Patents by Inventor Vincent A. Fischetti

Vincent A. Fischetti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • C1 bacteriophage lytic system
    Patent number: 6608187
    Abstract: The invention relates to the identification of C1 bacteriophage genes that express protein involved in the lysis of bacterial cells during the phage life cycle, lysin and holin. The invention further relates to methods for lysing certain bacteria using lysin, which are useful for example in the treatment of an oral cavity bacterial infection.
    Type: Grant
    Filed: May 23, 2001
    Date of Patent: August 19, 2003
    Assignee: The Rockefeller University
    Inventors: Daniel C. Nelson, Vincent A. Fischetti
  • Novel method to identify targets for antibiotic development
    Publication number: 20030148268
    Abstract: The present invention identifies a new approach for antibiotic development. By identifying molecules in the cell wall of bacteria responsible for binding bacteriophage lytic enzymes, the present invention focuses on the pathways for possible antibiotic development. The pathway for the bacterial molecule is critical for bacterial survival and thus serves as a target for antibiotic identification.
    Type: Application
    Filed: December 5, 2002
    Publication date: August 7, 2003
    Applicant: THE ROCKEFELLER UNIVERSITY
    Inventors: Vincent A. Fischetti, Daniel C. Nelson, Jutta Loeffler
  • Synthetic peptides from streptococcal M protein and vaccines prepared therefrom
    Patent number: 6602507
    Abstract: Synthetic polypeptides from the conserved exposed region of streptococcal M protein are useful to prepare vaccines for oral or intranasal administration which will protect against streptococcal infection.
    Type: Grant
    Filed: January 6, 1995
    Date of Patent: August 5, 2003
    Assignee: The Rockefeller University
    Inventor: Vincent A. Fischetti
  • The use of bacterial phage associated lysing proteins for treating bacterial dental caries
    Publication number: 20030129146
    Abstract: A composition and method for treating bacterial dental caries by the use of an effective amount of at least one lytic specific for the bacteria causing caries. The lytic enzyme is genetically coded for by a bacteriophage which may be specific for said bacteria.
    Type: Application
    Filed: August 16, 2002
    Publication date: July 10, 2003
    Inventors: Vincent Fischetti, Lawrence Loomis
  • Use of bacterial phage associated lysing proteins for treating bacterial dental caries
    Publication number: 20030129147
    Abstract: A composition and method for treating bacterial dental caries by the use of an effective amount of at least one lytic specific for the bacteria causing dental caries. The lytic enzyme is genetically coded for by a bacteriophage which may be specific for said bacteria.
    Type: Application
    Filed: August 16, 2002
    Publication date: July 10, 2003
    Inventors: Vincent Fischetti, Lawrence Loomis
  • Use of bacterial phage associated lysing proteins for the prophylactic and therapeutic treatment of various illnesses
    Publication number: 20030113298
    Abstract: A composition and method for treating bacterial infections is disclosed which comprises the treatment of an individual with an effective amount of at least one lytic protein, peptide, or peptide fragment thereof, wherein said at least one lytic protein or peptides is in a natural or modified form The composition further discloses several carrier compositions suitable for site-specific delivery of the composition. Further disclosed are the method of use of the composition of the invention. These methods include therapeutic, diagnostic, prognostic and drug screening methods.
    Type: Application
    Filed: May 2, 2001
    Publication date: June 19, 2003
    Inventors: Vincent Fischetti, LAwrance Loomis, David Trudil
  • Use of bacterial phage associated lysing proteins for treating bacterial dental caries
    Publication number: 20030082110
    Abstract: A composition and method for treating bacterial dental caries by the use of an effective amount of at least one lytic specific for the bacteria causing dental caries. The lytic enzyme is genetically coded for by a bacteriophage which may be specific for said bacteria.
    Type: Application
    Filed: June 21, 2002
    Publication date: May 1, 2003
    Inventors: Vincent Fischetti, Lawrence Loomis
  • Use of bacterial phage associated lysing enzymes for treating various illnesses
    Publication number: 20020187136
    Abstract: A composition and method for treating bacterial infections is disclosed which comprises the treatment of an individual with an effective amount of at least one lytic enzyme produced by a bacteria infected with a bacteriophage specific for said bacteria wherein at least one lytic enzyme is selected from the group consisting of shuffled lytic enzymes, chimeric lytic enzymes, holin enzymes, and combinations thereof. A carrier may be used for delivering the lytic enzyme. This method, and composition can be used for the treatment of upper respiratory infections, skin infections, wounds, and burns, vaginal infections, eye infections, intestinal disorders and dental problems.
    Type: Application
    Filed: April 30, 2001
    Publication date: December 12, 2002
    Inventors: Lawrence Loomis, Vincent Fischetti
  • Use of phage associated lytic enzymes for treating bacterial infections of the digestive tract
    Publication number: 20020159987
    Abstract: A composition for treatment of bacterial infections of the eye is disclosed which comprises a lytic enzyme composition specific for the infecting bacteria, and a carrier for delivering said lytic enzyme. The carrier for delivering at least one lytic enzyme to the eye may be but is not limited to the use of an isotonic solution.
    Type: Application
    Filed: May 1, 2002
    Publication date: October 31, 2002
    Inventors: Vincent Fischetti, Lawrence Loomis
  • Time release patch containing phage associated lytic enzymes for treating bacterial infections of the skin
    Publication number: 20020159988
    Abstract: A composition for treatment of bacterial infections of the eye is disclosed which comprises a lytic enzyme composition specific for the infecting bacteria, and a carrier for delivering said lytic enzyme.. The carrier for delivering at least one lytic enzyme to the eye may be but is not limited to the use of an isotonic solution. .
    Type: Application
    Filed: May 1, 2002
    Publication date: October 31, 2002
    Inventors: Vincent Fischetti, Lawrence Loomis
  • Method for the treatment of bacterial eye infections
    Publication number: 20020146403
    Abstract: A composition for treatment of bacterial infections of the eye is disclosed which comprises a lytic enzyme composition specific for the infecting bacteria, and a carrier for delivering said lytic enzyme. The carrier for delivering at least one lytic enzyme to the eye may be but is not limited to the use of an isotonic solution.
    Type: Application
    Filed: May 1, 2002
    Publication date: October 10, 2002
    Inventors: Vincent Fischetti, Lawrence Loomis
  • Method for the treatment of bacterial vaginal infections
    Publication number: 20020146402
    Abstract: A composition for treatment of bacterial infections of the eye is disclosed which comprises a lytic enzyme composition specific for the infecting bacteria, and a carrier for delivering said lytic enzyme. The carrier for delivering at least one lytic enzyme to the eye may be but is not limited to the use of an isotonic solution.
    Type: Application
    Filed: May 1, 2002
    Publication date: October 10, 2002
    Inventors: Vincent Fischetti, Lawrence Loomis
  • Parenteral use of bacterial phage associated lysing enzymes for the therapeutic treatment of bacterial infections
    Publication number: 20020127215
    Abstract: The present invention discloses a method and composition for the treatment of bacterial infections by the parenteral introduction of an effective amount of at least one lytic enzyme produced by a bacteria infected with a bacteriophage specific for said bacteria wherein the lytic enzyme is selected from the group consisting of shuffled lytic enzymes, chimerical lytic enzymes, holin enzymes. and combinations thereof, wherein said lytic enzyme is in an appropriate carrier for delivering the lytic enzyme into a patient. The injection can be done intramuscularly, subcutaneously, or intravenously.
    Type: Application
    Filed: January 3, 2001
    Publication date: September 12, 2002
    Inventors: Lawrence Loomis, Vincent Fischetti
  • Parenteral use of bacterial phage associated lysing enzymes for the therapeutic treatment of bacterial infections
    Publication number: 20020127206
    Abstract: The present invention discloses a method and composition for the treatment of bacterial infections by the parenteral introduction of at least one lytic enzyme produced by a bacteria infected with a bacteriophage specific for that bacteria and an appropriate carrier for delivering the lytic enzyme into a patient. The injection can be done intramuscularly, subcutaneously, or intravenously.
    Type: Application
    Filed: July 19, 2001
    Publication date: September 12, 2002
    Inventors: Vincent Fischetti, Lawrence Loomis
  • Use of bacterial phage associated lysing enzymes for the prophylactic and therapeutic treatment of various illnesses
    Publication number: 20020127212
    Abstract: A method for the prophylactic and therapeutic treatment of bacterial infections is disclosed which comprises the treatment of an individual with an effective amount of a lytic enzyme composition specific for the infecting bacteria, with the lytic enzyme comprising an effective amount of lytic enzyme, wherein the lytic enzyme is in an environment having a pH which allows for activity of said lytic enzyme; and a carrier for delivering said lytic enzyme. This method, and composition can be used for the treatment of upper respiratory infections, skin infections, wounds, and burns, vaginal infections, eye infections, intestinal disorders and dental problems.
    Type: Application
    Filed: May 25, 2001
    Publication date: September 12, 2002
    Inventors: Vincent Fischetti, Lawrence Loomis
  • Use of bacterial phage associated lysing enzymes for treating various illnesses
    Publication number: 20020119134
    Abstract: A composition for treatment of bacterial infections of the vagina is disclosed which comprises a lytic enzyme composition specific for the infecting bacteria, and a carrier for delivering said lytic enzyme. The carrier for delivering at least one lytic enzyme to the digestive tract is selected from the group consisting of suppositories,, syrups, or enteric coated pills.
    Type: Application
    Filed: March 25, 2002
    Publication date: August 29, 2002
    Inventors: Vincent Fischetti, Lawrence Loomis
  • Use of bacterial phage associated lysing enzymes for treating various illnesses
    Publication number: 20020119133
    Abstract: A composition for treatment of bacterial infections of the vagina is disclosed which comprises a lytic enzyme composition specific for the infecting bacteria, and a carrier for delivering said lytic enzyme.. The carrier for delivering at least one lytic enzyme to the digestive tract is selected from the group consisting of suppositories,, syrups, or enteric coated pills.
    Type: Application
    Filed: March 25, 2002
    Publication date: August 29, 2002
    Inventors: Vincent Fischetti, Lawrence Loomis
  • Use of bacterial phage associated lysing enzymes for treating various illnesses
    Publication number: 20020119132
    Abstract: A composition for treatment of bacterial infections of the vagina is disclosed which comprises a lytic enzyme composition specific for the infecting bacteria, and a carrier for delivering said lytic enzyme. The carrier for delivering at least one lytic enzyme to the digestive tract is selected from the group consisting of suppositories, syrups, or enteric coated pills.
    Type: Application
    Filed: March 25, 2002
    Publication date: August 29, 2002
    Inventors: Vincent Fischetti, Lawrence Loomis
  • Use of bacterial phage associated lysing enzymes for treating upper respiratory illnesses
    Publication number: 20020119131
    Abstract: A composition for treatment of bacterial infections of the eye is disclosed which comprises a lytic enzyme composition specific for the infecting bacteria, and a carrier for delivering said lytic enzyme. The carrier for delivering at least one lytic enzyme to the eye may be but is not limited to the use of an isotonic solution.
    Type: Application
    Filed: February 8, 2002
    Publication date: August 29, 2002
    Inventors: Vincent Fischetti, Lawrence Loomis
  • Use of bacterial phage associated lysing enzymes for treating dermatological infections
    Patent number: 6432444
    Abstract: A bandage for treating a bacterial infection of skin is disclosed wherein the bandage contains a composition produced by the method of obtaining an effective amount of at least one lytic enzyme genetically coded for by a specific bacteriophage specific for a bacteria infecting the skin, wherein the bacteria to be treated is selected from the group consisting of Staphylococcus, Pseudomonas, Streptococcus, and combinations thereof. This lytic enzyme is specific for and has the ability to digest a cell wall of one of the bacteria and is coded for by the same bacteriophage capable of infecting the bacteria being digested. The enzyme produced is mixed with a topical carrier.
    Type: Grant
    Filed: September 28, 2000
    Date of Patent: August 13, 2002
    Assignee: New Horizons Diagnostics Corp
    Inventors: Vincent Fischetti, Lawrence Loomis