Abstract: A pressure assisted oil recovery system and apparatus that has a pulsating effect unit, a multiphasic flow meter, and a production lift system that passes through a wellbore up to an oil reservoir. The pulsating effect unit has a control valve and a smart control unit. The production lift system has production tubing and a wellhead. The pulsating effect unit is connected to the production lift system. The multiphasic flow meter is connected to the production tubing to obtain well production parameters data. The control valve opens and closes having an opening/closing predetermined frequency. When the control valve opens and closes, it generates pressure variations along the production tubing. The pressure variations create a pulsating effect on walls of the wellbore. The multiphasic flow meter and the pulsating effect unit set an optimal opening/closing frequency of the control valve.

Abstract: A system for providing notifications to client devices that includes one or more processors and one or more storage devices. The storage devices may store instructions that, when executed, configure the processors to perform operations. The operations include receiving a transaction notification from a third party; identifying a user account associated with the transaction notification; generating a push notification with a payload describing instructions to display a message and an interactive icon, and a resource identifier associated with the interactive icon, where the resource identifier includes a message ID encoding an interactive session and an action ID encoding a requested action. The operations also include transmitting the push notification to a client device associated with the user account; receiving a first indication indicating a user interaction with the interactive icon, the first indication having the resource identifier and updating the user account based on the action request.

Abstract: A system for providing notifications to client devices that includes one or more processors and one or more storage devices. The storage devices may store instructions that, when executed, configure the processors to perform operations. The operations include receiving a transaction notification from a third party; identifying a user account associated with the transaction notification; generating a push notification with a payload describing instructions to display a message and an interactive icon, and a resource identifier associated with the interactive icon, where the resource identifier includes a message ID encoding an interactive session and an action ID encoding a requested action. The operations also include transmitting the push notification to a client device associated with the user account; receiving a first indication indicating a user interaction with the interactive icon, the first indication having the resource identifier and updating the user account based on the action request.

Abstract: The present disclosure relates to a circuit board that includes a first edge connector configured to communicatively couple the circuit board to a first connector of a second circuit board. The first edge connector extends from a side of the circuit board a first length. The circuit board also includes a second edge connector configured to communicatively couple the circuit board to a second connector of the second circuit board. The second edge connector extends from the side of the circuit board a second length that is different than the first length.

Abstract: A system for providing notifications to client devices that includes one or more processors and one or more storage devices. The storage devices may store instructions that, when executed, configure the processors to perform operations. The operations include receiving a transaction notification from a third party; identifying a user account associated with the transaction notification; generating a push notification with a payload describing instructions to display a message and an interactive icon, and a resource identifier associated with the interactive icon, where the resource identifier includes a message ID encoding an interactive session and an action ID encoding a requested action. The operations also include transmitting the push notification to a client device associated with the user account; receiving a first indication indicating a user interaction with the interactive icon, the first indication having the resource identifier and updating the user account based on the action request.

Abstract: A system for providing notifications to client devices that includes one or more processors and one or more storage devices. The storage devices may store instructions that, when executed, configure the processors to perform operations. The operations include receiving a transaction notification from a third party; identifying a user account associated with the transaction notification; generating a push notification with a payload describing instructions to display a message and an interactive icon, and a resource identifier associated with the interactive icon, where the resource identifier includes a message ID encoding an interactive session and an action ID encoding a requested action. The operations also include transmitting the push notification to a client device associated with the user account; receiving a first indication indicating a user interaction with the interactive icon, the first indication having the resource identifier and updating the user account based on the action request.

Abstract: The method comprises: (a) isolating a sample from the breast tumor; (b) determining the level of expression of GRP94, FN14 or both in the sample, and (c) comparing said level with the level of said gene(s) in a control sample, wherein if it is detected an overexpression of said gene(s), in respect of the control sample, it is indicative of the risk for developing brain metastasis. The kit to carry out the method of the invention comprises appropriate means to determine the level of expression of each one of the markers. Both, the method and kit provides accurate information about the risk of developing brain metastasis in an early state, which can lead to a reduction of the incidence of breast cancer brain metastasis.

Abstract: An instrument cluster system for a vehicle includes a speedometer gauge having markings indicative of speeds of the vehicle, a pointer, and a speed warning indicator including adjacent lights arranged in position to correlate with the markings. A control unit receives inputs including a speed of the vehicle. GPS provides a location of the vehicle so that the control unit can obtain a posted speed limit of a road on which the vehicle is located. The control unit sends processed data to the cluster so that the cluster can control the lights based on the posted speed limit, such that lights correlating with speeds below the posted speed limit can be illuminated green and lights correlating with speeds above the posted speed limit can be illuminated red, thereby providing a visual warning to a driver as to whether the vehicle is operating above or below the posted speed limit.

Abstract: An instrument cluster system for a vehicle includes a speedometer gauge having markings indicative of speeds of the vehicle, a pointer, and a speed warning indicator including adjacent lights arranged in position to correlate with the markings. A control unit receives inputs including a speed of the vehicle. GPS provides a location of the vehicle so that the control unit can obtain a posted speed limit of a road on which the vehicle is located. The control unit sends processed data to the cluster so that the cluster can control the lights based on the posted speed limit, such that lights correlating with speeds below the posted speed limit can be illuminated green and lights correlating with speeds above the posted speed limit can be illuminated red, thereby providing a visual warning to a driver as to whether the vehicle is operating above or below the posted speed limit.

Abstract: The invention provides: a cross-linkable therapeutic composition comprising a) a saccharide-siloxane copolymer; b) a crosslinking agent; c) one or more active/inactive ingredients; and d) optionally, a solvent, or solvent mixture, wherein the saccharide-siloxane copolymer has the following formula: R2aR1(3-a)SiO—[(SiR2R1O)m-(SiR12O)n]y-SiR1(3-a)R2a that is further formulaically defined and wherein the saccharide-siloxane copolymer is a reaction product of a functionalized organosiloxane polymer and at least one hydroxy-functional saccharide such that the organosiloxane component is covalently linked via a linking group to the saccharide component; films; and methods related thereto. The composition has therapeutic properties. The invention also provides articles of manufacture including topical and transdermal agent delivery patches comprising the novel film-forming composition and/or films.

Abstract: Dual drug paste compositions are disclosed containing a silicone organic elastomer gel, a hydrophobic drug, and a hydrophilic drug. The dual drug paste compositions are useful for the simultaneous delivery of a hydrophobic and hydrophilic drug to a substrate without the drawbacks of using traditional gels, solutions or emulsions.

Abstract: The method comprises: (a) isolating a sample from the breast tumour; (b) determining the level of expression of GRP94, FN14 or both in the sample, and (c) comparing said level with the level of said gene(s) in a control sample, wherein if it is detected an overexpression of said gene(s), in respect of the control sample, it is indicative of the risk for developing brain metastasis. The kit to carry out the method of the invention comprises appropriate means to determine the level of expression of each one of the markers. Both, the method and kit provides accurate information about the risk of developing brain metastasis in an early state, which can lead to a reduction of the incidence of breast cancer brain metastasis.

Abstract: A controlled-release composition for topical application to a substrate includes an oil-in-water emulsion and an active agent incorporated into the oil-in-water emulsion. The oil-in-water emulsion is substantially free of lipophilic solvent and is formed by mechanical inversion of a water-in-oil emulsion. The water-in-oil emulsion includes a silicone component, a surfactant, and water. A method of delivering the active agent to the substrate provides the oil-in-water emulsion and incorporates the active agent into the oil-in-water emulsion for delivery of the active agent to the substrate upon application of the oil-in-water emulsion to the substrate.

Abstract: An arrangement for extracting extraction products in caving in which the extraction product is extracted downwards through an extraction funnel into an extraction path and from this is transferred onto an extraction conveyor arranged in a conveyor path, in which arrangement the extraction path extends transversely between the conveyor path and an auxiliary path parallel to this, a loading ramp is arranged in the extraction path which forms a ramp surface orientated transversely to the conveying direction of the extraction conveyor and inclined towards it. The extraction path is provided with a rail guidance attached to the bottom and extending in the area between the auxiliary path and the conveying path, on which the loading ramp is guided and along which it can be moved by a displacement drive (20) in the direction of the conveyor path and in the opposite direction.

Abstract: The present invention relates to methods, polypeptides, and polynucleotides encoding immunogenic identical or analogous HIV polypeptides derived from the same or different strains within an HIV subtype and/or different subtypes. Uses of the polynucleotides and polypeptides in combination approaches for generating immune responses are also described. The combination approaches described herein induce broad and potent immune responses against diverse HIV strains from multiple strains within a given subtype and against diverse subtypes. Formulations of compositions for generating immune responses and methods of use for such compositions are also disclosed.

Abstract: In the arrangement in accordance with the invention for extracting extraction products in caving in which the extraction product is extracted downwards through an extraction funnel (10) into an extraction path (11) and from this is transferred onto an extraction conveyor arranged in a conveyor path, in which arrangement the extraction path extends transversely between the conveyor path (13) and an auxiliary path (12) parallel to this, a loading ramp (16) is arranged in the extraction path (11) which essentially forms a ramp surface orientated transversely to the conveying direction of the extraction conveyor and inclined towards it.

Abstract: The invention provides: a film-forming composition comprising a) a saccharide-siloxane copolymer; b) a crosslinking agent; c) one or more active/inactive ingredients; and d) optionally, a solvent, or solvent mixture, wherein the saccharide-siloxane copolymer has the following formula: R2aR1(3?a)SiO—[(SiR2R1O)m-(SiR12O)n]y-SiR1(3?a)R2a that is further formulaically defined and wherein the saccharide-siloxane copolymer is a reaction product of a functionalized organosiloxane polymer and at least one hydroxy-functional saccharide such that the organosiloxane component is covalently linked via a linking group to the saccharide component; films; and methods related thereto. The invention also provides articles of manufacture including topical and transdermal agent delivery patches comprising the novel film-forming composition and/or films.

Abstract: In the method according to the invention and the arrangement or according to the invention for extracting extraction products in underground mining operations using the caving method, the extraction products (20) collapsing in an upper gate area (10) are extracted via at least one extraction funnel (13) or the like into an extraction path (14) driven below the gate and are transported away therein by means of an extraction conveyor (15). According to the invention the extraction funnels (13) are arranged laterally beside the extraction conveyor (15) and lead at their lower end into a ramp surface (17) inclined towards the extraction conveyor, the extraction products extracted from the gate through the extraction funnels being transported slidingly over the inclined ramp surface to the extraction conveyor.

Abstract: A controlled-release composition for topical application to a substrate includes an oil-in-water emulsion and an active agent incorporated into the oil-in-water emulsion. The oil-in-water emulsion is substantially free of lipophilic solvent and is formed by mechanical inversion of a water-in-oil emulsion. The water-in-oil emulsion includes a silicone component, a surfactant, and water. A method of delivering the active agent to the substrate provides the oil-in-water emulsion and incorporates the active agent into the oil-in-water emulsion for delivery of the active agent to the substrate upon application of the oil-in-water emulsion to the substrate.

Abstract: A hydrophobic matrix is prepared by forming a semi-solid composition containing a solid powdered hydrophilic drug and/or a solid powdered hydrophilic excipient, and a silicone polyether, and then adding the semi-solid composition to a silicone pressure sensitive adhesive or a solution containing a solvent and a silicone pressure sensitive adhesive, and mixing the composition and the silicone pressure sensitive adhesive or the solution containing the solvent and the silicone pressure sensitive adhesive together to form the hydrophobic matrix. The hydrophobic matrix can be applied to a substrate, typically the human skin by means of a transdermal patch for continuous and controlled transdermal administration of drugs.