Abstract: The present invention is directed to cinnolinyl and quinolinyl pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.

Abstract: There is provided an electronically controlled, breath actuated vaporization device for generating vaporized material for inhalation by a user. The vaporization device includes a vaporization chamber for accommodating material to be vaporized and a mesh heater or other heater supported upstream of the vaporization chamber which is operable to heat air that passes through the mesh heater or other heater during an inhalation event. A closed loop control scheme may be employed to control heat generated by the heater to maintain a temperature of the air delivered to the vaporization chamber at or within a predetermined tolerance of a desired vaporization temperature for at least a majority of a duration of the inhalation event.

Abstract: Custom-form batteries can supply complex, practical systems with an optimal energy density that wouldn't otherwise be possible using traditional battery form-factors. For example, iron disulfide (FeS2) is a prominent conversion cathode of commercial interest. 3D direct-ink write (DIW) printing of FeS2 inks can be used to produce ridged cathodes from the filamentary extrusion of highly concentrated FeS2 inks (60-70% solids). These ridged cathodes exhibit optimal power, uniformity, and stability when cycled at higher rates (in excess of C/10). Meanwhile, functional cells with custom-form wave-shaped electrodes (e.g., printed FeS2 cathodes and pressed lithium anodes) exhibit improved performance over similar cells in planar configurations. In general, the DIW of concentrated inks is a viable path toward the making of custom-form conversion lithium batteries. More broadly, ridging is found to optimize rate capability.

Abstract: An enhanced safety coil that prevents crack formation and propagation to the coil windings from external sources and prevents exposure to fuel is provided. The enhanced safety coil may be used in a solenoid operated gas admission valve (SOGAV), and includes a plastic encapsulation body having at least one body de-stress feature, a coil wound on the plastic encapsulation body, a sleeve forming an outermost side protective wall configured to accommodate the plastic encapsulation body and coil therewithin, and potting provided between the plastic encapsulation body and the sleeve to seal the coil therein. The body de-stress feature is configured to reduce at least one of a formation or a propagation of a crack through the potting to the coil. The plastic encapsulation body forms retention latches configured to mate with a stator.

Abstract: A lubricant supply system is for a compressor that compresses a first working fluid in a heat transfer circuit. The lubricant supply system includes a lubricant tank, a lubricant pathway for supplying lubricant from the lubricant tank to one or more bearings of the compressor, and a lubricant refrigeration system with a lubricant heater and a lubricant cooler. The lubricant heater configured to heat the lubricant discharged from the one or more bearings and the lubricant cooler configured to cool the lubricant flowing through the lubricant pathway. A method of lubricating a compressor includes heating the lubricant, directing the lubricant from a lubricant tank through a lubricant pathway to one or more bearings of the compressor, and cooling the lubricant passing through the lubricant pathway.

Abstract: Centrifugal compressors can incorporate a side stream flow of intermediate pressure vapor between stages of that compressor. The side stream flow can be controlled by a side stream injection port controlled by a throttle ring disposed between stages of the compressor. The throttle ring can allow or obstruct flow through the side stream injection port. The throttle ring can extend and retract in a direction substantially perpendicular to the direction of flow from the first stage impeller to the second stage impeller. A method of operating a centrifugal compressor can include actuating a throttle ring by rotating a drive ring to adjust a flow of interstage fluid into the second stage impeller.

Abstract: An interstage throttle for a centrifugal compressor includes a flow guide plate, a throttle ring, a drive ring, and linkage assemblies. The flow guide plate includes guide vanes that form channels that direct working fluid in between stages of the compressor. The linkage assemblies connect the drive ring to the throttle ring such that rotation of the drive ring moves the throttle ring in an axial direction. Teeth of the throttle ring partially block the channels when the throttle ring is in an extended position. A method of operating a centrifugal compressor includes directing the working fluid discharged from the first stage to a second stage via channels in a interstage throttle. A centrifugal compressor includes a first stage with a first impeller, a second stage with a second impeller, and an interstage throttle fluidly connecting the first stage to the second stage.

Abstract: A lubricant supply system is for a compressor that compresses a first working fluid in a heat transfer circuit. The lubricant supply system includes a lubricant tank, a lubricant pathway for supplying lubricant from the lubricant tank to one or more bearings of the compressor, and a lubricant refrigeration system with a lubricant heater and a lubricant cooler. The lubricant heater configured to heat the lubricant discharged from the one or more bearings and the lubricant cooler configured to cool the lubricant flowing through the lubricant pathway. A method of lubricating a compressor includes heating the lubricant, directing the lubricant from a lubricant tank through a lubricant pathway to one or more bearings of the compressor, and cooling the lubricant passing through the lubricant pathway.

Abstract: Centrifugal compressors can incorporate a side stream flow of intermediate pressure vapor between stages of that compressor. The side stream flow can be controlled by a side stream injection port controlled by a capacity control valve that has a curved surface facing a flow of refrigerant from the first stage to the second stage. The capacity control valve can allow or obstruct flow through the side stream injection port. The capacity control valve can extend and retract in a direction substantially perpendicular to the direction of flow from the first stage impeller to the second stage impeller. The side stream injection port and the capacity control valve can be ring-shaped. The side stream injection port and the capacity control valve can allow at least some of the side stream to be introduced on a side of the capacity control valve opposite the curved surface.

Abstract: An interstage throttle for a centrifugal compressor includes a flow guide plate, a throttle ring, a drive ring, and linkage assemblies. The flow guide plate includes guide vanes that form channels that direct working fluid in between stages of the compressor. The linkage assemblies connect the drive ring to the throttle ring such that rotation of the drive ring moves the throttle ring in an axial direction. Teeth of the throttle ring partially block the channels when the throttle ring is in an extended position. A method of operating a centrifugal compressor includes directing the working fluid discharged from the first stage to a second stage via channels in a interstage throttle. A centrifugal compressor includes a first stage with a first impeller, a second stage with a second impeller, and an interstage throttle fluidly connecting the first stage to the second stage.

Abstract: Centrifugal compressors can incorporate a side stream flow of intermediate pressure vapor between stages of that compressor. The side stream flow can be controlled by a side stream injection port controlled by a throttle ring disposed between stages of the compressor. The throttle ring can allow or obstruct flow through the side stream injection port. The throttle ring can extend and retract in a direction substantially perpendicular to the direction of flow from the first stage impeller to the second stage impeller. A method of operating a centrifugal compressor can include actuating a throttle ring by rotating a drive ring to adjust a flow of interstage fluid into the second stage impeller.

Abstract: Centrifugal compressors can incorporate a side stream flow of intermediate pressure vapor between stages of that compressor. The side stream flow can be controlled by a side stream injection port controlled by a throttle ring disposed between stages of the compressor. The throttle ring can allow or obstruct flow through the side stream injection port. The throttle ring can extend and retract in a direction substantially perpendicular to the direction of flow from the first stage impeller to the second stage impeller. A method of operating a centrifugal compressor can include actuating a throttle ring by rotating a drive ring to adjust a flow of interstage fluid into the second stage impeller.

Abstract: Centrifugal compressors can incorporate a side stream flow of intermediate pressure vapor between stages of that compressor. The side stream flow can be controlled by a side stream injection port controlled by a capacity control valve that has a curved surface facing a flow of refrigerant from the first stage to the second stage. The capacity control valve can allow or obstruct flow through the side stream injection port. The capacity control valve can extend and retract in a direction substantially perpendicular to the direction of flow from the first stage impeller to the second stage impeller. The side stream injection port and the capacity control valve can be ring-shaped. The side stream injection port and the capacity control valve can allow at least some of the side stream to be introduced on a side of the capacity control valve opposite the curved surface.

Abstract: Centrifugal compressors can incorporate a side stream flow of intermediate pressure vapor between stages of that compressor. The side stream flow can be controlled by a side stream injection port controlled by a capacity control valve that has a curved surface facing a flow of refrigerant from the first stage to the second stage. The capacity control valve can allow or obstruct flow through the side stream injection port. The capacity control valve can extend and retract in a direction substantially perpendicular to the direction of flow from the first stage impeller to the second stage impeller. The side stream injection port and the capacity control valve can be ring-shaped. The side stream injection port and the capacity control valve can allow at least some of the side stream to be introduced on a side of the capacity control valve opposite the curved surface.

Abstract: Centrifugal compressors can incorporate a side stream flow of intermediate pressure vapor between stages of that compressor. The side stream flow can be controlled by a side stream injection port controlled by a throttle ring disposed between stages of the compressor. The throttle ring can allow or obstruct flow through the side stream injection port. The throttle ring can extend and retract in a direction substantially perpendicular to the direction of flow from the first stage impeller to the second stage impeller. A method of operating a centrifugal compressor can include actuating a throttle ring by rotating a drive ring to adjust a flow of interstage fluid into the second stage impeller.

Abstract: Systems and methods to clamp an impeller on a shaft in a centrifugal compressor. The embodiments as disclosed herein may include clamping individual impeller independently to the shaft, which may reduce the tolerance stack-up effect of a plurality of impellers. The impeller can be clamped to the shaft by positioning, for example, a relatively stiff support (e.g. a shaft locknut) on a front side of the impeller. The impeller can also be clamped to the shaft by a relatively flexible support to compensate for e.g. thermal expansion/contraction of the impeller. The embodiments as disclosed herein are particularly suitable for a multi-stage impeller.

Abstract: Centrifugal compressors can incorporate a side stream flow of intermediate pressure vapor between stages of that compressor. The side stream flow can be controlled by a side stream injection port controlled by a capacity control valve that has a curved surface facing a flow of refrigerant from the first stage to the second stage. The capacity control valve can allow or obstruct flow through the side stream injection port. The capacity control valve can extend and retract in a direction substantially perpendicular to the direction of flow from the first stage impeller to the second stage impeller. The side stream injection port and the capacity control valve can be ring-shaped. The side stream injection port and the capacity control valve can allow at least some of the side stream to be introduced on a side of the capacity control valve opposite the curved surface.

Abstract: Embodiments of the present systems and methods may provide techniques for deterministic training of cRBMs. Embodiments may utilize least square error estimates for the hidden variables, which is computationally tractable and provides improved results. For example, in an embodiment, a computer-implemented method for machine learning may comprise generating a continuous restricted Boltzman machine model by replacing discrete valued spins in a discrete restricted Boltzman machine model with continuous values, training the continuous restricted Boltzman machine model using a training dataset using a deterministic training process having hidden variables defined using least square error estimates, and using the trained continuous restricted Boltzman machine model to recognize patterns in new data.

Abstract: A chemical reaction system is disclosed for use in a device for delivering a therapeutic fluid comprising a liquid base and a polymeric acid. A reaction rate of the chemical reaction system is capable of being adjusted by adjusting at least one of surface area-to-volume ratio, acid concentration, and cross-linking of the polymeric acid.

Abstract: An apparatus for donning hygienic gloves comprising a stack of glove sheets, a box and a dispenser. The box contains the stack of glove sheets and the dispenser removably holds the box. Each glove sheet comprises a top and bottom layer sealed together at a hand-shaped seam that defines a glove and a frangibly attached remnant portion, the bottom layer being longer the top layer at a cuff of the glove, the cuff having a hand opening therein. The box has a removable flap, preferably including a hand-shaped portion on a front panel of the box. The dispenser includes an opening preferably including a hand-shaped portion on a front panel of the box. In a preferred embodiment, the hand-shaped seam, hand-shaped flap portion, and hand-shaped dispenser opening are configured to substantially match and align.