Abstract: Aspects of the present disclosure include methods, apparatuses, and computer readable media for transmitting a light such that it is incident on a multi-layer stack, wherein the multi-layer stack includes the feature and a region without the feature, detecting a narrow-band light from the feature and the region without the feature, wherein the feature has a first optical response in response to a wavelength of the narrow-band light and the region without the feature has a second optical response in response to the wavelength of the narrow-band light, and generating, based on the narrow-band light, an image indicative of where the first optical response and the second optical response occur on the multi-layer stack.

Abstract: Aspects of this disclosure relate to a process for rendering graphics that includes performing, with a hardware unit of a graphics processing unit (GPU) designated for vertex shading, a vertex shading operation to shade input vertices so as to output vertex shaded vertices, wherein the hardware unit adheres to an interface that receives a single vertex as an input and generates a single vertex as an output. The process also includes performing, with the hardware unit of the GPU designated for vertex shading, a hull shading operation to generate one or more control points based on one or more of the vertex shaded vertices, wherein the one or more hull shading operations operate on at least one of the one or more vertex shaded vertices to output the one or more control points.

Abstract: A texture processor based ray tracing accelerator method and system are described. The system includes a shader, texture processor (TP) and cache, which are interconnected. The TP includes a texture address unit (TA), a texture cache processor (TCP), a filter pipeline unit and a ray intersection engine. The shader sends a texture instruction which contains ray data and a pointer to a bounded volume hierarchy (BVH) node to the TA. The TCP uses an address provided by the TA to fetch BVH node data from the cache. The ray intersection engine performs ray-BVH node type intersection testing using the ray data and the BVH node data. The intersection testing results and indications for BVH traversal are returned to the shader via a texture data return path. The shader reviews the intersection results and the indications to decide how to traverse to the next BVH node.

Abstract: The present invention relates to novel spirobicyclic analogues of Formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

Abstract: The present disclosure provides methods for preparing an extruded product from a solid billet. The methods can include providing an as-cast billet for extrusion; applying a simultaneous rotational shear and axial extrusion force to the as-cast billet to plasticize the as-cast billet; and extruding the plasticized as-cast billet with an extrusion die to form an extruded product. Methods for preparing extruded products from billets can also include: providing a billet for extrusion; while maintaining a majority of the billet below 100° C., applying a simultaneous rotational shear and axial extrusion force to one end of the billet to plasticize the one end of the billet; and extruding the plasticized one end of the billet with an extrusion die to form an extruded product.

Abstract: Described herein are techniques for improving the effectiveness of depth culling. In a first technique, a binner is used to sort primitives into depth bins. Each depth bin covers a range of depths. The binner transmits the depth bins to the screen space pipeline for processing in near-to-far order. Processing the near bins first results in the depth buffer being updated, allowing fragments for the primitives in the farther bins to be culled more aggressively than if the depth binning did not occur. In a second technique, a buffer is used to initiate two-pass processing through the screen space pipeline. In the first pass, primitives are sent down to update the depth block and are then culled. The fragments are processed normally in the second pass, with the benefit of the updated depth values.

Abstract: Provided herein are, inter alia, methods and compositions to detect, monitor and treat cancer, wherein the cancer includes amplified extrachromosomal oncogenes. The methods are useful for personalized treatment and exploit differential expression of amplified extrachromosomal oncogenes in cancer cells versus healthy cells.

Abstract: The present invention is directed to a yeast strain, or strains, secreting a full suite, or any subset of that full suite, of enzymes to hydrolyze corn starch, corn fiber, lignocellulose, (including enzymes that hydrolyze linkages in cellulose, hemicellulose, and between lignin and carbohydrates) and to utilize pentose sugars (xylose and arabinose). The invention is also directed to the set of proteins that are well expressed in yeast for each category of enzymatic activity. The resulting strain, or strains can be used to hydrolyze starch and cellulose simultaneously. The resulting strain, or strains can be also metabolically engineered to produce less glycerol and uptake acetate. The resulting strain, or strains can also be used to produce ethanol from granular starch without liquefaction.

Abstract: A device is disclosed. The device includes a machine learning die including a memory and one or more machine learning accelerators; and a processing core die stacked with the machine learning die, the processing core die being configured to execute shader programs for controlling operations on the machine learning die, wherein the memory is configurable as either or both of a cache and a directly accessible memory.

Abstract: A system and method for computing a metric indicating a user operation of an application is described. The system accesses online activity data of a user operation of the application. The system filters the online activity data based on a preset time range. An after-hours activity score is calculated based on a type of activity or a duration of an activity from the filtered online activity data, and a weight assigned to the type of activity or the duration of the activity. The system computes an after-hours metric based on the after-hours activity score. A configuration setting for the application based on the after-hours metric is applied to the application.

Abstract: The present invention relates to novel novel monocyclic and bicyclic ring system substituted carbanucleoside analogues of Formula (I), wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

Abstract: Text-to-visual machine learning embedding techniques are described that overcome the challenges of conventional techniques in a variety of ways. These techniques include use of query-based training data which may expand availability and types of training data usable to train a model. Generation of negative digital image samples is also described that may increase accuracy in training the model using machine learning. A loss function is also described that also supports increased accuracy and computational efficiency by losses separately, e.g., between positive or negative sample embeddings a text embedding.

Abstract: A method includes receiving data characterizing a request to execute an analytic model. The analytic model can include an executable representation associated with a physical system. The method can also include determining, based on the request, a deployment type associated with the analytic model. The deployment type can characterize temporal and computing resource requirements for executing the analytic model using a plurality of computing resources. The method can also include providing the deployment type, deploying the analytic model based on the deployment type, and executing the analytic model. Related systems, techniques, and non-transitory computer readable mediums are also described.

Abstract: There is a need for more reliable and efficient disease spread forecasting. This need can be addressed by, for example, solutions for performing optimization-based disease spread forecasting using a multi-risk-level disease spread forecasting machine learning model.

Abstract: Methoxychalone derivatives with anti-cancer activity are provided.

Abstract: A semiconductor inference device that has a non-volatile memory (NVM) array including NVM cells arranged in rows and columns, in which each NVM cell comprises a charge trapping transistor configured to store one of N×analog values corresponding to N×levels of its drain current (ID) or threshold voltage (VT) levels, representing N×weight values for multiply accumulate (MAC) operations. The semiconductor inference device also includes digital-to-analog (DAC) function and multiplexor (mux) function configured to generate an analog MAC result based on the digital inputs converted results and the weight values read results, and analog-to-digital (ADC) function configured to convert the analog MAC result of the mux function to a digital value. Other embodiments of the semiconductor inference device and related methods and systems are also disclosed.

Abstract: Systems and methods for editing an image based on multiple constraints are described. Embodiments of the systems and methods may identify a change to a vector graphics data structure, generate an update for the vector graphics data structure based on strictly enforcing a handle constraint, a binding constraint, and a continuity constraint, adjust the vector graphics data structure sequentially for each of a plurality of sculpting constraints according to a priority ordering of the sculpting constraints, generate an additional update for the vector graphics data structure based on strictly enforcing the binding constraint and the continuity constraint and approximately enforcing the handle constraint and the sculpting constraints, adjust the vector graphics data structure sequentially for each of a plurality of sculpting constraints, and display the vector graphic based on the adjusted vector graphics data structure.

Abstract: Techniques are disclosed for populating a region of an image with a plurality of brush strokes. For instance, the image is displayed, with the region of the image bounded by a boundary. A user input is received that is indicative of a user-defined brush stroke within the region. One or more synthesized brush strokes are generated within the region, based on the user-defined brush stroke. In some examples, the one or more synthesized brush strokes fill at least a part of the region of the image. The image is displayed, along with the user-defined brush stroke and the one or more synthesized brush strokes within the region of the image.

Abstract: One embodiment provides a method, including: obtaining a plurality of conversational logs; generating a human agent emulator and a user emulator; providing a workspace for a conversational agent, so that an agent designer generates a conversational specification for the conversational agent, wherein the generating a conversational specification comprises: receiving a selection, by the agent designer, of at least one intent for the conversational agent, wherein the receiving a selection is responsive to the conversational agent workspace providing suggestions for intents; providing at least one suggestion for a dialog node that corresponds to the selected at least one intent; and generating a dialog flow for the conversational agent, wherein the generating comprises iteratively receiving, from the agent designer, selection of at least one aspect and receiving at least one selection of the at least one suggestion for dialog nodes; and providing the conversational agent.

Abstract: Systems and methods for biasing reroute to a user selected alternate route or a required route segment is provided. A network system receives an origin and a destination and determines a plurality of routes to navigate from the origin to the destination. The plurality of routes includes an optimal route and an alternate route. The network system receives, from a user device, a selection of the alternate route for navigation. The network system then monitors navigation of the alternate route by a user associated with the user device and detects deviation from the alternate route. In response to the detection, the network system determines a reroute by biasing to the alternate route over the optimal route. The reroute is then presented on the user device.