Patents by Inventor Venkata Ramana Doppalapudi

Venkata Ramana Doppalapudi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NUCLEIC ACID-POLYPEPTIDE COMPOSITIONS AND USES THEREOF
    Publication number: 20180371102
    Abstract: Disclosed herein are compositions and pharmaceutical formulations that comprise a binding moiety conjugated to a polynucleic acid molecule and a polymer. Also described herein include methods for treating a cancer which utilize a composition or a pharmaceutical formulation comprising a binding moiety conjugated to a polynucleic acid molecule and a polymer.
    Type: Application
    Filed: September 11, 2018
    Publication date: December 27, 2018
    Inventors: Andrew John GEALL, Venkata Ramana DOPPALAPUDI, David Sai-Ho CHU, Michael Caramian COCHRAN, Rachel Elizabeth JOHNS, Palani BALU, Rob BURKE, Beatrice Diana DARIMONT
  • TUBULYSIN ANALOGS AND METHODS FOR THEIR PREPARATION
    Publication number: 20180362519
    Abstract: The present invention is directed to novel cytotoxic tubulysin analogs and derivatives, to antibody drug conjugates thereof, and to methods for using the same to treat medical conditions including cancer.
    Type: Application
    Filed: January 27, 2017
    Publication date: December 20, 2018
    Applicants: PFIZER INC., CovX Technologies Ireland Limited
    Inventors: Chakrapani SUBRAMANYAM, Lawrence N. TUMEY, Longfei XIE, Carolyn LEVERETT, Beth C. VETELINO, Sai Chetan K. SUKURU, Sarah HUDSON, Venkata Ramana DOPPALAPUDI, Abhijit S. BHAT
  • NUCLEIC ACID-POLYPEPTIDE COMPOSITIONS AND USES THEREOF
    Publication number: 20170281795
    Abstract: Disclosed herein are compositions and pharmaceutical formulations that comprise a binding moiety conjugated to a polynucleic acid molecule and a polymer. Also described herein include methods for treating a cancer which utilize a composition or a pharmaceutical formulation comprising a binding moiety conjugated to a polynucleic acid molecule and a polymer.
    Type: Application
    Filed: March 31, 2017
    Publication date: October 5, 2017
    Inventors: Andrew John GEALL, Venkata Ramana DOPPALAPUDI, David Sai-Ho CHU, Michael Caramian COCHRAN, Rachel Elizabeth JOHNS, Palani BALU, Rob BURKE, Beatrice Diana DARIMONT
  • Anti-angiogenic compounds
    Patent number: 8937048
    Abstract: The present invention provides various uses of VEGF binding peptides, including methods to treat disorders associated with abnormal angiogenesis. In addition, the invention provides VEGF peptides conjugated to antibodies alone and in conjunction with other anti-angiogenic molecules.
    Type: Grant
    Filed: August 27, 2012
    Date of Patent: January 20, 2015
    Assignee: Covx Technologies Ireland, Limited
    Inventors: Venkata Ramana Doppalapudi, Jing-Yu Lai, Bin Liu, Dingguo Liu, Joel Desharnais, Abhijit Suresh Bhat, Yanwen Fu, Bryan Douglas Oates, Gang Chen, Curt William Bradshaw
  • ANTI-ANGIOGENIC COMPOUNDS
    Publication number: 20120321591
    Abstract: The present invention provides various uses of VEGF binding peptides, including methods to treat disorders associated with abnormal angiogenesis.
    Type: Application
    Filed: August 27, 2012
    Publication date: December 20, 2012
    Inventors: Venkata Ramana Doppalapudi, Jing-Yu Lai, Bin Liu, Dingguo Liu, Joel Desharnais, Abhijit Suresh Bhat, Yanwen Fu, Bryan Douglas Oates, Gang Chen, Curt William Bradshaw
  • Anti-angiogenic compounds
    Patent number: 8293714
    Abstract: The present invention provides VEGF binding peptides. In addition, the invention provides VEGF peptides conjugated to antibodies alone and in conjunction with other anti-angiogenic molecules. Various uses of the peptides and compounds are provided, including methods to treat disorders associated with abnormal angiogenesis.
    Type: Grant
    Filed: April 29, 2009
    Date of Patent: October 23, 2012
    Assignee: Covx Technology Ireland, Ltd.
    Inventors: Venkata Ramana Doppalapudi, Jing-Yu Lai, Bin Liu, Dingguo Liu, Joel Desharnais, Abhijit Suresh Bhat, Yanwen Fu, Bryan Douglas Oates, Gang Chen, Curt William Bradshaw
  • ANTI-ANGIOGENIC COMPOUNDS
    Publication number: 20110087010
    Abstract: The present invention provides AA targeting compounds which comprise AA targeting agent-linker conjugates which are linked to a combining site of an antibody. Various uses of the compounds are provided, including methods to treat disorders connected to abnormal angiogenesis.
    Type: Application
    Filed: October 4, 2010
    Publication date: April 14, 2011
    Inventors: Curt W. BRADSHAW, Venkata Ramana DOPPALAPUDI, Jing-Yu LAI, John RIZZO
  • ANTI-ANGIOGENIC COMPOUNDS
    Publication number: 20100003267
    Abstract: The present invention provides VEGF binding peptides. In addition, the invention provides VEGF peptides conjugated to antibodies alone and in conjunction with other anti-angiogenic molecules. Various uses of the peptides and compounds are provided, including methods to treat disorders associated with abnormal angiogenesis.
    Type: Application
    Filed: April 29, 2009
    Publication date: January 7, 2010
    Inventors: Venkata Ramana Doppalapudi, Jing-Yu Lai, Bin Liu, Dingguo Liu, Joel Desharnais, Abhijit Suresh Bhat, Yanwen Fu, Bryan Douglas Oates, Gang Chen, Curt William Bradshaw
  • Anti-angiogenic compounds
    Patent number: 7521425
    Abstract: The present invention provides AA targeting compounds which comprise AA targeting agent-linker conjugates which are linked to a combining site of an antibody. Various uses of the compounds are provided, including methods to treat disorders connected to abnormal angiogenesis.
    Type: Grant
    Filed: March 3, 2006
    Date of Patent: April 21, 2009
    Assignee: Covx Technologies Ireland Limited
    Inventors: Curt W. Bradshaw, Venkata Ramana Doppalapudi, Jing-Yu Lai, John Rizzo
  • Anti-Angiogenic Compounds
    Publication number: 20080152660
    Abstract: The present invention provides AA targeting compounds which comprise AA targeting agent-linker conjugates which are linked to a combining site of an antibody. Various uses of the compounds are provided, including methods to treat disorders connected to abnormal angiogenesis.
    Type: Application
    Filed: March 3, 2006
    Publication date: June 26, 2008
    Inventors: Curt W. Bradshaw, Venkata Ramana Doppalapudi, Jing-Yu Lai, John Rizzo
  • Peptide deformylase activated prodrugs
    Patent number: 7163923
    Abstract: This invention provides a method for inhibiting the growth of a microorganism that expresses Peptide Deformylase by contacting the microorganism with an effective amount of the compound described herein. This method inhibits the growth of gram-positive and gram-negative microorganism, e.g., S. aureus, S. epidermidis, K. pneumoniae, E. aerogenes, E. cloacae, M. catarrhalis, E. coli, E. faecalis, H. influenzae and P. aeruginosa. This method can be practiced in vitro, ex vivo and in vivo. Further provided is a method for alleviating the symptoms of an infection by a Peptide Deformylase expressing microorganism in a subject by administering or delivering to the subject an effective amount of the compound described above.
    Type: Grant
    Filed: May 9, 2002
    Date of Patent: January 16, 2007
    Assignee: Celmed Oncology (USA), Inc.
    Inventors: Maria V. Sergeeva, Venkata Ramana Doppalapudi
  • Penicillanic acid derivative compounds and methods of making
    Patent number: 7125986
    Abstract: Compounds of formula I: wherein R1, R2, R3, R4 and n have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for inhibiting ?-lactamase enzymes, for enhancing the activity of ?-lactam antibiotics, and for treating ?-lactam resistant bacterial infections in a mammal. The invention also provides pharmaceutical compositions, processes for preparing compounds of formula I, and novel intermediates useful for the synthesis of compounds of formula I.
    Type: Grant
    Filed: May 27, 2004
    Date of Patent: October 24, 2006
    Assignee: Southern Methodist University Foundation for Research
    Inventors: John D. Buynak, Akireddy Srinivasa Rao, Venkata Ramana Doppalapudi
  • Peptide deformylase activated prodrugs
    Patent number: 7001922
    Abstract: The invention provides compounds and methods for using them to inhibit the growth of microorganism that expresses Peptide Deformylase, the compounds having the general formula:
    Type: Grant
    Filed: November 14, 2003
    Date of Patent: February 21, 2006
    Assignee: Celmed Oncology (USA), Inc.
    Inventors: Carlo Ballatore, Maria V. Sergeeva, Venkata Ramana Doppalapudi
  • Compositions for inhibiting beta-lactamase
    Patent number: 6906054
    Abstract: The invention provides pharmaceutical compositions comprising compounds of formula I and IV: wherein R1-R11 and A have any of the values defined in the specification, and their pharmaceutically acceptable salts. The pharmaceutical compositions are useful for inhibiting ?-lactamase enzymes, for enhancing the activity of ?-lactam antibiotics, and for treating ?-lactam resistant bacterial infections in a mammal.
    Type: Grant
    Filed: May 10, 2002
    Date of Patent: June 14, 2005
    Assignee: Research Corporation Technologies, Inc.
    Inventors: John D. Buynak, A. Srinivasa Rao, Greg C. Adam, Sirishkumar D. Nidamarthy, Venkata Ramana Doppalapudi
  • Peptide deformylase activated prodrugs
    Publication number: 20040236096
    Abstract: The invention provides compounds and methods for using them to inhibit the growth of microorganism that expresses Peptide Deformylase, the compounds having the general formula: 1
    Type: Application
    Filed: November 14, 2003
    Publication date: November 25, 2004
    Inventors: Carlo Ballatore, Maria V. Sergeeva, Venkata Ramana Doppalapudi
  • Penicillanic acid derivative compounds and methods of making
    Publication number: 20040220399
    Abstract: 1
    Type: Application
    Filed: May 27, 2004
    Publication date: November 4, 2004
    Applicant: Research Corporation Technologies, Inc.
    Inventors: John D. Buynak, Akireddy Srinivasa Rao, Venkata Ramana Doppalapudi
  • Penicillanic acid derivative compounds and methods of making
    Patent number: 6770759
    Abstract: Compound of formula I: wherein R1, R2, R3, R4 and n have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for inhibiting &bgr;-lactamase enzymes, for enhancing the activity of &bgr;-lactam antibiotics, and for treating &bgr;-lactam resistant bacterial infections in a mammal. The invention also provides pharmaceutical compositions, processes for preparing compounds of formula I, and novel intermediates useful for the synthesis of compounds of formula I.
    Type: Grant
    Filed: June 5, 2002
    Date of Patent: August 3, 2004
    Assignee: Research Corporation Technologies, Inc.
    Inventors: John D. Buynak, Akireddy Srinivasa Rao, Venkata Ramana Doppalapudi
  • Peptide deformylase activated prodrugs
    Publication number: 20030091587
    Abstract: This invention provides a method for inhibiting the growth of a microorganism that expresses Peptide Deformylase by contacting the microorganism with an effective amount of the compound described herein. This method inhibits the growth of gram-positive and gram-negative microorganism, e.g., S. aureus, S. epidermidis, K. pneumoniae, E. aerogenes, E. cloacae, M. catarrhalis, E. coli, E. faecalis, H. influenzae and P. aeruginosa. This method can be practiced in vitro, ex vivo and in vivo. Further provided is a method for alleviating the symptoms of an infection by a Peptide Deformylase expressing microorganism in a subject by administering or delivering to the subject an effective amount of the compound described above.
    Type: Application
    Filed: May 9, 2002
    Publication date: May 15, 2003
    Inventors: Maria V. Sergeeva, Venkata Ramana Doppalapudi
  • Beta-lactamase inhibiting compounds
    Publication number: 20030036541
    Abstract: The invention provides compounds of formula I and IV: 1
    Type: Application
    Filed: May 10, 2002
    Publication date: February 20, 2003
    Applicant: Research Corporation Technologies, Inc.
    Inventors: John D. Buynak, A. Srinivasa Rao, Greg C. Adam, Sirishkumar D. Nidamarthy, Venkata Ramana Doppalapudi
  • Penicillanic acid derivative compounds and methods of making
    Publication number: 20020198180
    Abstract: Compounds of formula I: 1
    Type: Application
    Filed: June 5, 2002
    Publication date: December 26, 2002
    Applicant: Research Corporation Technologies, Inc.
    Inventors: John D. Buynak, Akireddy Srinivasa Rao, Venkata Ramana Doppalapudi