Abstract: The present application describes a conjugate between a natriuretic peptide, such as urodilatin, and the constant region of an immunoglobulin or a fragment thereof. Also described are compositions comprising the conjugate and methods for using the conjugate.

Abstract: Described herein are methods and compositions that can be used for diagnosis and treatment of cancer.

Abstract: Described herein are methods and compositions that can be used for diagnosis and treatment of cancer.

Abstract: A gearbox life estimation system includes a single sensor or multiple sensors configured for obtaining field operational data related to loading of a gearbox from a single gearbox component or different gearbox components. The system further includes a processor configured for receiving signals representative of the field operational data from the sensors, for providing calculated operational load data for the gearbox components based on the field operational data, and for providing an estimate of remaining life of gearbox using the calculated operational load data.

Abstract: GPR64 antibody compositions are provided. These antibodies may be used for diagnosis or treatment of cancer, especially ovarian cancer, Ewing's sarcoma, uterine cancer, and other GPR64 expressing tumor types.

Abstract: Described herein are methods and compositions that can be used for diagnosis and treatment of cancer.

Abstract: The present invention provides chimeric and humanized antibodies that specifically recognize ?5?1 integrin, and methods for using the antibodies for reducing or inhibiting angiogenesis in a tissue. Also provided are methods of determining therapeutically acceptable doses of the antibodies and pharmaceutical compositions including the same.

Abstract: Described herein are methods and compositions that can be used for diagnosis and treatment of cancer.

Abstract: A system for isolating effects of one or more process parameters on performance of a heat transfer device is provided. The system includes an efficiency correction unit that is adapted to receive data from the heat transfer device. The data is representative of one or more measurable process parameters or a change in the one or more measurable process parameters of the heat transfer device. The efficiency correction unit is also configured to compute a normalized efficiency of the heat transfer device. The normalized efficiency represents a corrected efficiency that isolates effects of one or more process parameters on performance of the heat transfer device.

Abstract: The present invention provides chimeric and humanized antibodies that specifically recognize ?5?1 integrin, and methods for using the antibodies for reducing or inhibiting angiogenesis in a tissue. Also provided are methods of determining therapeutically acceptable doses of the antibodies and pharmaceutical compositions including the same.

Abstract: GPR64 antibody compositions are provided. These antibodies may be used for diagnosis or treatment of cancer, especially ovarian cancer, Ewing's sarcoma, uterine cancer, and other GPR64 expressing tumor types.

Abstract: In a railroad locomotive having a plurality of systems which collectively are used for locomotive operations, a method of self-healing a system of the plurality of systems comprising monitoring operational conditions of the system, detecting at least one of a pending and a current failure, determining a self-healing procedure to correct the failure, and applying the self-healing procedure comprising at least one of a safe mode technique, a redundancy technique, and an automatic configuration technique.

Abstract: The present invention provides methods for direct killing of cancer cells using anti-?5?1 antibodies. Generally, the method comprises contacting a cancer cell that expresses ?5?1 on its surface with an anti-?5?1 antibody, and thereby inducing the death of the cancer cell. The methods of the invention may be employed at an early stage of cancer development in a patient to prevent tumor establishment. In addition, the methods may be used to treat previously formed tumors especially in cancer that have not proven susceptible to anti-angiogenesis therapy. The methods may be employed as a combination therapy of anti-?5?1 antibodies together with cancer chemotherapeutic agents or other molecular-based cancer therapeutic agents.

Abstract: In a railroad locomotive having a plurality of systems which collectively are used for locomotive operations, a method of self-healing a system of the plurality of systems comprising monitoring operational conditions of the system, detecting at least one of a pending and a current failure, determining a self-healing procedure to correct the failure, and applying the self-healing procedure comprising at least one of a safe mode technique, a redundancy technique, and an automatic configuration technique.

Abstract: The present invention provides chimeric and humanized antibodies that specifically recognize ?5?1 integrin, and methods for using the antibodies for reducing or inhibiting angiogenesis in a tissue. Also provided are methods of determining therapeutically acceptable doses of the antibodies and pharmaceutical compositions including the same.

Abstract: A method of servicing a mobile asset subject to utilization loss factors delaying the completion of servicing and the timely return of the asset to operation including identifying utilization loss factors that could delay the timely completion of servicing of the mobile asset. Identifying service procedures associated with each utilization loss factor and providing a database of events associated with the service procedures the events indicative of a status of completion of the procedures. A schedule may be established for at least one event for the timely completion of the respective service procedure. Monitoring the at least one event to determine when the event occurred relative to the scheduled time and if the at least one event is late, providing notice that the relevant utilization loss factor is likely to cause delay in the timely return of the asset to operation unless corrective action is taken.

Abstract: GPR64 antibody compositions are provided. These antibodies may be used for diagnosis or treatment of cancer, especially ovarian cancer, Ewing's sarcoma, uterine cancer, and other GPR64 expressing tumor types.

Abstract: In a railroad locomotive having a plurality of systems which collectively are used for locomotive operations, a method of self-healing a system of the plurality of systems comprising monitoring operational conditions of the system, detecting at least one of a pending and a current failure, determining a self-healing procedure to correct the failure, and applying the self-healing procedure comprising at least one of a safe mode technique, a redundancy technique, and an automatic configuration technique.

Abstract: A method for analyzing operational performance of industrial power plant machinery is disclosed. In an exemplary embodiment, the method includes receiving an input configuration for a power plant to be analyzed, and receiving inputted power plant operational information. A simulated power plant operation is then run for a specified period of time, based upon the power plant input configuration and the inputted power plant operational information. The simulated results of the simulated power plant operation are then outputted in accordance with selected economic parameters of the power plant.

Abstract: Described herein are methods and compositions that can be used for diagnosis and treatment of cancer.