Patents by Inventor Vladislav B. Bergo

Vladislav B. Bergo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MULTIPLEXED BEAD-BASED ANALYTICAL ASSAYS
    Publication number: 20240337662
    Abstract: Methods for performing bead-based analytical assays for detecting changes in abundance of target analytes in biological samples are disclosed. In an embodiment, a method involves eluting bead-captured analytes from a bead array under conditions that preserve spatial localization of the eluted analytes.
    Type: Application
    Filed: June 19, 2024
    Publication date: October 10, 2024
    Inventor: Vladislav B. Bergo
  • Bead-based assays for protein analysis
    Patent number: 12019070
    Abstract: Bead-based assays for measuring protein biomarkers of proteolytic activity in biological systems are disclosed. In an embodiment, an assay involves incubating a sample containing multiple fragments of a naturally occurring protein with a bead array and subsequently analyzing individual reactive sites of the bead array by mass spectrometry.
    Type: Grant
    Filed: December 18, 2020
    Date of Patent: June 25, 2024
    Assignee: ADEPTRIX CORP.
    Inventor: Vladislav B. Bergo
  • Global proteomic screening of random bead arrays using mass spectrometry imaging
    Patent number: 12013392
    Abstract: Methods for proteomic screening on random protein-bead arrays by mass spec is described. Photocleavable mass tags are utilized to code a protein library (bait molecules) displayed on beads randomly arrayed in an array substrate. A library of probes (prey) can be mixed with the protein-bead array to query the array. Because mass spec can detect multiple mass tags, it is possible to rapidly identify all of the interactions resulting from this mixing.
    Type: Grant
    Filed: September 2, 2021
    Date of Patent: June 18, 2024
    Assignee: AMBERGEN, INC.
    Inventors: Mark J Lim, Vladislav B Bergo, Kenneth J Rothschild
  • GLOBAL PROTEOMIC SCREENING OF RANDOM BEAD ARRAYS USING MASS SPECTROMETRY IMAGING
    Publication number: 20240069013
    Abstract: Methods for proteomic screening on random protein-bead arrays by mass spec is described. Photocleavable mass tags are utilized to code a protein library (bait molecules) displayed on beads randomly arrayed in an array substrate. A library of probes (prey) can be mixed with the protein-bead array to query the array. Because mass spec can detect multiple mass tags, it is possible to rapidly identify all of the interactions resulting from this mixing.
    Type: Application
    Filed: November 2, 2023
    Publication date: February 29, 2024
    Inventors: Mark J. Lim, Vladislav B. Bergo, Kenneth J. Rothschild
  • Multiplexed bead-based analytical assays
    Patent number: 11913964
    Abstract: Bead-based analytical assays suitable for detecting changes in the abundance of target analytes in biological samples are disclosed. In an embodiment, an assay involves incubating a sample with one or several beads that are capable of binding several distinct analytes in an amount sufficient for detection by mass spectrometry from a single bead.
    Type: Grant
    Filed: February 26, 2021
    Date of Patent: February 27, 2024
    Assignee: ADEPTRIX CORP.
    Inventor: Vladislav B. Bergo
  • Global proteomic screening of random bead arrays using mass spectrometry imaging
    Patent number: 11846634
    Abstract: Methods for proteomic screening on random protein-bead arrays by mass spec is described. Photocleavable mass tags are utilized to code a protein library (bait molecules) displayed on beads randomly arrayed in an array substrate. A library of probes (prey) can be mixed with the protein-bead array to query the array. Because mass spec can detect multiple mass tags, it is possible to rapidly identify all of the interactions resulting from this mixing.
    Type: Grant
    Filed: April 3, 2020
    Date of Patent: December 19, 2023
    Assignee: AMBERGEN, INC.
    Inventors: Mark J Lim, Vladislav B Bergo, Kenneth J Rothschild
  • Global proteomic screening of random bead arrays using mass spectrometry imaging
    Patent number: 11782056
    Abstract: Methods for proteomic screening on random protein-bead arrays by mass spec is described. Photocleavable mass tags are utilized to code a protein library (bait molecules) displayed on beads randomly arrayed in an array substrate. A library of probes (prey) can be mixed with the protein-bead array to query the array. Because mass spec can detect multiple mass tags, it is possible to rapidly identify all of the interactions resulting from this mixing.
    Type: Grant
    Filed: April 3, 2020
    Date of Patent: October 10, 2023
    Assignee: AmberGen, Inc.
    Inventors: Mark J Lim, Vladislav B Bergo, Kenneth J Rothschild
  • MULTIPLEXED BEAD-BASED ANALYTICAL ASSAYS
    Publication number: 20230258653
    Abstract: Methods for performing bead-based analytical assays for detecting changes in abundance of target analytes in biological samples are disclosed. In an embodiment, a method involves eluting bead-captured analytes from a bead array under conditions that preserve spatial localization of the eluted analytes.
    Type: Application
    Filed: March 21, 2023
    Publication date: August 17, 2023
    Inventor: Vladislav B. Bergo
  • Multiplexed bead-based analytical assays
    Patent number: 11639938
    Abstract: Bead-based analytical assays suitable for detecting changes in the abundance of target analytes in biological samples are disclosed. In an embodiment, an assay involves incubating a sample with one or several beads that are capable of binding several distinct analytes in an amount sufficient for detection by mass spectrometry from a single bead.
    Type: Grant
    Filed: July 18, 2020
    Date of Patent: May 2, 2023
    Assignee: ADEPTRIX CORP.
    Inventor: Vladislav B. Bergo
  • MULTIPLEXED BEAD ARRAYS FOR PROTEOMICS
    Publication number: 20220381774
    Abstract: Bead arrays suitable for analysis by mass spectrometry are disclosed. In an embodiment, a bead array includes multiple reactive sites, each of the reactive sites being capable of binding multiple distinct target analytes.
    Type: Application
    Filed: June 13, 2022
    Publication date: December 1, 2022
    Inventor: Vladislav B. Bergo
  • Multiplexed bead arrays for proteomics
    Patent number: 11391729
    Abstract: Bead arrays suitable for analysis by mass spectrometry are disclosed. In an embodiment, a bead array includes multiple reactive sites, each of the reactive sites being capable of binding multiple distinct target analytes.
    Type: Grant
    Filed: September 7, 2018
    Date of Patent: July 19, 2022
    Assignee: ADEPTRIX CORP.
    Inventor: Vladislav B. Bergo
  • MICROARRAY COMPOSITIONS AND METHODS OF THEIR USE
    Publication number: 20220128570
    Abstract: Microarray compositions suitable for analysis by one or several spectrographic methods are disclosed. In an embodiment, a microarray composition includes a three-dimensional solid support and a plurality of reactive microbeads positioned on the solid support in spatially distinct and addressable locations.
    Type: Application
    Filed: August 31, 2021
    Publication date: April 28, 2022
    Inventor: Vladislav B. Bergo
  • GLOBAL PROTEOMIC SCREENING OF RANDOM BEAD ARRAYS USING MASS SPECTROMETRY IMAGING
    Publication number: 20220026422
    Abstract: Methods for proteomic screening on random protein-bead arrays by mass spec is described. Photocleavable mass tags are utilized to code a protein library (bait molecules) displayed on beads randomly arrayed in an array substrate. A library of probes (prey) can be mixed with the protein-bead array to query the array. Because mass spec can detect multiple mass tags, it is possible to rapidly identify all of the interactions resulting from this mixing.
    Type: Application
    Filed: September 2, 2021
    Publication date: January 27, 2022
    Inventors: Mark J Lim, Vladislav B. Bergo, Kenneth J. Rothschild
  • MULTIPLEXED BEAD-BASED ANALYTICAL ASSAYS
    Publication number: 20210389333
    Abstract: Bead-based analytical assays suitable for detecting changes in the abundance of target analytes in biological samples are disclosed. In an embodiment, an assay involves incubating a sample with one or several beads that are capable of binding several distinct analytes in an amount sufficient for detection by mass spectrometry from a single bead.
    Type: Application
    Filed: February 26, 2021
    Publication date: December 16, 2021
    Inventor: Vladislav B. Bergo
  • Microarray compositions and methods of their use
    Patent number: 11131674
    Abstract: Microarray compositions suitable for analysis by one or several spectrographic methods are disclosed. In an embodiment, a microarray composition includes a three-dimensional solid support and a plurality of reactive microbeads positioned on the solid support in spatially distinct and addressable locations.
    Type: Grant
    Filed: September 7, 2019
    Date of Patent: September 28, 2021
    Assignee: ADEPTRIX CORP.
    Inventor: Vladislav B. Bergo
  • BEAD-BASED ASSAYS FOR PROTEIN ANALYSIS
    Publication number: 20210190773
    Abstract: Bead-based assays for measuring protein biomarkers of proteolytic activity in biological systems are disclosed. In an embodiment, an assay involves incubating a sample containing multiple fragments of a naturally occurring protein with a bead array and subsequently analyzing individual reactive sites of the bead array by mass spectrometry.
    Type: Application
    Filed: December 18, 2020
    Publication date: June 24, 2021
    Inventor: Vladislav B. Bergo
  • MULTIPLEXED BEAD-BASED ANALYTICAL ASSAYS
    Publication number: 20210018513
    Abstract: Bead-based analytical assays suitable for detecting changes in the abundance of target analytes in biological samples are disclosed. In an embodiment, an assay involves incubating a sample with one or several beads that are capable of binding several distinct analytes in an amount sufficient for detection by mass spectrometry from a single bead.
    Type: Application
    Filed: July 18, 2020
    Publication date: January 21, 2021
    Inventor: Vladislav B. Bergo
  • GLOBAL PROTEOMIC SCREENING OF RANDOM BEAD ARRAYS USING MASS SPECTROMETRY IMAGING
    Publication number: 20200264169
    Abstract: Methods for proteomic screening on random protein-bead arrays by mass spec is described. Photocleavable mass tags are utilized to code a protein library (bait molecules) displayed on beads randomly arrayed in an array substrate. A library of probes (prey) can be mixed with the protein-bead array to query the array. Because mass spec can detect multiple mass tags, it is possible to rapidly identify all of the interactions resulting from this mixing.
    Type: Application
    Filed: April 3, 2020
    Publication date: August 20, 2020
    Inventors: Mark J. Lim, Vladislav B. Bergo, Kenneth J. Rothschild
  • GLOBAL PROTEOMIC SCREENING OF RANDOM BEAD ARRAYS USING MASS SPECTROMETRY IMAGING
    Publication number: 20200240984
    Abstract: Methods for proteomic screening on random protein-bead arrays by mass spec is described. Photocleavable mass tags are utilized to code a protein library (bait molecules) displayed on beads randomly arrayed in an array substrate. A library of probes (prey) can be mixed with the protein-bead array to query the array. Because mass spec can detect multiple mass tags, it is possible to rapidly identify all of the interactions resulting from this mixing.
    Type: Application
    Filed: April 3, 2020
    Publication date: July 30, 2020
    Inventors: Mark J Lim, Vladislav B. Bergo, Kenneth J. Rothschild
  • MICROARRAY COMPOSITIONS AND METHODS OF THEIR USE
    Publication number: 20200011877
    Abstract: Microarray compositions suitable for analysis by one or several spectrographic methods are disclosed. In an embodiment, a microarray composition includes a three-dimensional solid support and a plurality of reactive microbeads positioned on the solid support in spatially distinct and addressable locations.
    Type: Application
    Filed: September 7, 2019
    Publication date: January 9, 2020
    Inventor: Vladislav B. Bergo