Patents by Inventor Valeriano Merli

Valeriano Merli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESS FOR PREPARING N-METHYL-3, 4-DIMETHOXYPHENYLETHYLAMINE
    Publication number: 20090171110
    Abstract: Provided are intermediates useful for the preparation of verapamil and methods for their preparation.
    Type: Application
    Filed: December 24, 2008
    Publication date: July 2, 2009
    Inventors: Davide ALBANI, Roberto Arosio, Valeriano Merli
  • PROCESSES FOR PREPARING DARIFENACIN HYDROBROMIDE
    Publication number: 20090156831
    Abstract: The invention encompasses processes for the preparation of darifenacin hydrobromide.
    Type: Application
    Filed: February 19, 2009
    Publication date: June 18, 2009
    Inventors: Valeriano MERLI, Augusto CANAVESI, Paola DAVERIO
  • Levalbuterol hydrochloride polymorph B
    Patent number: 7488758
    Abstract: The invention is directed to levalbuterol HCl Form B and methods of making the same.
    Type: Grant
    Filed: May 20, 2005
    Date of Patent: February 10, 2009
    Assignee: Teva Pharmaceutical Fine Chemicals, S.r.l.
    Inventors: Valeriano Merli, Silvia Mantovani, Stefano Bianchi, Paola Daverio, Angelo Spreafico, Judith Aronhime, Adrienne Kovacsne-Mezei
  • Enantiomerically pure (R)-albuterol dibenzoyltartrate and protected analogs thereof
    Patent number: 7482489
    Abstract: Provided are processes for the preparation of (R)-SLB.D-DBTA salt and levalbuterol hydrochloride. Also provided are levalbuterol hydrochloride degradation products and processes for preparing them. Pharmaceutical compositions comprising at least one levalbuterol hydrochloride of the invention and at least one pharmaceutically-acceptable excipient are also provided.
    Type: Grant
    Filed: May 20, 2005
    Date of Patent: January 27, 2009
    Assignee: Teva Pharmaceutical Fine Chemicals S.r.l.
    Inventors: Valeriano Merli, Silvia Mantovani, Stefano Bianchi, Paola Daverio
  • Levalbuterol hydrochloride Polymorph A
    Patent number: 7465831
    Abstract: The invention is directed to processes for making levalbuterol HCl Polymorph A from by suspending or forming a first slurry of (R)-SLB(D)-DBTA in at least a first organic solvent, adding HCl to the suspension or slurry of the solid (R)-SLB.D-DBTA until the (R)-SLB.D-DBTA forms levalbuterol HCl Polymorph A, and isolating the levalbuterol HCl Polymorph A.
    Type: Grant
    Filed: July 11, 2007
    Date of Patent: December 16, 2008
    Assignee: Teva Pharmaceutical Fine Chemicals s.r.l.
    Inventors: Valeriano Merli, Silvia Mantovani, Stefano Bianchi, Paola Daverio, Angelo Spreafico, Judith Aronhime, Adrienne Kovacsne-Mezei
  • Polymorphs of memantine hydrochloride
    Patent number: 7462743
    Abstract: A crystalline Form II of memantine hydrochloride, pharmaceutical compositions containing crystalline Form II, and methods of preparing crystalline Forms I and II of memantine hydrochloride are provided.
    Type: Grant
    Filed: January 11, 2006
    Date of Patent: December 9, 2008
    Assignee: Teva Pharmaceutical Fine Chemicals S.r.l.
    Inventors: Valeriano Merli, Paola Daverio, Adrienne Kovacsne-Mezei, Judith Aronhime
  • Processes for preparing darifenacin hydrobromide
    Publication number: 20080269505
    Abstract: The invention encompasses processes for the preparation of darifenacin hydrobromide.
    Type: Application
    Filed: July 1, 2008
    Publication date: October 30, 2008
    Inventors: Valeriano Merli, Augusto Canavesi, Paola Daverio
  • Processes for preparing darifenacin hydrobromide
    Publication number: 20080269503
    Abstract: The invention encompasses processes for the preparation of darifenacin hydrobromide.
    Type: Application
    Filed: July 1, 2008
    Publication date: October 30, 2008
    Inventors: Valeriano Merli, Augusto Canavesi, Paola Daverio
  • Pure darifenacin hydrobromide substantially free of oxidized darifenacin and salts thereof and processes for the preparation thereof
    Publication number: 20080269504
    Abstract: Provided are darifenacin hydrobromide free of oxidized darifenacin, and processes for the preparation thereof.
    Type: Application
    Filed: July 1, 2008
    Publication date: October 30, 2008
    Inventors: Valeriano Merli, Augusto Canavesi, Paola Daverio, Alessandra Vailati
  • Processes for preparing darifenacin hydrobromide
    Patent number: 7442806
    Abstract: The invention encompasses processes for the preparation of darifenacin hydrobromide.
    Type: Grant
    Filed: December 27, 2006
    Date of Patent: October 28, 2008
    Assignee: Teva Pharmaceutical Industries Ltd.
    Inventors: Valeriano Merli, Augusto Canavesi, Paola Daverio
  • Pure darifenacin hydrobromide substantially free of oxidized darifenacin and salts thereof and processes for the preparation thereof
    Publication number: 20080216562
    Abstract: Provided are darifenacin hydrobromide free of oxidized darifenacin, and processes for the preparation thereof.
    Type: Application
    Filed: May 6, 2008
    Publication date: September 11, 2008
    Inventors: Valeriano Merli, Augusto Canavesi, Paola Daverio, Alessandra Vailati
  • Processes for preparing darifenacin hydrobromide
    Publication number: 20080221338
    Abstract: The invention encompasses processes for the preparation of darifenacin hydrobromide.
    Type: Application
    Filed: May 6, 2008
    Publication date: September 11, 2008
    Inventors: Valeriano Merli, Augusto Canavesi, Paola Daverio
  • Processes for preparing darifenacin hydrobromide
    Publication number: 20080214835
    Abstract: The invention encompasses processes for the preparation of darifenacin hydrobromide.
    Type: Application
    Filed: May 6, 2008
    Publication date: September 4, 2008
    Inventors: Valeriano Merli, Augusto Canavesi, Paola Daverio
  • Pure darifenacin hydrobromide substantially free of oxidized darifenacin and salts thereof and processes for the preparation thereof
    Publication number: 20080214846
    Abstract: Provided are darifenacin hydrobromide free of oxidized darifenacin, and processes for the preparation thereof.
    Type: Application
    Filed: May 6, 2008
    Publication date: September 4, 2008
    Inventors: Valeriano Merli, Augusto Canavesi, Paola Daverio, Alessandra Vailati
  • Preparation of levalbuterol hydrochloride
    Publication number: 20080132579
    Abstract: Provided are processes for the preparation of (R)-SLB.D-DBTA salt and levalbuterol hydrochloride. Also provided are levalbuterol hydrochloride degradation products and processes for preparing them. Pharmaceutical compositions comprising at least one levalbuterol hydrochloride of the invention and at least one pharmaceutically-acceptable excipient are also provided.
    Type: Application
    Filed: December 27, 2007
    Publication date: June 5, 2008
    Inventors: Valeriano Merli, Silvia Mantovani, Stefano Bianchi, Paola Daverio
  • 1H-imidazo [4,5-c] quinolin-4-cyano and 1H-imidazo [4,5-c] quinolin-4-carboxamide intermediates
    Patent number: 7335772
    Abstract: The invention relates to a process for the synthesis of 1H-imidazo[4,5-c]quinoline 4-cyano and 1H-imidazo[4,5-c]quinoline 4-carboxamide intermediates useful in preparing 1H-imidazo[4,5-C]quinoline 4-amines, a process for preparing 1H-imidazo[4,5-C]quinoline 4-amines using such intermediates; and, to the 1H-imidazo[4,5-c]quinoline 4-cyano and 1H-imidazo[4,5-c]quinoline 4-carboxamide intermediates. More particularly, the invention relates to a process for the preparation of 1-isobutyl-1H-imidazo[4,5-C]quinoline 4-amine (Imiquimod) using two intermediates, 1-isobutyl-1H-imidazo[4,5-c]quinoline 4-cyano and 1-isobutyl-1H-imidazo[4,5-c]quinoline 4-carboxamide, and to the said intermediates.
    Type: Grant
    Filed: December 9, 2004
    Date of Patent: February 26, 2008
    Assignee: TEVA Gyógyszergyár Zártkörüen Müködö Részvénytársaság
    Inventors: Valeriano Merli, Silvia Mantovani, Stefano Bianchi
  • Process for preparing memantine hydrochloride substantially free of impurities
    Publication number: 20080033054
    Abstract: The present invention encompasses processes for preparing Memantine hydrochloride and its derivatives, substantially free of impurities.
    Type: Application
    Filed: March 27, 2007
    Publication date: February 7, 2008
    Inventors: Valeriano Merli, Paola Daverio, Alessandra Vailati
  • Levalbuterol hydrochloride Polymorph A
    Publication number: 20080021244
    Abstract: The invention is directed to processes for making levalbuterol HCl Polymorph A from by suspending or forming a first slurry of (R)-SLB(D)-DBTA in at least a first organic solvent, adding HCl to the suspension or slurry of the solid (R)-SLB.D-DBTA until the (R)-SLB.D-DBTA forms levalbuterol HCl Polymorph A, and isolating the levalbuterol HCl Polymorph A.
    Type: Application
    Filed: July 11, 2007
    Publication date: January 24, 2008
    Inventors: Valeriano Merli, Silvia Mantovani, Stefano Bianchi, Paola Daverio, Angelo Spreafico, Judith Aronhime, Adrienne Kovacsne-Mezei
  • Processes for preparing darifenacin hydrobromide
    Publication number: 20070203221
    Abstract: The invention encompasses processes for the preparation of darifenacin hydrobromide.
    Type: Application
    Filed: December 27, 2006
    Publication date: August 30, 2007
    Inventors: Valeriano Merli, Augusto Canavesi, Paola Daverio
  • Pure darifenacin hydrobromide substantially free of oxidized darifenacin and salts thereof and processes for the preparation thereof
    Publication number: 20070197630
    Abstract: Provided are darifenacin hydrobromide free of oxidized darifenacin, and processes for the preparation thereof.
    Type: Application
    Filed: December 27, 2006
    Publication date: August 23, 2007
    Inventors: Valeriano Merli, Augusto Canavesi, Paola Daverio, Alessandra Vailati