Abstract: The invention provides compositions and methods for treating conditions in a subject by providing an inhibitor of inosine phosphate dehydrogenase that promotes decreased levels of guanosine triphosphate and/or increased levels of hypoxanthine.

Abstract: The invention provides compositions and methods for treating conditions in a subject by inhibiting inosine monophosphate dehydrogenase. The invention provides compositions and methods that provide periods of sustained inhibition of inosine monophosphate dehydrogenase followed by periods in which enzyme activity is not inhibited. The invention also provides methods that include monitoring inhibition of inosine monophosphate dehydrogenase via analysis of GTP levels.

Abstract: The present disclosure provides for an apparatus for using a patterned stranded elastic laminate. The stranded elastic laminate is patterned by an anvil roll. The current disclosure also includes a process for making a patterned elastic laminate The patterned elastic laminate provides an aesthetic effect and is visible at least in both the stretched and unstretched states.

Abstract: Methods and systems for cutting or perforating webs are disclosed. A method of cutting or perforating a web can include providing a web including a film. The film can include a polyolefin polymer and a plurality of particles. The film can include a width and length defining a surface. The method can further include stretching the film to provide a stretched film. Stretching the film can provide a plurality of voids in the stretched film. The method can additionally include providing a laser assembly. The method can include directing abeam of light from the laser assembly upon the surface of the web to cut or perforate the web in at least one location.

Abstract: The present disclosure discloses an embossed patterned elastic laminate. The elastic laminate has an embossed pattern of at least three surface areas. The current disclosure also includes a process for making an embossed patterned elastic laminate. The embossed patterned elastic laminate provides a permanent change to visual aesthetic without adversely impacting the elastic film.

Abstract: The invention provides therapeutic compositions that contain an inhibitor of dihydroorotate dehydrogenase (DHODH) and promote sustained elevation of dihydroorotate (DHO) levels in a patient. The compositions are useful for treating disorders associated with unregulated DHODH activity, such as acute myeloid leukemia. The invention also provides methods of determining therapeutically effective doses of compositions that contain a DHODH inhibitor. The invention further provides methods of synthesis of 2-(2?-halo-1-1?-biphenyl-4-yl)-quinoline carboxylic acids, which are useful as DHODH inhibitors.

Abstract: The present disclosure relates generally to a wearable device, and more specifically to a wearable device for detecting biological events, monitoring health condition of an individual, and for providing automatic alerts and analytics reporting. An exemplary wearable device for monitoring health condition of an individual comprises a puck component attachable to the individual's clothing, wherein the puck component comprises a circuit of a moisture sensor; a strip component configured to be placed within the individual's clothing, wherein a proximal end portion of the strip comprises a pair of conductive pads, and wherein the pair of conductive pads is configured to interface with the circuit of the moisture sensor while the proximal end portion of the strip is enclosed within the puck via a coupling mechanism.

Abstract: The invention provided methods of treating viral infections, such as COVID-19, by providing an agent that inhibits a nucleotide synthesis pathway. In certain methods, the agent is an inhibitor of dihydroorotate dehydrogenase, such as a brequinar. In certain methods, brequinar is provided to a subject according to a dosing regimen that tailors levels of the drug in the lungs to achieve optimal therapeutic benefit. The dosing regimen may include defined levels of brequinar administered to the subject or defined levels of brequinar attained the lungs of the subject. The invention also provides combination therapies in which an inhibitor of dihydroorotate dehydrogenase is provided together with a second therapeutic agent.

Abstract: The invention provided methods of treating viral infections, such as COVID-19, by providing an agent that inhibits a nucleotide synthesis pathway. In certain methods, the agent is an inhibitor of dihydroorotate dehydrogenase, such as a brequinar. In certain methods, brequinar is provided to a subject according to a dosing regimen that tailors levels of the drug in the lungs to achieve optimal therapeutic benefit. The dosing regimen may include defined levels of brequinar administered to the subject or defined levels of brequinar attained the lungs of the subject. The invention also provides combination therapies in which an inhibitor of dihydroorotate dehydrogenase is provided together with a second therapeutic agent.

Abstract: The invention provided methods of treating viral infections, such as COVID-19, by providing an agent that inhibits a nucleotide synthesis pathway. In certain methods, the agent is an inhibitor of dihydroorotate dehydrogenase, such as a brequinar. In certain methods, brequinar is provided to a subject according to a dosing regimen that tailors levels of the drug in the lungs to achieve optimal therapeutic benefit. The dosing regimen may include defined levels of brequinar administered to the subject or defined levels of brequinar attained the lungs of the subject. The invention also provides combination therapies in which an inhibitor of dihydroorotate dehydrogenase is provided together with a second therapeutic agent.

Abstract: A material contains open pores in which the channels and pores that are internally coated with at least one layer of phosphorus-containing alumina. Such material is formed by infiltrating a porous material one or more times with a non-colloidal, low-viscosity liquid coating precursor, drying, and curing the coating precursor to form a phosphorus-containing alumina layer within pores of the material.

Abstract: The present disclosure relates generally to a wearable device, and more specifically to a wearable device for detecting biological events, monitoring health condition of an individual, and for providing automatic alerts and analytics reporting. An exemplary wearable device for monitoring health condition of an individual comprises a puck component attachable to the individual's clothing, wherein the puck component comprises a circuit of a moisture sensor; a strip component configured to be placed within the individual's clothing, wherein a proximal end portion of the strip comprises a pair of conductive pads, and wherein the pair of conductive pads is configured to interface with the circuit of the moisture sensor while the proximal end portion of the strip is enclosed within the puck via a coupling mechanism.

Abstract: The invention provides therapeutic compositions that contain an inhibitor of dihydroorotate dehydrogenase (DHODH) and promote sustained elevation of dihydroorotate (DHO) levels in a patient. The compositions are useful for treating disorders associated with unregulated DHODH activity, such as acute myeloid leukemia. The invention also provides methods of determining therapeutically effective doses of compositions that contain a DHODH inhibitor. The invention further provides methods of synthesis of 2-(2?-halo-1-1?-biphenyl-4-yl)-quinoline carboxylic acids, which are useful as DHODH inhibitors.

Abstract: The invention provides methods for adjusting a drug dosing regimen, including a drug dosage and schedule of administration, in individuals who have previously received at least one dose of the drug. Adjustments to the dosage and/or schedule are made based on measured levels of the drug or metabolite of the drug and a biomarker of engagement of the drug with its target. The methods are useful for administration of therapeutic agents, such as brequinar, that alter metabolic pathways.

Abstract: The invention provides methods for adjusting a drug dosing regimen, including a drug dosage and schedule of administration, in individuals who have previously received at least one dose of the drug. Adjustments to the dosage and/or schedule are made based on measured levels of the drug or metabolite of the drug and a biomarker of engagement of the drug with its target. The methods are useful for administration of therapeutic agents, such as brequinar, that alter metabolic pathways.

Abstract: The invention provides therapeutic compositions that contain an inhibitor of dihydroorotate dehydrogenase (DHODH) and promote sustained elevation of dihydroorotate (DHO) levels in a patient. The compositions are useful for treating disorders associated with unregulated DHODH activity, such as acute myeloid leukemia. The invention also provides methods of determining therapeutically effective doses of compositions that contain a DHODH inhibitor. The invention further provides methods of synthesis of 2-(2?-halo-1-1?-biphenyl-4-yl)-quinoline carboxylic acids, which are useful as DHODH inhibitors.

Abstract: Examples described herein include devices and systems utilizing backscatter communication to generate transmissions in accordance with wireless communication protocols. Examples are described including single sideband operation, generation of a carrier wave using Bluetooth, downlink communication to a backscatter device, and combinations thereof.

Abstract: The invention provides therapeutic compositions that contain an inhibitor of dihydroorotate dehydrogenase (DHODH) and promote sustained elevation of dihydroorotate (DHO) levels in a patient. The compositions are useful for treating disorders associated with unregulated DHODH activity, such as acute myeloid leukemia. The invention also provides methods of determining therapeutically effective doses of compositions that contain a DHODH inhibitor. The invention further provides methods of synthesis of 2-(2?-halo-1-1?-biphenyl-4-yl)-quinoline carboxylic acids, which are useful as DHODH inhibitors.

Abstract: Methods and systems for cutting or perforating webs are disclosed. A method of cutting or perforating a web can include providing a web including a film. The film can include a polyolefin polymer and a plurality of particles. The film can include a width and length defining a surface. The method can further include stretching the film to provide a stretched film. Stretching the film can provide a plurality of voids in the stretched film. The method can additionally include providing a laser assembly. The method can include directing abeam of light from the laser assembly upon the surface of the web to cut or perforate the web in at least one location.

Abstract: Disclosed are systems and methods of a health monitoring device comprising: a flexible circuit, an absorbent product, and, a processing unit. The flexible circuit comprises: an electrochemical biosensor, a color sensor, an LED, and, a moisture sensor. The electrochemical biosensor comprises a plurality of reference electrodes. The processing unit comprises: a GPS antenna, a power unit, a bluetooth low energy transceiver, a GPS transceiver, a microcontroller, and, an accelerometer. The processing unit is electronically coupled to the flexible circuit. The methods comprise: obtaining health data from health monitoring device; recording the health data on the memory unit; transmitting the health data to a data communication device; and, displaying the health data on the data communication device.