Patents by Inventor Valeriano Merli

Valeriano Merli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Processes for preparing darifenacin hydrobromide
    Publication number: 20070197631
    Abstract: The invention encompasses processes for the preparation of darifenacin hydrobromide.
    Type: Application
    Filed: December 27, 2006
    Publication date: August 23, 2007
    Inventors: Valeriano Merli, Augusto Canavesi, Paola Daverio
  • Preparation of 1H-imidazo [4,5-C] quinolin-4-amines via 1H-imidazo [4,5-C] quinolin-4-phthalimide intermediates
    Publication number: 20070060755
    Abstract: The invention provides 1H-imidazo (4,5-c) quinoline-4-phthalimide intermediates useful in the synthesis of 1H-imidazo (4,5-c) quinoline-4-amines, particularly Imiquimod. The invention further provides a method for making the intermediates and a method for making 1H-imidazo (4,5-c) quinoline-4-amines via the intermediates.
    Type: Application
    Filed: November 15, 2006
    Publication date: March 15, 2007
    Inventors: Valeriano Merli, Silvia Mantovani, Stefano Bianchi
  • Preparation of 1H-imidazo[4,5-C] quinolin 4-amines via novel 1H-imidazo[4,5-c] quinolin 4-cyano and 1H-imidazo[4,5-c] quinolin 4-carboxamide intermediates
    Patent number: 7166721
    Abstract: The invention relates to a process for the synthesis of 1H-imidazo[4,5-c] quinoline 4-cyano and 1H-imidazo[4,5-c]quinoline 4-carboxamide intermediates useful in preparing 1H-imidazo[4,5-C] quinoline 4-amines, a process for preparing 1H-imidazo[4,5-C] quinoline 4-amines using such intermediates; and, to the 1H-imidazo[4,5-c] quinoline 4-cyano and 1H-imidazo[4,5-c] quinoline 4-carboxamide intermediates. More particularly, the invention relates to a process for the preparation of 1-isobutyl-1H-imidazo[4,5-C] quinoline 4-amine (Imiquimod) using two intermediates, 1-isobutyl-1H-imidazo[4,5-c] quinoline 4-cyano and 1-isobutyl-1H-imidazo[4,5-c] quinoline 4-carboxamide, and to the said intermediates.
    Type: Grant
    Filed: December 9, 2004
    Date of Patent: January 23, 2007
    Assignee: TEVA Gyógyszergyár Zártkörűen Működő Részvénytársaság
    Inventors: Valeriano Merli, Silvia Mantovani, Stefano Bianchi
  • Preparation of 1H-imidazo [4,5-C] quinolin-4-amines via 1H-imidazo [4,5-C] quinolin-4-phthalimide intermediates
    Patent number: 7153967
    Abstract: The invention provides 1H-imidazo(4,5-C)quinolin-4-phthalimide intermediates useful in the synthesis of 1H-imidazo(4,5-C)quinoline-4-amines, particularly Imiquimod. The invention further provides a method for making the intermediates and a method for making 1H-imidazo(4,5-C)quinoline-4-amines via the intermediates.
    Type: Grant
    Filed: December 23, 2004
    Date of Patent: December 26, 2006
    Assignee: TEVA Gyógyszergyár Zártkörüen Müködö Részvénytársaság
    Inventors: Valeriano Merli, Silvia Mantovani, Stefano Bianchi
  • Polymorphs of memantine hydrochloride
    Publication number: 20060217573
    Abstract: A crystalline Form II of memantine hydrochloride, pharmaceutical compositions containing crystalline Form II, and methods of preparing crystalline Forms I and II of memantine hydrochloride are provided.
    Type: Application
    Filed: January 11, 2006
    Publication date: September 28, 2006
    Inventors: Valeriano Merli, Paola Daverio, Adrienne Kovacsne-Mezei, Judith Aronhime
  • Process for the preparation of 1-amino-3,5-dimethyladamantane hydrochloride
    Publication number: 20060173215
    Abstract: A process for the preparation of memantine hydrochloride, intermediates thereof and its hydrochloric acid form are provided.
    Type: Application
    Filed: January 11, 2006
    Publication date: August 3, 2006
    Inventors: Valeriano Merli, Silvia Mantovani, Paola Daverio, Stefano Bianchi, Alessandro Spreafico
  • Levalbuterol hydrochloride Polymorph A
    Publication number: 20050272821
    Abstract: The invention is directed to processes for making levalbuterol HCl Polymorph A from by suspending or forming a first slurry of (R)-SLB(D)-DBTA in at least a first organic solvent, adding HCl to the suspension or slurry of the solid (R)-SLB.D-DBTA until the (R)-SLB.D-DBTA forms levalbuterol HCl Polymorph A, and isolating the levalbuterol HCl Polymorph A.
    Type: Application
    Filed: May 20, 2005
    Publication date: December 8, 2005
    Inventors: Valeriano Merli, Silvia Mantovani, Stefano Bianchi, Paola Daverio, Angelo Spreafico, Judith Aronhime, Adrienne Kovacsne-Mezei
  • Levalbuterol hydrochloride polymorph B
    Publication number: 20050267216
    Abstract: The invention is directed to levalbuterol HCl Form B and methods of making the same.
    Type: Application
    Filed: May 20, 2005
    Publication date: December 1, 2005
    Inventors: Valeriano Merli, Silvia Mantovani, Stefano Bianchi, Paola Daverio, Angelo Spreafico, Judith Aronhime, Adrienne Kovacsne-Mezei
  • Preparation of levalbuterol hydrochloride
    Publication number: 20050261368
    Abstract: Provided are processes for the preparation of (R)-SLB.D-DBTA salt and levalbuterol hydrochloride. Also provided are levalbuterol hydrochloride degradation products and processes for preparing them. Pharmaceutical compositions comprising at least one levalbuterol hydrochloride of the invention and at least one pharmaceutically-acceptable excipient are also provided.
    Type: Application
    Filed: May 20, 2005
    Publication date: November 24, 2005
    Inventors: Valeriano Merli, Silvia Mantovani, Stefano Bianchi, Paola Daverio
  • Preparation of 1H-imidazo [4,5-c] quinolin-4-amines via novel 1H-imidazo [4,5-c] quinolin-4-cyano and 1H-imidazo [4,5-c] quinolin-4-carboxamide intermediates
    Publication number: 20050119294
    Abstract: The invention relates to a process for the synthesis of 1H-imidazo[4,5-c]quinoline 4-cyano and 1H-imidazo[4,5-c]quinoline 4-carboxamide intermediates useful in preparing 1H-imidazo[4,5-C]quinoline 4-amines, a process for preparing 1H-imidazo[4,5-C]quinoline 4-amines using such intermediates; and, to the 1H-imidazo[4,5-c]quinoline 4-cyano and 1H-imidazo[4,5-c]quinoline 4-carboxamide intermediates. More particularly, the invention relates to a process for the preparation of 1-isobutyl-1H-imidazo[4,5-C]quinoline 4-amine (Imiquimod) using two intermediates, 1-isobutyl-1H-imidazo[4,5-c]quinoline 4-cyano and 1-isobutyl-1H-imidazo[4,5-c]quinoline 4-carboxamide, and to the said intermediates.
    Type: Application
    Filed: December 9, 2004
    Publication date: June 2, 2005
    Inventors: Valeriano Merli, Silvia Mantovani, Stefano Bianchi
  • Preparation of 1H-imidazo [4,5-C] quinolin-4-amines via 1H-imidazo [4,5-C] quinolin-4-phthalimide intermediates
    Publication number: 20050113404
    Abstract: The invention provides 1H-imidazo(4,5-C)quinolin-4-phthalimide intermediates useful in the synthesis of 1H-imidazo(4,5-C)quinoline-4-amines, particularly Imiquimod. The invention further provides a method for making the intermediates and a method for making 1H-imidazo(4,5-C)quinoline-4-amines via the intermediates.
    Type: Application
    Filed: December 23, 2004
    Publication date: May 26, 2005
    Inventors: Valeriano Merli, Silvia Mantovani, Stefano Bianchi
  • Preparation of 1H-imidazo [4,5-C] quinolin-4 amines via novel 1h-imidazo [4,5-C] quinolin-4-cyano and 1h-imidazo [4,5-C] quinolin-4-carboxamide intermediates
    Publication number: 20050101627
    Abstract: The invention relates to a process for the synthesis of 1H-imidazo[4,5-c]quinoline 4-cyano and 1H-imidazo[4,5-c]quinoline 4-carboxamide intermediates useful in preparing 1H-imidazo [4,5-C]quinoline 4-amines, a process for preparing 1H-imidazo[4,5-C]quinoline 4-amines using such intermediates; and, to the 1H-imidazo[4,5-c]quinoline 4-cyano and 1H-imidazo[4,5-c]quinoline 4-carboxamide intermediates. More particularly, the invention relates to a process for the preparation of 1-isobutyl-1H-imidazo[4,5-C]quinoline 4-amine (Imiquimod) using two intermediates, 1-isobutyl-1H-imidazo[4,5-c] quinoline 4-cyano and 1-isobutyl-1H-imidazo[4,5-c]quinoline 4-carboxamide, and to the said intermediates.
    Type: Application
    Filed: December 9, 2004
    Publication date: May 12, 2005
    Inventors: Valeriano Merli, Silvia Mantovani, Stefano Bianchi
  • Preparation of 1H-imidazo [4,5-C] quinolin-4-amines via 1H-imidazo [4,5-C] quinolin-4-phthalimide intermediates
    Patent number: 6852861
    Abstract: The invention provides 1H-imidazo(4,5-C)quinolin-4-phthalimide intermediates useful in the synthesis of 1H-imidazo(4,5-C)quinoline-4-amines, particularly Imiquimod. The invention further provides a method for making the intermediates and a method for making 1H-imidazo(4,5-C)quinoline-4-amines via the intermediates.
    Type: Grant
    Filed: July 23, 2003
    Date of Patent: February 8, 2005
    Assignee: Biogal Gyogyszergyar Rt.
    Inventors: Valeriano Merli, Silvia Mantovani, Stefano Bianchi
  • Preparation of 1H-imidazo [4,5-C] quinolin-4-amines via novel 1H-imidazo [4,5-c] quinolin-4-cyano and 1H-imidazo [4,5-c] quinolin-4-carboxamide intermediates
    Patent number: 6841678
    Abstract: The invention relates to a process for the synthesis of 1H-imidazo[4,5-c] quinoline 4-cyano and 1H-imidazo[4,5-c] quinoline 4-carboxamide intermediates useful in preparing 1H-imidazo[4,5-C] quinoline 4-amines, a process for preparing 1H-imidazo[4,5-C] quinoline 4-amines using such intermediates; and, to the 1H-imidazo[4,5-c] quinoline 4-cyano and 1H-imidazo[4,5-c] quinoline 4-carboxamide intermediates. More particularly, the invention relates to a process for the preparation of 1-isobutyl-1H-imidazo[4,5-C] quinoline 4-amine (Imiquimod) using two intermediates, 1-isobutyl-1H-imidazo[4,5-c] quinoline 4-cyano and 1-isobutyl-1H-imidazo[4,5-c] quinoline 4-carboxamide, and to the said intermediates.
    Type: Grant
    Filed: July 28, 2003
    Date of Patent: January 11, 2005
    Assignee: Biogal Gyogyszergyar Rt.
    Inventors: Valeriano Merli, Silvia Mantovani, Stefano Bianchi
  • Preparation of 1H-imidazo [4,5-C] quinolin-4-amines via 1H-imidazo [4,5-C] quinolin-4-phthalimide intermediates
    Publication number: 20040138459
    Abstract: The invention provides 1H-imidazo(4,5-C)quinolin-4-phthalimide intermediates useful in the synthesis of 1H-imidazo(4,5-C)quinoline-4-amines, particularly Imiquimod. The invention further provides a method for making the intermediates and a method for making 1H-imidazo(4,5-C)quinoline-4-amines via the intermediates.
    Type: Application
    Filed: July 23, 2003
    Publication date: July 15, 2004
    Inventors: Valeriano Merli, Silvia Mantovani, Bianchi Stefano
  • Preparation of 1H-imidazo [4,5-C] quinolin-4-amines via novel 1H-imidazo [4,5-c] quinolin-4-cyano and 1H-imidazo [4,5-c] quinolin-4-carboxamide intermediates
    Publication number: 20040063743
    Abstract: The invention relates to a process for the synthesis of 1H-imidazo[4,5-c] quinoline 4-cyano and 1H-imidazo[4,5-c] quinoline 4-carboxamide intermediates useful in preparing 1H-imidazo[4,5-C] quinoline 4-amines, a process for preparing 1H-imidazo[4,5-C] quinoline 4-amines using such intermediates; and, to the 1H-imidazo[4,5-c] quinoline 4-cyano and 1H-imidazo[4,5-c] quinoline 4-carboxamide intermediates. More particularly, the invention relates to a process for the preparation of 1-isobutyl-1H-imidazo[4,5-C] quinoline 4-amine (Imiquimod) using two intermediates, 1-isobutyl-1H-imidazo[4,5-c] quinoline 4-cyano and 1-isobutyl-1H-imidazo[4,5-c] quinoline 4-carboxamide, and to the said intermediates.
    Type: Application
    Filed: July 28, 2003
    Publication date: April 1, 2004
    Inventors: Valeriano Merli, Silvia Mantovani, Bianchi Stefano
  • Process for the production of alkoxycarbonyldipeptides intermediates in the synthesis of the lisinopril
    Patent number: 6166217
    Abstract: Process for the production of alkoxycarbonyldipeptides intermediates in the synthesis of the lisinopril which comprises protecting both amino functions of the L-lysine with an alkoxycarbonyl group, subsequently making the N-carboxyanhydride of the N6-[alkoxycarbonyl]-L-lysine by treatment with thionyl chloride and making the desired alkoxycarbonyldipeptide by reaction with L-proline in alkaline medium.
    Type: Grant
    Filed: June 18, 1999
    Date of Patent: December 26, 2000
    Assignee: AlliedSignal Inc.
    Inventors: Vincenzo Cannata, Valeriano Merli, Stefano Saguatti
  • Process for the production of alkoxycarbonyl-dipeptides intermediates in the synthesis of the lisinopril
    Patent number: 6031112
    Abstract: Process for the production of alkoxycarbonyldipeptides intermediates in the synthesis of the lisinopril which comprises protecting both amino functions of the L-lysine with an alkoxycarbonyl group, subsequently making the N-carboxyanhydride of the N6-[alkoxycarbonyl]-L-lysine by treatment with thionyl chloride and making the desired alkoxycarbonyldipeptide by reaction with L-proline in alkaline medium.
    Type: Grant
    Filed: January 25, 1999
    Date of Patent: February 29, 2000
    Assignee: P.F.C. Italiana S.r.l.
    Inventors: Vincenzo Cannata, Valeriano Merli, Stefano Saguatti
  • Process for the preparation and purification of iodinated contrast agents
    Patent number: 5550287
    Abstract: A process for the preparation and purification of L-5-(2-hydroxypropionylamino)-2,4,6-triiodoisophthalic acid bis-(1,3-dihydroxypropylamide) by using ion-exchange resins is described.
    Type: Grant
    Filed: March 3, 1995
    Date of Patent: August 27, 1996
    Assignee: Zambon Group S.p.A.
    Inventors: Vincenzo Cannata, Valeriano Merli, Claudio Dal Santo
  • Resolution process of intermediates useful for the preparation of diltiazem
    Patent number: 5097059
    Abstract: A process of spontaneous resolution of compounds of formula ##STR1## wherein R has the meanings reported in the description, is described. The compounds of formula III are intermediates useful for the preparation of Diltiazem.
    Type: Grant
    Filed: July 26, 1990
    Date of Patent: March 17, 1992
    Assignee: Zambon Group S.p.A.
    Inventors: Claudio Giordano, Dario Tentorio, Roberto Casagrande, Placido Bertin, Valeriano Merli, Giorgio Sagramora