Patents by Inventor Venkatraman Ramakrishnan

Venkatraman Ramakrishnan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystal structure of antibiotics bound to the 30S ribosome and its use
    Patent number: 7079956
    Abstract: The invention provides high resolution X-ray crystal structures of the 30S ribosome, obtained from Thermus thermophilus 30S subunit, having a tetragonal space group P41212 to which are bound an antibiotic selected from the group paromomycin, streptomycin, spectinomycin, tetracycline, pactamycin and hygromycin B. An advantageous feature of the structure is that it diffracts at about 3 ? resolution. The invention also provides a crystal of 30S having the three dimensional atomic coordinates of the 30S ribosome, the coordinates being provided in any one of tables 1 to 4. The data may be used for the rational design and modelling of inhibitors for the 30S ribosome, which have potential use as antibiotics.
    Type: Grant
    Filed: September 17, 2001
    Date of Patent: July 18, 2006
    Assignee: Medical Research Council
    Inventors: Venkatraman Ramakrishnan, Ditlev Egeskov Brodersen, Andrew Philip Carter
  • Crystal structure of ribosomal protein L11/GTPase activating region rRNA and uses thereof
    Publication number: 20050233349
    Abstract: The present invention is broadly directed to methods of screening ribosomal protein L11/GTPase activating region (GAR) RNA-modulating compounds by using information from the high-resolution structure of the L11/GAR complex. The methods are useful in identifying compounds useful for anti-bacterial treatments.
    Type: Application
    Filed: December 2, 2004
    Publication date: October 20, 2005
    Inventors: Brian Wimberly, Venkatraman Ramakrishnan
  • Crystal structure of the 30s ribosome
    Patent number: 6925394
    Abstract: The invention provides an X-ray crystal structure of the 30S ribosome, obtained from Thermus thermophilus 30S subunit, having a tetragonal space group P41212 with unit cell dimensions of a=401.4±4.0 ?, b=401.4±4.0 ?, c=175.9±5.0 ?. An advantageous feature of the structure is that it diffracts beyond 3 ? resolution. The invention also provides a crystal of 30S having the three dimensional atomic coordinates of the 30S ribosome, the coordinates being provided in Tables 1A and 1B. The data may be used for the rational design and modelling of inhibitors for the 30S ribosome, which have potential use as antibiotics.
    Type: Grant
    Filed: July 13, 2001
    Date of Patent: August 2, 2005
    Assignees: University of Utah Research Foundation, Medical Research Council
    Inventors: Venkatraman Ramakrishnan, Ditlev Egeskov Brodersen, Andrew Philip Carter, Brian Thomas Wimberly, William Melvon Clemons, Jr.
  • Crystal structure of the 30S ribosome and its use
    Publication number: 20050154538
    Abstract: The invention provides an X-ray crystal structure of the 30S ribosome, obtained from Thermus thermophilus 30S subunit, having a tetragonal space group P41212 with unit cell dimensions of a=401.4±4.0 ?, b=401.4±4.0 ?, c=175.9±5.0 ?. An advantageous feature of the structure is that it diffracts beyond 3 ? resolution. The invention also provides a crystal of 30S having the three dimensional atomic coordinates of the 30S ribosome, the coordinates being provided in Tables 1A and 1B. The data may be used for the rational design and modelling of inhibitors for the 30S ribosome, which have potential use as antibiotics.
    Type: Application
    Filed: September 17, 2001
    Publication date: July 14, 2005
    Inventors: Venkatraman Ramakrishnan, Brian Wimberly, William Clemons, Ditlev Brodersen, Andrew Carter
  • Screening methods using the crystal structure of ribosomal protein L11/GTPase activating region rRNA complex
    Patent number: 6845328
    Abstract: The present invention is broadly directed to methods of screening ribosomal protein L11/GTPase activating region (GAR) RNA-modulating compounds by using information from the high-resolution structure of the L11/GAR complex. The methods are useful in identifying compounds useful for anti-bacterial treatments.
    Type: Grant
    Filed: November 1, 2001
    Date of Patent: January 18, 2005
    Assignee: University of Utah Research Foundation
    Inventors: Brian T. Wimberly, Venkatraman Ramakrishnan
  • Crystal structure of antibiotics bound to the 30S ribosome and its use
    Publication number: 20040034207
    Abstract: The invention provides high resolution X-ray crystal structures of the 30S ribosome, obtained from Thermus thermophilus 30S subunit, having a tetragonal space group P41212 to which are bound an antibiotic selected from the group paromomycin, streptomycin, spectinomycin, tetracycline, pactamycin and hygromycin B. An advantageous feature of the structure is that it diffracts at about 3 Å resolution. The invention also provides a crystal of 30S having the three dimensional atomic coordinates of the 30S ribosome, the coordinates being provided in any one of tables 1 to 4. The data may be used for the rational design and modelling of inhibitors for the 30S ribosome, which have potential use as antibiotics.
    Type: Application
    Filed: September 17, 2001
    Publication date: February 19, 2004
    Inventors: Venkatraman Ramakrishnan, Ditlev Egeskov Brodersen, Andrew Philip Carter
  • Crystal structure of ribosomal protein L11/GTPase activating region rRNA and uses thereof
    Publication number: 20030099955
    Abstract: The present invention is broadly directed to methods of screening ribosomal protein L11/GTPase activating region (GAR) RNA-modulating compounds by using information from the high-resolution structure of the L11/GAR complex. The methods are useful in identifying compounds useful for anti-bacterial treatments.
    Type: Application
    Filed: November 1, 2001
    Publication date: May 29, 2003
    Inventors: Brian T. Wimberly, Venkatraman Ramakrishnan
  • Crystal structure of the 30s ribosome and its use
    Publication number: 20020106660
    Abstract: The invention provides an X-ray crystal structure of the 30S ribosome, obtained from Thermus thermophilus 30S subunit, having a tetragonal space group P41212 with unit cell dimensions of a=401.4±4.0 Å, b=401.4±4.0 Å, c=175.9±5.0 Å. An advantageous feature of the structure is that it diffracts beyond 3 Å resolution. The invention also provides a crystal of 30S having the three dimensional atomic coordinates of the 30S ribosome, the coordinates being provided in Tables 1A and 1B. The data may be used for the rational design and modelling of inhibitors for the 30S ribosome, which have potential use as antibiotics.
    Type: Application
    Filed: July 13, 2001
    Publication date: August 8, 2002
    Inventors: Venkatraman Ramakrishnan, Ditlev Egeskov Brodersen, Andrew Philip Carter, Brian Thomas Wimberly, William Melvon Clemons
  • Crystal structure of antibiotics bound to the 30S ribosome and its use
    Publication number: 20020072861
    Abstract: The invention provides high resolution X-ray crystal structures of the 30S ribosome, obtained from Thermus thermophilus 30S subunit, having a tetragonal space group P41212 to which are bound an antibiotic selected from the group paromomycin, streptomycin, spectinomycin, tetracycline, pactamycin and hygromycin B. An advantageous feature of the structure is that it diffracts at about 3 Å resolution. The invention also provides a crystal of 30S having the three dimensional atomic coordinates of the 30S ribosome, the coordinates being provided in any one of tables 1 to 4. The data may be used for the rational design and modelling of inhibitors for the 30S ribosome, which have potential use as antibiotics.
    Type: Application
    Filed: July 13, 2001
    Publication date: June 13, 2002
    Inventors: Venkatraman Ramakrishnan, Ditlev Egeskov Brodersen, Andrew Philip Carter