Patents by Inventor Vinayak P. Dravid
Vinayak P. Dravid has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8337813Abstract: The present invention relates generally to multimodal magnetic resonance imaging (MRI) contrast agents. In particular, the present invention provides a MRI contrast agent configured to manipulate both the longitudinal (T1) and transverse (T2) relaxation times of surrounding water proton spins.Type: GrantFiled: September 15, 2008Date of Patent: December 25, 2012Assignee: Northwestern UniversityInventors: Elise A. Schultz Sikma, Mohammad Aslam, Vinayak P. Dravid, Thomas J. Meade, Bradley D. Ulrich
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Publication number: 20120308657Abstract: The present invention relates to magnetic nanostructures as theranostic agents, which provide dual function as diagnostic and therapeutic agents. In particular, the present invention relates to compositions comprising magnetic nanostructures and their use as targeted therapeutic agents for cancers (e.g., medulloblastoma) and Alzheimer's disease and related diseases and conditions.Type: ApplicationFiled: November 1, 2010Publication date: December 6, 2012Applicant: NORTHWESTERN UNIVERSITYInventors: Vinayak P. Dravid, Saurabh Sharma, Tadanori Tomita, Kirsten L. Viola, William L. Klein
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Patent number: 8316713Abstract: A high spatial resolution phase-sensitive technique employs a scanning near field ultrasound holography (SNFUH) methodology for imaging elastic as well as viscoelastic variations across a sample surface. SNFUH uses a near-field approach to measure time-resolved variations in ultrasonic oscillations at a sample surface. As such, it overcomes the spatial resolution limitations of conventional phase-resolved acoustic microscopy (i.e. holography) by eliminating the need for far-field acoustic lenses.Type: GrantFiled: September 21, 2010Date of Patent: November 27, 2012Assignee: Northwestern UniversityInventors: Gajendra Shekhawat, Vinayak P. Dravid
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Publication number: 20110081526Abstract: The present invention includes a method of fabricating organic/inorganic composite nanostructures on a substrate comprising depositing a solution having a block copolymer and an inorganic precursor on the substrate using dip pen nanolithography. The nanostructures comprises arrays of lines and/or dots having widths/diameters less than 1 micron. The present invention also includes a device comprising an organic/inorganic composite nanoscale region chemically bonded to a substrate, wherein the nanoscale region, wherein the nanoscale region has a nanometer scale dimension other than height.Type: ApplicationFiled: October 5, 2010Publication date: April 7, 2011Inventors: Chad A. Mirkin, Vinayak P. Dravid, Ming Su, Xiaogang Liu
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Publication number: 20110036169Abstract: A high spatial resolution phase-sensitive technique employs a scanning near field ultrasound holography (SNFUH) methodology for imaging elastic as well as viscoelastic variations across a sample surface. SNFUH uses a near-field approach to measure time-resolved variations in ultrasonic oscillations at a sample surface. As such, it overcomes the spatial resolution limitations of conventional phase-resolved acoustic microscopy (i.e. holography) by eliminating the need for far-field acoustic lenses.Type: ApplicationFiled: September 21, 2010Publication date: February 17, 2011Applicant: NORTHWESTERN UNIVERSITYInventors: Gajendra Shekhawat, Vinayak P. Dravid
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Publication number: 20110036170Abstract: A system and method for analyzing a sample is described. The system may include, for example, a light source and a scanning probe microscope probe. The light source may generate a coherent laser beam that is modulated by a waveform of a lower frequency. The modulated laser beam is absorbed by the sample causing thermally induced expansion and resulting in an excitation of acoustic waves. The probe is locally deployed near the sample and detects, in real time, perturbations in the excited acoustic waves to detect surface and buried structures of the sample.Type: ApplicationFiled: October 1, 2010Publication date: February 17, 2011Applicant: NORTHWESTERN UNIVERSITYInventors: Gajendra S. Shekhawat, Vinayak P. Dravid
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Patent number: 7811635Abstract: The present invention includes a method of fabricating organic/inorganic composite nanostructures on a substrate comprising depositing a solution having a block copolymer and an inorganic precursor on the substrate using dip pen nanolithography. The nanostructures comprises arrays of lines and/or dots having widths/diameters less than 1 micron. The present invention also includes a device comprising an organic/inorganic composite nanoscale region chemically bonded to a substrate, wherein the nanoscale region, wherein the nanoscale region has a nanometer scale dimension other than height.Type: GrantFiled: August 29, 2007Date of Patent: October 12, 2010Assignee: Northwestern UniversityInventors: Chad A. Mirkin, Vinayak P. Dravid, Ming Su, Xiaogang Liu
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Patent number: 7798001Abstract: A high spatial resolution phase-sensitive technique employs a scanning near field ultrasound holography (SNFUH) methodology for imaging elastic as well as viscoelastic variations across a sample surface. SNFUH uses a near-field approach to measure time-resolved variations in ultrasonic oscillations at a sample surface. As such, it overcomes the spatial resolution limitations of conventional phase-resolved acoustic microscopy (i.e. holography) by eliminating the need for far-field acoustic lenses.Type: GrantFiled: October 2, 2008Date of Patent: September 21, 2010Assignee: Northwestern UniversityInventors: Gajendra Shekhawat, Vinayak P. Dravid
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Patent number: 7759924Abstract: A sensor for detecting mechanical perturbations represented by a change in an electrical signal includes a structure such as a cantilever, membrane, etc. and a field effect transistor such as a MOSFET embedded in the structure. The drain current of the embedded transistor changes with mechanical perturbations in the structure caused, for example, by a biochemical interaction being sensed. A scanning probe microscope utilizes the embedded MOSFET with a BiMOS actuator.Type: GrantFiled: December 4, 2006Date of Patent: July 20, 2010Assignee: Northwestern UniversityInventors: Gajendra Shekhawat, Vinayak P Dravid, Soo-Hyun Tark, Arvind K Srivastava
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Patent number: 7744963Abstract: In one aspect, a method of nanolithography is provided, the method comprising providing a substrate; providing a scanning probe microscope tip; coating the tip with a deposition compound; and subjecting said coated tip to a driving force to deliver said deposition compound to said substrate so as to produce a desired pattern. Another aspect of the invention provides a tip for use in nanolithography having an internal cavity and an aperture restricting movement of a deposition compound from the tip to the substrate. The rate and extent of movement of the deposition compound through the aperture is controlled by a driving force.Type: GrantFiled: October 31, 2007Date of Patent: June 29, 2010Assignee: Northwestern UniversityInventors: Chad A. Mirkin, Seunghun Hong, Vinayak P. Dravid
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Patent number: 7722928Abstract: In one aspect, a method of nanolithography is provided using a driving force to control the movement of a deposition compound from a scanning probe microscope tip to a substrate. Another aspect of the invention provides a tip for use in nanolithography having an internal cavity and an aperture restricting movement of a deposition compound from the tip to the substrate. The rate and extent of movement of the deposition compound through the aperture is controlled by a driving force.Type: GrantFiled: April 7, 2005Date of Patent: May 25, 2010Assignee: Northwestern UniversityInventors: Chad A. Mirkin, Seunghun Hong, Vinayak P. Dravid
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Publication number: 20100077840Abstract: A light-assisted sensor and method of light-assisted sensing of gaseous species involves contacting a gaseous medium with a material selected to adsorb on its surface one or more gaseous species of interest and illuminating the surface of the material from a source to induce a change of an electrical property, such as conductivity, of the material in the presence of the one or more gaseous species. The change in the electrical property of the material is measured and can be used to identify and quantify the gaseous species of interest in the gaseous medium.Type: ApplicationFiled: June 26, 2009Publication date: April 1, 2010Inventors: Arvind Kumar Srivastava, Vinayak P. Dravid
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Publication number: 20090269284Abstract: The present invention relates generally to multimodal magnetic resonance imaging (MRI) contrast agents. In particular, the present invention provides a MRI contrast agent configured to manipulate both the longitudinal (T1) and transverse (T2) relaxation times of surrounding water proton spins.Type: ApplicationFiled: September 15, 2008Publication date: October 29, 2009Applicant: Northwestern UniversityInventors: Elise A. Schultz Sikma, Mohammad Aslam, Vinayak P. Dravid, Thomas J. Meade, Bradley D. Ulrich
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Publication number: 20090114024Abstract: A high spatial resolution phase-sensitive technique employs a scanning near field ultrasound holography (SNFUH) methodology for imaging elastic as well as viscoelastic variations across a sample surface. SNFUH uses a near-field approach to measure time-resolved variations in ultrasonic oscillations at a sample surface. As such, it overcomes the spatial resolution limitations of conventional phase-resolved acoustic microscopy (i.e. holography) by eliminating the need for far-field acoustic lenses.Type: ApplicationFiled: October 2, 2008Publication date: May 7, 2009Inventors: Gajendra Shekhawat, Vinayak P. Dravid
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Patent number: 7448269Abstract: A high spatial resolution phase-sensitive technique employs a scanning near field ultrasound holography (SNFUH) methodology for imaging elastic as well as viscoelastic variations across a sample surface. SNFUH uses a near-field approach to measure time-resolved variations in ultrasonic oscillations at a sample surface. As such, it overcomes the spatial resolution limitations of conventional phase-resolved acoustic microscopy (i.e. holography) by eliminating the need for far-field acoustic lenses.Type: GrantFiled: October 6, 2005Date of Patent: November 11, 2008Assignee: Northwestern UniversityInventors: Gajendra Shekhawat, Vinayak P. Dravid
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Publication number: 20080113099Abstract: In one aspect, a method of nanolithography is provided using a driving force to control the movement of a deposition compound from a scanning probe microscope tip to a substrate. Another aspect of the invention provides a tip for use in nanolithography having an internal cavity and an aperture restricting movement of a deposition compound from the tip to the substrate. The rate and extent of movement of the deposition compound through the aperture is controlled by a driving force.Type: ApplicationFiled: October 31, 2007Publication date: May 15, 2008Inventors: Chad Mirkin, Seunghun Hong, Vinayak P. Dravid
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Patent number: 7273636Abstract: The present invention includes a method of fabricating organic/inorganic composite nanostructures on a substrate comprising depositing a solution having a block copolymer and an inorganic precursor on the substrate using dip pen nanolithography. The process can comprise providing a substrate, providing a nanoscopic tip having an inking composition thereon, wherein the inking composition comprises at least one metal oxide precursor; and transferring the inking composition from the nanoscopic tip to the substrate to form a deposit on the substrate comprising at least one metal oxide precursor, and optionally further comprising the step of converting the metal oxide precursor on the substrate to form the metal oxide. The nanostructures comprises arrays of lines and/or dots having widths/diameters less than 1 micron.Type: GrantFiled: December 17, 2002Date of Patent: September 25, 2007Assignee: Northwestern UniversityInventors: Chad A. Mirkin, Vinayak P. Dravid, Ming Su, Xiaogang Liu
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Patent number: 7223438Abstract: A direct-write method for fabricating magnetic nanostructures, including hard magnetic nanostructures of barium hexaferrite, BaFe, based on nanolithographic printing and a sol-gel process. This method utilizes a conventional atomic force microscope tip, coated with a magnetic material precursor solution, to generate patterns that can be post-treated at elevated temperature to generate magnetic features consisting of barium ferrite in its hexagonal magnetoplumbite (M-type) structure. Features ranging from several hundred nm down to below 100 nm were generated and studied using AFM, magnetic force microscopy, and X-ray photoelectron spectroscopy. The approach offers a new way for patterning functional inorganic magnetic nanostructures with deliberate control over feature size and shape, as well as interfeature distance and location.Type: GrantFiled: September 17, 2003Date of Patent: May 29, 2007Assignee: Northwestern UniversityInventors: Chad A. Mirkin, Lei Fu, Xiaogang Liu, Vinayak P. Dravid
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Patent number: 7155959Abstract: The invention provides a sensor array with different nanodisk sensors that may be fabricated by direct site-specific dip-pen nanopatterning (DPN) using precursor inks. The good flow characteristics and strong affinity of the sols to measurement electrodes enable intimate ohmic contact. The measurable, reproducible and proportionate changes in the resistance of the sensors when exposed to trace quantities of oxidative and reducing gases constitute the basis for nanodisk gas sensors. The nanodisk sensors show rapid response and ultra-fast recovery for the detection of nitrogen dioxide and acetic acid vapor. Based on the principles of pattern recognition of the olfactory system, an electronic nose that can “smell” different gaseous species is provided with the multiple nanodisk sensor array.Type: GrantFiled: February 18, 2004Date of Patent: January 2, 2007Assignee: Northwestern UniversityInventors: Ming Su, Vinayak P. Dravid
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Patent number: 7157897Abstract: A sensor for detecting mechanical perturbations represented by a change in an electrical signal includes a structure such as a cantilever, membrane, etc. and a field effect transistor such as a MOSFET embedded in the structure. The drain current of the embedded transistor changes with mechanical perturbations in the structure caused, for example, by a bio-chemical interaction being sensed. A scanning probe microscope utilizes the embedded MOSFET with a BiMOS actuator.Type: GrantFiled: November 23, 2004Date of Patent: January 2, 2007Assignee: Northwestern UniversityInventors: Gajendra Shekhawat, Vinayak P. Dravid