Abstract: Chlorhexidine gluconate solubilized in a hydrophobic monoacylglyceride is described. Compositions incorporating such materials, as well as methods of preparing such materials are also described.

Abstract: The present disclosure provides antimicrobial compositions including a polyhaloolefin polymer, a cationic antimicrobial agent, and a vehicle that includes a plasticizer and a heat stabilizer. The cationic antimicrobial agent can be partially soluble in the vehicle. The present disclosure also provides for articles formed from the composition, with cationic antimicrobial agent incorporated throughout the polymer matrix, as well as methods of manufacturing the composition.

Abstract: A method of establishing a therapeutic window of wound fluid nitric oxide (WFNO) in the wound of a mammal, the method including: obtaining a wound fluid sample from a mammal; analyzing the WFNO level; determining whether the WFNO is at or below a lower threshold level, or is at or above an upper threshold level; wherein the lower threshold level and upper threshold level define the therapeutic window of WFNO; and treating the mammal with a substance that alters the WFNO level such that the therapeutic window of WFNO in the wound is established.

Abstract: The present disclosure provides devices and rapid methods to acquire a wound sample to detect and measure NOx, and optionally, one or more other analytes that are indicative of the status of a wound.

Abstract: A biomedical sensor system. The system can include a sensor adapted to create a signal based on a physiological characteristic from a subject, and a hub adapted to receive the signal from the sensor. The signal can include at least one of an electromagnetic signal, an electrical signal, an acoustic signal, a mechanical signal, a thermal signal, and a chemical signal. The system can further include a connector adapted to couple the sensor and the hub, the connector having a variable length, such that the sensor and the hub can be positioned a variable distance apart by changing the length of the connector. The connector can be adapted to provide a pathway between the sensor and the hub for the signal. A method of applying a biomedical sensor system to a subject can include changing the length of the variable-length connector to provide an appropriate distance between the sensor and the hub, and coupling the sensor to the subject.

Abstract: Methods and kits to detect and quantitate NOx compounds in a biological sample are provided. The methods include reacting a mixture that includes a nitrite compound and a chromogenic reagent to form a colored compound, contacting the mixture with a retention medium configured to retain the colored compound, and detecting the colored compound retained on the retention medium.

Abstract: A stretchable conductive connector. The conductive connector can include a viscoelastic support member having a variable length, and a conductor coupled to the support member. The conductor can include at least one bend to accommodate the variable length of the viscoelastic support member.

Abstract: The present disclosure provides devices and rapid methods to acquire a wound sample to detect the presence of NOx and, optionally, one or more other analytes that are indicative of the status of a wound.

Abstract: The present disclosure provides methods and kits to detect and quantitate NOx compounds in a biological sample. The methods include reacting a mixture comprising a nitrite compound a chromogenic reagent to form a colored compound, contacting the mixture with a retention medium configured to retain the colored compound, and detecting the colored compound retained on the retention medium.

Abstract: Articles and methods for the detection and/or quantification of organic analytes are described. The invention provides a chemical indicator test strip, comprising: a substrate; and a coating comprising a leuco dye complex on the substrate, the coating being insoluble in water and reactive with an organic analyte, the coating derived from a solution of leuco dye and developing agent. In another aspect, the coating further comprises adjuvant, in the form of a water-insoluble, polar, hydrophobic, aprotic material that extends the lower limit of detection for the analyte. In still another aspect, the present invention provides a method of using a chemical indicator test strip, comprising: (a) exposing the chemical indicator test strip to a sample comprising an organic analyte; (b) measuring a color change on the chemical indicator test strip following the exposing step; and (c) correlating the color change with the concentration of the analyte in the sample.

Abstract: A process is provided for preparing a pressure sensitive adhesive hydrogel, comprising: (A) providing an oligomeric precursor, the oligomeric precursor comprising a polyether moiety endcapped with ethylenic unsaturation, the oligomeric precursor being associated with methacrylic acid; (B) providing an ethylenically unsaturated crosslinking agent selected from the group consisting of difunctional ethylenically unsaturated monomer, trifunctional ethylenically unsaturated monomer and combinations of the foregoing; (C) free radically curing the oligomeric precursor and the ethylenically unsaturated crosslinking agent in water at a pH between about 3.5 and about 9 to provide the pressure sensitive adhesive hydrogel.

Abstract: The application discloses embodiments of detection devices including a sensor component in a flow path between a first flow path portion and a second flow path portion. In embodiments described, the sensor component includes a receptor in a polymerized composition. The receptor is configured to bind with an analyte in a test sample. Upon binding the sensor component undergoes a detectable change in response to interaction of the analyte with the receptor.

Abstract: A biomedical sensor system. The system can include a sensor adapted to create a signal based on a physiological characteristic from a subject, and a hub adapted to receive the signal from the sensor. The signal can include at least one of an electromagnetic signal, an electrical signal, an acoustic signal, a mechanical signal, a thermal signal, and a chemical signal. The system can further include a connector adapted to couple the sensor and the hub, the connector having a variable length, such that the sensor and the hub can be positioned a variable distance apart by changing the length of the connector. The connector can be adapted to provide a pathway between the sensor and the hub for the signal. A method of applying a biomedical sensor system to a subject can include changing the length of the variable-length connector to provide an appropriate distance between the sensor and the hub, and coupling the sensor to the subject.

Abstract: A stretchable conductive connector. The conductive connector can include a viscoelastic support member having a variable length, and a conductor coupled to the support member. The conductor can include at least one bend to accommodate the variable length of the viscoelastic support member.

Abstract: The invention relates to devices and methods for analyzing a sample (and preferably preparing a sample), which is particularly used in analysis, such as analysis of a sample for a bacterium of interest.

Abstract: A microfluidic processing device includes a tablet comprising a reagent, where the tablet is configured to fit within at least one chamber of the processing device. In addition, in some embodiments, at least two tablets are disposed within a single process chamber of the processing device. Further, in some embodiments, each tablet may comprise one or more different types of reagents. In some embodiments, the tablet is a microtablet including a greatest dimension of less than about five millimeters.

Abstract: A conductive adhesive composition is provided and articles that include the adhesive composition as a component thereof. The conductive adhesive composition comprises: (a) pressure sensitive adhesive; (b) electrolyte comprising water soluble or water dispersible organic chloride; and (c) humectant. In some embodiments, the conductive adhesive composition is a bicontinuous composition comprising an aqueous phase and an oil phase, and the bicontinuous composition may be derived from a polymerizable microemulsion composition, the microemulsion composition comprising: an aqueous phase comprising one or more hydrophilic monomers or oligomers and/or one or more amphiphilic monomers or oligomers in water, the water-soluble or water-dispersible organic chloride, surfactant and humectant; and an oil phase comprising one or more hydrophobic monomers or oligomers. Biomedical articles such as biomedical electrodes, may incorporate the foregoing adhesive as a component.

Abstract: Articles and methods for the detection and/or quantification of organic analytes are described. The invention provides a chemical indicator test strip, comprising: a substrate; and a coating comprising a leuco dye complex on the substrate, the coating being insoluble in water and reactive with an organic analyte, the coating derived from a solution of leuco dye and developing agent. In another aspect, the coating further comprises adjuvant, in the form of a water-insoluble, polar, hydrophobic, aprotic material that extends the lower limit of detection for the analyte. In still another aspect, the present invention provides a method of using a chemical indicator test strip, comprising: (a) exposing the chemical indicator test strip to a sample comprising an organic analyte; (b) measuring a color change on the chemical indicator test strip following the exposing step; and (c) correlating the color change with the concentration of the analyte in the sample.

Abstract: Articles and methods for using the articles are described. In one aspect, a chemical indicator test strip is provided, comprising: a substrate; and a coating comprising a leuco dye complex and surfactant on the substrate, the coating being insoluble in water and reactive with antimicrobial fatty acid monoester, the coating derived from a solution of leuco dye, developing agent and surfactant.

Abstract: A biomedical electrode is provided wherein the electrode comprises a conductor in contact with a conductive medium, the conductor comprises an electrically conductive surface comprising an active source of silver and the conductive medium comprises a peroxide scavenger. The biomedical electrode typically will include a non-conductive backing having a first side comprising a first major surface and a second side comprising a second major surface, the electrically conductive surface being associated with the second major surface of the non-conductive backing, and the conductive medium comprises an electrically conductive adhesive associated with the conductive substrate, the electrically conductive adhesive being a pressure sensitive adhesive comprising the at least one peroxide scavenger. A method for the manufacture of the foregoing electrodes is also provided.