Abstract: Aspects of the present disclosure relate to antibodies that specifically bind proMyostatin and/or latent Myostatin and uses thereof.

Abstract: A stabilizing connector includes a connector portion and a stabilization portion. The connector portion is configured to couple to an access device. The connector portion defines at least one lumen that is configured to be placed in fluid communication with a lumen of the access device. The stabilization portion is coupled to the connector portion. The stabilization portion is configured to be placed in contact with a surface of a patient's skin to stabilize at least one of the stabilizing connector or the access device.

Abstract: The present invention relates to methods and compositions for enhancing backscattering interferometry (BSI) in detection of biomolecular interactions, particularly to methods and compositions for enhancing BSI utilizing label-free aptamers, and more particularly to methods and compositions for enhancing BSI utilizing high conformational change aptamers, which may change in conformation when the aptamers bind to their target molecules.

Abstract: The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for simultaneously generating, for example, numerous different functional biomolecules, particularly to methods for generating numerous different functional nucleic acids against multiple target molecules simultaneously. The present invention further relates to functional ligands which bind with affinity to target molecules such as immunoglobulins, such as IgG.

Abstract: In an approach for providing dynamic services a computer receives a dietary plan for an individual. The computer tracks physical activity data for the individual. The computer creates one or more propositions for the individual based at least in part on the received dietary plan and the tracked physical activity data. The computer provides the created one or more propositions to the individual. The computer receives a selection from the created one or more propositions. The computer tracks the received selection.

Abstract: Methods, computer program products, and systems are presented. The methods include, for instance: a voice delivery application, running on a mobile device of a user, receives a text message from a user; by use of sensor inputs of the mobile device, the mobile device stores data regarding environment of the mobile device including external audio equipment, speed of the user, and bystanders within a hearing range of the environment; various data describing a sender of the text message and the bystanders are analyzed for respective relationships with the user and with each other to determine a confidentiality group dictating whether or not the text message may be heard by the bystander; the text message may be scanned for content screening, then according to configuration of the voice delivery application, the text message is securely delivered to the user by voice.

Abstract: The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for simultaneously generating, for example, numerous different functional biomolecules, particularly to methods for generating numerous different functional nucleic acids against multiple target molecules simultaneously.

Abstract: Methods, computer program products, and systems are presented. The methods include, for instance: a voice delivery application, running on a mobile device of a user, receives a text message from a user; by use of sensor inputs of the mobile device, the mobile device stores data regarding environment of the mobile device including external audio equipment, speed of the user, and bystanders within a hearing range of the environment; various data describing a sender of the text message and the bystanders are analyzed for respective relationships with the user and with each other to determine a confidentiality group dictating whether or not the text message may be heard by the bystander; the text message may be scanned for content screening, then according to configuration of the voice delivery application, the text message is securely delivered to the user by voice.

Abstract: The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for simultaneously generating, for example, numerous different functional biomolecules, particularly to methods for generating numerous different functional nucleic acids against multiple target molecules simultaneously. The present invention further relates to functional ligands which bind with affinity to target molecules, such as tetrahydrocannabinol (THC).

Abstract: The presently disclosed inventive concept(s) include inhibitors of antiplasmin cleaving enzyme (APCE) and fibroblast activation protein alpha (FAP) which can be used in various therapies related to disorders of fibrin and ?2-antiplasmin and abnormal cell proliferation. The presently disclosed inventive concept(s) also include substrates of APCE and FAP, which may be used, for example, in screening methods for identifying such inhibitors. The presently disclosed inventive concept(s) further include, but are not limited to, methods of treating or inhibiting atherosclerosis and thrombus disorders by altering the ratios of types of plasma ?2-antiplasmin and to methods of treating conditions involving abnormal cell proliferation such as cancers.

Abstract: In an approach for providing dynamic services a computer receives a dietary plan for an individual. The computer tracks physical activity data for the individual. The computer creates one or more propositions for the individual based at least in part on the received dietary plan and the tracked physical activity data. The computer provides the created one or more propositions to the individual. The computer receives a selection from the created one or more propositions. The computer tracks the received selection.

Abstract: In an approach for providing dynamic services a computer receives a dietary plan for an individual. The computer tracks physical activity data for the individual. The computer creates one or more propositions for the individual based at least in part on the received dietary plan and the tracked physical activity data. The computer provides the created one or more propositions to the individual. The computer receives a selection from the created one or more propositions. The computer tracks the received selection.

Abstract: Disclosed subject matter includes an artificial lift system including a rodless hydraulic pump actuator including an actuator housing assembly, an actuator piston assembly supported for reciprocal translation stroke movement relative to the actuator piston assembly, an actuator piston assembly production fluid passage extending through the actuator piston assembly, and a tubular coupling below the actuator housing assembly having a coupling flow passage to pass production fluid into the actuator piston assembly production fluid passage.

Abstract: A system includes a diagnostic module that selectively performs a purge valve leak diagnostic to diagnose a leak in a purge valve in a fuel system of a vehicle. Performing the purge valve leak diagnostic includes determining a level of vacuum in a fuel tank. A control module determines at least one operating condition associated with the vehicle. The at least one operating condition corresponds to an operating condition that affects the level of vacuum in the fuel tank. The control module, based on the at least one operating condition, selectively modifies the purge valve leak diagnostic. Selectively modifying the purge valve leak diagnostic includes at least one of preventing the diagnostic module from performing the purge valve leak diagnostic, preventing the diagnostic module from completing the purge valve leak diagnostic, and causing the diagnostic module to indicate that a result of the purge valve leak diagnostic was indeterminate.

Abstract: Inhibitors of fibroblast activation protein alpha (FAP) and Prolyl Oligopeptidase (POP) are disclosed, along with their use in various therapies related to conditions, diseases, and disorders involving abnormal cell proliferation such as malignancies and angiogenesis, and in neural disorders such as Alzheimer's disease. Stalk portions of the inhibitor molecules, and substrates of FAP and POP, are also disclosed and may be used, for example, in screening methods for identifying such inhibitors.

Abstract: Method, system, and computer-readable program product for modifying at least one virtual activity capability of an avatar in a virtual reality setting based on a real-world physical activity metric of a user of the virtual reality setting. The user's physical activity metrics are tracked via a fitness tracker or other biometric sensor. As the user's physical activity metric(s) improve, the virtual activity capabilities of the user's avatar in the virtual reality setting also improve.

Abstract: The subcellular localization of mRNA, and small RNA movement and trafficking of these molecules in an organism are important components of cellular and organismal regulation and communication. The next frontier for analysis of RNA will involve analysis at a single-molecule level, and at the subcellular level. This invention relates to methods and materials for sensitive detection of target molecules, particularly to methods and materials for binding or otherwise associating with target molecules and producing a signal for detection of, for example, spatial and/or temporal localization, and more particularly to methods and materials for the above using aptamers which bind to a chromophore or otherwise produce fluorescence or other detectable signal. This invention further relates to aptamers which bind to chromophores such as, for example, biliverdin or other related molecules, and also to such molecules which exhibit fluorescence or other detectable signals.

Abstract: Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit beta-lactamase. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.

Abstract: A roll-formed steel slat for use in a reciprocating floor slat conveyor system. The roll-formed steel slat is formed in a manner so as to have an upper, load-carrying surface, and a pair of downwardly depending side legs. Each side leg terminates in a foot. One foot is vertically offset from the other to provide a “hold-down” function that prevents the slat from vertically rising as the slat reciprocates back-and-forth.