Patents by Inventor W. Harry Mandeville, III

W. Harry Mandeville, III has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Alkylated amine polymers
    Patent number: 5693675
    Abstract: The invention relates to alkylated amine polymers and a method for removing bile salts from a patient that includes administering to the patient a therapeutically effective amount of product produced by a process comprising alkylating one or more crosslinked amine polymers, salts or copolymers thereof with at least one alkylating agent. The reaction product is characterized in that: (i) at least some of the nitrogen atoms are unreacted with alkylating agent; and (ii) less than 10 mol % of the nitrogen atoms in the polymer react with the alkylating agent to form quaternary ammonium units.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: December 2, 1997
    Assignee: GelTex Pharmaceuticals Inc.
    Inventors: W. Harry Mandeville, III, Stephen Randall Holmes-Farley
  • Method for removing bile salts from a patient with alkylated amine polymers
    Patent number: 5679717
    Abstract: A method for removing bile salts from a patient that includes administering to the patient a therapeutically effective amount of product produced by a process comprising alkylating one or more crosslinked amine polymers, salts or copolymers thereof with at least one alkylating agent. The reaction product is characterized in that: (i) at least some of the nitrogen atoms are unreacted with alkylating agent; and (ii) less than 10 mol% of the nitrogen atoms in the polymer react with the alkylating agent to form quaternary ammonium units.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: October 21, 1997
    Assignee: GelTex Pharmaceuticals, Inc.
    Inventors: W. Harry Mandeville, III, Stephen Randall Holmes-Farley
  • Phosphate-binding polymers for oral administration
    Patent number: 5667775
    Abstract: Phosphate-binding polymers are provided for removing phosphate from the gastrointestinal tract. The polymers are orally administered, and are useful for the treatment of hyperphosphatemia.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: September 16, 1997
    Assignee: GelTex Pharmaceuticals, Inc.
    Inventors: Stephen Randall Holmes-Farley, W. Harry Mandeville, III, George M. Whitesides
  • Process for removing bile salts from a patient and compositions therefor
    Patent number: 5624963
    Abstract: A method for removing bile salts from a patient by ion exchange by administering to the patient a therapeutically effective amount of one or more highly crosslinked polymers characterized by a repeat unit having the formula ##STR1## or copolymer thereof, where n is an integer; R.sup.1 is H or a C.sub.1 -C.sub.8 alkyl group; M is ##STR2## or --Z--R.sup.2 ; Z is O, NR.sup.3, S, or (CH.sub.2).sub.m ; m=0-10; R.sup.3 is H or a C.sub.1 -C.sub.8 alkyl group; and R.sup.2 is ##STR3## where p=0-10, and each R.sup.4, R.sup.5, and R.sup.6, independently, is H, a C.sub.1 -C.sub.8 alkyl group, or an aryl group, the polymers being non-toxic and stable once ingested.
    Type: Grant
    Filed: June 10, 1994
    Date of Patent: April 29, 1997
    Assignee: GelTex Pharmaceuticals, Inc.
    Inventors: W. Harry Mandeville, III, Stephen R. Holmes-Farley
  • Hydrophobic amine polymer sequestrant and method of cholesterol depletion
    Patent number: 5618530
    Abstract: An amine polymer includes a substituent bound to an amine of the polymer. The substituent includes a quaternary amine-containing moiety having at least one hydrophobic moiety. A method for binding bile salts of bile acids in a mammal includes orally administering to the mammal a therapeutically-effective amount of the amine polymer.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: April 8, 1997
    Assignee: GelTex Pharmaceuticals, Inc.
    Inventors: W. Harry Mandeville, III, Stephen R. Holmes-Farley, John S. Petersen
  • Amine polymer sequestrant and method of cholesterol depletion
    Patent number: 5607669
    Abstract: An amine polymer includes first and second substituents bound to amines of the polymer. The first substituent includes a hydrophobic moiety. The second substituent includes a quaternary amine-containing moiety. A method for binding bile salts of bile acids in a mammal includes orally administering to the mammal a therapeutically-effective amount of the amine polymer.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: March 4, 1997
    Assignee: GelTex Pharmaceuticals, Inc.
    Inventors: W. Harry Mandeville, III, Stephen R. Holmes-Farley
  • Phosphate-binding polymers for oral administration
    Patent number: 5496545
    Abstract: Phosphate-binding polymers are provided for removing phosphate from the gastrointestinal tract. The polymers are orally administered, and are useful for the treatment of hyperphosphatemia.
    Type: Grant
    Filed: May 5, 1994
    Date of Patent: March 5, 1996
    Assignee: GelTex Pharmaceuticals, Inc.
    Inventors: Stephen R. Holmes-Farley, W. Harry Mandeville, III, George M. Whitesides
  • Iron-binding polymers for oral administration
    Patent number: 5487888
    Abstract: Iron binding polymers are provided for decreasing the absorption of iron from the gastrointestinal tract. The polymers are orally administered, and are useful for treatment of iron overload disorders.
    Type: Grant
    Filed: May 20, 1993
    Date of Patent: January 30, 1996
    Assignee: GelTex, Inc.
    Inventors: W. Harry Mandeville, III, Stephen R. Holmes-Farley