Patents by Inventor Vera Gorfinkel
Vera Gorfinkel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10664238Abstract: A true random number generator including a light source configured to produce randomly distributed photons, a plurality of detection channels configured to receive the randomly distributed photons produced by the light source, each detection channel including a photon sensor configured to detect a receipt of at least one photon during successive integration time-periods and generate an output signal by assigning a value for each integration time-period based on whether at least one photon was received during each integration time-period, a signal conditioning unit configured to condition the output signal of each of the plurality of detection channels and generate a conditioned output signal for each of the plurality of detection channels, and a signal processing unit configured to combine the conditioned output signals and generate a true random number based on the combination of the conditioned output signals.Type: GrantFiled: January 26, 2018Date of Patent: May 26, 2020Assignee: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORKInventors: Vera Gorfinkel, Boris Gorbovitski, Dmytro Gudkov
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Publication number: 20180217817Abstract: A true random number generator including a light source configured to produce randomly distributed photons, a plurality of detection channels configured to receive the randomly distributed photons produced by the light source, each detection channel including a photon sensor configured to detect a receipt of at least one photon during successive integration time-periods and generate an output signal by assigning a value for each integration time-period based on whether at least one photon was received during each integration time-period, a signal conditioning unit configured to condition the output signal of each of the plurality of detection channels and generate a conditioned output signal for each of the plurality of detection channels, and a signal processing unit configured to combine the conditioned output signals and generate a true random number based on the combination of the conditioned output signals.Type: ApplicationFiled: January 26, 2018Publication date: August 2, 2018Inventors: Vera GORFINKEL, Boris GORBOVITSKI, Dmytro GUDKOV
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Publication number: 20150017654Abstract: The present application provides methods and devices for absolute quantification of polymerase chain reaction target nucleic acids. In particular, the methods and devices of the present application provide for splitting a nucleic acid sample to be analyzed into small, isolated volumes, conducting the method of polymerase chain reaction (PCR) on said volumes, detecting PCR amplification products, analyzing said detected PCR amplification products, performing absolute quantification of the PCR target and presenting said quantification results.Type: ApplicationFiled: July 30, 2014Publication date: January 15, 2015Inventors: Vera Gorfinkel, Boris Gorbovitski
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Publication number: 20150017653Abstract: The present application provides methods and devices for absolute quantification of polymerase chain reaction target nucleic acids. In particular, the methods and devices of the present application provide for splitting a nucleic acid sample to be analyzed into small, isolated volumes, conducting the method of polymerase chain reaction (PCR) on said volumes, detecting PCR amplification products, analyzing said detected PCR amplification products, performing absolute quantification of the PCR target and presenting said quantification results.Type: ApplicationFiled: July 30, 2014Publication date: January 15, 2015Inventors: Vera Gorfinkel, Boris Gorbovitski
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Patent number: 8828209Abstract: This invention discloses a highly efficient method, system and apparatus for nucleic acid analysis, including sequencing (both automated re-sequencing and de-novo sequencing). The system is capable of sequencing DNA sizes ranging from fragments to mammalian size genomes having mouse draft quality at a much reduced cost. The system comprises a massive parallel capillary electrophoretic separation using two-dimensional monolith multi-capillary arrays (2D-MMCA). Sequence identification can be performed using fluorescent or otherwise labeled dideoxynucleotide-terminated DNA extension product generated by gel matrix-, or beads-, or substrate tethered-, or otherwise immobilized colonies of single template molecules.Type: GrantFiled: June 22, 2006Date of Patent: September 9, 2014Assignee: The Research Foundation for the State University of New YorkInventors: Vera Gorfinkel, Evgeni A. Kabotyanski, Boris Gorbovitski
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Patent number: 8831887Abstract: The present application provides methods and devices for absolute quantification of polymerase chain reaction target nucleic acids. In particular, the methods and devices of the present application provide for splitting a nucleic acid sample to be analyzed into small, isolated volumes, conducting the method of polymerase chain reaction (PCR) on said volumes, detecting PCR amplification products, analyzing said detected PCR amplification products, performing absolute quantification of the PCR target and presenting said quantification results.Type: GrantFiled: October 12, 2006Date of Patent: September 9, 2014Assignee: The Research Foundation for the State University of New YorkInventors: Vera Gorfinkel, Boris Gorbovitski
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Publication number: 20140186966Abstract: A fiberized single photon sensitive spectrometer on a 32-channel PMT sensor is highly sensitive with broad detection dynamic range. The spectrometer enables accurate and high speed detection, identification and analysis of biological samples labeled with multiple fluorescent markers, such as compositions of multi-color fluorescence signals or radiation emitted by multiple fluorescence dyes. A fiberized optical input of the spectrometer allows an easy and efficient coupling to any measurement system based on fiber collection of the analyzed fluorescence. The spectrometer provides highly accurate DNA sequencing. A 32 channel PMT single photon detector has a detection dynamic range of more than 20 bits and has a frame rate of about 3300 frames per second. The dynamic range of the detector's pixels reaches 108 photocounts per second.Type: ApplicationFiled: September 23, 2013Publication date: July 3, 2014Applicant: The Research Foundation of State University of New YorkInventors: Dmytro Gudkov, Vera Gorfinkel, Dmitriy Gavrilov, Ivan Tovkach, Andriy Tsupryk, Tetyana Gudkova, Boris Gorbovitski
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Publication number: 20140117217Abstract: A fiberized single photon sensitive spectrometer on a 32-channel PMT sensor is highly sensitive with broad detection dynamic range. The spectrometer enables accurate and high speed detection, identification and analysis of biological samples labeled with multiple fluorescent markers, such as compositions of multi-color fluorescence signals or radiation emitted by multiple fluorescence dyes. A fiberized optical input of the spectrometer allows an easy and efficient coupling to any measurement system based on fiber collection of the analyzed fluorescence. The spectrometer provides highly accurate DNA sequencing. A 32 channel PMT single photon detector has a detection dynamic range of more than 20 bits and has a frame rate of about 3300 frames per second. The dynamic range of the detector's pixels reaches 108 photocounts per second.Type: ApplicationFiled: September 23, 2013Publication date: May 1, 2014Applicant: The Research Foundation of State University of New YorkInventors: Boris Gorbovitski, Dmitriy Gavrilov, Ivan Tovkach, Andriy Tsupryk, Tetyana Gudkova, Vera Gorfinkel, Dmytro Gudkov
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Patent number: 8582098Abstract: A fiberized single photon sensitive spectrometer based on a 32-channel PMT sensor is highly sensitive with broad detection dynamic range. The spectrometer enables accurate and high speed detection, identification and analysis of biological samples labeled with multiple fluorescent markers, such as compositions of multi-color fluorescence signals or radiation emitted by multiple fluorescence dyes. A fiberized optical input of the spectrometer allows an easy and efficient coupling to any measurement system based on fiber collection of the analyzed fluorescence. The spectrometer provides highly accurate DNA sequencing. A 32 channel PMT single photon detector has a detection dynamic range of more than 20 bits and has a frame rate of about 3300 frames per second. The dynamic range of the detector's pixels reaches 108 photocounts per second.Type: GrantFiled: October 24, 2008Date of Patent: November 12, 2013Assignee: The Research Foundation of State University of New YorkInventors: Andriy Tsupryk, Ivan Tovkach, Dmitriy Gavrilov, Vera Gorfinkel, Boris Gorbovitski, Dmytro Gudkov, Tetyana Gudkova
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Patent number: 8304712Abstract: The invention relates to devices that contain linear channels having optically transparent substances for focusing light. In some embodiments, the invention relates to improved nucleic acid sequencing methods using devices disclosed herein. In other embodiments, the invention relates to the arrangement of materials in and around capillary tubes with refractive indexes that maximize the number of channels useful for fluorescent detection of compositions after capillary electrophoresis.Type: GrantFiled: August 11, 2006Date of Patent: November 6, 2012Assignee: The Research Foundation of State University of New YorkInventors: Vera Gorfinkel, Michael Gorbovitski, Andriy Tsupryk
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Patent number: 8231844Abstract: The present invention relates to microfluidic systems having components with specially designed and fabricated areas of enhanced and/or reduced capillarity (flow guides). The methods and devices of the present invention permit the bubble-less dispensing and mixing of small volumes of different liquids for subsequent incubation and/or detection of products of various biological reactions. Thus present invention is well-suited to applications such as polymerase chain reaction and capillary electrophoresis.Type: GrantFiled: October 22, 2007Date of Patent: July 31, 2012Assignee: The Research Foundation Of State University Of New YorkInventors: Vera Gorfinkel, Evgeni A. Kabotyanski
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Publication number: 20120152742Abstract: This invention discloses a highly efficient method, system and apparatus for nucleic acid analysis, including sequencing (both automated re-sequencing and de-novo sequencing). The system is capable of sequencing DNA sizes ranging from fragments to mammalian size genomes having mouse draft quality at a much reduced cost. The system comprises a massive parallel capillary electrophoretic separation using two-dimensional monolith multi-capillary arrays (2D-MMCA). Sequence identification can be performed using fluorescent or otherwise labeled dideoxynucleotide-terminated DNA extension product generated by gel matrix-, or beads-, or substrate tethered-, or otherwise immobilized colonies of single template molecules.Type: ApplicationFiled: June 22, 2006Publication date: June 21, 2012Inventors: Vera Gorfinkel, Evgeni A. Kabotyanski, Boris Gorbovitski
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Publication number: 20110108711Abstract: A fiberized single photon sensitive spectrometer based on a 32-channel PMT sensor is highly sensitive with broad detection dynamic range. The spectrometer enables accurate and high speed detection, identification and analysis of biological samples labeled with multiple fluorescent markers, such as compositions of multi-color fluorescence signals or radiation emitted by multiple fluorescence dyes. A fiberized optical input of the spectrometer allows an easy and efficient coupling to any measurement system based on fiber collection of the analyzed fluorescence. The spectrometer provides highly accurate DNA sequencing. A 32 channel PMT single photon detector has a detection dynamic range of more than 20 bits and has a frame rate of about 3300 frames per second. The dynamic range of the detector's pixels reaches 108 photocounts per second.Type: ApplicationFiled: October 24, 2008Publication date: May 12, 2011Inventors: Andriy Tsupryk, Ivan Tovkach, Dmitriy Gavrilov, Georgiy Gudkov, Tetyana Gudkova, Vera Gorfinkel, Boris Gorbovitski, Dmytro Gudkov
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Publication number: 20100163715Abstract: The invention relates to devices that contain linear channels having optically transparent substances for focusing light. In some embodiments, the invention relates to improved nucleic acid sequencing methods using devices disclosed herein. In other embodiments, the invention relates to the arrangement of materials in and around capillary tubes with refractive indexes that maximize the number of channels useful for fluorescent detection of compositions after capillary electrophoresis.Type: ApplicationFiled: August 11, 2006Publication date: July 1, 2010Applicant: THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORKInventors: Vera Gorfinkel, Michael Gorbovitski, Andriy Tsupryk
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Publication number: 20100137152Abstract: The present application provides methods and devices for absolute quantification of polymerase chain reaction target nucleic acids. In particular, the methods and devices of the present application provide for splitting a nucleic acid sample to be analyzed into small, isolated volumes, conducting the method of polymerase chain reaction (PCR) on said volumes, detecting PCR amplification products, analyzing said detected PCR amplification products, performing absolute quantification of the PCR target and presenting said quantification results.Type: ApplicationFiled: October 12, 2006Publication date: June 3, 2010Inventors: Vera Gorfinkel, Boris Gorbovitski
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Publication number: 20090203148Abstract: The invention relates to methods and devices used in the sequencing, separation, detection, and identification of objects and biological molecules. In preferred embodiments, the invention relates to a DNA sequencing system based on cyclic sequencing by synthesis which is performed on beads in three-dimensional vessels and detected using monolithic multicapillary arrays. In other embodiments, the invention relates to a bead comprising two or more luminescent labels coupled to a nucleic acid sequence. In further embodiments, said luminescent labels are quantum dots.Type: ApplicationFiled: January 19, 2007Publication date: August 13, 2009Inventors: Vera Gorfinkel, Boris Gorbovitski, Michael Gorbovitski
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Publication number: 20090071833Abstract: The present invention relates to microfluidic systems having components with specially designed and fabricated areas of enhanced and/or reduced capillarity (flow guides). The methods and devices of the present invention permit the bubble-less dispensing and mixing of small volumes of different liquids for subsequent incubation and/or detection of products of various biological reactions. Thus present invention is well-suited to applications such as polymerase chain reaction and capillary electrophoresis.Type: ApplicationFiled: October 22, 2007Publication date: March 19, 2009Inventors: Vera Gorfinkel, Evgeni A. Kabotyanski
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Patent number: 7402817Abstract: The present invention is directed to a system and method for cross-talk cancellation for multi-lane fluorescence detectors. The invention may be implemented in accordance with a variety of systems, including systems for multi-capillary electrophoresis. The present invention is based on a special calibration procedure for determination of a channel cross-talk matrix and enables an accurate separation of the fluorescence emitted from individual capillary lanes. The proposed method for cross-talk calibration and removal is very useful for design and development of multi-lane single photon counting detection systems.Type: GrantFiled: January 25, 2007Date of Patent: July 22, 2008Assignee: The Research Foundation of State University of New YorkInventors: Dmitri N. Gavrilov, Boris Gorbovitski, Vera Gorfinkel, Georgiy Gudkov, Marina Tcherevishnik
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Publication number: 20070194249Abstract: The present invention is directed to a system and method for cross-talk cancellation for multi-lane fluorescence detectors. The invention may be implemented in accordance with a variety of systems, including systems for multi-capillary electrophoresis. The present invention is based on a special calibration procedure for determination of a channel cross-talk matrix and enables an accurate separation of the fluorescence emitted from individual capillary lanes. The proposed method for cross-talk calibration and removal is very useful for design and development of multi-lane single photon counting detection systems.Type: ApplicationFiled: January 25, 2007Publication date: August 23, 2007Inventors: Dmitri Gavrilov, Boris Gorbovitski, Vera Gorfinkel, Georgiy Gudkov, Marina Tcherevishnik
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Patent number: 6944407Abstract: In analyzing radiation from a communication link, single-photon counting can be used to advantage especially at low levels of radiation energy, e.g. in the detection of optical radiation. Preferred detection techniques include methods in which (i) received optical radiation is intensity-modulated in accordance with a preselected code, (ii) wherein it is the optical radiation which is intensity-modulated with the preselected code, and (iii) wherein the radiation modulated with a preselected code is received. For registration of the signals received by a sensing element of a single-photon detector, time of arrival is recorded, optionally in conjunction with registration of time intervals. Advantageously, in the interest of minimizing the number of pulses missed due to close temporal spacing of pulses, D-triggers can be included in counting circuitry.Type: GrantFiled: December 18, 2002Date of Patent: September 13, 2005Assignee: The Research Foundation of State University of New YorkInventors: Serge Luryi, Vera Gorfinkel, Mikhail Gouzman