Patents by Inventor Vincent A. Fischetti

Vincent A. Fischetti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Vaginal suppository for treating group B Streptococcus infection
    Patent number: 6428784
    Abstract: A composition for treatment of bacterial infections of the vagina is disclosed which comprises a lytic enzyme composition specific for the infecting bacteria, and a carrier for delivering said lytic enzyme. The lytic enzyme is which is specific for the group B Streptococcus, is genectically coded for by a specific bacteriophage.
    Type: Grant
    Filed: September 28, 2000
    Date of Patent: August 6, 2002
    Assignee: New Horizons Diagnostics Corp
    Inventors: Vincent Fischetti, Lawrence Loomis
  • A Composition for treatment of a bacterial infection of the digestive tract
    Publication number: 20020098234
    Abstract: A composition for treatment of bacterial infections of the digestive tract is disclosed which comprises a lytic enzyme composition specific for the infecting bacteria, and a carrier for delivering said lytic enzyme. The bacteria to be treated is selected from the group consisting of Listeria, Salmonella, E. coli, Campylobacter, and combinations thereof. The carrier for delivering at least one lytic enzyme to the digestive tract is selected from the group consisting of suppository enemas, syrups, or enteric coated pills.
    Type: Application
    Filed: February 27, 2002
    Publication date: July 25, 2002
    Inventors: Vincent Fischetti, Lawrence Loomis
  • Composition for treatment of a bacterial infection of an upper respiratory tract
    Patent number: 6423299
    Abstract: An aerosol composition for treating bacterial infections of the respiratory tract by delivering said aerosol to the mouth, throat or nasal passage, wherein the bacteria to be treated is selected from the group consisting of Streptococcus pneumoniae, Haemophilus influenzae, Streptococcus Group A, and combinations thereof, said aerosol comprising an effective amount of at least one lytic enzyme genetically coded by a bacteriophage specific for a specific said bacteria of the respiratory tract, whereby said at least one lytic enzyme has the ability to digest the cell wall of said specific bacteria; and a carrier for delivering said enzyme.
    Type: Grant
    Filed: September 1, 2000
    Date of Patent: July 23, 2002
    Inventors: Vincent Fischetti, Lawrence Loomis
  • THE USE OF BACTERIAL PHAGE ASSOCIATED LYSING ENZYMES FOR TREATING BACTERIAL INFECTIONS OF THE UPPER RESPIRATORY SYSTEM
    Publication number: 20020094319
    Abstract: The present invention discloses a composition for treating bacterial infections of the mouth or teeth, comprising an effective amount of at least one lytic enzyme produced by bacteria infected with a bacteriophage specific for that bacteria and a pharmaceutically acceptable carrier for topical application of at least one lytic enzyme.
    Type: Application
    Filed: December 11, 2001
    Publication date: July 18, 2002
    Inventors: Vincent Fischetti, Lawrence Loomis
  • Therapeutic treatment of upper respiratory infections
    Publication number: 20020094330
    Abstract: A composition for treatment of bacterial infections of the eye is disclosed which comprises a lytic enzyme composition specific for the infecting bacteria, and a carrier for delivering said lytic enzyme. The carrier for delivering at least one lytic enzyme to the eye may be but is not limited to the use of an isotonic solution.
    Type: Application
    Filed: February 8, 2002
    Publication date: July 18, 2002
    Inventors: Vincent Fischetti, Lawrence Loomis
  • Therapeutic treatment of upper respiratory infections
    Publication number: 20020090367
    Abstract: A composition for treatment of bacterial infections of the eye is disclosed which comprises a lytic enzyme composition specific for the infecting bacteria, and a carrier for delivering said lytic enzyme. The carrier for delivering at least one lytic enzyme to the eye may be but is not limited to the use of an isotonic solution.
    Type: Application
    Filed: February 8, 2002
    Publication date: July 11, 2002
    Inventors: Vincent Fischetti, Lawrence Loomis
  • Composition for treatment of a bacterial infection of the upper respiratory tract
    Publication number: 20020081265
    Abstract: A composition for the treatment of upper respiratory bacterial infections is disclosed which comprises a composition comprising an effective amount of a lytic enzyme composition specific for the infecting bacteria, and a carrier for delivering said lytic enzyme. The bacteria being treated is selected from the group consisting of Streptococcus pneumoniae and Hemophilus influenza. The carrier may be a candy, chewing gum, lozenge, troche, tablet, a powder, an aerosol, a liquid or a liquid spray.
    Type: Application
    Filed: February 27, 2002
    Publication date: June 27, 2002
    Inventors: Vincent Fischetti, Lawrence Loomis
  • Composition for treatment of an ocular bacterial infection
    Patent number: 6406692
    Abstract: A composition for treatment of bacterial infections of the eye is disclosed which comprises a lytic enzyme composition specific for the infecting bacteria, and a carrier for delivering said lytic enzyme. The carrier for delivering at least one lytic enzyme to the eye may be but is not limited to the use of an isotonic solution.
    Type: Grant
    Filed: September 28, 2000
    Date of Patent: June 18, 2002
    Assignee: New Horizons Diagnostics Corp
    Inventors: Vincent Fischetti, Lawrence Loomis
  • Composition for treatment of a bacterial infection of the digestive tract
    Patent number: 6399097
    Abstract: An enteric coated pill for treating bacterial infections of the digestive tract, wherein the bacteria to be treated are selected from the group consisting of Listeria, Salmonella, E. coli, Campylobacter and combinations thereof, said pill comprising an effective amount of at least one lytic enzyme genetically coded by a bacteriophage specific for said bacteria of the digestive tract, whereby said enzyme has the ability to digest the cell wall of said bacteria; and a carrier for said enzyme.
    Type: Grant
    Filed: September 1, 2000
    Date of Patent: June 4, 2002
    Assignee: New Horizons Diagnostics Corporation
    Inventors: Vincent Fischetti, Lawrence Loomis
  • Composition for treating dental caries caused by streptococcus mutans
    Patent number: 6399098
    Abstract: The present invention discloses a method for treating baterial dental caries caused by Streptococcus mutans, comprising administering a composition comprising an effective amount of at least one lytic enzyme produced by a bacteriophage specific for Streptococcus mutans, with the lytic enzyme having the ability to exclusively digest a cell wall of the Streptococcus mutans infecting all or part of a mouth or teeth, and a toothpaste for delivering the enzyme to the mouth and teeth.
    Type: Grant
    Filed: September 28, 2000
    Date of Patent: June 4, 2002
    Assignee: New Horizons Diagnostics Corp
    Inventors: Vincent Fischetti, Lawrence Loomis
  • C1 bacteriophage lytic system
    Publication number: 20020058027
    Abstract: The invention relates to the identification of C1 bacteriophage genes that express protein involved in the lysis of bacterial cells during the phage life cycle, lysin and holin. The invention further relates to methods for lysing certain bacteria using lysin, which are useful for example in the treatment of an oral cavity bacterial infection.
    Type: Application
    Filed: May 23, 2001
    Publication date: May 16, 2002
    Applicant: The Rockefeller University
    Inventors: Daniel C. Nelson, Vincent A. Fischetti
  • Fibronectin and fibrinogen binding protein from group A streptococci
    Patent number: 6355477
    Abstract: This invention relates to a novel fibrinogen and fibronectin binding protein from group A streptococci, and the DNA encoding the protein. The protein and its DNA are useful in the preparation of compositions for the diagnosis, treatment, and prevention of streptococcal infection.
    Type: Grant
    Filed: June 8, 1999
    Date of Patent: March 12, 2002
    Assignee: The Rockefeller University
    Inventors: Vincent A. Fischetti, Claudia Rocha
  • Use of bacterial phage associated lysing enzymes for treating various illnesses
    Publication number: 20020022051
    Abstract: A composition for treatment of bacterial infections of burns and wounds of the skin, comprising an effective amount of at least one lytic enzyme produced by a bacteria infected with a bacteriophage specific for said bacteria, and a carrier for delivering said at least one lytic enzyme to the skin. The carrier may be, but is not limited to, a liquid solution applied to a bandage.
    Type: Application
    Filed: August 20, 2001
    Publication date: February 21, 2002
    Inventors: Vincent Fischetti, Lawrence Loomis
  • Use of bacterial phage associated lysing enzymes for treating bacterial infections of the mouth and teeth
    Patent number: 6335012
    Abstract: The present invention discloses a method for treating dental caries, comprising administering a composition comprising an effective amount of at least one lytic enzyme produced by a bacteriophage specific for said bacteria, the lytic enzyme having the ability to digest a cell wall of the bacteria infecting all or part of a mouth or teeth, and a carrier for delivering the enzyme to the mouth and teeth.
    Type: Grant
    Filed: September 28, 2000
    Date of Patent: January 1, 2002
    Inventors: Vincent Fischetti, Lawrence Loomis
  • Receptor for Mycobacterium leprae and methods of use thereof
    Patent number: 6331405
    Abstract: The present invention relates to the discovery that the &agr;-dystroglycan receptor is required for Mycobacterium leprae entry into cells, assays for high throughput screening of drugs for use in treatments against leprosy, and methods for studying the role of the receptor in neurodegenerative and musculodegenerative diseases, and the like.
    Type: Grant
    Filed: December 10, 1998
    Date of Patent: December 18, 2001
    Assignee: The Rockefeller University
    Inventors: Anura Rambukkana, Vincent A. Fischetti, Kevin P. Campbell
  • Use of bacterial phage associated lysing enzymes for treating streptococcal infections of the upper respiratory tract
    Patent number: 6326002
    Abstract: The present invention discloses a method for treating Streptococcal infections of the upper respiratory tract, comprising administering an effective amount of a lysin enzyme produced by group C Streptococcal bacteria infected with a C1 bacteriophage specific for the bacteria to a mouth, throat, or nasal passage of a mammal, the method providing a concentration of from about 100 to 500,000 active enzyme units per milliliter of fluid in the environment of said nasal or oral passages.
    Type: Grant
    Filed: September 28, 2000
    Date of Patent: December 4, 2001
    Assignee: New Horizons Diagnostics Corporation
    Inventors: Vincent Fischetti, Lawrence Loomis
  • Composition incorporating bacterial phage associated lysing enzymes for treating dermatological infections
    Patent number: 6277399
    Abstract: A composition for treatment of bacterial infections of burns and wounds of the skin comprises an effective amount of at least one lytic enzyme produced by a bacteria infected with a bacteriophage specific for said bacteria, and a carrier for delivering said at least one lytic enzyme to the skin. The carrier may be, but is not limited to, a liquid solution applied to a bandage.
    Type: Grant
    Filed: September 28, 2000
    Date of Patent: August 21, 2001
    Assignee: New Horizon Diagnostics Corporation
    Inventors: Vincent Fischetti, Lawrence Loomis
  • Parenteral use of bacterial phage associated lysing enzymes for the therapeutic treatment of bacterial infections
    Patent number: 6264945
    Abstract: The present invention discloses a method and composition for the treatment of bacterial infections by the parenteral introduction of at least one lytic enzyme produced by a bacteria infected with a bacteriophage specific for that bacteria and an appropriate carrier for delivering the lytic enzyme into a patient. The injection can be done intramuscularly, subcutaneously, or intravenously.
    Type: Grant
    Filed: January 14, 2000
    Date of Patent: July 24, 2001
    Inventors: Vincent A Fischetti, Lawrence Loomis
  • Use of phage associated lytic enzymes for treating bacterial infections of the digestive tract
    Patent number: 6254866
    Abstract: A method for treatment of bacterial infections of the digestive tract is disclosed which comprises administering a lytic enzyme specific for the infecting bacteria. The lytic enzyme is preferably in a carrier for delivering said lytic enzyme. The bacteria to be treated is selected from the group consisting of Listeria, Salmonella, E. coli, Campylobacter, and combinations thereof. The carrier for delivering at least one lytic enzyme to the digestive tract is selected from the group consisting of suppository enemas, syrups, or enteric coated pills.
    Type: Grant
    Filed: September 1, 2000
    Date of Patent: July 3, 2001
    Assignee: New Horizons Diagnostics Corporation
    Inventors: Vincent Fischetti, Lawrence Loomis
  • Bacterial phage associated lysing enzymes for treating dermatological infections
    Patent number: 6248324
    Abstract: The present invention discloses a composition for dermatological infections by the use of a lytic enzyme in a carrier suitable for topical application to dermal tissues. The method for the treatment of dermatological infections comprises administering a composition comprising effective amount of a therapeutic agent, with the therapeutic agent comprising a lytic enzyme produced by infecting a bacteria with phage specific for that bacteria.
    Type: Grant
    Filed: September 28, 2000
    Date of Patent: June 19, 2001
    Inventors: Vincent Fischetti, Lawrence Loomis