Abstract: Systems and methods are provided to detect and analyze arrhythmia drivers. In one example, a system can include a wave front analyzer programmed to compute wave front lines extending over a surface for each of the plurality of time samples based on phase information computed from electrical data at nodes distributed across the surface. A trajectory detector can be programmed to compute wave break points for each of the wave front lines and to determine a trajectory of at least one rotor core across the surface. A stability detector can be programmed to identify at least one stable rotor portion corresponding to subtrajectories of the determined trajectory.

Abstract: A non-transitory computer-readable medium can have instructions executable by a processor. The instructions can include an electrogram reconstruction method to generate reconstructed electrogram signals for each of a multitude of points residing on or near a predetermined cardiac envelope based on geometry data and non-invasively measured body surface electrical signals. The instructions can include a phase calculator to compute phase signals for the multitude of points based on the reconstructed electrogram signals and a visualization engine to generate an output based on the computed phase signals.

Abstract: Systems and methods are provided to detect and analyze arrhythmia drivers. In one example, a system can include a wave front analyzer programmed to compute wave front lines extending over a surface for each of the plurality of time samples based on phase information computed from electrical data at nodes distributed across the surface. A trajectory detector can be programmed to compute wave break points for each of the wave front lines and to determine a trajectory of at least one rotor core across the surface. A stability detector can be programmed to identify at least one stable rotor portion corresponding to subtrajectories of the determined trajectory.

Abstract: A map generator can be programmed to generate a multi-parameter graphical map by encoding at least two different physiological parameters for a geometric surface, corresponding to tissue of a patient, using different color components of a multi-dimensional color model such that each of the different physiological parameters is encoded by at least one of the different color components.

Abstract: A method can include storing input electrical signal data representing at least a given electrophysiological signal acquired from a patient. A non-local mean filter can be applied to the given electrophysiological signal, the non-local mean filter including a spatial filter component and an intensity filter component. The method can also include controlling parameters to establish weighting of each of the spatial filter component and the intensity filter component in response to a control input. Filtered signal data can be stored based on the applying and the controlling.

Abstract: A method can include storing a plurality of data sets including values computed for each of a plurality of points for a given spatial region of tissue, the values in each of the data sets characterizing electrical information for each respective point of the plurality of points for a different time interval. The method can also include combining the values computed for each of a plurality of points in a first interval, corresponding to a first map, with the values for computed for each of the respective plurality of points in another interval and to normalize the combined values relative to a common scale. The method can also include generating a composite map for the given spatial region based on the combined values that are normalized.

Abstract: A method can determine one or more origins of focal activation. The method can include computing phase for the electrical signals at a plurality of nodes distributed across a geometric surface based on the electrical data across time. The method can determine whether or not a given candidate node of the plurality of nodes is a focal point based on the analyzing the computed phase and magnitude of the given candidate node. A graphical map can be generated to visualize focal points detected on the geometric surface.

Abstract: A method to calculate and visualize dynamic wave front propagation of electrical signals on a geometric surface is described. Wave front locations are identified on the geometric surface between each identified pair of adjacent nodes on the geometric surface. A graphical map can be generated to represent the identified wave front locations on at least a portion of the geometric surface.

Abstract: A vitrectomy surgical system includes a vitrectomy probe having a cutting portion comprising an inner tube, an outer tube, and an aspiration port. The inner tube may be movable relative to the outer tube to cut vitreous fibers. The system also includes a controller associated with the vitrectomy probe and configured to control movement of the inner tube by generating control signals corresponding to a cutting scheme including a plurality of series of cuts with each cut being evenly spaced in time, the plurality of series of cuts separated by a recovery period.

Abstract: A non-transitory computer-readable medium can have instructions executable by a processor. The instructions can include an electrogram reconstruction method to generate reconstructed electrogram signals for each of a multitude of points residing on or near a predetermined cardiac envelope based on geometry data and non-invasively measured body surface electrical signals. The instructions can include a phase calculator to compute phase signals for the multitude of points based on the reconstructed electrogram signals and a visualization engine to generate an output based on the computed phase signals.

Abstract: A computer-implemented method can include determining an amplitude for each of a plurality of input channels, corresponding to respective nodes. A measure of similarity can be computed between the input channel of each node and the input channel of its neighboring nodes. The method can also include comparing an amplitude for each node relative to other nodes to determine temporary bad channels. For each of the temporary bad channels, a measure of similarity can be computed between the input channel of each node and the input channel of its neighboring nodes. Channel integrity can then be identified based on the computed measures of similarity.

Abstract: An apparatus for moving the esophagus includes an elongate body having a distal tip, a controlled curvature section, and a flexible section. A handle is coupled to the flexible section to adjust the curvature of the controlled curvature section. The length of the controlled curvature section is less than the length of the thoracic portion of the esophagus. Further, a method of adjusting the curvature of the esophagus during a therapeutic procedure in a treatment area outside of the esophagus includes positioning within the esophagus an elongate body having a distal tip, a controlled curvature section, and a flexible section and adjusting the curvature of the controlled curvature section to increase the distance between the esophagus and a treatment area outside of the esophagus.

Abstract: Aspects of the invention relate to an apparatus for moving the esophagus having an elongate body having a distal tip, a controlled curvature section, and a flexible section. A handle is coupled to the flexible section having means for adjusting the curvature of the controlled curvature section. Additionally, the length of the controlled curvature section is less than the length of the thoracic portion of the esophagus. Alternatively, there is an apparatus for moving the esophagus having a flexible elongate body having a distal tip, a controlled curvature section, and a proximal section. A bendable element is within the controlled curvature section that, when bent, moves and holds the controlled curvature section into a corresponding bent shape. There is provided various methods of adjusting the curvature of the esophagus during a therapeutic procedure in a treatment area outside of the esophagus.

Abstract: Embodiments of the invention include an electrical cable apparatus and method for making. The electrical cable comprises a plurality of paired conductive elements such as twisted pairs of individually insulated copper wire, a flame retardant yarn layer formed or wrapped helically around the conductor pairs or groups of conductor pairs, and a dielectric jacket formed around the conductive pairs and the yarn layer(s). The yarn layer is formed or wrapped around individual conductor pairs or, alternatively, around groups of conductor pairs. The yarn layer is made of, e.g., glass yarn, non-woven glass yarn tape, polyimides such as Kapton® tape, polyaramid yarns such as Kevlar® and Nomex®, or other suitable flame retardant materials and/or material combinations.