Abstract: The present disclosure provides binding proteins, such as antibodies and antigen-binding fragments, which specifically bind to human CD96 receptor protein (hu-CD96) and are capable of decreasing, inhibiting, and/or fully-blocking immune regulatory effects mediated by hu-CD96. The present disclosure also provides methods of using the antibodies (and compositions thereof) to treat diseases and conditions responsive to decreasing, inhibiting and/or blocking immune regulatory function or activity mediated by CD96 binding to CD155, including effects arising from CD96 interactions with CD226 and/or TIGIT.

Abstract: The present invention provides antibody conjugates that include antibodies (e.g., anti-VEGF antibodies) covalently linked to polymers (e.g., hyaluronic acid (HA) polymers), cysteine engineered antibodies, pharmaceutical compositions thereof, and uses thereof, for example for treatment of disorders associated with pathological angiogenesis (e.g., ocular disorders).

Abstract: The present invention provides anti-VEGF antibodies and compositions that include anti-VEGF antibodies (e.g., antibody conjugates, fusion proteins, and polymeric formulations), and uses thereof, for example for treatment of disorders associated with pathological angiogenesis. The present invention also provides methods of identifying antibody variants with improved properties, for example, enhanced binding affinity, stability, pharmacokinetics, and/or expression.

Abstract: The present invention provides anti-VEGF antibodies and compositions that include anti-VEGF antibodies (e.g., antibody conjugates, fusion proteins, and polymeric formulations), and uses thereof, for example for treatment of disorders associated with pathological angiogenesis. The present invention also provides methods of identifying antibody variants with improved properties, for example, enhanced binding affinity, stability, pharmacokinetics, and/or expression.

Abstract: Techniques described herein provide a domain split display. One or more implementations generate a parent page comprising a content iframe that is a child iframe of the parent page, where the parent page is associated with a first domain and the content iframe is associated with a second domain. Various implementations then generate, within the content iframe, a plurality of grandchild iframes of the parent page that are sibling iframes at a same level within the parent page, where the grandchild iframes are enabled to communicate with each other regardless of domain, such as a first grandchild iframe associated with the first domain and a second grandchild iframe associated with the second domain. In turn, the parent page resizes the content iframe by: receiving, via the first grandchild iframe, size information from the second grandchild iframe and use the size information to resize the content iframe.

Abstract: The present invention provides anti-VEGF antibodies and compositions that include anti-VEGF antibodies (e.g., antibody conjugates, fusion proteins, and polymeric formulations), and uses thereof, for example for treatment of disorders associated with pathological angiogenesis. The present invention also provides methods of identifying antibody variants with improved properties, for example, enhanced binding affinity, stability, pharmacokinetics, and/or expression.

Abstract: Systems and methods for a domain split display are provided. A first request call directed to a first domain is received. In response, a first response is transmitted to a client device, which causes generation of a parent page comprising a content iframe that is a child frame of the parent page. The parent page is associated with the first domain and the content iframe is associated with a second domain. A second request call directed to a second domain is received and a second response is transmitted to the client device. The second response causes a plurality of grandchild iframes to be generated within the content iframe, whereby a first grandchild iframe is associated with the first domain and a second grandchild iframe is associated with the second domain. The plurality of grandchild iframes are sibling iframes at a same level that are enabled to communicate with each other regardless of domain.

Abstract: The invention provides anti-cluster of differentiation 3 (CD3) antibodies and methods of using the same.

Abstract: Embodiments include a method, apparatus, program, and system for distributing data items among a plurality of data storage units, the data items being an aggregation of data from a plurality of data sources. The method comprises generating a semantic description of each of the plurality of data sources; calculating, for each pair of data sources from among the plurality of data sources, a degree of similarity between the semantic descriptions of the pair of data sources; and allocating data items to data storage units in dependence upon the calculated degree of similarity between the data source of a data item being allocated and the or each data source of data items already allocated to the data storage units.

Abstract: The present invention provides anti-VEGF antibodies and compositions that include anti-VEGF antibodies (e.g., antibody conjugates, fusion proteins, and polymeric formulations), and uses thereof, for example for treatment of disorders associated with pathological angiogenesis. The present invention also provides methods of identifying antibody variants with improved properties, for example, enhanced binding affinity, stability, pharmacokinetics, and/or expression.

Abstract: Systems and methods for a domain split display are provided. A first request call directed to a first domain is received. In response, a first response is transmitted to a client device, which causes generation of a parent page comprising a content iframe that is a child frame of the parent page. The parent page is associated with the first domain and the content iframe is associated with a second domain. A second request call directed to a second domain is received and a second response is transmitted to the client device. The second response causes a plurality of grandchild iframes to be generated within the content iframe, whereby a first grandchild iframe is associated with the first domain and a second grandchild iframe is associated with the second domain. The plurality of grandchild iframes are sibling iframes at a same level that are enabled to communicate with each other regardless of domain.

Abstract: In various example embodiments, systems and methods for a domain split display are provided. A first request call directed to a first domain is received. In response, first served content including content retrieved based on the first domain is transmitted to a client device. The first served content is used by the client device to generate a parent page comprising a content iframe, which is associated with a second domain. A second request call directed to a second domain is received and second served content is transmitted to the client device. The second served content includes content retrieved from the second domain. The second served content causes a data receiver iframe associated with the first domain and an event receiver iframe associated with the second domain to be displayed within the content iframe. User-generated content for display in the data receiver iframe is then transmitted.

Abstract: A dataflow controller to store dataflow specifications and to control execution of the dataflow specified the specification specifying a series of linked data processing steps, each step specifying a processing operation to generate output data, and each link defining a consecutive pair relationship between two steps within the series, the link instructing the dataflow controller to trigger execution of the preceding member of the pair by, providing the output data of the member as the input data of the member; and a cache memory and memory controller, the memory controller to maintain an accumulation of the output data generated by the most recent execution of the operation of each member of a set of the steps specified by the dataflow controller; the dataflow controller upon execution of the operation of the step, to provide the output data to the memory controller; the memory controller, to update the maintained accumulation.

Abstract: A system includes: a data storage apparatus to store a data graph comprising: data nodes each representing a data item; labeled data-data links each linking a pair of data nodes and representing a relationship between data items; functional nodes each representing a procedure modifying a data item; data-function links each linking a data node to a functional node and representing the procedure of the functional node, and modifying the data item represented by the data node. The mapper, receiving a process description including indications of a process start entity and end entity, to map the start entity indication to a first data node from the data nodes, and to map the end entity indication to a second data node from the data nodes; and a path finder, to find the shortest path from the first to the second data node along data-function links.

Abstract: A management apparatus including data storage storing a graph of resources encoded as a plurality of data items, each item being a value for: a subject, a resource identifier; an object, either an identifier of an object resource or a literal value; and a predicate, a named relationship between the subject and the object. A dynamic dataflow controller stores a processor instance specifying an input range, a process, and an output range, and, when triggered by t an item within the input range, generating an output item within the output range, by performing the process. The controller responding to a modification event involving a data item within the input range by providing the data item to the instance; where the controller following the generation of the output provides an item of the output as the input to an instance specifying an input range covering the item in the output.

Abstract: An app programming environment that enables a smartphone or tablet app to incorporate real toys or objects into the app, by use of a NFC chip located in the toy or object and a database comprising information regarding the toy or object used.

Abstract: The invention is a soft, comfortably fitting upper body undergarment constructed for the comfort and convenience of individuals whose medical treatment or condition requires using a gastric feeding tube comprising a tubular pocket which is open at one end to accommodate a gastric tube safely, cleanly and comfortably.

Abstract: A document ranking apparatus ranking electronic documents (Di) on a file path of a file system taking into account relevance of the documents to a search term (t), the apparatus including: a semantic description generating module generating a semantic description (SDi) of a document using the document contents and to store the description in a semantic description repository; a similarity-based scoring module computing a similarity score based on similarity between the SDi of a document and the term (t); a quality indicator-based scoring module computing a quality score of a document based on completeness, correctness and freshness of the document; a combining module accepting user input for relative weighting of the similarity and quality scores combining the resultant relatively-weighted similarity score and quality score to give a final score for a document; and a ranking module ranking the documents on the file path based on the final score.

Abstract: A method of selecting a public data source by dynamically ranking publicly available data sources with respect to a search term, including a plurality of ranking processes carried out on the dataset for each data source and including: using metadata for each dataset to rank the datasets by comparing the search term against a dataset information for each source; creating a temporary ranking list of the data sources based on the metadata ranking; measuring availability for each of the data sources and updating the temporary ranking list based on availability; carrying out instance-based ranking based on fitness of the dataset in each data source against the search term to finalize the ranking list and using the finalized ranking list to select one or more data sources.