkage having such a ball joint, and the two-point linkage is a steering rod or a track rod.

Abstract: A radial ball joint (1, 50, 70) for a vehicle having a housing (2, 51) for holding a joint ball (11) of a ball stud (6) so that the ball stud can rotate and pivot. An upper bearing shell (7), made from a steel sheet, is arranged between an inside wall (10) of the housing (2, 51) and the joint ball (11). The upper bearing shell (7) is in contact with the joint ball (11) over a contact zone (21) to provide the joint ball (11) with a circumferential slide bearing between its equator (12) and its upper pole (13). The upper bearing shell (7) is in the form of an annular, circumferentially closed drawn component and has in the contact zone (21) with the joint ball (11). A number of lubrication grooves (14), pass through a wall (20) of the upper bearing shell (7), in an embossment manner.

Abstract: The present invention relates to Orally Inhaled and Nasal Drug Product (OINDP) comprising a benzodiazepine, in particular remimazolam.

Abstract: A sealing element for a ball joint. The sealing element has a sealing area on the housing side and a sealing area a distance away therefrom in an axial direction of the sealing element on the stud side. Arranged between the housing-side sealing area and the stud-side sealing area is an outlet opening which extends through the sealing element to allow the passage of spent lubricant. The outlet opening extends in the axial direction of the sealing element, passing all the way through the sealing element in the axial direction. Further, a ball joint having a sealing element and a two-point control arm with such a ball joint.

Abstract: A sealing bellows for a ball joint having a housing-side sealing area, a stud-side sealing area, and an outlet opening arranged between the sealing areas and which penetrates a wall of the sealing bellows. The outlet opening is open in the unassembled state of the sealing bellows. The outlet opening is closed in the assembled state of a ball joint. The sealing bellows and/or the ball joint can be used for a multi-point link, particularly a two-point link.

Abstract: The present invention relates to Orally Inhaled and Nasal Drug Product (OINDP) comprising a benzodiazepine, in particular remimazolam.

Abstract: The present invention relates to an anti-NMDA antibody or fragment or derivative thereof which is effective in inhibiting the deleterious effects of tissue-type plasminogen activator (t-PA) mediated by N-methyl-D-aspartate (NMDA) receptors and to medical uses, in particular for the treatment of neurological or neurodegenerative disorders, e.g. multiple sclerosis.

Abstract: A ball joint for a chassis component in the form of a two-point linkage. The ball joint includes a housing and a ball stud fitted and able to be deflected in the housing, as well as a sealing element arranged between the housing and the ball stud, which surrounds the ball stud all round. Deflection movement of the ball stud, relative to the housing, is restricted at least in some areas by the sealing element. The sealing element is attached to the housing by an interlocked connection. The sealing element of the ball joint is attached to the housing by a snap-on connection. A two-point linkage having such a ball joint, and the two-point linkage is a steering rod or a track rod.

Abstract: A radial ball joint (1, 50, 70) for a vehicle having a housing (2, 51) for holding a joint ball (11) of a ball stud (6) so that the ball stud can rotate and pivot. An upper bearing shell (7), made from a steel sheet, is arranged between an inside wall (10) of the housing (2, 51) and the joint ball (11). The upper bearing shell (7) is in contact with the joint ball (11) over a contact zone (21) to provide the joint ball (11) with a circumferential slide bearing between its equator (12) and its upper pole (13). The upper bearing shell (7) is in the form of an annular, circumferentially closed drawn component and has in the contact zone (21) with the joint ball (11). A number of lubrication grooves (14), pass through a wall (20) of the upper bearing shell (7), in an embossment manner.

Abstract: The present invention relates to an anti-NMDA antibody or fragment or derivative thereof which is effective in inhibiting the deleterious effects of tissue-type plasminogen activator (t-PA) mediated by N-methyl-D-aspartate (NMDA) receptors and to medical uses, in particular for the treatment of neurological or neurodegenerative disorders, e.g. multiple sclerosis.

Abstract: The present invention relates to an anti-NMDA antibody or fragment or derivative thereof which is effective in inhibiting the deleterious effects of tissue-type plasminogen activator (t-PA) mediated by N-methyl-D-as-partate (NMDA) receptors and to medical uses, in particular for the treatment of neurological or neurodegenerative disorders, e.g. multiple sclerosis.

Abstract: The present invention relates to the use of thrombomodulin analogues for the manufacture of a medicament for the treatment of coagulopathy with hyperfibrinolysis, such as haemophilia disorders. These thrombomodulin analogs exhibit at therapeutically effective dosages an antifibrinolytic effect. Novel protein modifications together with methods for their identification are disclosed.

Abstract: The invention relates to a protein or peptide consisting of a kringle protein or peptide and its use for the treatment of neurological or neurodegenerative disorders, in particular stroke. The invention relates also to an isolated antibody of fragment thereof which binds to the N-terminal domain of the NMDA receptor subunit NR1 (anti-NR1 antibody), whereas binding of the antibody or the fragment thereof prevents the cleavage of the extracellular domain of the NR1 subunit, or the fragment and its use for the treatment of neurological or neurodegenerative disorders, in particular stroke. The invention relates further to a pharmaceutical composition containing said kringle protein or peptide or anti-NR1 antibody.

Abstract: The present invention relates to the use of thrombomodulin analogues for the manufacture of a medicament for the treatment of coagulopathy with hyperfibrinolysis, such as haemophilia disorders. These thrombomodulin analogs exhibit at therapeutically effective dosages an antifibrinolytic effect. Novel protein modifications together with methods for their identification are disclosed.

Abstract: The invention relates to inhalable quinolonecarboxylic acid derivative compositions for local control of diseases of the respiratory organs, in particular of lung diseases.

Abstract: The invention relates to inhalable quinolonecarboxylic acid derivative compositions for local control of diseases of the respiratory organs, in particular of lung diseases.

Abstract: The invention relates to the field of radiation injury. More particularly, this invention relates to the protection against/prevention of and treatment of diseases caused by ionizing radiation by the use of thrombomodulin.