Patents by Inventor Virendra Kumar

Virendra Kumar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
    Patent number: 6057323
    Abstract: Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics and anti-pruritic agents are provided.The compound of formula I, having the structure: ##STR1## wherein R.sub.1, R.sub.2 ;X; and ArY, Z and n are as described in the specification.
    Type: Grant
    Filed: October 30, 1998
    Date of Patent: May 2, 2000
    Assignee: Adolor Corporation
    Inventors: Wei Yuan Zhang, Alan L. Maycock, Michael Anthony Marella, Virendra Kumar, Forrest Gaul, An-Chih Chang, Deqi Guo
  • Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritis therewith
    Patent number: 6054445
    Abstract: Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics and anti-pruritic agents are provided. The compound of formulae IIA, having the structure: ##STR1## wherein R.sub.1, R.sub.2 ;X.sub.4, X.sub.5 ; andAr and n are as described in the specification.
    Type: Grant
    Filed: May 7, 1999
    Date of Patent: April 25, 2000
    Assignee: Adolor Corporation
    Inventors: Wei Yuan Zhang, Alan L. Maycock, Michael Anthony Marella, Virendra Kumar, Forrest Gaul, An-Chih Chang, Deqi Guo
  • Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith
    Patent number: 6048860
    Abstract: Anti-pruritic pharmaceutical formulations containing kappa agonist compounds and methods of prevention or treatment of pruritus in a mammal with the anti-pruritic formulations.
    Type: Grant
    Filed: October 4, 1999
    Date of Patent: April 11, 2000
    Assignee: Adolor Corporation
    Inventors: John J. Farrar, An-Chih Chang, Virendra Kumar, Wei Yuan Zhang, Alan Cowan
  • Kappa agonist compounds, pharmaceutical formulations and method of prevention and treatment of pruritus therewith
    Patent number: 6028063
    Abstract: Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics and anti-pruritic agents are provided.The compounds of formula III having the structure: ##STR1## wherein Ar and X.sup.7 ;R.sub.1 and R.sub.2 ; andn are as described in the specification.
    Type: Grant
    Filed: May 7, 1999
    Date of Patent: February 22, 2000
    Assignee: Adolor Corporation
    Inventors: Lawrence I. Kruse, An-Chih Chang, Diane L. DeHaven-Hudkins, John J. Farrar, Forrest Gaul, Virendra Kumar, Michael Anthony Marella, Alan L. Maycock, Wei Yuan Zhang
  • Substituted N-arylmethyl and heterocylylmethyl-1H-pyrazolo[3,4-b]quinolin-4-amines and compositions and methods of use thereof
    Patent number: 6008226
    Abstract: Substituted N-arylmethyl and heterocyclylmethyl-1H-pyrazolo[3,4-b]quinolin-4-amines, pharmaceutical compositions containing them and methods for a) effecting c-GMP-phosphodiesterase inhibition, b) treating heart failure and/or hypertension, c) reversing or reducing nitrate-induced tolerance and d) treating angina pectoris, congestive heart disease and myocardial infarction utilizing them.
    Type: Grant
    Filed: September 10, 1998
    Date of Patent: December 28, 1999
    Assignee: Sanofi-Synthelabo
    Inventors: Virendra Kumar, John Alan Dority, Jr.
  • Kappa agonist anti-pruritic pharmaceutical formulaitons and method of treating pruritus therewith
    Patent number: 6004964
    Abstract: Anti-pruritic pharmaceutical formulations containing kappa agonist compounds and methods of prevention or treatment of pruritus in a mammal with the anti-pruritic formulations.
    Type: Grant
    Filed: November 2, 1998
    Date of Patent: December 21, 1999
    Assignee: Adolor Corporation
    Inventors: John J. Farrar, An-Chih Chang, Virendra Kumar, Wei Yuan Zhang, Alan Cowan
  • Kappa agonist compounds, pharmaceutical formulations and method of prevention and treatment of pruritus therewith
    Patent number: 5981513
    Abstract: Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics and anti-pruritic agents are provided. The compounds of formula II having the structure: ##STR1## wherein X.sub.4, X.sub.5 ;R.sub.1, R.sub.2 ; andAr and n are as described in the specification.
    Type: Grant
    Filed: March 21, 1998
    Date of Patent: November 9, 1999
    Assignee: Adolor Corporation
    Inventors: Lawrence I. Kruse, An-Chih Chang, Diane L. DeHaven-Hudkins, John J. Farrar, Forrest Gaul, Virendra Kumar, Michael Anthony Marella, Alan L. Maycock, Wei Yuan Zhang
  • Kappa agonist compounds and pharmaceutical formulations thereof
    Patent number: 5945443
    Abstract: Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics are provided. The compound of formulae IV having the structure: ##STR1## wherein X.sub.9 ;R.sub.1, R.sub.2, R.sub.3, R.sub.4 ;and n are as described in the specification.
    Type: Grant
    Filed: March 3, 1998
    Date of Patent: August 31, 1999
    Assignee: Adolor Corporation
    Inventors: Lawrence I. Kruse, An-Chih Chang, Diane L. DeHaven-Hudkins, John J. Farrar, Forrest Gaul, Virendra Kumar, Michael Anthony Marella, Alan L. Maycock, Wei Yuan Zhang
  • Film-forming compositions of antihyperalgesic opiates and method of treating hyperalgesic and pruritic conditions therewith
    Patent number: 5888494
    Abstract: Topical film-forming compositions for the prevention and treatment of prutitus containing an opiate that is substantially devoid of central nervous system effects.
    Type: Grant
    Filed: July 14, 1997
    Date of Patent: March 30, 1999
    Assignee: Adolor Corporation
    Inventors: John J. Farrar, Alan L. Maycock, Virendra Kumar, Imre Jim Balogh
  • Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith
    Patent number: 5869521
    Abstract: Anti-pruritic pharmaceutical formulations containing kappa agonist compounds and methods of prevention or treatment of pruritus in a mammal with the anti-pruritic formulations.
    Type: Grant
    Filed: April 22, 1998
    Date of Patent: February 9, 1999
    Assignee: Adolor Corporation
    Inventors: John J. Farrar, An-Chih Chang, Virendra Kumar, Wei Yuan Zhang, Alan Cowan
  • 2-Saccharinylmethyl heterocyclic carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof
    Patent number: 5856349
    Abstract: 4-R.sup.4 -R.sup.5 -2-Saccharinylmethyl heterocyclic carboxylates, useful in the treatment of degenerative diseases, are prepared by reacting a 4-R.sup.4 -R.sup.5 -2-halomethylsaccharin with either a heterocyclic carboxylic acid in the presence of an acid-acceptor or the alkali metal salt of a heterocyclic carboxylic acid.
    Type: Grant
    Filed: June 6, 1997
    Date of Patent: January 5, 1999
    Assignee: Sanofi
    Inventors: Richard Paul Dunlap, Dennis John Hlasta, Ranjit Chimanlal Desai, Lee Hamilton Latimer, Chakrapani Subramanyam, John Joseph Court, Malcolm Rice Bell, Virendra Kumar
  • Substituted N-arylmethyl and heterocyclylmethyl-1H-pyrazolo (3,4-b) quinolin-4-amines and compositions and methods of use thereof
    Patent number: 5843956
    Abstract: Substituted N-arylmethyl and heterocyclylmethyl-1H-pyrazolo?3,4-b!quinolin-4-amines, pharmaceutical compositions containing them and methods for a) effecting c-GMP-phosphodiesterase inhibition, b) treating heart failure and/or hypertension, c) reversing or reducing nitrate-induced tolerance and d) treating angina pectoris, congestive heart disease and myocardial infarction utilizing them.
    Type: Grant
    Filed: February 18, 1997
    Date of Patent: December 1, 1998
    Assignee: Sanofi
    Inventors: Virendra Kumar, John Alan Dority, Jr.
  • 3-arylcarbonyl-1-(C-attached-N-heteryl)-1H-indoles
    Patent number: 5817651
    Abstract: 2-R.sub.2 --R.sub.4 -substituted-3-R.sub.3 --CO-1-?(C-attached-N-heteryl)-(Alk) .sub.n !-1H-indoles useful as analgesic, anti-rheumatic, anti-inflammatory or anti-glaucoma agents.
    Type: Grant
    Filed: January 14, 1997
    Date of Patent: October 6, 1998
    Assignee: Sanofi
    Inventors: Thomas Edward D'Ambra, Edward Richard Bacon, Malcolm Rice Bell, Philip Michael Carabateas, Michael Allen Eissenstat, Virendra Kumar, John Peter Mallamo, Susan Jean Ward
  • Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
    Patent number: 5763445
    Abstract: Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics and anti-pruritic agents are provided.The compounds of formular I, II, III and IV have the structure: ##STR1## wherein X, X.sub.4, X.sub.5, X.sub.7, X.sub.9 ;R.sub.1, R.sub.2, R.sub.3, R.sub.4 ; andY, Z and n are as described in the specification.
    Type: Grant
    Filed: July 14, 1997
    Date of Patent: June 9, 1998
    Assignee: Adolor Corporation
    Inventors: Lawrence I. Kruse, An-Chih Chang, Diane L. DeHaven-Hudkins, John J. Farrar, Forrest Gaul, Virendra Kumar, Michael Anthony Marella, Alan L. Maycock, Wei Yuan Zhang
  • Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith
    Patent number: 5760023
    Abstract: Anti-pruritic pharmaceutical formulations containing kappa agonist compounds and methods of prevention or treatment of pruritus in a mammal with the anti-pruritic formulations.
    Type: Grant
    Filed: July 14, 1997
    Date of Patent: June 2, 1998
    Assignee: Adolor Corporation
    Inventors: John J. Farrar, An-Chih Chang, Virendra Kumar, Wei Yuan Zhang, Alan Cowan
  • Kappa agonist compounds and pharmaceutical formulations thereof
    Patent number: 5744458
    Abstract: Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics are provided.The compound of formula II has the structure: ##STR1## wherein X.sub.4, X.sub.5 ;R.sub.1, R.sub.2 ; andAr and n are as described in the specification.
    Type: Grant
    Filed: July 23, 1997
    Date of Patent: April 28, 1998
    Assignee: Adolor Corporation
    Inventors: Lawrence I. Kruse, An-Chih Chang, Diane L. DeHaven-Hudkins, John J. Farrar, Forrest Gaul, Virendra Kumar, Michael Anthony Marella, Alan L. Maycock, Wei Yuan Zhang
  • Kappa agonist compounds and pharmaceutical formulations thereof
    Patent number: 5688955
    Abstract: Compounds having kappa opioid agonist activity, compositions containing them and method of using them as analgesics are provided.The compounds of formulae I, II, III and IV have the structure: ##STR1## wherein X, X.sub.4, X.sub.5, X.sub.7, X.sub.9 ;R.sub.1, R.sub.2, R.sub.3, R.sub.4 ; andY, Z and n are as described in the specification.
    Type: Grant
    Filed: February 5, 1997
    Date of Patent: November 18, 1997
    Assignee: Adolor Corporation
    Inventors: Lawrence I. Kruse, An-Chih Chang, Diane L. DeHaven-Hudkins, John J. Farrar, Forrest Gaul, Virendra Kumar, Michael Anthony Marella, Alan L. Maycock, Wei Yuan Zhang
  • Film-forming compositions of antihyperalgesic opiates and method of treating hyperalgesic conditions therewith
    Patent number: 5667773
    Abstract: Topical anti-hyperalgesic film-forming compositions and methods of using compositions for the treatment of peripheral hyperalgesia comprising:a) a compound of the formula ##STR1## wherein M is ##STR2## wherein: R, R.sup.2, R.sup.3, R.sup.4, R.sup.7, Ar.sup.1 and Ar.sup.2 are as defined in the specification;b) a film-forming polymeric material containing the hyperalgesic compound; andc) an aqueous pharmaceutically acceptable carrier.
    Type: Grant
    Filed: March 12, 1996
    Date of Patent: September 16, 1997
    Assignee: Adolor Corporation
    Inventors: John J. Farrar, Alan L. Maycock, Virendra Kumar, Imre (Jim) Balogh
  • 2-saccharinylmethyl heterocyclic carboxylates useful as proteolytic enzyme inhibitors and compositions and method of use thereof
    Patent number: 5652254
    Abstract: 4-R.sup.4 -R.sup.5 -2-Saccharinylmethyl heterocyclic carboxylates, useful in the treatment of degenerative diseases, are prepared by reacting a 4-R.sup.4 -R.sup.5 -2-halomethylsaccharin with either a heterocyclic carboxylic acid in the presence of an acid-acceptor or the alkali metal salt of a heterocyclic carboxylic acid.
    Type: Grant
    Filed: August 28, 1996
    Date of Patent: July 29, 1997
    Assignee: Sanofi, S.A.
    Inventors: Richard Paul Dunlap, Dennis John Hlasta, Ranjit Chimanlal Desai, Lee Hamilton Latimer, Chakrapani Subramanyam, John Joseph Court, Malcolm Rice Bell, Virendra Kumar
  • Kappa agonist compounds and pharmaceutical formulations thereof
    Patent number: 5646151
    Abstract: Compounds, compositions and method of treating hyperalgesia comprising a compound of formula I, II, III and IV as defined in the specification.
    Type: Grant
    Filed: March 8, 1996
    Date of Patent: July 8, 1997
    Assignee: Adolor Corporation
    Inventors: Lawrence I. Kruse, Virendra Kumar, An-Chih Chang, Diane L. DeHaven-Hudkins, John J. Farrar, Alan L. Maycock