Patents by Inventor Vi-en Choong
Vi-en Choong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11008612Abstract: Provided herein are systems and methods for nucleotide incorporation reactions. The systems comprise polymerases having altered nucleotide incorporation kinetics and are linked to an energy transfer donor moiety, and nucleotide molecules linked with at least one energy transfer acceptor moiety. The donor and acceptor moieties undergo energy transfer when the polymerase and nucleotide are proximal to each other during nucleotide binding and/or nucleotide incorporation. As the donor and acceptor moieties undergo energy transfer, they generate an energy transfer signal which can be associated with nucleotide binding or incorporation. Detecting a time sequence of the generated signals, or the change in the signals, can be used to determine the order of the incorporated nucleotides, and can therefore be used to deduce the sequence of the target molecule.Type: GrantFiled: September 6, 2018Date of Patent: May 18, 2021Assignee: Life Technologies CorporationInventors: Joseph Beechem, Theo Nikiforov, Vi-En Choong, Xinzhan Peng, Guobin Luo, Cheng-Yao Chen, Michael Previte
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Publication number: 20190062829Abstract: Provided herein are systems and methods for nucleotide incorporation reactions. The systems comprise polymerases having altered nucleotide incorporation kinetics and are linked to an energy transfer donor moiety, and nucleotide molecules linked with at least one energy transfer acceptor moiety. The donor and acceptor moieties undergo energy transfer when the polymerase and nucleotide are proximal to each other during nucleotide binding and/or nucleotide incorporation. As the donor and acceptor moieties undergo energy transfer, they generate an energy transfer signal which can be associated with nucleotide binding or incorporation. Detecting a time sequence of the generated signals, or the change in the signals, can be used to determine the order of the incorporated nucleotides, and can therefore be used to deduce the sequence of the target molecule.Type: ApplicationFiled: September 6, 2018Publication date: February 28, 2019Inventors: Joseph BEECHEM, Theo NIKIFOROV, Vi-En CHOONG, Xinzhan PENG, Guobin LUO, Cheng-Yao CHEN, Michael PREVITE
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Patent number: 10093974Abstract: Provided herein are systems and methods for nucleotide incorporation reactions. The systems comprise polymerases having altered nucleotide incorporation kinetics and are linked to an energy transfer donor moiety, and nucleotide molecules linked with at least one energy transfer acceptor moiety. The donor and acceptor moieties undergo energy transfer when the polymerase and nucleotide are proximal to each other during nucleotide binding and/or nucleotide incorporation. As the donor and acceptor moieties undergo energy transfer, they generate an energy transfer signal which can be associated with nucleotide binding or incorporation. Detecting a time sequence of the generated signals, or the change in the signals, can be used to determine the order of the incorporated nucleotides, and can therefore be used to deduce the sequence of the target molecule.Type: GrantFiled: June 13, 2017Date of Patent: October 9, 2018Assignee: Life Technologies CorporationInventors: Joseph Beechem, Theo Nikiforov, Vi-En Choong, Xinzhan Peng, Guobin Luo, Cheng-Yao Chen, Michael Previte
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Publication number: 20170283868Abstract: Provided herein are systems and methods for nucleotide incorporation reactions. The systems comprise polymerases having altered nucleotide incorporation kinetics and are linked to an energy transfer donor moiety, and nucleotide molecules linked with at least one energy transfer acceptor moiety. The donor and acceptor moieties undergo energy transfer when the polymerase and nucleotide are proximal to each other during nucleotide binding and/or nucleotide incorporation. As the donor and acceptor moieties undergo energy transfer, they generate an energy transfer signal which can be associated with nucleotide binding or incorporation. Detecting a time sequence of the generated signals, or the change in the signals, can be used to determine the order of the incorporated nucleotides, and can therefore be used to deduce the sequence of the target molecule.Type: ApplicationFiled: June 13, 2017Publication date: October 5, 2017Inventors: Joseph BEECHEM, Theo NIKIFOROV, Vi-En CHOONG, Xinzhan PENG, Guobin LUO, Cheng-Yao CHEN, Michael PREVITE
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Patent number: 9695471Abstract: Provided herein are systems and methods for nucleotide incorporation reactions. The systems comprise polymerases having altered nucleotide incorporation kinetics and are linked to an energy transfer donor moiety, and nucleotide molecules linked with at least one energy transfer acceptor moiety. The donor and acceptor moieties undergo energy transfer when the polymerase and nucleotide are proximal to each other during nucleotide binding and/or nucleotide incorporation. As the donor and acceptor moieties undergo energy transfer, they generate an energy transfer signal which can be associated with nucleotide binding or incorporation. Detecting a time sequence of the generated signals, or the change in the signals, can be used to determine the order of the incorporated nucleotides, and can therefore be used to deduce the sequence of the target molecule.Type: GrantFiled: December 29, 2014Date of Patent: July 4, 2017Assignee: Life Technologies CorporationInventors: Joseph Beechem, Theo Nikiforov, Vi-En Choong, Xinzhan Peng, Guobin Luo, Cheng-Yao Chen, Michael Previte
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Publication number: 20150118679Abstract: Provided herein are systems and methods for nucleotide incorporation reactions. The systems comprise polymerases having altered nucleotide incorporation kinetics and are linked to an energy transfer donor moiety, and nucleotide molecules linked with at least one energy transfer acceptor moiety. The donor and acceptor moieties undergo energy transfer when the polymerase and nucleotide are proximal to each other during nucleotide binding and/or nucleotide incorporation. As the donor and acceptor moieties undergo energy transfer, they generate an energy transfer signal which can be associated with nucleotide binding or incorporation. Detecting a time sequence of the generated signals, or the change in the signals, can be used to determine the order of the incorporated nucleotides, and can therefore be used to deduce the sequence of the target molecule.Type: ApplicationFiled: December 29, 2014Publication date: April 30, 2015Inventors: Joseph BEECHEM, Theo NIKIFOROV, Vi-En CHOONG, Xinzhan PENG, Guobin LUO, Cheng-Yao CHEN, Michael PREVITE
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Patent number: 8999674Abstract: Provided herein are systems and methods for nucleotide incorporation reactions. The systems comprise polymerases having altered nucleotide incorporation kinetics and are linked to an energy transfer donor moiety, and nucleotide molecules linked with at least one energy transfer acceptor moiety. The donor and acceptor moieties undergo energy transfer when the polymerase and nucleotide are proximal to each other during nucleotide binding and/or nucleotide incorporation. As the donor and acceptor moieties undergo energy transfer, they generate an energy transfer signal which can be associated with nucleotide binding or incorporation. Detecting a time sequence of the generated signals, or the change in the signals, can be used to determine the order of the incorporated nucleotides, and can therefore be used to deduce the sequence of the target molecule.Type: GrantFiled: July 30, 2012Date of Patent: April 7, 2015Assignee: Life Technologies CorporationInventors: Joseph Beechem, Theo Nikiforov, Vi-En Choong, Xinzhan Peng, Guobin Luo, Cheng-Yao Chen, Michael Previte
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Patent number: 8610114Abstract: A radiation emitting device comprising a first electrode, which emits first charge carriers having a first charge during operation, a first charge carrier transporting layer, which comprises a fluorescent substance, a second charge carrier transporting layer, which contains a phosphorescent substance, and a second electrode, which emits second charge carriers having a second charge during operation, wherein during operation the second charge carrier transporting layer is largely free of first charge carriers.Type: GrantFiled: February 28, 2012Date of Patent: December 17, 2013Assignee: OSRAM Opto Semiconductors GmbHInventors: Vi-En Choong, Stelios A. Choulis, Matthew K. Mathai
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Publication number: 20120329042Abstract: Provided herein are systems and methods for nucleotide incorporation reactions. The systems comprise polymerases having altered nucleotide incorporation kinetics and are linked to an energy transfer donor moiety, and nucleotide molecules linked with at least one energy transfer acceptor moiety. The donor and acceptor moieties undergo energy transfer when the polymerase and nucleotide are proximal to each other during nucleotide binding and/or nucleotide incorporation. As the donor and acceptor moieties undergo energy transfer, they generate an energy transfer signal which can be associated with nucleotide binding or incorporation. Detecting a time sequence of the generated signals, or the change in the signals, can be used to determine the order of the incorporated nucleotides, and can therefore be used to deduce the sequence of the target molecule.Type: ApplicationFiled: July 30, 2012Publication date: December 27, 2012Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Joseph BEECHEM, Theo NIKIFOROV, Vi-En CHOONG, Xinzhan PENG, Guobin LUO, Cheng-Yao CHEN, Michael PREVITE
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Publication number: 20120153305Abstract: A radiation emitting device comprising a first electrode, which emits first charge carriers having a first charge during operation, a first charge carrier transporting layer, which comprises a fluorescent substance, a second charge carrier transporting layer, which contains a phosphorescent substance, and a second electrode, which emits second charge carriers having a second charge during operation, wherein during operation the second charge carrier transporting layer is largely free of first charge carriers.Type: ApplicationFiled: February 28, 2012Publication date: June 21, 2012Applicant: OSRAM Opto Semiconductors GmbHInventors: Vi-En CHOONG, Stelios A. Choulis, Matthew K. Mathai
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Patent number: 8173998Abstract: A radiation emitting device comprising a first electrode, which emits first charge carriers having a first charge during operation, a first charge carrier transporting layer, which comprises a fluorescent substance, a second charge carrier transporting layer, which contains a phosphorescent substance, and a second electrode, which emits second charge carriers having a second charge during operation, wherein during operation the second charge carrier transporting layer is largely free of first charge carriers.Type: GrantFiled: June 6, 2008Date of Patent: May 8, 2012Assignee: OSRAM Opto Semiconductors GmbHInventors: Vi-En Choong, Stelios A. Choulis, Mathew K. Mathai
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Patent number: 8101941Abstract: In at least one embodiment of the invention, an OLED device is disclosed in which the surface of one or more layers of the OLED are conditioned with metal nano-particles such that they are disposed along the interface between adjacent layers.Type: GrantFiled: September 26, 2005Date of Patent: January 24, 2012Assignee: Osram Opto Semiconductors GmbHInventors: Stelios A. Choulis, Mathew Mathai, Vi-En Choong
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Publication number: 20110281740Abstract: Provided herein are methods and compositions for real time single molecule sequencing of a polymeric molecule, such as a polynucleotide, by isolating the polymeric molecule in a nanofluidic device, subjecting it in situ to a polymerase reaction wherein various components of the polymerase reaction mixture are labeled, and determining the time-sequence of incorporation of monomeric subunits during the polymerization process.Type: ApplicationFiled: June 30, 2009Publication date: November 17, 2011Inventors: Joseph Beechem, Vi-En Choong, Theo Nikiforov
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Publication number: 20100255487Abstract: Provided herein are systems and methods for nucleotide incorporation reactions. The systems comprise polymerases having altered nucleotide incorporation kinetics and are linked to an energy transfer donor moiety, and nucleotide molecules linked with at least one energy transfer acceptor moiety. The donor and acceptor moieties undergo energy transfer when the polymerase and nucleotide are proximal to each other during nucleotide binding and/or nucleotide incorporation. As the donor and acceptor moieties undergo energy transfer, they generate an energy transfer signal which can be associated with nucleotide binding or incorporation. Detecting a time sequence of the generated signals, or the change in the signals, can be used to determine the order of the incorporated nucleotides, and can therefore be used to deduce the sequence of the target molecule.Type: ApplicationFiled: March 26, 2010Publication date: October 7, 2010Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: JOSEPH BEECHEM, THEO NIKIFOROV, Vi-En Choong, Xinzhan Peng, Guobin Luo, Cheng-Yao Chen, Michael Previte
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Patent number: 7772761Abstract: Techniques are described for forming an organic light emitting diode device with improved device efficiency. Materials having at least one energy level that is similar to those of a phosphorescent light emitting material in the diode are incorporated into the device to directly inject holes or electrons to the light emitting material.Type: GrantFiled: September 28, 2005Date of Patent: August 10, 2010Assignee: Osram Opto Semiconductors GmbHInventors: Stelios A. Choulis, Mathew Mathai, Vi-En Choong, Franky So
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Patent number: 7679282Abstract: An organic electroluminescent device, includes: a substrate; a hole-injecting electrode (anode) coated over the substrate; a hole injection layer coated over the anode; a hole transporting layer coated over the hole injection layer; a polymer based light emitting layer, coated over the hole transporting layer; a small molecule based light emitting layer, thermally evaporated over the polymer based light emitting layer; and an electron-injecting electrode (cathode) deposited over the electroluminescent polymer layer.Type: GrantFiled: December 5, 2005Date of Patent: March 16, 2010Assignee: Osram Opto Semiconductors GmbHInventors: Vi-En Choong, Stelios Choulis, Benjamin Claus Krummacher, Mathew Mathai, Franky So
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Patent number: 7667383Abstract: At least one stacked organic or polymeric light emitting diode (PLEDs) devices to comprise a light source is disclosed. At least one of the PLEDs includes a patterned cathode which has regions which transmit light. The patterned cathodes enable light emission from the PLEDs to combine together. The light source may be top or bottom emitting or both.Type: GrantFiled: February 15, 2006Date of Patent: February 23, 2010Assignee: Osram Opto Semiconductors GmbHInventor: Vi-En Choong
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Publication number: 20100035268Abstract: Provided herein are methods and compositions for real time single molecule sequencing of short nucleotide sequences using nucleotide fluorescent semiconductor nanocrystals-conjugated nucleotide primers.Type: ApplicationFiled: February 21, 2008Publication date: February 11, 2010Inventors: Joseph Beechem, Vi-En Choong, Theo Nikiforov
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Patent number: 7554257Abstract: An electroluminescent apparatus includes an OLED device emitting light in the blue and green spectrums, and at least one down conversion layer. The down conversion layer absorbs at least part of the green spectrum light and emits light in at least one of the orange spectra and red spectra.Type: GrantFiled: June 22, 2005Date of Patent: June 30, 2009Assignee: Osram Opto Semiconductors GmbHInventors: Benjamin C. Krummacher, Mathew Mathai, Vi-En Choong, Stelios A. Choulis
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Patent number: 7550915Abstract: In a first embodiment of the present invention, in order to increase the number of holes injected into the emissive layer, an intermixed layer is formed from the intermixing of the hole transport layer (“HTL”) and the emissive layer. The intermixed layer is between the HTL and the emissive layer of the OLED device. Alternatively, in a second embodiment of the present invention, in order to increase the number of holes injected into the emissive layer, a separate interlayer is incorporated within the OLED device. The interlayer is comprised of a hole transport material in which one of its components is at least partially replaced with one of the components of the emissive layer that is responsible for hole injection and transport. The separate interlayer is between the anode and the emissive layer of the OLED device. One or more intermediate layers may be present between the interlayer and the anode such as, for example, a HTL may be present between those two layers.Type: GrantFiled: May 11, 2004Date of Patent: June 23, 2009Assignee: Osram Opto Semiconductors GmbHInventors: Reza Stegamat, Vi-En Choong