Abstract: The present disclosure relates to oral compositions of Compound I or a derivative thereof. Methods of use for treating an inflammatory condition are also disclosed.

Abstract: The present disclosure relates to oral compositions of Compound I or a derivative thereof. Methods of use for treating an inflammatory condition are also disclosed.

Abstract: This disclosure, and the exemplary embodiments provided herein, include AM processed Ti-MMCs reinforced with either aluminum oxide or tantalum pentoxide. According to an exemplary embodiment, composite feedstock powders of Ti-6Al-4V (Ti64) with 1% and 3% (by volume) reinforcements of either nano-Al2O3 or Ta2O5 are prepared by high energy ball milling and then 3-D printed using SLM.

Abstract: The present disclosure relates to oral compositions of Compound I or a derivative thereof. Methods of use for treating an inflammatory condition are also disclosed.

Abstract: The present disclosure relates methods for treating skin disorders caused by an immune deficiency with topical formulations comprising ethyl (R)-4-((1-(2-cyanoacetyl)piperidin-3-yl)amino)-1H-pyrrolo[2,3-b]pyridine-5-carboxylate (Compound I) or pharmaceutically acceptable derivative thereof. In particular, the topical formulations described herein may be used to treat atopic dermatitis, alopecia areata, or vitiligo.

Abstract: The present disclosure relates to oral compositions of Compound I or a derivative thereof. Methods of use for treating an inflammatory condition are also disclosed.

Abstract: An oil-based composition for use in a rinse off or leave on hair product for protecting hair cuticles, the composition including a triglyceride carrier, squalene, a coconut oil-based alkane, melon seed oil, argan seed oil, and argan seed oil unsaponifiables. Using 0.001% to 25% of the composition in a rinse off/leave on product provides many improvements in the condition of hair, such as improving the hair moisture content; hair shine; reduction in flyaways; reduction in inter fiber friction; improved curl retention; improved hair smoothness; fill in/correction of hair cuticle defects; improved appearance of hair: increased hair break strength; and/or hair elasticity. The use of the 0.001%-25% of the composition can also prevent: the loss of hair moisture; the formation of split ends; the formation of cuticle gaps and voids; the loss of hair tensile strength; the loss of hair elasticity; hair breakage; and/or increase inter fiber friction.

Abstract: A concrete wall section manufactured with a weight that allows the user of the concrete wall section to transport manually the concrete wall section. Combinations of concrete wall sections can be used to replace traditional frames of a structure.

Abstract: Compositions and methods that may be useful for the treatment of a viral infection as well as for treating infection induced cytokine release syndrome (CRS) or acute respiratory distress syndrome (ARDS) are described herein. For example, pharmaceutical compositions containing Compound I as disclosed herein may be used to treat infection by a coronavirus, such as SARS-CoV-2 (“COVID-19”).

Abstract: This disclosure, and the exemplary embodiments provided herein, include AM processed Ti-MMCs reinforced with either aluminum oxide or tantalum pentoxide. According to an exemplary embodiment, composite feedstock powders of Ti-6Al-4V (Ti64) with 1% and 3% (by volume) reinforcements of either nano-Al2O3 or Ta2O5 are prepared by high energy ball milling and then 3-D printed using SLM.

Abstract: A concrete wall section manufactured with a weight that allows the user of the concrete wall section to transport manually the concrete wall section. Combinations of concrete wall sections can be used to replace traditional frames of a structure.

Abstract: The present disclosure relates to oral compositions of Compound I or a derivative thereof. Methods of use for treating an inflammatory condition are also disclosed.

Abstract: A concrete wall section manufactured with a weight that allows the user of the concrete wall section to transport manually the concrete wall section. Combinations of concrete wall sections can be used to replace traditional frames of a structure.

Abstract: A grip for removably supporting a needle holder includes a base portion that has a longitudinal channel sized for accepting a needle holder. The grip has a lever pivotally attached to the base portion. The lever has a lobe that interferes with the longitudinal channel when the lever is in a closed position and the lobe is positioned away from the channel when the lever is rotated into an open position. The lobe holds the needle holder within the longitudinal channel while the lever is in the closed position and the needle holder is released while the lever is in the open position.

Abstract: Methods and compositions for reducing and/or inhibiting inflammation by topical application of dermatocosmetic compositions comprising effective amounts of extracts of Coriolus versicolor that have been hydrolyzed by an acid protease, preferably Rhizomucor miehei, and thereafter rendered substantially devoid of acid-protease activity.

Abstract: An audiovisual recording of a user reading a book aloud is generated for playback with a virtual book. A book reading user interface presents a virtual book concurrently with a current image of the user. The virtual book may be presented based at least in part on an aspect ratio of the virtual book. As the user reads the virtual book aloud, an audiovisual recording of the user is generated. In addition, synchronization information is recorded that enables the audiovisual recording to be synchronized with the presentation of pages of the virtual book during playback. The generated audiovisual recording is stored in a database and may be played back to a recipient on demand.

Abstract: A method of making siding for attachment to a frame of a building. The siding has the appearance of antique hewn wood logs, and the siding includes modular lengthwise sections and corner modular sections of reinforced concrete façade logs.