Abstract: This document describes an exoskeleton device that includes a cable, a lever that is connected to the cable, a frame comprising a strut that redirects the cable toward the lever, wherein the frame is coupled to the lever by a rotational joint; and a motor that is connected to the cable and configured to cause the cable to provide a torque about the rotational joint, wherein the cable is configured to provide the torque by exerting a first force on the lever and a second force on the frame, and wherein the cable is further configured to provide the torque in a first rotational direction and is prevented from applying the torque in an opposite rotational direction to the first rotational direction.

Abstract: The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for simultaneously generating, for example, numerous different functional biomolecules, particularly to methods for generating numerous different functional nucleic acids against multiple target molecules simultaneously. The present invention further relates to functional ligands which bind with affinity to target molecules, such as opioids and opioid derivatives.

Abstract: A cannula insertion system for cannulating a blood vessel includes a cannula system having a cannula that defines a cannula lumen and has a distal and proximal end. The system includes a cannula insertion device for coupling with the system that includes a dilator having a dilator body and a dilator lumen; a needle having a needle body and a needle lumen, the needle being translatable within the dilator lumen along a first direction; a movable dilator actuator configured to cause the dilator to move along the first direction; a movable needle actuator configured to cause movement of the needle along the first direction; and a housing defining a housing recess. The housing recess is configured to receive the cannula system, the dilator, and the needle. The needle and the dilator are configured to be moved within the cannula lumen along the first direction.

Abstract: Disclosed herein are monoclonal antibodies and antigen-binding fragments thereof capable of selectively inhibiting TGF?1. Related compositions, methods and therapeutic use are also disclosed.

Abstract: A coated substrate has a substrate and a coating system having one or more ceramic layers. At least a first layer of one of the one or more ceramic layers is a columnar layer having as-deposited columns and intercolumn gaps. The intercolumn gaps have a mean width at least one of: at least 4.0 micrometers; and at least 1.5% of a thickness of said first layer.

Abstract: A catheter device for crossing occlusions includes an elongate body, a central lumen extending within the elongate body from the proximal end to the distal end, a rotatable tip at the distal end of the elongate body, and an OCT imaging sensor. The rotatable tip is configured to rotate relative to the elongate body. The OCT imaging sensor includes an optical fiber coupled with the rotatable tip and configured to rotate therewith. A distal end of the elongate body includes one or more markers configured to occlude the OCT imaging sensor as it rotates. A fixed jog in the elongate body proximal to the distal end of the catheter positions the distal end of the catheter at an angle relative to the region of the catheter proximal to the fixed jog and is aligned with the one or more markers on the elongate body.

Abstract: Aspects of the present disclosure relate to antibodies that specifically bind proMyostatin and/or latent Myostatin and uses thereof.

Abstract: Disclosed herein are monoclonal antibodies and antigen-binding fragments thereof capable of selectively inhibiting TGF?1 with high potency. Related compositions, methods and therapeutic use are also disclosed.

Abstract: This invention relates to methods and materials for multiplexed utilization of collections of functional ligands, particularly to methods and materials for selecting for and/or utilizing particular desirable traits of functional ligands in a multiplexed manner, and more particularly to methods and materials for selecting for and/or utilizing particular structural changes of functional ligands in a multiplexed manner.

Abstract: The present invention relates to methods and compositions for enhancing backscattering interferometry (BSI) in detection of biomolecular interactions, particularly to methods and compositions for enhancing BSI utilizing label-free aptamers, and more particularly to methods and compositions for enhancing BSI utilizing high conformational change aptamers, which may change in conformation when the aptamers bind to their target molecules.

Abstract: An integrated pressure washer is disclosed. The integrated pressure washer has an engine. At the bottom of the engine is an engine bottom cover. The engine bottom cover has a recess formed by a cylindrical wall that extends up from a base of the engine bottom cover. The pressure washer also has a pump assembly. The pump assembly is attached to the engine bottom cover and extends into the recess. The pump assembly receives water and applies pressure to the water and directs the pressurized water out a high pressure hose.

Abstract: A cargo tie-down for installation on a vehicle body is provided. The vehicle body includes a rear seat and a child restraint tether anchorage located rearward of the rear seat for attachment of an associated child restraint tether hook provided as part of an associated child restraint for securing the associated child restraint on the rear seat. The cargo tie-down includes a base having a mounting bracket configured for attachment to the vehicle body, a cover member rotatably mounted to the base for covering the base, and a hook main body rotatably mounted to the base. The hook-main body is configured to prevent the associated child restraint tether hook from being secured to the cargo tie-down.

Abstract: A system for imaging a body lumen includes a controller and a display. The controller is configured to connect to a proximal end of a catheter having an optical fiber extending along the length of an elongate catheter body. The controller is further configured to rotate a distal end of the optical fiber from a location near a proximal end of the elongate catheter body, acquire optical coherence tomography (OCT) images using the optical fiber as the distal end of the optical fiber rotates, and determine a rotational lag of the distal end of the optical fiber. The display is configured to display one or more OCT images corrected for the rotational lag.

Abstract: A system comprises a database stored on a server and a processing device of the server. The processing device is in communication with a user device accessible to a user. The processing device includes a hosting unit, a communications unit, an image processing unit, and a validation unit. The hosting unit is configured to generate and display a web-based application on a user device. The communications unit is configured to enable the user to access and interact with the web-based application on the user device and receive at least one user-submitted image and a plurality of user-submitted data from the user. The image processing unit is configured to process the at least one user-submitted image to retrieve game data. The validation unit is configured to compare the plurality of user-submitted data with the game data and validate the game data.

Abstract: A system comprises a database stored on a server and a processing device of the server. The processing device is in communication with a user device accessible to a user. The processing device includes a hosting unit, a communications unit, an image processing unit, and a validation unit. The hosting unit is configured to generate and display a web-based application on a user device. The communications unit is configured to enable the user to access and interact with the web-based application on the user device and receive at least one user-submitted image and a plurality of user-submitted data from the user. The image processing unit is configured to process the at least one user-submitted image to retrieve game data. The validation unit is configured to compare the plurality of user-submitted data with the game data and validate the game data.

Abstract: Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit beta-lactamase. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.

Abstract: A method, system and computer program product for controlling the delivery of voice communications. A profile is created for the user of a mobile device that specifies the thresholds for switching between a cellular network and a wireless network to conduct voice communications as well as stores a list of contacts and associated security levels. If the signal strength of the cellular radio signal is below a threshold, then the mobile device detects one or more wireless networks that are in the area of the user of the mobile device. The profile of the user of the mobile device is then checked to determine if the mobile device is authorized to switch to one of the detected wireless networks to deliver voice communications based on a security level associated with the party communicating with the user. In this manner, the user is able to control the delivery of voice communications.

Abstract: Disclosed herein are monoclonal antibodies and antigen-binding fragments thereof capable of selectively inhibiting TGF?1 with high potency. Related compositions, methods and therapeutic use are also disclosed.