Patents by Inventor Vincent Linder

Vincent Linder has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10472582
    Abstract: The invention is directed to a process and apparatus for removing hydrogen sulfide from a gas stream comprising biogas. In accordance with the invention the gas stream is contacted with an oxidizing agent present in a vessel, whereby said hydrogen sulfide is oxidized into elemental sulfur and said oxidizing agent is reduced, wherein oxygen containing gas is also fed to said vessel, wherein said oxygen oxidizes at least part of said reduced oxidizing agent.
    Type: Grant
    Filed: December 11, 2014
    Date of Patent: November 12, 2019
    Assignee: NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO
    Inventors: Leon Christian Stille, Marco Johannes Gerardus Linders, Earl Lawrence Vincent Goetheer
  • Publication number: 20190336968
    Abstract: Fluidic devices and methods are provided.
    Type: Application
    Filed: March 18, 2019
    Publication date: November 7, 2019
    Applicant: OPKO Diagnostics, LLC
    Inventors: Matthew Dirckx, Jason Taylor, Vincent Linder
  • Patent number: 10456784
    Abstract: Systems and methods for analysis of samples, and in certain embodiments, microfluidic sample analyzers configured to receive a cassette containing a sample therein to perform an analysis of the sample are described. The microfluidic sample analyzers may be used to control fluid flow, mixing, and sample analysis in a variety of microfluidic systems such as microfluidic point-of-care diagnostic platforms. Advantageously, the microfluidic sample analyzers may be, in some embodiments, inexpensive, reduced in size compared to conventional bench top systems, and simple to use. Cassettes that can operate with the sample analyzers are also described.
    Type: Grant
    Filed: May 5, 2017
    Date of Patent: October 29, 2019
    Assignee: OPKO Diagnostics, LLC
    Inventors: Vincent Linder, David Steinmiller, Jason Taylor
  • Patent number: 10413899
    Abstract: The specification generally discloses systems and methods for mixing and delivering fluids in microfluidic systems. The fluids can contain, in some embodiments reagents that can participate in one or more chemical or biological reactions.
    Type: Grant
    Filed: July 12, 2017
    Date of Patent: September 17, 2019
    Assignee: OPKO Diagnostics, LLC
    Inventors: Enqing Tan, Vincent Linder
  • Patent number: 10408824
    Abstract: Fluidic connectors, methods, and devices for performing analyses (e.g., immunoassays) in microfluidic systems are provided. In some embodiments, a fluidic connector having a fluid path is used to connect two independent channels formed in a substrate so as to allow fluid communication between the two independent channels. One or both of the independent channels may be pre-filled with reagents (e.g., antibody solutions, washing buffers and amplification reagents), which can be used to perform the analysis. These reagents may be stored in the channels of the substrate for long periods amounts of time (e.g., 1 year) prior to use.
    Type: Grant
    Filed: November 24, 2015
    Date of Patent: September 10, 2019
    Assignee: OPKO Diagnostics, LLC
    Inventors: Vincent Linder, David Steinmiller, Samuel K. Sia
  • Patent number: 10279345
    Abstract: Fluidic devices and methods involving incubation and/or mixing of assay components are provided. In some embodiments, a biological and/or chemical assay may be performed in a fluidic device. The fluidic device may be designed to allow for controlled incubation and/or mixing of two or more assay components. In some such embodiments, the fluidic device may include an incubation channel having a relatively large cross-sectional dimension in fluid communication with a detection channel. The incubation channel may allow for adequate mixing and/or incubation of two or more assay components prior to analysis of the assay. In certain embodiments, the detection channel may be used to provide feedback on the extent of incubation and/or mixing. Based on the feedback, one or more component of the fluidic system may be regulated to allow the requisite degree of mixing and/or incubation to be achieved.
    Type: Grant
    Filed: December 11, 2015
    Date of Patent: May 7, 2019
    Assignee: OPKO Diagnostics, LLC
    Inventors: Matthew Dirckx, Jason Taylor, Vincent Linder
  • Publication number: 20190072555
    Abstract: Aspects of the disclosure relate to improved assay systems for measuring certain markers (e.g., kallikrein proteins) and determining their presence and/or level in a sample. Further, aspects of the disclosure related to improved methods are provided for determining the probability of an event associated with prostate cancer in a subject.
    Type: Application
    Filed: August 3, 2018
    Publication date: March 7, 2019
    Applicant: OPKO Diagnostics, LLC
    Inventor: Vincent Linder
  • Publication number: 20190072552
    Abstract: An assay device and method are described. The assay may involve immobilizing a binding partner (e.g., an antigen or antibody) for an analyte to be detected (e.g., an antibody or antigen) on a portion of a surface of a microfluidic chamber; passing a fluid sample over the surface and allowing the analyte to bind to the binding partner; allowing a metal colloid, e.g., a gold-conjugated antibody, to associate with the bound analyte; flowing a metal solution, e.g., a silver solution, over the surface such as to form an opaque metallic layer; and detecting the presence of said metallic layer, e.g., by visual inspection or by measuring light transmission through the layer, conductivity or resistance of the layer, or metal concentration in the metal solution after flowing the metal solution over the surface.
    Type: Application
    Filed: September 20, 2018
    Publication date: March 7, 2019
    Applicant: President and Fellows of Harvard College
    Inventors: Samuel K. Sia, Vincent Linder, Babak Parviz, Adam Carlyn Siegel, George M. Whitesides
  • Patent number: 10159978
    Abstract: Microfluidic systems and methods including those that provide control of fluid flow are provided. Such systems and methods can be used, for example, to control pressure-driven flow based on the influence of channel geometry and the viscosity of one or more fluids inside the system.
    Type: Grant
    Filed: November 17, 2017
    Date of Patent: December 25, 2018
    Assignee: OPKO Diagnostics, LLC
    Inventors: Vincent Linder, David Steinmiller
  • Patent number: 10082507
    Abstract: An assay method is described, which comprises the steps of immobilizing a binding partner (e.g., an antigen or antibody) for an analyte to be detected (e.g., an antibody or antigen) on a portion of a surface of a microfluidic chamber; passing a fluid sample over the surface and allowing the analyte to bind to the binding partner; allowing a metal colloid, e.g., a gold-conjugated antibody, to associate with the bound analyte; flowing a metal solution, e.g., a silver solution, over the surface such as to form an opaque metallic layer; and detecting the presence of said metallic layer, e.g., by visual inspection or by measuring light transmission through the layer, conductivity or resistance of the layer, or metal concentration in the metal solution after flowing the metal solution over the surface.
    Type: Grant
    Filed: September 30, 2013
    Date of Patent: September 25, 2018
    Assignee: President and Fellows of Harvard College
    Inventors: Samuel K. Sia, Vincent Linder, Babak Parviz, Adam Siegel, George M. Whitesides
  • Publication number: 20180236448
    Abstract: Systems and methods for controlling fluids in microfluidic systems are generally described. In some embodiments, control of fluids involves the use of feedback from one or more processes or events taking place in the microfluidic system. For instance, a detector may detect one or more fluids at a measurement zone of a microfluidic system and one or more signals, or a pattern of signals, may be generated corresponding to the fluid(s). In some cases, the signal or pattern of signals may correspond to an intensity, a duration, a position in time relative to a second position in time or relative to another process, and/or an average time period between events. Using this data, a control system may determine whether to modulate subsequent fluid flow in the microfluidic system. In some embodiments, these and other methods can be used to conduct quality control to determine abnormalities in operation of the microfluidic system.
    Type: Application
    Filed: April 19, 2018
    Publication date: August 23, 2018
    Applicant: OPKO Diagnostics, LLC
    Inventors: Vincent Linder, David Steinmiller
  • Patent number: 10048252
    Abstract: A method and apparatus for delivering one or more fluids. Fluids may be delivered from a common vessel to a chemical, biological or biochemical process.
    Type: Grant
    Filed: May 1, 2015
    Date of Patent: August 14, 2018
    Assignee: President and Fellows of Harvard College
    Inventors: Vincent Linder, Samuel K. Sia, George M. Whitesides
  • Patent number: 9981266
    Abstract: Systems and methods for controlling fluids in microfluidic systems are generally described. In some embodiments, control of fluids involves the use of feedback from one or more processes or events taking place in the microfluidic system. For instance, a detector may detect one or more fluids at a measurement zone of a microfluidic system and one or more signals, or a pattern of signals, may be generated corresponding to the fluid(s). In some cases, the signal or pattern of signals may correspond to an intensity, a duration, a position in time relative to a second position in time or relative to another process, and/or an average time period between events. Using this data, a control system may determine whether to modulate subsequent fluid flow in the microfluidic system. In some embodiments, these and other methods can be used to conduct quality control to determine abnormalities in operation of the microfluidic system.
    Type: Grant
    Filed: July 20, 2015
    Date of Patent: May 29, 2018
    Assignee: OPKO Diagnostics, LLC
    Inventors: Vincent Linder, David Steinmiller
  • Publication number: 20180099272
    Abstract: Fluidic devices and methods including those that provide storage and/or facilitate fluid handling of reagents are provided. Fluidic devices described herein may include channel segments positioned on two sides of an article, optionally connected by an intervening channel passing through the article. The channel segments may be used to store reagents in the device prior to first use by an end user. The stored reagents may include fluid plugs positioned in linear order so that during use, as fluids flow to a reaction site, they are delivered in a predetermined sequence. The specific geometries of the channel segments and the positions of the channel segments within the fluidic devices described herein may allow fluid reagents to be stored for extended periods of time without mixing, even during routine handling of the devices such as during shipping of the devices, and when the devices are subjected to physical shock or vibration.
    Type: Application
    Filed: December 13, 2017
    Publication date: April 12, 2018
    Applicant: OPKO Diagnostics, LLC
    Inventors: Jason Taylor, Vincent Linder
  • Publication number: 20180085753
    Abstract: Fluidic systems and methods for analyses are provided. In some embodiments, systems and methods for improved measurement of absorbance/transmission through fluidic systems are described. Specifically, in one set of embodiments, optical elements are fabricated on one side of a transparent fluidic device opposite a series of fluidic channels. The optical elements may guide incident light passing through the device such that most of the light is dispersed away from specific areas of the device, such as intervening portions between the fluidic channels. By decreasing the amount of light incident upon these intervening portions, the amount of noise in the detection signal can be decreased when using certain optical detection systems.
    Type: Application
    Filed: October 18, 2017
    Publication date: March 29, 2018
    Applicant: OPKO Diagnostics, LLC
    Inventors: David Steinmiller, Vincent Linder
  • Publication number: 20180078938
    Abstract: The specification generally discloses systems and methods for mixing and delivering fluids in microfluidic systems. The fluids can contain, in some embodiments reagents that can participate in one or more chemical or biological reactions. Some embodiments relate to systems and methods employing one or more vent valves to controllably flow and/or mix portions of fluid within the microfluidic system. Advantageously, fluid control such as a sequence of fluid flow and/or a change in flow rate, can be achieved by opening and closing one or more vent valves and by applying a single source of fluid flow (e.g., a vacuum) operated at a substantially constant pressure. This can simplify the operation and use of the device by an intended user.
    Type: Application
    Filed: December 1, 2017
    Publication date: March 22, 2018
    Applicant: OPKO Diagnostics, LLC
    Inventors: Enqing Tan, Vincent Linder, Jason Taylor, David Steinmiller
  • Publication number: 20180071735
    Abstract: Microfluidic systems and methods including those that provide control of fluid flow are provided. Such systems and methods can be used, for example, to control pressure-driven flow based on the influence of channel geometry and the viscosity of one or more fluids inside the system.
    Type: Application
    Filed: November 17, 2017
    Publication date: March 15, 2018
    Applicant: OPKO Diagnostics, LLC
    Inventors: Vincent Linder, David Steinmiller
  • Patent number: 9878324
    Abstract: Fluidic devices and methods including those that provide storage and/or facilitate fluid handling of reagents are provided. Fluidic devices described herein may include channel segments positioned on two sides of an article, optionally connected by an intervening channel passing through the article. The channel segments may be used to store reagents in the device prior to first use by an end user. The stored reagents may include fluid plugs positioned in linear order so that during use, as fluids flow to a reaction site, they are delivered in a predetermined sequence. The specific geometries of the channel segments and the positions of the channel segments within the fluidic devices described herein may allow fluid reagents to be stored for extended periods of time without mixing, even during routine handling of the devices such as during shipping of the devices, and when the devices are subjected to physical shock or vibration.
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: January 30, 2018
    Assignee: OPKO Diagnostics, LLC
    Inventors: Jason Taylor, Vincent Linder
  • Patent number: 9861980
    Abstract: The specification generally discloses systems and methods for mixing and delivering fluids in microfluidic systems. The fluids can contain, in some embodiments reagents that can participate in one or more chemical or biological reactions. Some embodiments relate to systems and methods employing one or more vent valves to controllably flow and/or mix portions of fluid within the microfluidic system. Advantageously, fluid control such as a sequence of fluid flow and/or a change in flow rate, can be achieved by opening and closing one or more vent valves and by applying a single source of fluid flow (e.g., a vacuum) operated at a substantially constant pressure. This can simplify the operation and use of the device by an intended user.
    Type: Grant
    Filed: December 20, 2016
    Date of Patent: January 9, 2018
    Assignee: OPKO Diagnostics, LLC
    Inventors: Enqing Tan, Vincent Linder, Jason Taylor, David Steinmiller
  • Patent number: D817511
    Type: Grant
    Filed: June 30, 2017
    Date of Patent: May 8, 2018
    Assignee: OPKO Diagnostics, LLC
    Inventors: Jason Taylor, Matthew Dirckx, David Steinmiller, Vincent Linder