Patents by Inventor Veli-Matti Mukkala

Veli-Matti Mukkala has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8221719
    Abstract: This invention relates to a group of novel chelating agents, novel chelates, biomolecules labeled with said chelates or chelating agents as well as solid supports conjugated with said chelates, chelating agents or labeled biomolecules. Especially the invention relates to novel chelating agents useful in solid phase synthesis of oligonucleotides or oligopeptides and the oligonucleotides and oligopeptides so obtained.
    Type: Grant
    Filed: September 5, 2008
    Date of Patent: July 17, 2012
    Assignee: Wallac Oy
    Inventors: Jari Peuralahti, Jari Hovinen, Janne Ketola, Lassi Jaakkola, Veli-Matti Mukkala, Päivi Liitti
  • Patent number: 8143057
    Abstract: This invention relates to a group of novel chelating agents, novel chelates, biomolecules labeled with said chelates or chelating agents as well as solid supports conjugated with said chelates, chelating agents or labeled biomolecules. Especially the invention relates to novel chelating agents useful in solid phase synthesis of oligonucleotides or oligopeptides and the oligonucleotides and oligopeptides so obtained.
    Type: Grant
    Filed: October 16, 2009
    Date of Patent: March 27, 2012
    Assignee: Wallac Oy
    Inventors: Jari Hovinen, Veli-Matti Mukkala, Harri Hakala, Jari Peuralahti
  • Patent number: 8071626
    Abstract: This invention relates to a group of novel chelating agents, novel chelates, biomolecules labeled with said chelates or chelating agents as well as solid supports conjugated with said chelates, chelating agents or labeled biomolecules. Especially the invention relates to novel chelating agents useful in solid phase synthesis of oligonucleotides or oligopeptides and the oligonucleotides and oligopeptides so obtained.
    Type: Grant
    Filed: December 17, 2007
    Date of Patent: December 6, 2011
    Assignee: Wallac Oy
    Inventors: Jari Hovinen, Veli-Matti Mukkala, Harri Hakala, Jari Peuralahti
  • Publication number: 20110117571
    Abstract: This invention concerns a non-radioactive homogenous proximity assay for cellular transport system. The assay format disclosed here takes advantageous of the fact that ABC transporters have two similar ATP binding sites, and thus allowing two ATP molecules to bind simultaneously to these adjacent sites.
    Type: Application
    Filed: November 27, 2008
    Publication date: May 19, 2011
    Applicant: WALLAC OY
    Inventors: Heini Frang, Jari Hovinen, Veli-Matti Mukkala, Pertti Hurskainen, Ilkka Hemmilä
  • Publication number: 20100204442
    Abstract: This invention relates to a group of novel chelating agents, novel chelates, biomolecules labeled with said chelates or chelating agents as well as solid supports conjugated with said chelates, chelating agents or labeled biomolecules. Especially the invention relates to novel chelating agents useful in solid phase synthesis of oligonucleotides or oligopeptides and the oligonucleotides and oligopeptides so obtained.
    Type: Application
    Filed: September 5, 2008
    Publication date: August 12, 2010
    Applicant: WALLAC OY
    Inventors: Jari Peuralahti, Jari Hovinen, Janne Ketola, Lassi Jaakkola, Veli-Matti Mukkala, Päivi Liitti
  • Publication number: 20100036102
    Abstract: This invention relates to a group of novel chelating agents, novel chelates, biomolecules labeled with said chelates or chelating agents as well as solid supports conjugated with said chelates, chelating agents or labeled biomolecules. Especially the invention relates to novel chelating agents useful in solid phase synthesis of oligonucleotides or oligopeptides and the oligonucleotides and oligopeptides so obtained.
    Type: Application
    Filed: October 16, 2009
    Publication date: February 11, 2010
    Applicant: WALLAC OY
    Inventors: Jari HOVINEN, Veli-Matti Mukkala, Harri Hakala, Jari Peuralahti
  • Patent number: 7625930
    Abstract: This invention relates to a group of novel chelating agents, novel chelates, biomolecules labeled with said chelates or chelating agents as well as solid supports conjugated with said chelates, chelating agents or labeled biomolecules. Especially the invention relates to novel chelating agents useful in solid phase synthesis of oligonucleotides or oligopeptides and the oligonucleotides and oligopeptides so obtained.
    Type: Grant
    Filed: December 6, 2004
    Date of Patent: December 1, 2009
    Assignee: Walloc Oy
    Inventors: Jari Hovinen, Veli-Matti Mukkala, Harri Hakala, Jari Peuralahti
  • Publication number: 20080176339
    Abstract: This invention concerns novel neutral labeling reactants. The novel reactants are derivatives of diethylenetriaminepentaacetic acid (DTPA) diamides, wherein a suitable group is linked to the molecule allowing introduction of the chelating agent or the neutral chelate to bioactive molecules.
    Type: Application
    Filed: March 25, 2008
    Publication date: July 24, 2008
    Applicant: WALLAC OY
    Inventors: Jari HOVINEN, Jari Peuralahti, Veli-Matti Mukkala, Kaj Blomberg
  • Publication number: 20080176338
    Abstract: This invention concerns novel labeling reactants suitable for labeling of a biospecific binding reactant using solid-phase synthesis. The novel reactants are derivatives of diethylenetriaminepentaacetic acid (DTPA), wherein a suitable group is linked to the DTPA molecule, thus allowing site specific introduction of the ligand of said derivatives to bioactive molecules on solid phase in an oligopeptide synthesizer.
    Type: Application
    Filed: March 25, 2008
    Publication date: July 24, 2008
    Applicant: WALLAC OY
    Inventors: Jari HOVINEN, Jari Peuralahti, Veli-Matti Mukkala
  • Publication number: 20080167443
    Abstract: This invention relates to a group of novel chelating agents, novel chelates, biomolecules labeled with said chelates or chelating agents as well as solid supports conjugated with said chelates, chelating agents or labeled biomolecules. Especially the invention relates to novel chelating agents useful in solid phase synthesis of oligonucleotides or oligopeptides and the oligonucleotides and oligopeptides so obtained.
    Type: Application
    Filed: December 17, 2007
    Publication date: July 10, 2008
    Applicant: WALLAC OY
    Inventors: Jari Hovinen, Veli-Matti Mukkala, Harri Hakala, Jari Peuralahti
  • Patent number: 7381567
    Abstract: The invention relates to an enhancement solution for an assay technology using lanthanide ions or their chelates as labels and dissociative fluorescence enhancement as a tool for detection, wherein said enhancement solution comprises a ?-diketone of formula I wherein R1 is an aryl, optionally mono- or multi-substituted, and R2 is a straight or branched alkyl chain with 2 to 9 carbon atoms substituted with four or more fluorine atoms. The invention further relates to a bioaffinity assay using lanthanide ions or their chelates as labels and dissociative fluorescence enhancement as a tool for detection comprising the use of said enhancement solution.
    Type: Grant
    Filed: September 7, 2006
    Date of Patent: June 3, 2008
    Assignee: Wallac Oy
    Inventors: Ilkka Hemmilä, Kaj Blomberg, Veli-Matti Mukkala, Harri Hakala
  • Patent number: 7381420
    Abstract: This invention concerns novel labeling reactants suitable for labeling of a biospecific binding reactant using solid-phase synthesis. The novel reactants are derivatives of diethylenetriaminepentaacetic acid (DTPA), wherein a suitable group is linked to the DTPA molecule, thus allowing site specific introduction of the ligand of the derivatives to bioactive molecules on solid phase in an oligopeptide synthesizer.
    Type: Grant
    Filed: December 1, 2006
    Date of Patent: June 3, 2008
    Assignee: Wallac Oy
    Inventors: Jari Hovinen, Jari Peuralahti, Veli-Matti Mukkala
  • Publication number: 20070286810
    Abstract: The invention concerns a method for preparing a particle comprising a lanthanide chelate, comprising polymerizing a lanthanide chelate derivative with one or more monomers, wherein the lanthanide chelate derivative has the formula M-L-Y (I), wherein Y is a lanthanide chelate; L is a linker and M is a polymerizable moiety. The invention concerns also the novel lanthanide chelate derivative M-L-Y (I). Further, the invention concerns a novel particle comprising a lanthanide chelate covalently bound to an organic polymer or copolymer via a linker.
    Type: Application
    Filed: June 8, 2006
    Publication date: December 13, 2007
    Applicant: WALLAC OY
    Inventors: Jari Hovinen, Veli-Matti Mukkala, Harri Hakala
  • Publication number: 20070166228
    Abstract: This invention concerns novel neutral labeling reactants. The novel reactants are derivatives of diethylenetriaminepentaacetic acid (DTPA) diamides, wherein a suitable group is linked to the molecule allowing introduction of the chelating agent or the neutral chelate to bioactive molecules.
    Type: Application
    Filed: January 17, 2007
    Publication date: July 19, 2007
    Applicant: WALLAC OY
    Inventors: Jari Hovinen, Jari Peuralahti, Veli-Matti Mukkala, Kaj Blomberg
  • Publication number: 20070134162
    Abstract: This invention concerns novel labeling reactants suitable for labeling of a biospecific binding reactant using solid-phase synthesis. The novel reactants are derivatives of diethylenetriaminepentaacetic acid (DTPA), wherein a suitable group is linked to the DTPA molecule, thus allowing site specific introduction of the ligand of said derivatives to bioactive molecules on solid phase in an oligopeptide synthesizer.
    Type: Application
    Filed: December 1, 2006
    Publication date: June 14, 2007
    Applicant: WALLAC OY
    Inventors: Jari Hovinen, Jari Peuralahti, Veli-Matti Mukkala
  • Patent number: 7211440
    Abstract: The invention relates to an enhancement solution for an assay technology using lanthanide ions or their chelates as labels and dissociative fluorescence enhancement as a tool for detection, wherein said enhancement solution comprises a ?-diketone of formula I wherein R1 is an aryl, optionally mono- or multi-substituted, and R2 is a straight or branched alkyl chain with 2 to 9 carbon atoms substituted with four or more fluorine atoms. The invention further relates to a bioaffinity assay using lanthanide ions or their chelates as labels and dissociative fluorescence enhancement as a tool for detection comprising the use of said enhancement solution.
    Type: Grant
    Filed: March 8, 2002
    Date of Patent: May 1, 2007
    Assignee: Wallac Oy
    Inventors: Iikka Hemmilä, Kaj Blomberg, Veli-Matti Mukkala, Harri Hakala
  • Publication number: 20070015284
    Abstract: The invention relates to an enhancement solution for an assay technology using lanthanide ions or their chelates as labels and dissociative fluorescence enhancement as a tool for detection, wherein said enhancement solution comprises a ?-diketone of formula I wherein R1 is an aryl, optionally mono- or multi-substituted, and R2 is a straight or branched alkyl chain with 2 to 9 carbon atoms substituted with four or more fluorine atoms. The invention further relates to a bioaffinity assay using lanthanide ions or their chelates as labels and dissociative fluorescence enhancement as a tool for detection comprising the use of said enhancement solution.
    Type: Application
    Filed: September 7, 2006
    Publication date: January 18, 2007
    Inventors: Ilkka Hemmila, Kaj Blomberg, Veli-Matti Mukkala, Harri Hakala
  • Publication number: 20050181393
    Abstract: This invention relates to a group of novel chelating agents, novel chelates, biomolecules labeled with said chelates or chelating agents as well as solid supports conjugated with said chelates, chelating agents or labeled biomolecules. Especially the invention relates to novel chelating agents useful in solid phase synthesis of oligonucleotides or oligopeptides and the oligonucleotides and oligopeptides so obtained.
    Type: Application
    Filed: December 6, 2004
    Publication date: August 18, 2005
    Applicant: WALLAC OY
    Inventors: Jari Hovinen, Veli-Matti Mukkala, Harri Hakala, Jari Peuralahti
  • Publication number: 20050084451
    Abstract: This invention relates to a group of novel chelating agents, novel chelates, biomolecules labeled with said chelates or chelating agents as well as solid supports conjugated with said chelates, chelating agents or labeled biomolecules. Especially the invention relates to novel chelating agents useful in solid phase synthesis of oligonucleotides or oligopeptides and the oligonucleotides and oligopeptides so obtained.
    Type: Application
    Filed: August 30, 2004
    Publication date: April 21, 2005
    Inventors: Jari Hovinen, Veli-Matti Mukkala, Harri Hakala, Jari Peuralahti
  • Publication number: 20030170907
    Abstract: The invention relates to an enhancement solution for an assay technology using lanthanide ions or their chelates as labels and dissociative fluorescence enhancement as a tool for detection, wherein said enhancement solution comprises a &bgr;-dietone of formula I 1
    Type: Application
    Filed: March 8, 2002
    Publication date: September 11, 2003
    Inventors: Ilkka Hemmila, Kaj Blomberg, Veli-Matti Mukkala, Harri Hakala