Patents by Inventor W. Harry Mandeville, III
W. Harry Mandeville, III has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6083495Abstract: Phosphate-binding polymers are provided for removing phosphate from the gastrointestinal tract. The polymers are orally administered, and are useful for the treatment of hyperphosphatemia.Type: GrantFiled: September 15, 1997Date of Patent: July 4, 2000Assignee: GelTex Pharmaceuticals, Inc.Inventors: Stephen Randall Holmes-Farley, W. Harry Mandeville, III, George M. Whitesides
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Patent number: 6066678Abstract: The invention relates to a method for removing bile salts from a patient in need thereof and compositions useful in the method. The method comprises administering to the patient a therapeutically effective amount of an alkylated and crosslinked polymer. The alkylated and crosslinked polymer comprises the reaction product of polymers, or salts and copolymers thereof having amine containing repeat units, with at least one aliphatic alkylating agent and a crosslinking agent.Type: GrantFiled: September 2, 1999Date of Patent: May 23, 2000Assignee: GelTex Pharmaceuticals, Inc.Inventors: W. Harry Mandeville, III, Stephen Randall Holmes-Farley
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Patent number: 6060517Abstract: A method for removing bile salts from a patient by ion exchange by administering to the patient a therapeutically effective amount of one or more highly crosslinked polymers characterized by a repeat unit having the formula ##STR1## or copolymer thereof, where n is an integer; R.sup.1 is H or a C.sub.1 -C.sub.8 alkyl group; M is ##STR2## Z is O, NR.sup.3 R, S, or (CH.sub.2).sub.m ; m=0-10; R.sup.3 is H or a C.sub.1 -C.sub.8 alkyl group; and R.sup.2 is ##STR3## where p=0-10, and each R.sup.4, R.sup.5, and R.sup.6, independently, is H, C.sub.1 -C.sub.8 alkyl group, or an aryl group.Type: GrantFiled: November 12, 1998Date of Patent: May 9, 2000Assignee: GelTex Pharmaceuticals, Inc.Inventors: W. Harry Mandeville, III, Stephen Randall Holmes-Farley
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Patent number: 6060235Abstract: The present invention relates to a method of treating a viral infection in an animal, such as a human, by administering to the animal a therapeutically effective amount of a polymer comprising a plurality of pendant hydrophobic groups and a plurality of pendant acid functional groups. The acid functional groups are connected directly to the polymer backbone or via an aliphatic spacer group of 1 to about 20 atoms in length.Type: GrantFiled: September 19, 1997Date of Patent: May 9, 2000Assignee: GelTex Pharmaceuticals, Inc.Inventors: Thomas X. Neenan, W. Harry Mandeville, III
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Patent number: 6034129Abstract: A method for treating a microbial infection in a mammal, such as a human, comprising treating the mammal with a therapeutically effective amount of a polymer comprising an amino group or an ammonium group attached to the polymer backbone via an aliphatic spacer group. The polymer can be a homopolymer or a copolymer. In one embodiment, the polymer is a copolymer comprising a monomer having a pendant ammonium group and a hydrophobic monomer.Type: GrantFiled: June 24, 1996Date of Patent: March 7, 2000Assignee: GelTex Pharmaceuticals, Inc.Inventors: W. Harry Mandeville, III, Thomas X. Neenan, Stephen Randall Holmes-Farley
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Patent number: 6007803Abstract: A method for treating pathogenic toxins in a mammal, such as a human, comprising treating the mammal with a therapeutically effective amount of a polymer comprising a cationic group attached to the polymer backbone. The polymer can be a homopolymer or a copolymer. In one embodiment, the polymer is a copolymer comprising a monomer having a pendant ammonium group and a hydrophobic monomer.Type: GrantFiled: September 19, 1997Date of Patent: December 28, 1999Assignee: GelTex Pharmaceuticals, Inc.Inventors: W. Harry Mandeville, III, Thomas X. Neenan
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Patent number: 5985938Abstract: A method for reducing oxalate levels in a patient that includes administering to the patient a therapeutically effective amount of non-absorbable amine polymers such as a polymer characterized by a repeat unit having the formula: ##STR1## and salts and copolymers thereof, where n is a positive integer and x is zero or an integer between 1 and about 4.Type: GrantFiled: November 5, 1997Date of Patent: November 16, 1999Assignee: Geltex Pharmaceuticals, Inc.Inventors: Stephen Randall Holmes-Farley, W. Harry Mandeville, III
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Patent number: 5981693Abstract: The invention relates to a method for removing bile salts from a patient in need thereof and compositions useful in the method. The method comprises administering to the patient a therapeutically effective amount of an alkylated and crosslinked polymer. The alkylated and crosslinked polymer comprises the reaction product of polymers, or salts and copolymers thereof having amine containing repeat units, with at least one aliphatic alkylating agent and a crosslinking agent.Type: GrantFiled: April 8, 1999Date of Patent: November 9, 1999Assignee: GelTex Pharmaceuticals, Inc.Inventors: W. Harry Mandeville, III, Stephen Randall Holmes-Farley
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Patent number: 5969090Abstract: The present invention relates to a poly(allylamine) polymer and, more generally, a hydrocarbon amine polymer. Preferably, these polymers are crosslinked. The present invention also relates to methods of forming these polymers and methods for their use. Further, the present invention relates to alkylating agents that can be employed to form the polymers and to methods for forming the alkylating agents. Generally, the polymer sequestrant includes a substituent bound to an amine of the polymer. The substituent includes a quaternary amine-containing moiety having one, two or three terminal hydrophobic substituents. A method of preparing quaternary amine-containing alkylating agents includes reacting an unsymmetrical dihalide with a tertiary amine having at least one hydrophobic substituent. A method for binding bile salts of bile acids in a mammal includes orally administering to the mammal a therapeutically-effective amount of the polymer sequestrant.Type: GrantFiled: November 3, 1998Date of Patent: October 19, 1999Assignee: GelTex Pharmaceuticals, Inc.Inventors: W. Harry Mandeville, III, Stephen Randall Holmes-Farley, John S. Petersen
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Patent number: 5939537Abstract: The present invention includes polymerizable monomers comprising an acid-functionalized glycoside moiety. The monomer can have a polymerizable functional group, such as an olefinic bond, to which the acid-functionalized glycoside moiety is attached by a spacer group, for example, an alkylene group, or an alkylene group wherein one or more carbon atoms are substituted by heteroatoms, such as oxygen, nitrogen or sulfur atoms. The present invention also includes polymers comprising pendant acid-functionalized glycoside moieties. The present invention also provides a method for treating a microbial infection in a mammal by administering to the mammal a therapeutically effective amount of a polymer comprising one or more acid-functionalized glycoside moieties.Type: GrantFiled: June 25, 1997Date of Patent: August 17, 1999Assignee: GelTex Pharmaceuticals Inc.Inventors: W. Harry Mandeville, III, Venkata R. Garigapati
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Patent number: 5925379Abstract: The present invention relates to a method for removing bile salts from a patient, comprising the step of administering to the patient a therapeutically effective amount of a polymer network composition comprising a cationic polymer. In one embodiment, the polymer network is an interpenetrating polymer network. In another embodiment, the polymer network is a semi-interpenetrating polymer network.Type: GrantFiled: March 27, 1997Date of Patent: July 20, 1999Assignee: GelTex Pharmaceuticals, Inc.Inventors: W. Harry Mandeville, III, Stephen Randall Holmes-Farley, Thomas X. Neenan, George M. Whitesides
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Patent number: 5919832Abstract: An amine polymer includes first and second substituents bound to amines of the polymer. The first substituent includes a hydrophobic moiety. The second substituent includes a quaternary amine-containing moiety. A method for binding bile salts of bile acids in a mammal includes orally administering to the mammal a therapeutically-effective amount of the amine polymer.Type: GrantFiled: January 7, 1997Date of Patent: July 6, 1999Assignee: Geltex Pharmaceuticals Inc.Inventors: W. Harry Mandeville, III, Stephen Randall Holmes-Farley
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Patent number: 5917007Abstract: The invention relates to a method for removing bile salts from a patient in need thereof and compositions useful in the method. The method comprises administering to the patient a therapeutically effective amount of an alkylated and crosslinked polymer. The alkylated and crosslinked polymer comprises the reaction product of polymers, or salts and copolymers thereof having amine containing repeat units, with at least one aliphatic alkylating agent and a crosslinking agent.Type: GrantFiled: August 5, 1998Date of Patent: June 29, 1999Assignee: GelTex Pharmaceuticals, Inc.Inventors: W. Harry Mandeville, III, Stephen Randall Holmes-Farley
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Patent number: 5900475Abstract: The present invention relates to a poly(allylamine) polymer and, more generally, a hydrocarbon amine polymer. Preferably, these polymers are crosslinked. The present invention also relates to methods of forming these polymers and methods for their use. Further, the present invention relates to alkylating agents that can be employed to form the polymers and to methods for forming the alkylating agents Generally, the polymer sequestrant includes a substituent bound to an amine of the polymer. The substituent includes a quaternary amine-containing moiety having one, two or three terminal hydrophobic substituents. A method of preparing quaternary amine-containing alkylating agents includes reacting an unsymmetrical dihalide with a tertiary amine having at least one hydrophobic substituent. A method for binding bile salts of bile acids in a mammal includes orally administering to the mammal a therapeutically-effective amount of the polymer sequestrant.Type: GrantFiled: June 6, 1996Date of Patent: May 4, 1999Assignee: GelTex Pharmaceuticals, Inc.Inventors: W. Harry Mandeville, III, Stephen Randall Holmes-Farley, John S. Petersen
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Patent number: 5891862Abstract: The present invention includes polymerizable monomers comprising a fucoside moiety. In one embodiment, the monomer has a polymerizable functional group, such as an olefinic bond, to which the fucoside moiety is attached by a spacer group, for example, an alkylene group, or an alkylene group wherein one or more carbon atoms are substituted by heteroatoms, such as oxygen, nitrogen or sulfur atoms. The present invention also includes polymers comprising one or more fucoside moieties, such as pendant fucoside moieties, which can inhibit or prevent rotavirus infection in a mammal. Such a polymer can comprise, for example, a monomer of the present invention. The polymer can be a homopolymer or a copolymer, and can have, for example, a polyacrylamide, polyacrylate or polystyrene backbone.Type: GrantFiled: September 20, 1996Date of Patent: April 6, 1999Assignee: GelTex Pharmaceuticals, Inc.Inventors: W. Harry Mandeville, III, John S. Petersen, Venkata R. Garigapati, Thomas X. Neenan
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Patent number: 5840766Abstract: A method for removing bile salts from a patient by ion exchange by administering to the patient a therapeutically effective amount of one or more highly crosslinked polymers characterized by a repeat unit having the formula ##STR1## or copolymer thereof, where n is an integer; R.sup.1 is H or a C.sub.1 -C.sub.8 alkyl group: M is ##STR2## Z is O, NR.sup.3, S, or (CH.sub.2).sub.m ; m=0-10; R.sup.3 is H or a C.sub.1 -C.sub.8 alkyl group; and R.sup.2 is ##STR3## where p=0-10, and each R.sup.4, R.sup.5, and R.sup.6, independently, is H, a C.sub.1 -C.sub.8 alkyl group, or an aryl group.Type: GrantFiled: October 28, 1997Date of Patent: November 24, 1998Assignee: GelTex Pharmaceuticals, Inc.Inventors: W. Harry Mandeville, III, Stephen Randall Holmes-Farley
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Patent number: 5821312Abstract: The present invention includes polymerizable monomers comprising an acid-functionalized glycoside moiety. The monomer can have a polymerizable functional group, such as an olefinic bond, to which the acid-functionalized glycoside moiety is attached by a spacer group, for example, an alkylene group, or an alkylene group wherein one or more carbon atoms are substituted by heteroatoms, such as oxygen, nitrogen or sulfur atoms. The present invention also includes polymers comprising pendant acid-functionalized glycoside moieties. The present invention also provides a method for treating a microbial infection in a mammal by administering to the mammal a therapeutically effective amount of a polymer comprising one or more acid-functionalized glycoside moieties.Type: GrantFiled: June 25, 1997Date of Patent: October 13, 1998Assignee: GelTex Pharmaceuticals, Inc.Inventors: W. Harry Mandeville, III, Venkata R. Garigapati
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Patent number: 5703188Abstract: A method for removing bile salts from a patient by ion exchange by administering to the patient a therapeutically effective amount of one or more highly crosslinked polymers characterized by a repeat unit having the formula ##STR1## or copolymer thereof, where n is an integer; R.sup.1 is H or a C.sub.1 -C.sub.8 alkyl group: M is ##STR2## Z is O, NR.sup.3, S, or (CH.sub.2).sub.m ; m=0-10; R.sup.3 is H or a C.sub.1 -C.sub.8 alkyl group; and R.sup.2 is ##STR3## where p=0-10, and each R.sup.4, R.sup.5, and R.sup.6, independently is H, a C.sub.1 -C.sub.8 alkyl group, or an aryl group.Type: GrantFiled: June 7, 1995Date of Patent: December 30, 1997Assignee: GelTex Pharmaceuticals, Inc.Inventors: W. Harry Mandeville, III, Stephen Randall Holmes-Farley
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Patent number: 5702696Abstract: Iron binding polymers are provided for decreasing the absorption of iron from the gastrointestinal tract. The polymers are orally administered, and are useful for treatment of iron overload disorders.Type: GrantFiled: December 6, 1995Date of Patent: December 30, 1997Assignee: GelTex PharmaceuticalsInventors: W. Harry Mandeville, III, Stephen Randall Holmes-Farley
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Patent number: 5700458Abstract: The present invention includes polymerizable monomers comprising an acid-functionalized glycoside moiety. In one embodiment, the monomer has a polymerizable functional group, such as an olefinic bond, to which the acid-functionalized glycoside moiety is attached by a spacer group, for example, an alkylene group, or an alkylene group wherein one or more carbon atoms are substituted by heteroatoms, such as oxygen, nitrogen or sulfur atoms.The present invention also includes polymers comprising one or more acid-functionalized glycoside moieties, such as pendant acid-functionalized glycoside moieties, which can inhibit or prevent rotavirus infection in a mammal. Such a polymer can comprise, for example, a monomer of the present invention. The polymer can be a homopolymer or a copolymer, and can have, for example, a polyacrylamide, polyacrylate or polystyrene backbone.Type: GrantFiled: September 20, 1996Date of Patent: December 23, 1997Assignee: GelTex Pharmaceuticals Inc.Inventors: W. Harry Mandeville, III, Venkata R. Garigapati