Patents by Inventor Venkata R. Garigapati
Venkata R. Garigapati has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20240091414Abstract: The invention provides, inter cilia, ultra-thin conformal coated biological surfaces, such as living cells, cell clusters, tissues, organs, and hybrid synthetic organs, and methods of making the same, e.g., using click reactive water soluble polymers, under conditions that do not damage or significantly modify the biological surfaces. In some embodiments, the coated biological surfaces are suitable for delivery to a subject in need thereof.Type: ApplicationFiled: July 19, 2023Publication date: March 21, 2024Applicant: Takeda Pharmaceutical Company LimitedInventors: Venkata R. Garigapati, Tetsuya Matsuura
-
Publication number: 20230348675Abstract: The present application provides a semi-permeable hydrogel composition comprising an alginate matrix that is covalently crosslinked in its periphery to a multi-armed water soluble polymer, along with related methods and uses thereof.Type: ApplicationFiled: May 2, 2023Publication date: November 2, 2023Applicant: Takeda Pharmaceutical Company LimitedInventors: Venkata R. Garigapati, Tetsuo Hoshino, Amit Garle
-
Patent number: 11655343Abstract: The present application provides a semi-permeable hydrogel composition comprising an alginate matrix that is covalently crosslinked in its periphery to a multi-armed water soluble polymer, along with related methods and uses thereof.Type: GrantFiled: March 21, 2017Date of Patent: May 23, 2023Assignee: Takeda Pharmaceutical Company LimitedInventors: Venkata R. Garigapati, Tetsuo Hoshino, Amit Garle
-
Publication number: 20190100628Abstract: The present application provides a semi-permeable hydrogel composition comprising an alginate matrix that is covalently crosslinked in its periphery to a multi-armed water soluble polymer, along with related methods and uses thereof.Type: ApplicationFiled: March 21, 2017Publication date: April 4, 2019Inventors: Venkata R. GARIGAPATI, Tetsuo HOSHINO, Amit GARLE
-
Publication number: 20150079145Abstract: The present invention is directed to stabilizing Bone Morphogenetic Protein in various lyophilized formulations and compositions. The present invention comprises formulations primarily including trehalose as an excipient for lyophilized compositions and their subsequent storage and reconstitution, and can also optionally include other excipients, including buffers and surfactants.Type: ApplicationFiled: November 21, 2014Publication date: March 19, 2015Inventors: Venkata R. Garigapati, Dongling Su, Rehan Khanzada, Steven J. Sawamura
-
Patent number: 8895506Abstract: The present invention is directed to stabilizing Bone Morphogenetic Protein in various lyophilized formulations and compositions. The present invention comprises formulations primarily including trehalose as an excipient for lyophilized compositions and their subsequent storage and reconstitution, and can also optionally include other excipients, including buffers and surfactants.Type: GrantFiled: March 7, 2013Date of Patent: November 25, 2014Assignee: DePuy Synthes Products, LLCInventors: Venkata R. Garigapati, Dongling Su, Rehan Khanzada, Steven J. Sawamura
-
Patent number: 8435943Abstract: The present invention is directed to stabilizing Bone Morphogenetic Protein in various lyophilized formulations and compositions. The present invention comprises formulations primarily including trehalose as an excipient for lyophilized compositions and their subsequent storage and reconstitution, and can also optionally include other excipients, including buffers and surfactants.Type: GrantFiled: April 19, 2011Date of Patent: May 7, 2013Assignee: Advanced Technogies and Regenerative Medicine, LLCInventors: Venkata R. Garigapati, Dongling Su, Rehan Khanzada, Steven J. Sawamura
-
Publication number: 20110237506Abstract: The present invention is directed to stabilizing Bone Morphogenetic Protein in various lyophilized formulations and compositions. The present invention comprises formulations primarily including trehalose as an excipient for lyophilized compositions and their subsequent storage and reconstitution, and can also optionally include other excipients, including buffers and surfactants.Type: ApplicationFiled: April 19, 2011Publication date: September 29, 2011Applicant: Advanced Technologies and Regenerative Medicine, LLCInventors: Venkata R. Garigapati, Dongling Su, Rehan Khanzada, Steven J. Sawamura
-
Patent number: 7956028Abstract: The present invention is directed to stabilizing Bone Morphogenetic Protein in various lyophilized formulations and compositions. The present invention comprises formulations primarily including trehalose as an excipient for lyophilized compositions and their subsequent storage and reconstitution, and can also optionally include other excipients, including buffers and surfactants.Type: GrantFiled: December 4, 2007Date of Patent: June 7, 2011Assignee: Johnson & Johnson Regenerative Therapeutics, LLCInventors: Venkata R. Garigapati, Dongling Su, Rehan Khanzada, Steven J. Sawamura
-
Publication number: 20080147077Abstract: The present invention is directed to stabilizing Bone Morphogenetic Protein in various lyophilized formulations and compositions. The present invention comprises formulations primarily including trehalose as an excipient for lyophilized compositions and their subsequent storage and reconstitution, and can also optionally include other excipients, including buffers and surfactants.Type: ApplicationFiled: December 4, 2007Publication date: June 19, 2008Inventors: Venkata R. Garigapati, Dongling Su, Rehan Khanzada, Steven J. Sawamura
-
Patent number: 7048917Abstract: The present invention relates to a method for treating obesity, a method for reducing the absorption of dietary fat, and a method for treating hypertriglyceridemia in a patient and to particular polymers for use in the methods or in a manufacture of a medicament. The methods comprise the step of orally administering to a mammal, such as a human, a therapeutically effective amount of one or more fat-binding polymers. The administration of the fat-binding polymer of the invention facilitates the removal of fat from the body prior to digestion, with minimal side effects and low toxicity. In a preferred embodiment, the one or more fat-binding polymers are administered in combination with one or more lipase inhibitors, for example, lipstatin and tetrahydrolipstatin.Type: GrantFiled: November 22, 2000Date of Patent: May 23, 2006Assignee: Genzyme CorporationInventors: Thomas Jozefiak, Stephen Randall Holmes-Farley, W. Harry Mandeville, III, Chad Cori Huval, Venkata R. Garigapati, Keith K. Shackett, Danny Concagh
-
Patent number: 6875428Abstract: The invention features a method for treating obesity in a patient by administering to the patient a polymer that has been substituted with one or more groups that inhibit lipases, which are enzymes responsible for the hydrolysis of fat. The invention further relates to the polymers employed in the methods described herein as well as novel intermediates and methods for preparing the polymers.Type: GrantFiled: February 5, 2003Date of Patent: April 5, 2005Assignee: Genzyme CorporationInventors: W. Harry Mandeville, III, Molly Kate Boie, Venkata R. Garigapati
-
Patent number: 6726906Abstract: The present invention relates to a method for treating obesity, a method for reducing the absorption of dietary fat, and a method for treating hypertriglyceridemia in a patient and to particular polymers for use in the methods or in a manufacture of a medicament. The methods comprise the step of orally administering to a mammal, such as a human, a therapeutically effective amount of one or more fat-binding polymers. The administration of the fat-binding polymer of the invention facilitates the removal of fat from the body prior to digestion, with minimal side effects and low toxicity. In a preferred embodiment, the one or more fat-binding polymers are administered in combination with one or more lipase inhibitors, for example, lipstatin and tetrahydrolipstatin.Type: GrantFiled: November 22, 2000Date of Patent: April 27, 2004Assignee: Genzyme CorporationInventors: Thomas Jozefiak, Stephen Randall Holmes-Farley, W. Harry Mandeville, III, Chad Cori Huval, Venkata R. Garigapati, Keith K. Shackett, Danny Concagh
-
Publication number: 20030185789Abstract: The invention features a method for treating obesity in a patient by administering to the patient a polymer that has been substituted with one or more groups that inhibit lipases, which are enzymes responsible for the hydrolysis of fat. The invention further relates to the polymers employed in the methods described herein as well as novel intermediates and methods for preparing the polymers.Type: ApplicationFiled: February 5, 2003Publication date: October 2, 2003Applicant: GelTex Pharmaceuticals, Inc.Inventors: W. Harry Mandeville, Molly Kate Boie, Venkata R. Garigapati
-
Patent number: 6572850Abstract: The invention features a method for treating obesity in a patient by administering to the patient a polymer that has been substituted with one or more groups that inhibit lipases, which are enzymes responsible for the hydrolysis of fat. The invention further relates to the polymers employed in the methods described herein as well as novel intermediates and methods for preparing the polymers.Type: GrantFiled: November 16, 2000Date of Patent: June 3, 2003Assignee: GelTex Pharmaceuticals, Inc.Inventors: W. Harry Mandeville, III, Molly Kate Boie, Venkata R. Garigapati
-
Patent number: 6558657Abstract: The invention features a method for treating obesity in a patient by administering to the patient a polymer that has been substituted with one or more groups that inhibit lipases, which are enzymes responsible for the hydrolysis of fat. The invention further relates to the polymers employed in the methods described herein as well as novel intermediates and methods for preparing the polymers.Type: GrantFiled: November 16, 2000Date of Patent: May 6, 2003Assignee: GelTex Pharmaceuticals, Inc.Inventors: W. Harry Mandeville, III, Molly Kate Boie, Venkata R. Garigapati
-
Patent number: 6352692Abstract: The invention features a method for treating obesity in a patient by administering to the patient a polymer that has been substituted with one or more groups that inhibit lipases, which are enzymes responsible for the hydrolysis of fat. The invention further relates to the polymers employed in the methods described herein as well as novel intermediates and methods for preparing the polymers.Type: GrantFiled: January 6, 1999Date of Patent: March 5, 2002Assignee: GelTex Pharmaceuticals, Inc.Inventors: W. Harry Mandeville, III, Molly Kate Boie, Venkata R. Garigapati
-
Patent number: 6299868Abstract: The present invention relates to a method for treating obesity, a method for reducing the absorption of dietary fat, and a method for treating hypertriglyceridemia in a patient and to particular polymers for use in the methods or in a manufacture of a medicament. The methods comprise the step of orally administering to a mammal, such as a human, a therapeutically effective amount of one or more fat-binding polymers. The administration of the fat-binding polymer of the invention facilitates the removal of fat from the body prior to digestion, with minimal side effects and low toxicity. In a preferred embodiment, the one or more fat-binding polymers are administered in combination with one or more lipase inhibitors, for example, lipstatin and tetrahydrolipstatin.Type: GrantFiled: July 14, 1999Date of Patent: October 9, 2001Assignee: GelTex Pharmaceuticals, Inc.Inventors: Thomas Jozefiak, Stephen Randall Holmes-Farley, W. Harry Mandeville, III, Chad Cori Huval, Venkata R. Garigapati, Keith K. Shackett, Danny Concagh
-
Patent number: 6267952Abstract: The invention features a method for treating obesity in a patient by administering to the patient a polymer that has been substituted with one or more groups that inhibit lipases, which are enzymes responsible for the hydrolysis of fat. The invention further relates to the polymers employed in the methods described herein as well as novel intermediates and methods for preparing the polymers.Type: GrantFiled: October 5, 1998Date of Patent: July 31, 2001Assignee: GelTex Pharmaceuticals, Inc.Inventors: W. Harry Mandeville, III, Molly Kate Boie, Venkata R. Garigapati
-
Patent number: 6235720Abstract: The present invention includes polymerizable monomers comprising an acid-functionalized glycoside moiety. The monomer can have a polymerizable functional group, such as an olefinic bond, to which the acid-functionalized glycoside moiety is attached by a spacer group, for example, an alkylene group, or an alkylene group wherein one or more carbon atoms are substituted by heteroatoms, such as oxygen, nitrogen or sulfur atoms. The present invention also includes polymers comprising pendant acid-functionalized glycoside moieties. The present invention also provides a method for treating a microbial infection in a mammal by administering to the mammal a therapeutically effective amount of a polymer comprising one or more acid-functionalized glycoside moieties.Type: GrantFiled: June 1, 2000Date of Patent: May 22, 2001Assignee: GelTex Pharmaceuticals, Inc.Inventors: W. Harry Mandeville, III, Venkata R. Garigapati