Abstract: This technology relates to polynucleotides comprising optimized FMR1 open reading frame (ORF) sequences, viral vectors comprising the same, and methods of using the same for delivery of the ORF to a cell or a subject and to treat disorders associated with aberrant expression of FMR1, such as Fragile X syndrome (“FXS”).

Abstract: An image light guide including a surface having a coating, a first plurality of diffractive features arranged in the coating, and a second plurality of diffractive features arranged in the coating. Wherein at least one of the first and second pluralities of diffractive features comprise a sub-wavelength stepped pattern configured to diffract incident light as if the stepped pattern diffractive features were linear diffractive features.

Abstract: A method for use in a touch-sensitive panel includes generating electric fields by applying drive signals to a plurality of row electrodes and a plurality of column electrodes included in the touch-sensitive panel, and sensing at least one information signal capacitively coupled to the touch-sensitive panel by detecting impedance changes associated with the plurality of row electrodes and the plurality of column electrodes. The impedance changes are converted to received data. Based on the received data a transmission pattern associated with the at least one information signal is determined. It is further determined that the transmission pattern corresponds to an identification code.

Abstract: A system and apparatus for increasing the amplitude of accommodation and/or changing the refractive power and/or enabling the removal of the clear or cataractous lens material of a natural crystalline lens is provided. Generally, the system comprises a laser, optics for delivering the laser beam and a control system for delivering the laser beam to the lens in a particular pattern. There is further provided apparatus for determining the shape and position of the lens with respect to the laser. There is yet further provided a method and system for delivering a laser beam in the lens of the eye in a predetermined shot pattern.

Abstract: A method includes determining, by a processing module of a foot force detection system, an athletic mode. The method further includes, when the athletic mode is active, determining, by the processing module, an athletic burst mode. The method further includes determining, by the processing module, a sampling rate for the foot force detection system based on the athletic burst mode for sampling foot force data.

Abstract: A foot force detection system includes variable capacitors, drive sense circuits, a processing module, and a power unit. A drive sense circuit supplies a reference signal to the variable capacitor. It then generates a sensed signal regarding a characteristic of the variable capacitor based on the reference signal. It then converts the sensed signal into a digital signal. The processing module generates a digital impedance value for the variable capacitor based on the digital signal and writes the digital impedance value in memory. The power unit include a battery and a power harvesting circuit, where the battery and/or the power harvesting circuit provide power for the foot force detection system.

Abstract: A hierarchical network enables access for a stacked memory system including or more memory dies that each include multiple memory tiles. The processor die includes multiple processing tiles that are stacked with the one or more memory die. The memory tiles that are vertically aligned with a processing tile are directly coupled to the processing tile and comprise the local memory block for the processing tile. The hierarchical network provides access paths for each processing tile to access the processing tile's local memory block, the local memory block coupled to a different processing tile within the same processing die, memory tiles in a different die stack, and memory tiles in a different device. The ratio of memory bandwidth (byte) to floating-point operation (B:F) may improve 50× for accessing the local memory block compared with conventional memory. Additionally, the energy consumed to transfer each bit may be reduced by 10×.

Abstract: Systems and methods are provided to provide guidance to a user regarding management of a physiologic condition such as diabetes. The determination may be based upon a patient glucose concentration level. The glucose concentration level may be provided to a stored model to determine a state. The guidance may be determined based at least in part on the determined state.

Abstract: Pre-connected analyte sensors are provided. A pre-connected analyte sensor includes a sensor carrier attached to an analyte sensor. The sensor carrier includes a substrate configured for mechanical coupling of the sensor to testing, calibration, or wearable equipment. The sensor carrier also includes conductive contacts for electrically coupling sensor electrodes to the testing, calibration, or wearable equipment.

Abstract: A foot force detection system includes first and second shoe force detection units. The first shoe force detection unit includes pressure sensors, a processing module, and a communication unit. The pressure sensors are operably coupled to produce first force data. The processing module is operably coupled to produce a first digital representation of the first force data. The second shoe force detection unit includes its own pressure sensors, a processing module, and a communication unit. The first and second shoe force detection units communicate with each other via the communication units.

Abstract: A capacitive touch screen display operates by: providing a display configured to render frames of data into visible images; providing a plurality of electrodes integrated into the display to facilitate touch sense functionality based on electrode signals having a drive signal component and a receive signal component; generating, via a plurality of drive-sense circuits coupled to at least some of the plurality of electrodes, a plurality of sensed signals; receiving the plurality of sensed signals; generating capacitance image data associated with the plurality of cross points that includes capacitance variation data corresponding to variations of the capacitance image data from a nominal value; and processing the capacitance image data to determine a touchless indication proximal to the touch screen display based on a touchless indication threshold.

Abstract: A touch screen display includes a plurality of electrodes configured to facilitate touch sense functionality based on electrode signals having a drive signal component and a receive signal component, a plurality of drive-sense circuits coupled to at least some of the plurality of electrodes to generate a plurality of sensed signals, and a processing module. The processing module is configured to cause the touch screen display to receive the plurality of sensed signals. A stream of capacitance image data associated with the plurality of cross points is generated based on the plurality of sensed signals. The stream of capacitance image data is processed to detect a touchless gesture.

Abstract: A method of fabricating a substrate includes providing a substrate having a flat surface and a beam writing system operable to write in a first direction and a second direction, wherein the second direction is perpendicular to the first direction, The method further includes providing a diffraction grating layout pattern having a first diffraction grating, a second diffraction grating, and a third diffraction grating. The method also includes locating the substrate in the beam writing system, whereby the beam writing system is operable to write into the flat surface, and aligning one of the first, second, and third diffraction gratings parallel with the beam writing system first direction. Additionally, the method includes writing the diffraction grating layout pattern into the substrate flat surface via the beam writing machine.

Abstract: A personal display device for displaying virtual images to a wearer including a frame having a right temple section, a left temple section, a right eye see-through section, and a left eye see-through section; a projection display device connected to the frame; a processor connected to the projection display device and arranged within the left temple section or right temple section; and at least one waveguide stack module connected to the frame, the at least one waveguide stack module being configured to receive image-bearing light beams from the projection display device.

Abstract: An imaging apparatus for stereoscopic viewing having a frame operable to be reshaped from a first shape to a second shape. A left-eye imaging apparatus and a right-eye imaging apparatus supported by the frame, wherein the left-eye imaging apparatus and the right-eye imaging apparatus have a first relative alignment operable to convey stereoscopic virtual images to the viewer when the frame is in the first shape, and wherein the left-eye imaging apparatus and the right-eye imaging apparatus are arranged at a second relative alignment when the frame is in the second shape. An adjustment mechanism operable to change an angular alignment of one or more components of the left-eye imaging apparatus and/or the right-eye imaging apparatus relative to the frame to restore the first relative alignment of the left-eye imaging apparatus and the right-eye imaging apparatus when the frame is in the second shape.

Abstract: Systems and methods for switching between data connections establishing between an augmented reality display unit and a peripheral device. The systems and methods can automatically switch between communication modules, antennas, or frequencies based on sensor data to reduce or eliminate the effects of proximity to or submersion beneath water. In some examples, switching between communication modules, antennas, or frequencies is based on motion of the user's head or the electrical resistance, salinity, or chemical composition of a body of water the augmented reality display unit is placed within.

Abstract: A light secure image light guide including an image source operable to generate image-bearing light beams and a waveguide operable to propagate the image-bearing light beams. An in-coupling diffractive optic formed along the waveguide, wherein the in-coupling diffractive optic is operable to diffract a portion of the image-bearing light beams from the image source into the waveguide in an angularly encoded form, and an out-coupling diffractive optic formed along the waveguide, wherein the out-coupling diffractive optic is operable to expand the portion of image-bearing light beams, direct a first portion of expanded image-bearing light beams from the waveguide in an angularly decoded form in a first direction toward an eyebox, and direct a second portion of expanded image-bearing light beams from the waveguide in a second direction different from said first direction.

Abstract: Establishing a transfer mode between devices for large bulk records over a TLS protocol by fragmenting an encrypted bulk record into a set of pre-defined block sizes for convenient transfer. The pre-defined block sizes are specifically sized to indicate a beginning and an end of the transfer of the associated blocks making up the large bulk record. A middle box is unaware of the association between the blocks and permits transfer according to the maximum transmission unit of the transport layer security (TLS) protocol. The fragmented bulk record is reconstructed and decrypted for use after the transfer.

Abstract: An image light guide for conveying a virtual image, including a waveguide, an in-coupling diffractive optic operable to direct image-bearing light beams into the waveguide, and an out-coupling diffractive optic operable to direct the image-bearing light beams from the waveguide toward an eyebox. The out-coupling diffractive optic having two or more zones each including a set of diffractive features, wherein successive zones along one dimension of the out-coupling diffractive optic have different respective sets of diffractive features, wherein the diffractive features are operable to direct image-bearing light beams of a first pixel incident upon the diffractive features at a first angle whereby the directed image-bearing light beams of the first pixel further propagate within the waveguide, and wherein the diffractive features are operable to out-couple a portion of the image-bearing light beams of the first pixel incident upon the diffractive features at a second angle.

Abstract: Transport Layer Security (TLS) connection establishment between a client and a server for a new session is enabled using an ephemeral (temporary) key pair. In response to a request, the server generates a temporary certificate by signing an ephemeral public key using the server's private key. A certificate chain comprising at least the temporary certificate that includes the ephemeral public key, together with a server certificate, is output to the client by the server, which acts as a subordinate Certificate Authority. The client validates the certificates, generates a session key and outputs the session key wrapped by the ephemeral public key. To complete the connection establishment, the server applies the ephemeral private key to recover the session key derived at the client for the new session. The client and server thereafter use the session key to encrypt and decrypt data over the link. The ephemeral key pair is not reused.