Patents by Inventor Venkataramanan Krishnaswamy

Venkataramanan Krishnaswamy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10973589
    Abstract: A method for guiding resection of local tissue from a patient includes generating at least one image of the patient, automatically determining a plurality of surgical guidance cues indicating three-dimensional spatial properties associated with the local tissue, and generating a visualization of the surgical guidance cues relative to the surface. A system for generating surgical guidance cues for resection of a local tissue from a patient includes a location module for processing at least one image of the patient to determine three-dimensional spatial properties of the local tissue, and a surgical cue generator for generating the surgical guidance cues based upon the three-dimensional spatial properties. A patient-specific locator form for guiding resection of local tissue from a patient includes a locator form surface matching surface of the patient, and a plurality of features indicating a plurality of surgical guidance cues, respectively.
    Type: Grant
    Filed: April 27, 2020
    Date of Patent: April 13, 2021
    Assignee: THE TRUSTEES OF DARTMOUTH COLLEGE
    Inventors: Venkataramanan Krishnaswamy, Richard J. Barth, Jr., Keith D. Paulsen
  • Publication number: 20200346041
    Abstract: A Cherenkov-based imaging system uses a radio-optical triggering unit (RTU) that detects scattered radiation in a fast-response scintillator to detect pulses of radiation to permit capture of Cherenkov-light images during pulses of radiation and background images at times when pulses of radiation are not present without need for electrical interface to the accelerator that provides the pulses of radiation. The Cherenkov images are corrected by background subtraction and used for purposes including optimization of treatment, commissioning, routine quality auditing, R&D, and manufacture. The radio-optical triggering unit employs high-speed, highly sensitive radio-optical sensing to generate a digital timing signal which is synchronous with the treatment beam for use in triggering Cherenkov radiation detection.
    Type: Application
    Filed: July 18, 2020
    Publication date: November 5, 2020
    Inventors: Venkataramanan Krishnaswamy, Petr Bruza, Michael Jermyn, Brian W. Pogue
  • Publication number: 20200330163
    Abstract: A method for guiding resection of local tissue from a patient includes generating at least one image of the patient, automatically determining a plurality of surgical guidance cues indicating three-dimensional spatial properties associated with the local tissue, and generating a visualization of the surgical guidance cues relative to the surface. A system for generating surgical guidance cues for resection of a local tissue from a patient includes a location module for processing at least one image of the patient to determine three-dimensional spatial properties of the local tissue, and a surgical cue generator for generating the surgical guidance cues based upon the three-dimensional spatial properties. A patient-specific locator form for guiding resection of local tissue from a patient includes a locator form surface matching surface of the patient, and a plurality of features indicating a plurality of surgical guidance cues, respectively.
    Type: Application
    Filed: April 27, 2020
    Publication date: October 22, 2020
    Inventors: Venkataramanan KRISHNASWAMY, Richard J. BARTH, JR., Keith D. PAULSEN
  • Publication number: 20200261164
    Abstract: A method for guiding resection of local tissue from a patient includes generating at least one image of the patient, automatically determining a plurality of surgical guidance cues indicating three-dimensional spatial properties associated with the local tissue, and generating a visualization of the surgical guidance cues relative to the surface. A system for generating surgical guidance cues for resection of a local tissue from a patient includes a location module for processing at least one image of the patient to determine three-dimensional spatial properties of the local tissue, and a surgical cue generator for generating the surgical guidance cues based upon the three-dimensional spatial properties. A patient-specific locator form for guiding resection of local tissue from a patient includes a locator form surface matching surface of the patient, and a plurality of features indicating a plurality of surgical guidance cues, respectively.
    Type: Application
    Filed: April 27, 2020
    Publication date: August 20, 2020
    Inventors: Venkataramanan KRISHNASWAMY, Richard J. BARTH, JR., Keith D. PAULSEN
  • Patent number: 10667870
    Abstract: A method for guiding resection of local tissue from a patient includes generating at least one image of the patient, automatically determining a plurality of surgical guidance cues indicating three-dimensional spatial properties associated with the local tissue, and generating a visualization of the surgical guidance cues relative to the surface. A system for generating surgical guidance cues for resection of a local tissue from a patient includes a location module for processing at least one image of the patient to determine three-dimensional spatial properties of the local tissue, and a surgical cue generator for generating the surgical guidance cues based upon the three-dimensional spatial properties. A patient-specific locator form for guiding resection of local tissue from a patient includes a locator form surface matching surface of the patient, and a plurality of features indicating a plurality of surgical guidance cues, respectively.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: June 2, 2020
    Assignee: THE TRUSTEES OF DARTMOUTH COLLEGE
    Inventors: Venkataramanan Krishnaswamy, Richard J. Barth, Jr., Keith D. Paulsen
  • Publication number: 20200138541
    Abstract: The present disclosure includes customized guidance devices in the form of guidance templates configured to fit over a given area of a patient's body and provide guidance during a tissue treatment or tissue removal procedure of that given area, which may include administration of an agent to a target tissue, target tissue biopsy, target tissue resection, or target tissue ablation. The customized guidance templates are generally constructed via an additive manufacturing process (i.e., three-dimensional (3D) printing) or subtractive manufacturing process (i.e., milling) based on a fabrication instruction file, which may include imaging data of the given area of the patient's body in which targeted tissue treatment is to be performed. The fabrication instruction file may further include additional data, such as the type of procedure to be performed (i.e., biopsy of the tissue abnormality, destruction or resection of the tissue abnormality, etc.).
    Type: Application
    Filed: December 19, 2019
    Publication date: May 7, 2020
    Inventors: Venkataramanan Krishnaswamy, Robert F. Rioux, David Danielsen, George Bourne
  • Patent number: 10631936
    Abstract: A method for guiding resection of local tissue from a patient includes generating at least one image of the patient, automatically determining a plurality of surgical guidance cues indicating three-dimensional spatial properties associated with the local tissue, and generating a visualization of the surgical guidance cues relative to the surface. A system for generating surgical guidance cues for resection of a local tissue from a patient includes a location module for processing at least one image of the patient to determine three-dimensional spatial properties of the local tissue, and a surgical cue generator for generating the surgical guidance cues based upon the three-dimensional spatial properties. A patient-specific locator form for guiding resection of local tissue from a patient includes a locator form surface matching surface of the patient, and a plurality of features indicating a plurality of surgical guidance cues, respectively.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: April 28, 2020
    Assignee: THE TRUSTEES OF DARTMOUTH COLLEGE
    Inventors: Venkataramanan Krishnaswamy, Richard J. Barth, Jr., Keith D. Paulsen
  • Publication number: 20200069187
    Abstract: A method for determining sub-diffuse scattering parameters of a material includes illuminating the material with structured light and imaging remission by the material of the structured light. The method further includes determining, from captured remission images, sub-diffuse scattering parameters of the material. A structured-light imaging system for determining sub-diffuse scattering parameters of a material includes a structured-light illuminator, for illuminating the material with structured light of periodic spatial structure, and a camera for capturing images of the remission of the structured light by the material. The structured-light imaging system further includes an analysis module for processing the images to quantitatively determine the sub-diffuse scattering parameters. A software product includes machine-readable instructions for analyzing images of remission of structured light by a material to determine sub-diffuse scattering parameters of the material.
    Type: Application
    Filed: November 4, 2019
    Publication date: March 5, 2020
    Inventors: Stephen Chad Kanick, Brian William Pogue, Keith D. Paulsen, Jonathan T. Elliott, David M. McClatchy, III, Venkataramanan Krishnaswamy
  • Publication number: 20200061391
    Abstract: The present invention relates to advanced Cherenkov-based imaging systems, tools, and methods of feedback control, temporal control sequence image capture, and quantification in high resolution dose images. In particular, the present invention provides a system and method for simple, accurate, quick, robust, real-time, water-equivalent characterization of beams from LINACs and other systems producing external-therapy radiation for purposes including optimization, commissioning, routine quality auditing, R&D, and manufacture. The present invention also provides a system and method for rapid and economic characterization of complex radiation treatment plans prior to patient exposure. Further, the present invention also provides a system and method of economically detecting Cherenkov radiation emitted by tissue and other media in real-world clinical settings (e.g., settings illuminated by visible light).
    Type: Application
    Filed: October 23, 2017
    Publication date: February 27, 2020
    Inventors: Venkataramanan Krishnaswamy, Brian W. Pogue
  • Patent number: 10555791
    Abstract: The present disclosure includes customized guidance devices in the form of guidance templates configured to fit over a given area of a patient's body and provide guidance during a tissue treatment or tissue removal procedure of that given area, which may include administration of an agent to a target tissue, target tissue biopsy, target tissue resection, or target tissue ablation. The customized guidance templates are generally constructed via an additive manufacturing process (i.e., three-dimensional (3D) printing) or subtractive manufacturing process (i.e., milling) based on a fabrication instruction file, which may include imaging data of the given area of the patient's body in which targeted tissue treatment is to be performed. The fabrication instruction file may further include additional data, such as the type of procedure to be performed (i.e., biopsy of the tissue abnormality, destruction or resection of the tissue abnormality, etc.).
    Type: Grant
    Filed: June 11, 2019
    Date of Patent: February 11, 2020
    Assignee: CairnSurgical, Inc.
    Inventors: Venkataramanan Krishnaswamy, Robert F. Rioux, David Danielsen, George Bourne
  • Publication number: 20190365475
    Abstract: A method for guiding resection of local tissue from a patient includes generating at least one image of the patient, automatically determining a plurality of surgical guidance cues indicating three-dimensional spatial properties associated with the local tissue, and generating a visualization of the surgical guidance cues relative to the surface. A system for generating surgical guidance cues for resection of a local tissue from a patient includes a location module for processing at least one image of the patient to determine three-dimensional spatial properties of the local tissue, and a surgical cue generator for generating the surgical guidance cues based upon the three-dimensional spatial properties. A patient-specific locator form for guiding resection of local tissue from a patient includes a locator form surface matching surface of the patient, and a plurality of features indicating a plurality of surgical guidance cues, respectively.
    Type: Application
    Filed: June 10, 2016
    Publication date: December 5, 2019
    Inventors: Venkataramanan KRISHNASWAMY, Richard J. BARTH, Jr., Keith D. PAULSEN
  • Patent number: 10485425
    Abstract: A structured-light imaging system includes a structured light projector for illuminating a surface and an electronic camera configured to image the surface. An image processor receives the images and has structured light scatteroscopy (SLS) firmware with machine readable instructions that illuminate the surface with structured light having a spatial frequency of at least 0.5 mm?1, and process the images to determine a map of scattering parameters at the surface independent of absorption properties. In an embodiment, the system also has cameras configured to obtain a stereo pair of images of the surface, the image processor having 3D firmware for extracting a three dimensional model of the surface from the stereo pair of images and compensating the map for non-flat surfaces.
    Type: Grant
    Filed: February 4, 2015
    Date of Patent: November 26, 2019
    Assignee: THE TRUSTEES OF DARTMOUTH COLLEGE
    Inventors: Venkataramanan Krishnaswamy, Brian W. Pogue, Keith D. Paulsen, Jonathan T. Elliott, David M. McClatchy, III
  • Publication number: 20190350491
    Abstract: The present disclosure includes support devices configured to be prevent breast deformation during an MRI imaging procedure. One embodiment of a support device comprises a foam insert shaped and sized to rest between a patient's breasts, generally upon the patient's sternum. The support device has a surface configured to engage an imaging modality component (i.e., coil of MRI machine) and prevent and/or minimize contact between the portion of the MRI coil and the pair of breasts when the support device is placed on the surface of the patient, which, in turn, reduces or eliminates any deformation of the breasts upon application of force from the MRI coil in a direction towards the breasts during an MRI imaging procedure.
    Type: Application
    Filed: June 11, 2019
    Publication date: November 21, 2019
    Inventors: Venkataramanan Krishnaswamy, David Danielsen, George Bourne
  • Publication number: 20190350492
    Abstract: The present disclosure includes support devices configured to be prevent breast deformation during an MRI imaging procedure. One embodiment of a support device comprises a foam insert shaped and sized to rest between a patient's breasts, generally upon the patient's sternum. The support device has a surface configured to engage an imaging modality component (i.e., coil of MRI machine) and prevent and/or minimize contact between the portion of the MRI coil and the pair of breasts when the support device is placed on the surface of the patient, which, in turn, reduces or eliminates any deformation of the breasts upon application of force from the MRI coil in a direction towards the breasts during an MRI imaging procedure.
    Type: Application
    Filed: June 11, 2019
    Publication date: November 21, 2019
    Inventors: Venkataramanan Krishnaswamy, David Danielsen
  • Publication number: 20190350668
    Abstract: The present disclosure includes customized guidance devices in the form of guidance templates configured to fit over a given area of a patient's body and provide guidance during a tissue treatment or tissue removal procedure of that given area, which may include administration of an agent to a target tissue, target tissue biopsy, target tissue resection, or target tissue ablation. The customized guidance templates are generally constructed via an additive manufacturing process (i.e., three-dimensional (3D) printing) or subtractive manufacturing process (i.e., milling) based on a fabrication instruction file, which may include imaging data of the given area of the patient's body in which targeted tissue treatment is to be performed. The fabrication instruction file may further include additional data, such as the type of procedure to be performed (i.e., biopsy of the tissue abnormality, destruction or resection of the tissue abnormality, etc.).
    Type: Application
    Filed: June 11, 2019
    Publication date: November 21, 2019
    Inventors: Venkataramanan Krishnaswamy, Robert F. Rioux, David Danielsen, George Bourne
  • Patent number: 10463256
    Abstract: A method for determining sub-diffuse scattering parameters of a material includes illuminating the material with structured light and imaging remission by the material of the structured light. The method further includes determining, from captured remission images, sub-diffuse scattering parameters of the material. A structured-light imaging system for determining sub-diffuse scattering parameters of a material includes a structured-light illuminator, for illuminating the material with structured light of periodic spatial structure, and a camera for capturing images of the remission of the structured light by the material. The structured-light imaging system further includes an analysis module for processing the images to quantitatively determine the sub-diffuse scattering parameters. A software product includes machine-readable instructions for analyzing images of remission of structured light by a material to determine sub-diffuse scattering parameters of the material.
    Type: Grant
    Filed: February 2, 2016
    Date of Patent: November 5, 2019
    Assignee: THE TRUSTEES OF DARTMOUTH COLLEGE
    Inventors: Stephen Chad Kanick, Brian William Pogue, Keith D. Paulsen, Jonathan T. Elliott, David M. McClatchy, III, Venkataramanan Krishnaswamy
  • Publication number: 20170164836
    Abstract: A structured-light imaging system includes a structured light projector for illuminating a surface and an electronic camera configured to image the surface. An image processor receives the images and has structured light scatteroscopy (SLS) firmware with machine readable instructions that illuminate the surface with structured light having a spatial frequency of at least 0.5 mm?1, and process the images to determine a map of scattering parameters at the surface independent of absorption properties. In an embodiment, the system also has cameras configured to obtain a stereo pair of images of the surface, the image processor having 3D firmware for extracting a three dimensional model of the surface from the stereo pair of images and compensating the map for non-flat surfaces.
    Type: Application
    Filed: February 4, 2015
    Publication date: June 15, 2017
    Inventors: Venkataramanan Krishnaswamy, Brian W. Pogue, Keith D. Paulsen, Jonathan T. Elliott, David M. McClatchy, III
  • Publication number: 20160157723
    Abstract: A method for determining sub-diffuse scattering parameters of a material includes illuminating the material with structured light and imaging remission by the material of the structured light. The method further includes determining, from captured remission images, sub-diffuse scattering parameters of the material. A structured-light imaging system for determining sub-diffuse scattering parameters of a material includes a structured-light illuminator, for illuminating the material with structured light of periodic spatial structure, and a camera for capturing images of the remission of the structured light by the material. The structured-light imaging system further includes an analysis module for processing the images to quantitatively determine the sub-diffuse scattering parameters. A software product includes machine-readable instructions for analyzing images of remission of structured light by a material to determine sub-diffuse scattering parameters of the material.
    Type: Application
    Filed: February 2, 2016
    Publication date: June 9, 2016
    Inventors: Stephen Chad Kanick, Brian William Pogue, Keith D. Paulsen, Jonathan T. Elliott, David M. McClatchy, III, Venkataramanan Krishnaswamy
  • Publication number: 20160038252
    Abstract: A method for guiding resection of local tissue from a patient includes generating at least one image of the patient, automatically determining a plurality of surgical guidance cues indicating three-dimensional spatial properties associated with the local tissue, and generating a visualization of the surgical guidance cues relative to the surface. A system for generating surgical guidance cues for resection of a local tissue from a patient includes a location module for processing at least one image of the patient to determine three-dimensional spatial properties of the local tissue, and a surgical cue generator for generating the surgical guidance cues based upon the three-dimensional spatial properties. A patient-specific locator form for guiding resection of local tissue from a patient includes a locator form surface matching surface of the patient, and a plurality of features indicating a plurality of surgical guidance cues, respectively.
    Type: Application
    Filed: October 21, 2015
    Publication date: February 11, 2016
    Inventors: Richard J. Barth, JR., Keith D. Paulsen, Venkataramanan Krishnaswamy
  • Patent number: 9254103
    Abstract: An imaging system has a microscope having an objective lens and a projection device configured to project spatially modulated light in one of several preselected predetermined pattern through the objective lens and onto tissue. The system camera configured to record an image of the tissue through the microscope and objective lens as illuminated by the spatially modulated light, and an image processor having a memory with a routine for performing spatial Fourier analysis on the image of the tissue to recover spatial frequencies. The image processor also constructs a three dimensional model of the tissue, and performs fitting of at least absorbance and scattering parameters of voxels of the model to match the recovered spatial frequencies. The processor then displays tomographic slices of the three dimensional model.
    Type: Grant
    Filed: August 15, 2012
    Date of Patent: February 9, 2016
    Assignee: The Trustees of Dartmouth College
    Inventors: Venkataramanan Krishnaswamy, Brian William Pogue