Abstract: The invention relates to methods and uses of modulating fetal hemoglobin expression (HbF) in a hematopoietic progenitor cells via inhibitors of BCL11A expression or activity, such as RNAi and antibodies.

Abstract: A multi-factor user authentication framework using asymmetric key includes a host device, a user agent, a gesture system, and an authentication system. The multiple factors include a user credential as well as a user gesture that indicates that the user is present. The user interacts with the user agent via the host device in order to obtain access to something for which user authentication is needed. The authentication system maintains the user credentials, which are provided to authenticate the user in response to the authentication system determining that the user is present (which can be determined in different manners, such as using a personal identification number (PIN), biometric information regarding the user, geographic location of the gesture system, etc.). The user agent, gesture system, and authentication system can be implemented on the same device (e.g., the host device), or alternatively implemented across one or more different devices.

Abstract: Negotiating a multi-vehicle environment using vehicle-to-vehicle network tokens for intra-vehicle communication. Preliminary routing assignments are efficiently improved by available intra-vehicle communication.

Abstract: Negotiating a multi-vehicle environment using vehicle-to-vehicle network tokens for intra-vehicle communication. Preliminary routing assignments are efficiently improved by available intra-vehicle communication.

Abstract: A flyback converter can include a series-parallel mode (SPM) active clamp circuit. The active clamp circuit, coupled in parallel with the primary coil, may include multiple networks in parallel. The first network, comprising a switch, one or more snubber capacitors, and one or more diodes, may be configured to absorb and retain the leakage energy from the leakage inductance of the flyback converter. The second network, comprising another switch and a diode, may be configured to create a circulating circuit for the flow of current through the primary coil in a reverse direction and clamp the current to a threshold level. With the active clamp circuit, the flyback converter may first re-capture the leakage energy in the active clamp circuit and then recover it back to the power source.

Abstract: A flyback converter can include a series-parallel mode (SPM) active clamp circuit. The active clamp circuit, coupled in parallel with the primary coil, may include multiple networks in parallel. The first network, comprising a switch, one or more snubber capacitors, and one or more diodes, may be configured to absorb and retain the leakage energy from the leakage inductance of the flyback converter. The second network, comprising another switch and a diode, may be configured to create a circulating circuit for the flow of current through the primary coil in a reverse direction and clamp the current to a threshold level. With the active clamp circuit, the flyback converter may first re-capture the leakage energy in the active clamp circuit and then recover it back to the power source.

Abstract: A method and system for managing a large number of servers and their server components distributed throughout a heterogeneous computing environment is provided. In one embodiment, an authenticated user, such as a IT system administrator, can securely and simultaneously control and configure multiple servers, supporting different operating systems, through a “virtual server.” A virtual server is an abstract model representing a collection of actual target servers. To represent multiple physical servers as one virtual server, abstract system calls that extend execution of operating-system-specific system calls to multiple servers, regardless of their supported operating systems, are used. A virtual server is implemented by a virtual server client and a collection of virtual server agents associated with a collection of actual servers.

Abstract: The invention relates to methods and uses of modulating fetal hemoglobin expression (HbF) in a hematopoietic progenitor cells via inhibitors of BCL11A expression or activity, such as RNAi and antibodies.

Abstract: Disclosed herein are methods for producing red blood cells (RBCs) from a population of stem cells and/or progenitor cells. In at least one of the stem cells or progenitor cells, SH2B3 protein activity is decreased, SH2B3 mRNA level is decreased, and/or SH2B3 protein level is decreased. The methods provided herein permit the production of RBCs with increased quantity and/or quality as compared to a method using the same population of stem cells and/or progenitor cells without SH2B3 inhibition or disruption. Also provided herein are methods of use of the RBCs produced using the methods described herein.

Abstract: A method and system for managing a large number of servers and their server components distributed throughout a heterogeneous computing environment is provided. In one embodiment, an authenticated user, such as a IT system administrator, can securely and simultaneously control and configure multiple servers, supporting different operating systems, through a “virtual server.” A virtual server is an abstract model representing a collection of actual target servers. To represent multiple physical servers as one virtual server, abstract system calls that extend execution of operating-system-specific system calls to multiple servers, regardless of their supported operating systems, are used. A virtual server is implemented by a virtual server client and a collection of virtual server agents associated with a collection of actual servers.

Abstract: A directivity pattern generator for producing sound patterns using a modal architecture is described. The directivity pattern generator may include a beam pattern mixing unit, which defines sound patterns to be emitted by an audio system in terms of a set of frequency invariant modes or modal patterns. The beam pattern mixing unit produces a set of modal gains representing the level or degree each of the predefined modal patterns is to be applied to a set of audio streams. Modal filters may be used to modal amplitudes that compensate for inefficiencies of the each modal pattern at low frequencies. The directivity pattern generator may include a modal decomposition unit for generating driving signals for each transducer in one or more loudspeaker arrays based on weighted values for the modal gains/amplitudes.

Abstract: Binding a security token to a client token binder, such as a trusted platform module, is provided. A bound security token can only be used on the client on which it was obtained. A secret binding key (kbind) is established between the client and an STS. The client derives a key (kmac) from kbind, signs a security token request with kmac, and instructs the STS to bind the requested security token to kbind. The STS validates the request by deriving kmac using a client-provided nonce and kbind to MAC the message and compare the MAC values. If the request is validated, the STS generates a response comprising the requested security token, derives two keys from kbind: one to sign the response and one to encrypt the response, and sends the response to the client. Only a device comprising kbind is enabled to use the bound security token, providing increased security.

Abstract: The invention relates to methods and uses of modulating fetal hemoglobin expression (HbF) in a hematopoietic progenitor cells via inhibitors of BCL11A expression or activity, such as RNAi and antibodies.

Abstract: A multi-factor user authentication framework using asymmetric key includes a host device, a user agent, a gesture system, and an authentication system. The multiple factors include a user credential as well as a user gesture that indicates that the user is present. The user interacts with the user agent via the host device in order to obtain access to something for which user authentication is needed. The authentication system maintains the user credentials, which are provided to authenticate the user in response to the authentication system determining that the user is present (which can be determined in different manners, such as using a personal identification number (PIN), biometric information regarding the user, geographic location of the gesture system, etc.). The user agent, gesture system, and authentication system can be implemented on the same device (e.g., the host device), or alternatively implemented across one or more different devices.

Abstract: Negotiating a multi-vehicle environment using vehicle-to-vehicle network tokens for intra-vehicle communication. Preliminary routing assignments are efficiently improved by available intra-vehicle communication.

Abstract: Negotiating a multi-vehicle environment using vehicle-to-vehicle network tokens for intra-vehicle communication. Preliminary routing assignments are efficiently improved by available intra-vehicle communication.

Abstract: Techniques for secure data synchronization are described. In one or more implementations, a determination is made as to whether enterprise data is stored locally on a first device corresponding to an enterprise device. Based on a determination that the second device is a non-enterprise device, a determination is made as to whether a permission associated with the first device indicates that the first device is permitted to propagate the enterprise data to non-enterprise devices. If the first device lacks permission to propagate the enterprise data to non-enterprise devices, the enterprise data is prevented from being propagated to the second device.

Abstract: In one general aspect, a method can include forming a redistribution layer on a substrate using a first electroplating process, and forming a conductive pillar on the redistribution layer using a second electroplating process. The method can include coupling a semiconductor die to the redistribution layer, and can include forming a molding layer encapsulating at least a portion of the redistribution layer and at least a portion of the conductive pillar.

Abstract: Negotiating a multi-vehicle environment using vehicle-to-vehicle network tokens for intra-vehicle communication. Preliminary routing assignment are efficiently improved by available intra-vehicle communication.

Abstract: Techniques for secure data synchronization are described. In one or more implementations, techniques may be employed to conserve high cost data storage by storing larger portions of encrypted data in low cost storage, while storing relatively smaller encryption keys in higher cost storage. A device that is granted access to the encryption keys can retrieve the encrypted data from the low cost storage and use the encryption keys to decrypt the encrypted data.