Abstract: Novel NTRK1 fusion molecules, detection reagents, and uses and kits for evaluating, identifying, assessing and/or treating a subject having a cancer are disclosed.

Abstract: A system for the fabrication of dome shaped low temperature cofired ceramic (LTCC) substrates comprises a plurality of prefired substrates, a first mandrel, and a second mandrel. The prefired substrates may form a stack and each may include a circular central portion and a plurality of segments uniformly distributed along the circumference of the central portion. Each segment may include a first edge, an opposing second edge, and an end edge. The first and second edges each may have an inner end and an opposing outer end. The end edge may be coupled to the outer end of the first and second edges. The first mandrel may have a first circumference and may be configured to receive the prefired substrates while the stack is formed. The second mandrel may have a second circumference smaller than the first circumference and may be configured to retain the stack during a firing process.

Abstract: Provided are systems and methods for capturing outcome information associated with various cancer treatments. The system facilitates capture and analysis of cancer treatment information and associated outcome information. The treatment and outcome information can include genomic analysis and information on treatment of different cancers. The system can store and analyze any one or more of: tumor type, genomic alterations (e.g., genes and associated alterations, gene sequence mutations, alterations, amplifications, deletions, etc.), and treatment data (including, for example, treatments targeted to specific genes and/or genomic alterations). Users of the outcome system can supply and use the treatment and outcome information to facilitate diagnosis and therapy decisions. User interfaces within the system can be configured to allow users to easily locate outcome information associated with particular treatments of tumors having certain genomic alterations.

Abstract: Novel mutant ESR1 molecules and uses are disclosed.

Abstract: A system for the fabrication of dome shaped low temperature cofired ceramic (LTCC) substrates comprises a plurality of prefired substrates, a first mandrel, and a second mandrel. The prefired substrates may form a stack and each may include a circular central portion and a plurality of segments uniformly distributed along the circumference of the central portion. Each segment may include a first edge, an opposing second edge, and an end edge. The first and second edges each may have an inner end and an opposing outer end. The end edge may be coupled to the outer end of the first and second edges. The first mandrel may have a first circumference and may be configured to receive the prefired substrates while the stack is formed. The second mandrel may have a second circumference smaller than the first circumference and may be configured to retain the stack during a firing process.

Abstract: Development of acquired resistance to the therapeutic effects of an epidermal growth factor (EGFR) tyrosine kinase inhibitor in a patient that is suffering from a cancer is predicted by: (a) obtaining a sample from the patient, wherein the cancer harbors a somatic gain-of-function mutation in the tyrosine kinase domain of EGFR that enhances the sensitivity of the cancer to the tyrosine kinase inhibitor, and (b) testing the sample to determine whether the gene encoding EGFR is present in a mutant form that encodes a T790M mutant of EGFR in addition to the somatic gain of function mutation. A finding that the mutant form is present indicates that the cancer has become or will become resistant to the EGFR tyrosine kinase inhibitor.

Abstract: Development of acquired resistance to the therapeutic effects of an epidermal growth factor (EGFR) tyrosine kinase inhibitor in a patient that is suffering from a cancer is predicted by: (a) obtaining a sample from the patient, wherein the cancer harbors a somatic gain-of-function mutation in the tyrosine kinase domain of EGFR that enhances the sensitivity of the cancer to the tyrosine kinase inhibitor, and (b) testing the sample to determine whether the gene encoding EGFR is present in a mutant form that encodes a T790M mutant of EGFR in addition to the somatic gain of function mutation. A finding that the mutant form is present indicates that the cancer has become or will become resistant to the EGFR tyrosine kinase inhibitor.

Abstract: Polymerase chain reaction primers and methods directed to detecting the EGFR mutant C?T at the position corresponding to base 2369 of EGFR cDNA. The invention provides a PCR primer that hybridizes under suitable PCR conditions to a polynucleotide sequence 5? in each respective strand to a mutation of an EGFR gene that encodes a substitution of threonine by methionine at position 790 of the EGFR polypeptide. The invention also provides a PCR primer hybridizes to a sequence that includes a mutant T at the position corresponding to base 2369 of EGFR cDNA but not to a second EGFR polynucleotide containing a wild type C. The invention provides several methods and kits for detecting a mutant epidermal growth factor receptor (EGFR) gene in a sample comprising probing the sample with a means for selectively detecting a nucleotide sequence comprising a mutant T at the position corresponding to base 2369 of EGFR cDNA, and identifying that the base at said position is T.

Abstract: Polymerase chain reaction primers and methods directed to detecting the EGFR mutant C?T at the position corresponding to base 2369 of EGFR cDNA. The invention provides a PCR primer that hybridizes under suitable PCR conditions to a polynucleotide sequence 5? in each respective strand to a mutation of an EGFR gene that encodes a substitution of threonine by methionine at position 790 of the EGFR polypeptide. The invention also provides a PCR primer hybridizes to a sequence that includes a mutant T at the position corresponding to base 2369 of EGFR cDNA but not to a second EGFR polynucleotide containing a wild type C. The invention provides several methods and kits for detecting a mutant epidermal growth factor receptor (EGFR) gene in a sample comprising probing the sample with a means for selectively detecting a nucleotide sequence comprising a mutant T at the position corresponding to base 2369 of EGFR cDNA, and identifying that the base at said position is T.

Abstract: An electrical safety backpack contains all of the products needed for working near or on energized circuits in a single transportable container which can be carried from various vantage points and which provides easy, immediate access to insulated tools, electrical test equipment and personal protective equipment (PPE) and clothing. This collection of disparate tools puts all the necessary items that are needed to work on energized equipment in one portable container.

Abstract: A method and apparatus for sanitizing carcasses in a conveyor system, wherein a cabinet is provided within which the carcasses are sprayed with a super-saturated solution of chlorine dioxide, are de-watered by passage through a pair of counter-rotating brushes, and are subsequently exposed to chlorine dioxide gas produced from the outgassing of the solution.

Abstract: The pin count of an integrated ISA-type bus controller and PCMCIA-type bus controller is reduced by utilizing a single external bus which supports both ISA-type and PCMCIA-type devices, and by placing control over the bus with the controller that controls the device that corresponds with the input address ADD.

Abstract: Apparatus and method for preventing leakage of refrigerant fluid from a closed air conditioning or refrigeration system having a sealed compressor, an evaporator, a receiver and a condenser, the apparatus including a solenoid-actuated valve for segmenting the refrigerant within the closed system away from the most leak-prone area of the system. A pump is provided for the periodic spraying of lubrication fluid onto a condenser seal to prevent drying of the seal. A containment compartment or trap is provided for catching refrigerant diverted by a diversion valve, the containment compartment having an improved high pressure relief valve, with an indicator for indicating the occurrence of a high pressure exhaust of refrigerant into the atmosphere.