Abstract: Described herein are methods and compositions for treating cancer. Aspects of the invention relate to administering to a subject having cancer an inhibitor of the super elongation complex (SEC). In various embodiments, the cancer is a blood cancer. Wherein the blood cancer is selected from the group consisting of leukemia, lymphoma, myeloma, and myeloproliferative neoplasms (MPNs).

Abstract: An AC-DC power supply can include a PFC stage that receives a rectified AC input voltage and produces an intermediate DC bus voltage; a DC-DC stage that receives the intermediate DC bus voltage and produces a regulated DC output voltage; and a digital controller. The digital controller can include a relatively faster DC-DC stage controller that receives DC-DC stage feedback signal(s) and produces DC-DC drive signal(s) for switching device(s) of the DC-DC stage; a relatively slower PFC stage controller that receives PFC feedback signal(s) and produces PFC drive signal(s) for switching device(s) of the PFC stage; and control logic that receives periodic output power indications of the AC-DC power supply and uses them to cause the PFC drive signal(s) to respond to a change in output power of the AC-DC power supply more quickly than would be achieved by the relatively slower PFC stage controller.

Abstract: A cellular magnetic energy storage component can include a plurality of magnetic core segments each having at least one winding disposed about at least a portion thereof; and at least one common magnetic core segment. The plurality of magnetic core segments and the at least one common magnetic core segment can be joined such that there is an air gap between a portion of each of the plurality of magnetic core segments and the common magnetic core segment; and magnetic flux in the at least one common magnetic core segment induced by one or more of the at least one windings substantially cancels a corresponding magnetic flux in the common magnetic core segment induced by one or more other at least one windings. The cellular magnetic energy storage component can be an inductor or a flyback transformer.

Abstract: A buck-fed current multiplier battery charging circuit can include a buck converter having an input configured to receive an input voltage and an output configured to deliver a regulated current, a current multiplier having an input configured to receive the regulated current from the buck converter and an output configured to deliver a multiple of the regulated current to a battery, wherein the current multiplier comprises one or more flying capacitor stages each including a resonant tank circuit; and controller circuitry coupled to the buck converter that operates switches of the buck converter to produce the regulated current and coupled to the current multiplier that operates switches of the current multiplier to deliver the multiple of the regulated current to the battery.

Abstract: A switched capacitor converter battery charging circuit can include an input that receives an input current, an output that delivers an integer multiple of the input current to a battery, a plurality of flying capacitor stages disposed between the input and output, and controller circuitry coupled to the flying capacitor stages that selectively enables or disables one or more of the flying capacitor stages to select the integer multiple responsive to a voltage supplied at the input. The flying capacitor stages can include a first plurality of flying capacitor stages forming a first phase of the converter and a second plurality of flying capacitor stages forming a second phase of the converter. The first and second phases can be operated in an interleaved manner to reduce current or voltage ripple. The converter can include three flying capacitor stages, providing for selection of integer multiples of 4×, 3×, 2×, or 1×.

Abstract: Embodiments disclosed herein provide methods of using somatic mutations in mitochondrial genomes to retrospectively infer cell lineages in native contexts and to serve as genetic barcodes to measure clonal dynamics in complex cellular populations. Further, somatic mutations in mitochondrial DNA (mtDNA) are tracked by single cell genomic approaches for simultaneous analysis of single cell lineage and state. Applicants further show that mitochondrial mutations can be readily detected with contemporary single cell transcriptomic and epigenomic technologies to concomitantly capture gene expression profiles and chromatin accessibility, respectively.

Abstract: A magnetic core for use with a printed circuit board transformer can include one or more inside corners of the magnetic core formed to include a curved channel that serves as a strain relief and facilitates positioning a printed circuit board within a core window defined by the core. The magnetic core can be an E-core. A center post of the E-core can define a notch configured to receive a complementary tab of a printed circuit board of the printed circuit board transformer. A center post of the E-core can be shorter than outside legs of the E-core, so that when assembled with an I-core a resulting core has an air gap. The core can be made of a ferrite material. A printed circuit board transformer can include a printed circuit board having one or more turns of a conductive trace disposed thereon and a magnetic core as described above.

Abstract: A quasi-planar transformer can include a first winding comprising one or more turns of wire, a second winding comprising one or more turns of a conductive trace disposed on a printed circuit board, and a magnetic core positioned with respect to the first and second windings so as to provide a magnetic flux path coupling the first and second windings. The first winding can be a primary winding having a first half wound in a clockwise direction on a first side of the printed circuit board and a second half wound in a counterclockwise direction on a second side of the printed circuit board, wherein the first and second halves are formed of a single continuous wire. The single continuous wire can pass through an opening in the printed circuit board. The first and second halves of the primary winding can be secured to the printed circuit board.

Abstract: A method of assembling a quasi-planar transformer can include passing a continuous wire through an opening in a printed circuit board having one or more printed circuit traces that define one or more printed circuit windings of the quasi-planar transformer, winding the continuous wire in a first direction to form a first half of a wire-wound winding on a first side of the printed circuit board, and winding the continuous wire in a second direction opposite the first to form a second half of the wire-wound winding on a second side of the printed circuit board. The method can further include securing the first and second halves of the winding to the printed circuit board. The continuous magnet wire can be self-bonding wire and securing the first and second halves of the winding can include applying heat to the assembly.

Abstract: A rotating detonation combustor includes a nozzle coupled to the combustor body at or near the exhaust opening to choke the exhaust opening. A rotating detonation combustor may include a diverting plate positioned radially inward of the inlet annulus and inlet channels for diverting flow of a mixture in an axial direction. A rotating detonation combustor may include a combustor body including an outer shell at least partially defining a detonation combustion chamber and extending axially from a base toward an exhaust opening of the detonation combustion chamber. The base defines a passageway in fluid communication with the detonation combustion chamber and includes an inlet annulus for axially directing a second fluid into the passageway and a plurality of inlet channels for radially directing a third fluid into at least one of the passageway or the detonation combustion chamber, and the detonation combustion chamber is free of any inner body.

Abstract: Disclosed herein is an improved flyback converter that separates the magnetic components of the converter into a transformer and a separate, discrete energy storage inductor. This arrangement can improve the operating efficiency of the converter by reducing the commutation losses as compared to a conventional flyback converter. The magnetic components may be constructed on separate magnetic cores or may be constructed on magnetic cores having at least one common element, thereby allowing for at least partial magnetic flux cancellation in a portion of the core, reducing core losses.

Abstract: Disclosed herein is an improved flyback converter that separates the magnetic components of the converter into a transformer and a separate, discrete energy storage inductor. This arrangement can improve the operating efficiency of the converter by reducing the commutation losses as compared to a conventional flyback converter. The magnetic components may be constructed on separate magnetic cores or may be constructed on magnetic cores having at least one common element, thereby allowing for at least partial magnetic flux cancellation in a portion of the core, reducing core losses.

Abstract: A two-stage power converter can incorporate a buck pre-regulator and a resonant bus converter. Such a converter may be operated to achieve unconditional soft switching operation (zero voltage switching a/k/a ZVS) over a wide input and output range, while delivering excellent power conversion efficiency at lower power levels and in a no load condition.

Abstract: The described shielding system comprises a first shield and a second shield. The first shield comprises a first plurality of conductive segments extending from a first location. The first plurality of conductive segments are separated from each other by a first plurality of gaps. The second shield comprises a second plurality of conductive segments extending from a second location. The second plurality of conductive segments are separated from each other by a second plurality of gaps. An insulator may be interposed between the first shield and the second shield. The first plurality of gaps may at least partially align with the second plurality of conductive segments and the second plurality of gaps may at least partially align with the first plurality of conductive segments.

Abstract: Isolated buck converters can be an efficient solution in applications that deal with wide variations in input and/or output voltage. The double ended embodiments of such converters can also offer improved transformer utilization. Such converters can be operated in fixed frequency DCM mode operation or variable frequency boundary conduction mode (BCM). The buck/energy storage inductor may be placed in series with primary or secondary winding of the isolation transformer The inherent leakage inductance of the isolation transformer may also utilized as part of the buck inductance. If the leakage inductance of the isolation transformer is sufficiently high (such as in wireless power transfer applications), such converters can use the leakage inductance as the buck inductor.

Abstract: Disclosed herein is an improved flyback converter that separates the magnetic components of the converter into a transformer and a separate, discrete energy storage inductor. This arrangement can improve the operating efficiency of the converter by reducing the commutation losses as compared to a conventional flyback converter. The magnetic components may be constructed on separate magnetic cores or may be constructed on magnetic cores having at least one common element, thereby allowing for at least partial magnetic flux cancellation in a portion of the core, reducing core losses.

Abstract: Disclosed herein is an improved flyback converter that separates the magnetic components of the converter into a transformer and a separate, discrete energy storage inductor. This arrangement can improve the operating efficiency of the converter by reducing the commutation losses as compared to a conventional flyback converter. The magnetic components may be constructed on separate magnetic cores or may be constructed on magnetic cores having at least one common element, thereby allowing for at least partial magnetic flux cancellation in a portion of the core, reducing core losses.

Abstract: A two-stage power converter can incorporate a buck pre-regulator and a resonant bus converter. Such a converter may be operated to achieve unconditional soft switching operation (zero voltage switching a/k/a ZVS) over a wide input and output range, while delivering excellent power conversion efficiency at lower power levels and in a no load condition.

Abstract: Described herein are methods and compositions related to GATA-1 gene therapy for the treatment of Diamond-Blackfan anemia.

Abstract: A two-stage power converter can incorporate a buck pre-regulator and a resonant bus converter. Such a converter may be operated to achieve unconditional soft switching operation (zero voltage switching a/k/a ZVS) over a wide input and output range, while delivering excellent power conversion efficiency at lower power levels and in a no load condition.