Abstract: Antibodies that modulate insulin receptor signaling are provided.

Abstract: Isolated antibodies that bind to human CD38 and cynomolgus CD38 are disclosed. Also disclosed are pharmaceutical compositions comprising the disclosed antibodies, and therapeutic and diagnostic methods for using the disclosed antibodies.

Abstract: A system for optically monitoring a gas turbine engine includes an optical multiplexer configured to receive multiple images from respective viewports into the gas turbine engine. The optical multiplexer includes a movable reflective device configured to selectively direct at least a portion of each image toward a detector array, and the detector array is directed toward a fixed location on the optical multiplexer.

Abstract: A system is disclosed. The system includes a processing subsystem that receives component data signals corresponding to a plurality of parameters of a device, wherein the processing subsystem generates one or more sets of state category component data by allocating the component data signals into respective one or more sets of state category component data, determines a plurality of first dynamic thresholds and a plurality of second dynamic thresholds corresponding to at least one of the one or more sets of state category component data based upon a respective set of state category component data in the one or more sets of state category component data and a respective parameter in the plurality of parameters, and determines an impending trip of the device utilizing the plurality of first dynamic thresholds and the plurality of second dynamic thresholds.

Abstract: Isolated antibodies that bind to human CD38 and cynomolgus CD38 are disclosed. Also disclosed are pharmaceutical compositions comprising the disclosed antibodies, and therapeutic and diagnostic methods for using the disclosed antibodies.

Abstract: Isolated antibodies that bind to human CD38 and cynomolgus CD38 are disclosed. Also disclosed are pharmaceutical compositions comprising the disclosed antibodies, and therapeutic and diagnostic methods for using the disclosed antibodies.

Abstract: Isolated antibodies that bind to human CD38 and cynomolgus CD38 are disclosed. Also disclosed are pharmaceutical compositions comprising the disclosed antibodies, and therapeutic and diagnostic methods for using the disclosed antibodies.

Abstract: Antibodies that modulate insulin receptor signaling are provided.

Abstract: A system for optically monitoring a gas turbine engine includes an optical multiplexer configured to receive multiple images from respective viewports into the gas turbine engine. The optical multiplexer includes a movable reflective device configured to selectively direct at least a portion of each image toward a detector array, and the detector array is directed toward a fixed location on the optical multiplexer.

Abstract: A system is disclosed. The system includes a processing subsystem that receives component data signals corresponding to a plurality of parameters of a device, wherein the processing subsystem generates one or more sets of state category component data by allocating the component data signals into respective one or more sets of state category component data, determines a plurality of first dynamic thresholds and a plurality of second dynamic thresholds corresponding to at least one of the one or more sets of state category component data based upon a respective set of state category component data in the one or more sets of state category component data and a respective parameter in the plurality of parameters, and determines an impending trip of the device utilizing the plurality of first dynamic thresholds and the plurality of second dynamic thresholds.

Abstract: Isolated antibodies that bind to human CD38 and cynomolgus CD38 are disclosed. Also disclosed are pharmaceutical compositions comprising the disclosed antibodies, and therapeutic and diagnostic methods for using the disclosed antibodies.

Abstract: Embodiments of the invention include an inspection system to inspect internal components of a compressor of a gas turbine engine. The inspection system includes an image recording assembly having one or more image recording devices, light sources, storage devices, and power supplies. The image recording assembly may be inserted into a compressor without removal of the compressor housing or disassembly of the compressor. The image recording assembly may be removably coupled to a rotary component of the compressor, e.g., a rotor blade, and used to record images of stationary components, e.g., stator vanes, of the compressor. The images may be inspected to identify wear and/or defects in the stationary components, e.g., stator vanes.

Abstract: A system is disclosed that includes an image recording assembly for recording images of a stator vane of a compressor and a mechanism configured to magnetically couple the image recording assembly to a rotor blade of a compressor. Additional systems are provided that include image recording assemblies. Methods implementing the disclosed systems are also provided.

Abstract: A system is presented. The system includes a data acquisition system that generates time of arrival (TOA) data corresponding to a plurality of blades in a device, a central processing subsystem that determines features of each of the plurality of blades utilizing the TOA data, and evaluates the health of each of the plurality of blades based upon the determined features.

Abstract: A method for monitoring the health of a compressor of a gas turbine is disclosed. The method includes receiving a plurality of turbine data points, wherein the plurality of turbine data points may include one or more operating parameters, at least one of a computer discharge temperature (CTD), and one or more performance parameters. The plurality of turbine data points may be categorized based on the one or more operating parameters. A statistical variability measure of at least one of the CTD and the one or more performance parameters may be computed for each of the plurality of bands. An alarm indicator may be computed based on the at least one statistical variability measure. The method may also include combining two or more of the operating parameters, the CTD and the performance parameters using sensor fusion techniques. The alarm indicator may be computed based on the combined parameters.

Abstract: Isolated antibodies that bind to human CD38 and cynomolgus CD38 are disclosed. Also disclosed are pharmaceutical compositions comprising the disclosed antibodies, and therapeutic and diagnostic methods for using the disclosed antibodies.

Abstract: The present invention provides chimeric and humanized antibodies that specifically recognize ?5?1 integrin, and methods for using the antibodies for reducing or inhibiting angiogenesis in a tissue. Also provided are methods of determining therapeutically acceptable doses of the antibodies and pharmaceutical compositions including the same.

Abstract: The invention relates to the identification and generation of antibodies that bind to TMEFF2 proteins which are involved in cancer. Further, the invention provides for the use of these antibodies in the treatment of cancer.

Abstract: Systems and methods for prediction of gas turbine trips due to component failures such as electro-hydraulic valve (gas control valve) system failures. Exemplary embodiments include prediction of gas turbine trips due to component failures, the method including collecting raw gas turbine operational data and using the raw gas turbine operational data to generate a prognostic indicator for the prediction of a turbine trip due to the failed gas control valves.

Abstract: Isolated antibodies that bind to human CD38 and cynomolgus CD38 are disclosed. Also disclosed are pharmaceutical compositions comprising the disclosed antibodies, and therapeutic and diagnostic methods for using the disclosed antibodies.