Abstract: Compounds, methods of use, and processes for making inhibitors of complement factor D comprising Formula I, or a pharmaceutically acceptable salt or composition thereof, wherein R12 or R13 on the A group is an amino substituent (R32) are provided. The inhibitors described herein target factor D and inhibit or regulate the complement cascade at an early and essential point in the alternative complement pathway, and reduce factor D's ability to modulate the classical and lectin complement pathways. The inhibitors of factor D described herein are capable of reducing the excessive activation of complement, which has been linked to certain autoimmune, inflammatory, and neurodegenerative diseases, as well as ischemia-reperfusion injury and cancer.

Abstract: Compounds, methods of use, and processes for making inhibitors of complement Factor D are provided comprising Formula I, I? and I?? or a pharmaceutically acceptable salt or composition thereof. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade. The inhibitors of Factor D described herein reduces the excessive activation of complement.

Abstract: Compounds, methods of use, and processes for making inhibitors of complement Factor D comprising Formula I, or a pharmaceutically acceptable salt or composition thereof wherein R12 or R13 on the A group is an amino substituent (R32) are provided. The inhibitors of Factor D described herein reduce the excessive activation of complement.

Abstract: The present disclosure relates to methods and apparatus for graphics processing. In some aspects, the apparatus may receive, by a first device from a second device, first position information corresponding to a first orientation of the second device. The apparatus can also generate, by the first device, first graphical content based on the first position information. Further, the apparatus can also generate, by the first device, motion information for warping the first graphical content. The apparatus can also encode, by the first device, the first graphical content. Additionally, the apparatus can provide, by the first device to the second device, the motion information and the encoded first graphical content.

Abstract: Methods, systems, and devices for frequency synchronization and phase correction at a rendering device are described. One method may include receiving, from a display device (e.g., a head-mounted display (HMD) device), a vertical sync count and an indication of one or more frame repeats. The rendering device may estimate a vertical sync frequency based on the received vertical sync count, and determine a phase corresponding to a minimum frame repeat based on the indication of the one or more frame repeats. The rendering device may adjust a vertical sync frequency to the estimated vertical sync frequency and a phase to the determined phase. The rendering device may transmit one or more frames to the display device using the adjusted frequency and/or the adjusted phase.

Abstract: An improved wireless split rendering system for displaying Extended Reality (XR) content is discussed. A rendering server and client head-mounted device (HMD) may communicate over a wireless medium, where communication control is given to a server application layer logic. This allows the server to use request pose information from the HMD only when needed for rendering, while preserving bandwidth on the wireless medium for transmitting frames of the rendered content. This reduces contention and improves channel efficiency.

Abstract: A method, an apparatus, and a computer-readable medium for wireless communication are provided. In one aspect, an example method may include determining to control a bit rate of a content encoder. The method may include generating a first number of shaded texture atlases for use in rendering a second number of frames by a second device based on the determination to control the bit rate of the content encoder. Each respective shaded texture atlas may include a respective plurality of shaded primitives. The method may include encoding, by the content encoder of the first device, a first shaded texture atlas of the first number of shaded texture atlases. The method may include transmitting, by the first device, the encoded first shaded texture atlas to the second device.

Abstract: Complement Factor D inhibitors, pharmaceutical compositions, and uses thereof, as well as processes for their manufacture are provided. The compounds provided include Formula I, Formula II, Formula III, Formula IV, and Formula V, or a pharmaceutically acceptable salt, prodrug, isotopic analog, N-oxide, or isolated isomer thereof, optionally in a pharmaceutically acceptable composition. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade.

Abstract: Compounds, methods of use, and processes for making inhibitors of complement factor D comprising Formula I, or a pharmaceutically acceptable salt or composition thereof wherein R12 or R13 on the A group is an aryl, heteroaryl or heterocycle (R32) are provided. The inhibitors described herein target factor D and inhibit or regulate the complement cascade at an early and essential point in the alternative complement pathway, and reduce factor D's ability to modulate the classical and lectin complement pathways. The inhibitors of factor D described herein are capable of reducing the excessive activation of complement, which has been linked to certain autoimmune, inflammatory, and neurodegenerative diseases, as well as ischemia-reperfusion injury and cancer.

Abstract: Compounds, methods of use, and processes for making inhibitors of complement factor D comprising Formula I, or a pharmaceutically acceptable salt or composition thereof wherein R12 or R13 on the A group is an ether (R32) are provided. The inhibitors described herein target factor D and inhibit or regulate the complement cascade at an early and essential point in the alternative complement pathway, and reduce factor D's ability to modulate the classical and lectin complement pathways. The inhibitors of factor D described herein are capable of reducing the excessive activation of complement, which has been linked to certain autoimmune, inflammatory, and neurodegenerative diseases, as well as ischemia-reperfusion injury and cancer.

Abstract: Macrocyclic Complement Factor D inhibitors, pharmaceutical compositions, and uses thereof, as well as processes for their manufacture are provided. The compounds provided include Formula I, Formula II, Formula III, Formula IV, Formula V, Formula VI, Formula VII, and Formula VIII or a pharmaceutically acceptable salt, prodrug, isotopic analog, N-oxide, or isolated isomer thereof, optionally in a pharmaceutically acceptable composition. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade.

Abstract: Complement Factor D inhibitors, pharmaceutical compositions, and uses thereof, as well as processes for their manufacture are provided. The compounds provided include Formula I, Formula II, Formula III, and Formula IV or a pharmaceutically acceptable salt, prodrug, isotopic analog, N-oxide, or isolated isomer thereof, optionally in a pharmaceutically acceptable composition. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade.

Abstract: An intermetallic or iron aluminide magnetically readable medium and a method of forming and reading the same are provided herein. Also provided is an identification card or tag, a key, an anti-counterfeiting measure, an anti-forging measure. The intermetallic or iron aluminide magnetically readable medium includes a magnetically readable surface, wherein the magnetically readable surface contains one or more first magnetically readable regions of the intermetallic or iron aluminide surrounded by one or more second magnetically readable regions. Additionally, the intermetallic or iron aluminide magnetically readable medium can be coated, encapsulated or concealed within a material.

Abstract: A method, an apparatus, and a computer-readable medium for wireless communication are provided. In one aspect, an example method may include determining to control a bit rate of a content encoder. The method may include generating a first number of shaded texture atlases for use in rendering a second number of frames by a second device based on the determination to control the bit rate of the content encoder. Each respective shaded texture atlas may include a respective plurality of shaded primitives. The method may include encoding, by the content encoder of the first device, a first shaded texture atlas of the first number of shaded texture atlases. The method may include transmitting, by the first device, the encoded first shaded texture atlas to the second device.

Abstract: One or more processors may perform one or more lookup table (LUT)-based image processing operations on an input image to produce an output image, wherein performing the one or more image processing operations on the input image introduces one or more banding artifacts in the output image. The one or more processors may determine one or more sub-regions of the output image that include the one or more banding artifacts. The one or more processors may perform one or more artifact reduction operations on the one or more sub-regions of the output image without performing the one or more artifact reduction operations on remaining sub-regions of the output image.

Abstract: Methods, systems, and devices for frequency synchronization and phase correction at a rendering device are described. One method may include receiving, from a display device (e.g., a head-mounted display (HMD) device), a vertical sync count and an indication of one or more frame repeats. The rendering device may estimate a vertical sync frequency based on the received vertical sync count, and determine a phase corresponding to a minimum frame repeat based on the indication of the one or more frame repeats. The rendering device may adjust a vertical sync frequency to the estimated vertical sync frequency and a phase to the determined phase. The rendering device may transmit one or more frames to the display device using the adjusted frequency and/or the adjusted phase.

Abstract: Compounds, methods of use, and processes for making inhibitors of complement factor D comprising Formula I, or a pharmaceutically acceptable salt or composition thereof wherein R12 or R13 on the A group is an aryl, heteroaryl or heterocycle (R32) are provided. The inhibitors described herein target factor D and inhibit or regulate the complement cascade at an early and essential point in the alternative complement pathway, and reduce factor D's ability to modulate the classical and lectin complement pathways. The inhibitors of factor D described herein are capable of reducing the excessive activation of complement, which has been linked to certain autoimmune, inflammatory, and neurodegenerative diseases, as well as ischemia-reperfusion injury and cancer.

Abstract: A method and a system for warping a rendered frame is disclosed. On a host device of a split-rendering system, the method includes generating the rendered frame based on head tracking information of a user. The method also includes identifying a region of interest (ROI) of the rendered frame. The method also includes generating metadata for a warping operation from the ROI. The method further include transmitting the rendered frame and the metadata for a warping operation of the rendered frame. On a client device of the split-rendering system, the method includes transmitting head tracking information of a user by a client device. The method also includes receiving the rendered frame and metadata. The method further includes warping the rendered frame using the metadata and display pose information. The host device and the client device may be combined into an all-in-one head mounted display.

Abstract: Aspects of the present disclosure provide a method for compressing a point cloud. The method includes determining a sub-division technique for the volume based on one or more numbers derived from a distribution of points in the volume, dividing the volume into a number of sub-volumes according to the sub-division technique, and determining whether each sub-volume of the sub-volumes is occupied by at least one point. The method includes generating a bit sequence for the volume comprising a control code that is based on the sub-division technique and an occupancy indicator that indicates whether or not each sub-volume is occupied by at least one point.

Abstract: Methods, systems, and devices for split rending of multiple graphic layers are described. An extended reality (XR) system may include a processing device that generates and renders multiple graphic layers and a display device that displays the graphic layers to create a virtual environment. The processing device may divide the multiple graphic layer into sets of graphic layers and composite each set into a composite layer for transmission to the display device over a respective stream. Each group of graphic layers may include graphic layers of the same type that are consecutively ordered with respect to their Z orders and that have similar frame rates.