Patents by Inventor Victor Lyamichev

Victor Lyamichev has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for detecting target sequences
    Patent number: 7256020
    Abstract: The present invention relates to compositions and methods for the detection and characterization of nucleic acid sequences and variations in nucleic acid sequences. The present invention relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the nucleic acid cleavage structure in a site-specific manner. For example, in some embodiments, a 5? nuclease activity from any of a variety of enzymes is used to cleave the target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.
    Type: Grant
    Filed: February 3, 2003
    Date of Patent: August 14, 2007
    Assignee: Third Wave Technologies, Inc.
    Inventors: Victor Lyamichev, Bruce P. Neri, Jeff Hall, Andrew Lukowiak
  • Methods and compositions for detecting target sequences
    Patent number: 7195871
    Abstract: The present invention relates to compositions and methods for the detection and characterization of nucleic acid sequences and variations in nucleic acid sequences. The present invention relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the nucleic acid cleavage structure in a site-specific manner. For example, in some embodiments, a 5? nuclease activity from any of a variety of enzymes is used to cleave the target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.
    Type: Grant
    Filed: November 7, 2002
    Date of Patent: March 27, 2007
    Assignee: Third Wave Technologies, Inc
    Inventors: Victor Lyamichev, Bruce P. Neri, Jeff Hall, Andrew A. Lukowiak
  • Methods for genotyping hepatitis C virus
    Publication number: 20070065815
    Abstract: The present invention relates to methods and compositions for analyzing nucleic acids. In particular, the present invention provides methods and compositions for the detection and characterization of nucleic acid sequences and sequence changes. The methods of the present invention permit the detection and/or identification of genetic polymorphism such as those associated with human disease and permit the identification of pathogens (e.g., viral and bacterial strain identification).
    Type: Application
    Filed: September 5, 2006
    Publication date: March 22, 2007
    Inventors: Fang Dong, Victor Lyamichev, James Prudent, Lance Fors, Bruce Neri, Mary Brow, Todd Anderson, James Dahlberg
  • Invasive cleavage of nucleic acids
    Publication number: 20070003942
    Abstract: The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the nucleic acid cleavage structure in a site-specific manner. The structure-specific nuclease activity of a variety of enzymes is used to cleave the target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.
    Type: Application
    Filed: July 15, 2005
    Publication date: January 4, 2007
    Inventors: James Prudent, Jeff Hall, Victor Lyamichev, Mary Ann Brow, James Dahlberg
  • Cleavage of nucleic acids
    Publication number: 20060292580
    Abstract: The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the nucleic acid cleavage structure in a site-specific manner. The structure-specific nuclease activity of a variety of enzymes is used to cleave the target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.
    Type: Application
    Filed: July 15, 2005
    Publication date: December 28, 2006
    Inventors: James Prudent, Jeff Hall, Victor Lyamichev, Mary Ann Brow, James Dahlberg
  • RNA detection assays
    Patent number: 7150982
    Abstract: The present invention provides novel cleavage agents and polymerases for the cleavage and modification of nucleic acid. The cleavage agents and polymerases find use, for example, for the detection and characterization of nucleic acid sequences and variations in nucleic acid sequences. In some embodiments, the 5? nuclease activity of a variety of enzymes is used to cleave a target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.
    Type: Grant
    Filed: February 26, 2002
    Date of Patent: December 19, 2006
    Assignee: Third Wave Technologies, Inc.
    Inventors: Hatim T. Allawi, Brad T. Argue, Christian Tor Bartholomay, LuAnne Chehak, Michelle L. Curtis, Peggy S. Eis, Jeff G. Hall, Hon S. Ip, Lin Ji, Michael W. Kaiser, Robert W. Kwiatkowski, Andrew A. Lukowiak, Victor Lyamichev, Natalie E. Lyamicheva, WuPo Ma, Bruce P. Neri, Sarah M. Olson, Marilyn C. Olson-Munoz, James J. Schaefer, Zbigniev Skrzypczynski, Tsetska Y. Takova, Lisa C. Thompson, Kevin L. Vedvik
  • Detection of human herpesviruses
    Publication number: 20060252032
    Abstract: The present invention provides methods, compositions, and kits related to nucleic acid detection assays for detecting human herpes virus. For example, the present invention provides detection assays for detecting human herpes virus subtypes HHV1- through HHV-8.
    Type: Application
    Filed: January 30, 2006
    Publication date: November 9, 2006
    Applicant: Third Wave Technologies, Inc.
    Inventors: Azamat Aslanukov, Victor Lyamichev, Hatim Allawi, Vecheslav Elagin
  • Compositions and methods for increased dynamic range detection of nucleic acids
    Publication number: 20060246475
    Abstract: The present invention provides systems, methods and kits for increasing the dynamic range of detection of a target nucleic acid in a sample. In particular, the present invention provides methods and kits for increasing the dynamic range of detection of a target nucleic acid in a sample through the use of one or more probe oligonucleotides (e.g., analyte-specific probe oligonucleotides).
    Type: Application
    Filed: January 23, 2006
    Publication date: November 2, 2006
    Inventors: Patrick Peterson, Hatim Allawi, Victor Lyamichev, Scott Law, Vecheslav Elagin, Jeff Hall
  • Detection of allelic expression imbalance
    Publication number: 20060199202
    Abstract: The present invention provides compositions and methods for the detection and characterization of allelic expression imbalance from a heterozygous gene locus. More particularly, the present invention provides compositions, kits, and methods for the determination of allelic expression imbalance by the comparison of expression levels from each of two alleles of a given gene locus through the use of an invasive cleavage structure assay (e.g. the INVADER assay).
    Type: Application
    Filed: February 8, 2006
    Publication date: September 7, 2006
    Applicant: Third Wave Technologies, Inc.
    Inventors: Victor Lyamichev, Hatim Allawi
  • FEN endonucleases
    Publication number: 20060183207
    Abstract: The present invention provides novel cleavage agents and polymerases for the cleavage and modification of nucleic acid. The cleavage agents and polymerases find use, for example, for the detection and characterization of nucleic acid sequences and variations in nucleic acid sequences. In some embodiments, the 5? nuclease activity of a variety of enzymes is used to cleave a target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.
    Type: Application
    Filed: October 27, 2005
    Publication date: August 17, 2006
    Applicant: Third Wave Technologies, Inc.
    Inventors: Victor Lyamichev, Michael Kaiser, Natasha Lyamicheva
  • Cleavage of nucleic acids
    Publication number: 20060183109
    Abstract: The present invention relates to means for cleaving a nucleic acid cleavage structure in a site-specific manner. Enzymes, including 5? nucleases and 3? exonucleases, are used to detect and identify nucleic acids derived from microorganisms. Methods are provided which allow for the detection and identification of bacterial and viral pathogens in a sample.
    Type: Application
    Filed: August 5, 2005
    Publication date: August 17, 2006
    Inventors: James Dahlberg, Mary Brow, Victor Lyamichev
  • Cleavage of nucleic acids
    Publication number: 20060177835
    Abstract: The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the nucleic acid cleavage structure in a site-specific manner. The structure-specific nuclease activity of a variety of enzymes is used to cleave the target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.
    Type: Application
    Filed: July 15, 2005
    Publication date: August 10, 2006
    Inventors: James Prudent, Jeff Hall, Victor Lyamichev, Mary Brow, James Dahlberg
  • Cleavage of nucleic acids
    Publication number: 20060154269
    Abstract: The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the nucleic acid cleavage structure in a site-specific manner. The structure-specific nuclease activity of a variety of enzymes is used to cleave the target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.
    Type: Application
    Filed: July 15, 2005
    Publication date: July 13, 2006
    Inventors: James Prudent, Jeff Hall, Victor Lyamichev, Mary Ann Brow, James Dahlberg
  • Single step detection assay
    Publication number: 20060147955
    Abstract: The present invention provides methods and routines for developing and optimizing nucleic acid detection assays for use in basic research, clinical research, and for the development of clinical detection assays. In particular, the present invention provides methods for designing oligonucleotide primers to be used in multiplex amplification reactions. The present invention also provides methods to optimize multiplex amplification reactions. The present invention also provides methods for combined target and signal generation assays.
    Type: Application
    Filed: November 3, 2005
    Publication date: July 6, 2006
    Applicant: Third Wave Technologies, Inc.
    Inventors: Hatim Allawi, Victor Lyamichev, Vecheslav Elagin, Scott Law, Jeff Hall
  • Nucleic acid accessible hybridization sites
    Patent number: 7060436
    Abstract: The present invention relates to methods and compositions for analyzing nucleic acids, and in particular, methods and compositions for detection and characterization of nucleic acid sequences and sequence changes. The present invention also provides methods and compositions for identifying oligonucleotides with desired hybridization properties to nucleic acid targets containing secondary structure.
    Type: Grant
    Filed: June 15, 2001
    Date of Patent: June 13, 2006
    Assignee: Third Wave Technologies, Inc.
    Inventors: Victor Lyamichev, Hatim Allawi, Fang Dong, Bruce P. Neri, Tatiani I. Vener
  • Cleavage of nucleic acids
    Publication number: 20060110750
    Abstract: The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the nucleic acid cleavage structure in a site-specific manner. The structure-specific nuclease activity of a variety of enzymes is used to cleave the target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.
    Type: Application
    Filed: September 9, 2005
    Publication date: May 25, 2006
    Inventors: James Prudent, Jeff Hall, Victor Lyamichev, Mary Brow, James Dahlberg
  • Detection of RNA Sequences
    Patent number: 7045289
    Abstract: The present invention provides novel cleavage agents and polymerases for the cleavage and modification of nucleic acid. The cleavage agents and polymerases find use, for example, for the detection and characterization of nucleic acid sequences and variations in nucleic acid sequences. In some embodiments, the 5? nuclease activity of a variety of enzymes is used to cleave a target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.
    Type: Grant
    Filed: May 24, 2001
    Date of Patent: May 16, 2006
    Assignee: Third Wave Technologies, Inc.
    Inventors: Hatim Allawi, Christian Tor Bartholomay, LuAnne Chehak, Michelle L. Curtis, Peggy S. Eis, Jeff G. Hall, Hon S. Ip, Michael Kaiser, Robert W. Kwiatkowski, Jr., Andrew A. Lukowiak, Victor Lyamichev, WuPo Ma, Marilyn C. Olson-Munoz, Sarah M. Olson, James J. Schaefer, Zbigniew Skrzypczynski, Tsetska Y. Takova, Kevin L. Vedvik, Natalie Lyamichev, Bruce P. Neri
  • Kits for the detection of target sequences
    Publication number: 20060068383
    Abstract: The present invention relates to means for cleaving a nucleic acid cleavage structure in a site-specific manner. Enzymes, including 5? nucleases and 3? exonucleases, are used to detect and identify nucleic acids derived from microorganisms. Methods are provided which allow for the detection and identification of bacterial and viral pathogens in a sample.
    Type: Application
    Filed: August 28, 2001
    Publication date: March 30, 2006
    Inventors: James Dahlberg, Mary Brow, Victor Lyamichev
  • Cleavage of nucleic acids
    Publication number: 20060040299
    Abstract: The present invention relates to means for cleaving a nucleic acid cleavage structure in a site-specific manner. Enzymes, including 5? nucleases and 3? exonucleases, are used to detect and identify nucleic acids derived from microorganisms. Methods are provided which allow for the detection and identification of bacterial and viral pathogens in a sample.
    Type: Application
    Filed: August 5, 2005
    Publication date: February 23, 2006
    Inventors: James Dahlberg, Mary Ann Brow, Victor Lyamichev
  • Cleavage of nucleic acids
    Publication number: 20060040294
    Abstract: The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the nucleic acid cleavage structure in a site-specific manner. The structure-specific nuclease activity of a variety of enzymes is used to cleave the target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.
    Type: Application
    Filed: July 15, 2005
    Publication date: February 23, 2006
    Inventors: James Prudent, Jeff Hall, Victor Lyamichev, Mary Brow, James Dahlberg