Patents by Inventor W. David Lee
W. David Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240016387Abstract: Embodiments related to methods of use of an image analysis system for identifying residual cancer cells after surgery are disclosed. In some embodiments, the image analysis system collects a surgical site image and indicates on a display one or more locations of the identified cancer cells. In some embodiments, the method for identifying residual cancer cells comprises determining and selecting a portion of the surgical site image responsive to an intensity parameter; modifying the selected portion of the surgical site image to determine one or more groups of residual cancer cells based on size; and identifying at least one of the one or more groups of residual cancer cells from the modified portion of the surgical site image using a local-based threshold.Type: ApplicationFiled: July 27, 2023Publication date: January 18, 2024Applicant: Lumicell, Inc.Inventors: David B. Strasfeld, W. David Lee, Jorge Ferrer
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Publication number: 20240008807Abstract: Disclosed techniques include wound care image analysis using light signatures. A light wavelength is excited on a material sample. The exciting enables capture of fluorescence characteristics of the material sample. The material sample exhibits fluorescence characteristics along the Red-Green-Blue light wavelength spectrum. The material sample is illuminated with at least three additional light wavelengths. The illuminating enables capture of reflectance characteristics of the material sample. The material sample exhibits reflectance characteristics along the Red-Green-Blue light wavelength spectrum. An output indicative of biophysical status of the material sample is generated. The output is based on analysis of the fluorescence characteristics and the reflectance characteristics. The analysis includes identifying a wound topology within the material sample. The wound topology is identified based on measurements in the wound sample. A thermal image of the material sample is captured.Type: ApplicationFiled: September 19, 2023Publication date: January 11, 2024Applicant: Precision Healing, Inc.Inventors: Ryan Daniel Williams, David B. Strasfeld, Ira M. Herman, W. David Lee
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Publication number: 20230397970Abstract: Embodiments related to methods of use of an image analysis system for identifying residual cancer cells after surgery are disclosed. In some embodiments, a patient-specific threshold used to detect abnormal cells in a surgical site can be determined. A medical imaging device can be configured to produce a set of images of an anatomy of a patient. An image analysis system, comprising one or more processors, can be configured to receive the set of images, and analyze the set of images to determine a patient-specific threshold to use to detect abnormal tissue of the patient.Type: ApplicationFiled: August 7, 2023Publication date: December 14, 2023Applicant: Lumicell, Inc.Inventors: David B. Strasfeld, Jorge Ferrer, W. David Lee
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Publication number: 20230363646Abstract: A method and system for medical imaging employs an excitation source configured to cause an object having a plurality of cells to at least one of emit, reflect, and fluoresce light. An optical receptor is employed that is configured to receive the light from the object. A filter assembly receives the light from the optical receptor and filters the light. An image processor having a field of view (FOV) substantially greater than a diameter of a cell of the object and an analysis resolution substantially matched to the diameter of a cell of the object that receives the filtered light from the filter and analyzes the filtered light corresponding to each cell in the FOV. A feedback system is provided that is configured to provide an indication of a state of each cell in the FOV and a location of a cell in the FOV meeting a predetermined condition.Type: ApplicationFiled: July 24, 2023Publication date: November 16, 2023Applicants: Massachusetts Institute of Technology, Duke UniversityInventors: Moungi G. Bawendi, Jorge M. Ferrer, W. David Lee, Lisa F. Marshall, David G. Kirsch
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Patent number: 11793594Abstract: Embodiments related to methods of use of an image analysis system for identifying residual cancer cells after surgery are disclosed. In some embodiments, a patient-specific threshold used to detect abnormal cells in a surgical site can be determined. A medical imaging device can be configured to produce a set of images of an anatomy of a patient. An image analysis system, comprising one or more processors, can be configured to receive the set of images, and analyze the set of images to determine a patient-specific threshold to use to detect abnormal tissue of the patient.Type: GrantFiled: December 10, 2019Date of Patent: October 24, 2023Assignee: Lumicell, Inc.Inventors: David B. Strasfeld, Jorge Ferrer, W. David Lee
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Patent number: 11771324Abstract: Embodiments related to methods of use of an image analysis system for identifying residual cancer cells after surgery are disclosed. In some embodiments, the image analysis system collects a surgical site image and indicates on a display one or more locations of the identified cancer cells. In some embodiments, the method for identifying residual cancer cells comprises determining and selecting a portion of the surgical site image responsive to an intensity parameter; modifying the selected portion of the surgical site image to determine one or more groups of residual cancer cells based on size; and identifying at least one of the one or more groups of residual cancer cells from the modified portion of the surgical site image using a local-based threshold.Type: GrantFiled: July 5, 2022Date of Patent: October 3, 2023Assignee: Lumicell, Inc.Inventors: David B. Strasfeld, W. David Lee, Jorge Ferrer
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Patent number: 11730371Abstract: A method and system for medical imaging employs an excitation source configured to cause an object having a plurality of cells to at least one of emit, reflect, and fluoresce light. An optical receptor is employed that is configured to receive the light from the object. A filter assembly receives the light from the optical receptor and filters the light. An image processor having a field of view (FOV) substantially greater than a diameter of a cell of the object and an analysis resolution substantially matched to the diameter of a cell of the object that receives the filtered light from the filter and analyzes the filtered light corresponding to each cell in the FOV. A feedback system is provided that is configured to provide an indication of a state of each cell in the FOV and a location of a cell in the FOV meeting a predetermined condition.Type: GrantFiled: April 15, 2019Date of Patent: August 22, 2023Assignees: Massachusetts Institute of Technology, Duke UniversityInventors: Moungi G. Bawendi, Jorge M. Ferrer, W. David Lee, Lisa F. Marshall, David G. Kirsch
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Publication number: 20230228684Abstract: The present invention provides compositions and methods for imaging tumor resections.Type: ApplicationFiled: January 23, 2023Publication date: July 20, 2023Applicant: Lumicell, Inc.Inventors: W. David Lee, Moungi G. Bawendi, Jorge Ferrer
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Patent number: 11592396Abstract: The present invention provides compositions and methods for imaging tumor resections.Type: GrantFiled: March 25, 2020Date of Patent: February 28, 2023Assignee: Lumicell, Inc.Inventors: W. David Lee, Moungi G. Bawendi, Jorge Ferrer
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Publication number: 20230056031Abstract: Embodiments related to medical imaging devices including rigid imaging tips and their methods of use for identifying abnormal tissue within a surgical bed are disclosed.Type: ApplicationFiled: September 1, 2022Publication date: February 23, 2023Applicant: Lumicell, Inc.Inventors: W. David Lee, Jorge Ferrer, David Benjamin Strasfeld
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Publication number: 20220387108Abstract: The invention provides systems and method for the removal of diseased cells during surgeryType: ApplicationFiled: August 17, 2022Publication date: December 8, 2022Applicant: Lumicell, Inc.Inventors: W. David Lee, Jorge Ferrer
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Patent number: 11471056Abstract: Embodiments related to medical imaging devices including rigid imaging tips and their methods of use for identifying abnormal tissue within a surgical bed are disclosed.Type: GrantFiled: July 11, 2016Date of Patent: October 18, 2022Assignee: Lumicell, Inc.Inventors: W. David Lee, Jorge Ferrer, David B. Strasfeld
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Patent number: 11446088Abstract: The invention provides systems and method for the removal of diseased cells during surgery.Type: GrantFiled: March 28, 2019Date of Patent: September 20, 2022Assignee: Lumicell, Inc.Inventors: W. David Lee, Jorge Ferrer
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Patent number: 11426075Abstract: Embodiments related to methods of use of an image analysis system for identifying residual cancer cells after surgery are disclosed. In some embodiments, the image analysis system collects a surgical site image and indicates on a display one or more locations of the identified cancer cells. In some embodiments, the method for identifying residual cancer cells comprises determining and selecting a portion of the surgical site image responsive to an intensity parameter; modifying the selected portion of the surgical site image to determine one or more groups of residual cancer cells based on size; and identifying at least one of the one or more groups of residual cancer cells from the modified portion of the surgical site image using a local-based threshold.Type: GrantFiled: August 23, 2017Date of Patent: August 30, 2022Assignee: Lumicell, Inc.Inventors: David B. Strasfeld, W. David Lee, Jorge Ferrer
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Patent number: 11266313Abstract: A method and system for medical imaging employs an excitation source configured to cause an object having a plurality of cells to at least one of emit, reflect, and fluoresce light. An optical receptor is employed that is configured to receive the light from the object. A filter assembly receives the light from the optical receptor and filters the light. An image processor having a field of view (FOV) substantially greater than a diameter of a cell of the object and an analysis resolution substantially matched to the diameter of a cell of the object that receives the filtered light from the filter and analyzes the filtered light corresponding to each cell in the FOV. A feedback system is provided that is configured to provide an indication of a state of each cell in the FOV and a location of a cell in the FOV meeting a predetermined condition.Type: GrantFiled: February 6, 2015Date of Patent: March 8, 2022Assignees: Massachusetts Institute of Technology, Duke UniversityInventors: Moungi G. Bawendi, Jorge M. Ferrer, W. David Lee, Lisa F. Marshall, David G. Kirsch
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Publication number: 20210228083Abstract: Disclosed techniques include skin diagnostics using optical signatures. A plurality of optical excitation light wavelength bands is scanned on a material sample, wherein the material sample exhibits optical spectral characteristics along the light wavelength spectrum. Excitation response wavelengths emitted by the material sample are captured in response to the plurality of optical excitation light wavelength bands, wherein the capturing is accomplished using an imaging sensor. Output values of a plurality of pixels of an image from the imaging sensor are measured, wherein the image represents excitation response wavelengths captured by the imaging sensor, wherein the measuring detects optical spectral characteristics of the material sample, and wherein the optical spectral characteristics are in response to the plurality of optical excitation light wavelength bands.Type: ApplicationFiled: January 22, 2021Publication date: July 29, 2021Applicant: Precision Healing, Inc.Inventors: David B. Strasfeld, Ira M. Herman, W. David Lee, Ryan Daniel Williams, Sean P. Madden
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Publication number: 20210231566Abstract: Disclosed techniques include exudate analysis using optical signatures. Access to a tissue exudate sample is obtained, wherein the tissue exudate sample contains one or more analytes representing a state of the tissue. The one or more analytes are isolated from the exudate sample on a substrate. The exudate is transferred from the substrate to an immunoassay. The immunoassay is illuminated with photons, wherein the illuminating comprises a controlled photon exposure. The controlled photon exposure comprises ambient lighting and/or one or more fluorescence excitation light wavelength bands. Light emanating from the immunoassay is imaged, wherein the imaging captures intensities of light wavelengths across the light wavelength spectrum. The imaging captures reflected light and fluorescent emanating light. A signature for the one or more analytes is generated, based on analysis of the intensities that were imaged. The signature expresses a magnitude for each of the one or more analytes.Type: ApplicationFiled: January 22, 2021Publication date: July 29, 2021Applicant: Precision Healing, Inc.Inventors: Ryan Daniel Williams, Ira M. Herman, W David Lee, David B. Strasfeld, Sean P. Madden
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Publication number: 20210048491Abstract: This invention relates generally to detection devices having one or more small wells each surrounded by, or in close proximity to, an NMR micro coil, each well containing a liquid sample with magnetic nanoparticles that self-assemble or disperse in the presence of a target analyte, thereby altering the measured NMR properties of the liquid sample. The device may be used, for example, as a portable unit for point of care diagnosis and/or field use, or the device may be implanted for continuous or intermittent monitoring of one or more biological species of interest in a patient.Type: ApplicationFiled: March 25, 2020Publication date: February 18, 2021Inventor: W. David Lee
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Patent number: 10813554Abstract: Embodiments related to medical imaging devices including rigid imaging tips and their methods of use for identifying abnormal tissue within a surgical bed are disclosed.Type: GrantFiled: March 14, 2014Date of Patent: October 27, 2020Assignee: Lumicell, Inc.Inventors: W. David Lee, Jorge Ferrer, David B. Strasfeld
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Patent number: 10791937Abstract: Embodiments related to medical imaging devices including rigid imaging tips and their methods of use for identifying abnormal tissue within a surgical bed are disclosed.Type: GrantFiled: March 14, 2014Date of Patent: October 6, 2020Assignee: Lumicell, Inc.Inventors: W. David Lee, Jorge Ferrer, David B. Strasfeld