Abstract: The present invention is based on the findings that BACE2, a homolog of ?-secretase BACE, is able to stimulate processing of APP in a non-amyloidogenic pathway, thereby suppressing the level of A?. Accordingly, the present invention provides methods and means for the identification and use of modulators of this unique activity of BACE2 to suppress A? production. The compounds identified using the methods and means provided herein may be used as potential candidates for the treatment of Alzheimer's disease and other neurological diseases by reducing ?-amyloid deposit formation.

Abstract: A method for forming a tubular member includes preparing a longitudinal Teflon strap, winding the Teflon strap around a longitudinal core to form a tubular prototype having two or more layers, and welding the two or more layers of the Teflon strap together to form the tubular member. The layers of the Teflon strap are preferably arranged at different angles or inclined relative to each other, or arranged at different angles with respect to the longitudinal axis of the core or of the elongate tubular member. The tubular member may further be shaped to various shapes or configurations with such as extending, stretching, expanding, enlarging, or shaping process.

Abstract: The present invention provides a device and method for applying 1-D and 2-D DCT and IDCT transforms to sets of input data, typically 8×8 or 16×16 matricies of coefficients. In one embodiment, the present invention provides input lines, logic to pre-add input values and generate operands and one or more adder networks that effectively carry out the multiplication operations required to apply a DCT/IDCT transform. The device may apply a 1-D transform twice to accomplish a 2-D transform. Alternatively, the present invention may either include successive stages of logic for the second 1-D transform or it may send data transformed once back through the same logic to pre-add and adder networks for the second 1-D transform. Calculations may be carried out after Booth encoding of operands. The processing may be split between producing vp, a vector of sums of output values, and producing vn, a vector of differences of output values, which vectors may be recombined to produce an output vector v.

Abstract: The invention concerns a novel ?-secretase, a method of partially purifying this novel ?-secretase, and its use in assays to screen for potential drug candidates against Alzheimer's disease and other neurological diseases. The novel ?-secretase has an estimated molecular weight of about 32-39 kDa or 22-26 kDa in HEK293 cell membrane extracts and human brain samples, respectively, as calculated from radiation inactivation analysis, and has a pH optimum at about pH 6.5-7.0.

Abstract: The invention concerns a novel ?-secretase, a method of partially purifying this novel ?-secretase, and its use in assays to screen for potential drug candidates against Alzheimer's disease and other neurological diseases. The novel ?-secretase has an estimated molecular weight of about 32-39 kDa or 22-26 kDa in HEK293 cell membrane extracts and human brain samples, respectively, as calculated from radiation inactivation analysis, and has a pH optimum at about pH 6.5-7.0.

Abstract: The invention concerns a novel ?-secretase, a method of partially purifying this novel ?-secretase, and its use in assays to screen for potential drug candidates against Alzheimer's disease and other neurological diseases. The novel ?-secretase has an estimated molecular weight of about 32–39 kDa or 22–26 kDa in HEK293 cell membrane extracts and human brain samples, respectively, as calculated from radiation inactivation analysis, and has a pH optimum at about pH 6.5–7.0.

Abstract: A device and method are described that apply 1-D and 2-D discrete cosine transforms (DCT) and inverse discrete cosine transforms (IDCT) to sets of input data, typically 8×8 or 16×16 matricies of coefficients. One device includes input lines, logic to pre-add input values and generate opcrands and one or more adder networks that effectively carry out the multiplication operations required to apply a DCT/IDCT transform. The device may apply a 1-D transform twice to accomplish a 2-D transform. Alternatively, the device may either include successive stages of logic for the second 1-D transform or it may send data transformed once back through the same logic or pre-add and adder networks for the second 1-D transform. Calculations may be carried out after Booth encoding of operands. The processing may be split between producing vp, a vector of sums of output values, and producing vn, a vector of differences of output values, which vectors may be recombined to produce an output vector v.

Abstract: The present invention provides a device and method for applying 1-D and 2-D DCT and IDCT transforms to sets of input data, typically 8×8 or 16×16 matrices of coefficients. In one embodiment, the present invention provides input lines, logic to pre-add input values and generate operands and one or more adder networks that effectively carry out the multiplication operations required to apply a DCT/IDCT transform: The device may apply a 1-D transform twice to accomplish a 2-D transform. Alternatively, the present invention may either include successive stages of logic for the second 1-D transform or it may send data transformed once back through the same logic to pre-add and adder networks for the second 1-D transform. Calculations may be carried out after Booth encoding of operands. The processing may be split between producing vp, a vector of sums of output values, and producing vn, a vector of differences of output values, which vectors may be recombined to produce an output vector v.

Abstract: The present invention is based on the findings that BACE2, a homolog of &bgr;-secretase BACE, is able to stimulate processing of APP in a non-amyloidogenic pathway, thereby suppressing the level of A&bgr;. Accordingly, the present invention provides methods and means for the identification and use of modulators of this unique activity of BACE2 to suppress A&bgr; production. The compounds identified using the methods and means provided herein may be used as potential candidates for the treatment of Alzheimer's disease and other neurological diseases.

Abstract: The invention concerns a novel &bgr;-secretase, a method of partially purifying this novel &bgr;-secretase, and its use in assays to screen for potential drug candidates against Alzheimer's disease and other neurological diseases. The novel &bgr;-secretase has an estmated molecular weight of about 32-39 kDa or 22-26 kDa in HEK293 cell membrane extracts and human brain samples, respectively, as calculated from radiation inactivation analysis, and has a pH optimum at about pH 6.5-7.0.

Abstract: The present invention is based on the findings that BACE 2, a homolog of &bgr;-secretase BACE, is able to stimulate processing of APP in a non-amyloidogenic pathway, thereby suppressing the level of A&bgr;. Accordingly, the present invention provides methods and means for the identification and use of modulators of this unique activity of BACE 2 to suppress A&bgr; production. The compounds identified using the methods and means provided herein may be used as potential candidates for the treatment of Alzheimer's disease and other neurological diseases.

Abstract: Heterocyclic organoaluminum and organoboron coordination complexes that are photoluminescent and electroluminescent, emitting intense blue light. Methods of synthesizing such compounds, methods of producing photoluminescence and electroluminescence, methods of applying the compounds in thin films, and uses of the compounds of the invention in luminescent probes, electroluminescent displays and the like.

Abstract: The present invention is based on the findings that BACE2, a homolog of &bgr;-secretase BACE, is able to stimulate processing of APP in a non-amyloidogenic pathway, thereby suppressing the level of A&bgr;. Accordingly, the present invention provides methods and means for the identification and use of modulators of this unique activity of BACE2 to suppress A&bgr; production. The compounds identified using the methods and means provided herein may be used as potential candidates for the treatment of Alzheimer's disease and other neurological diseases.

Abstract: The invention provides heterocyclic organoaluminum and organoboron coordination complexes that are photoluminescent and electroluminescent, emitting intense blue light. The invention further provides methods of synthesizing such compounds, methods of producing photoluminescence and electroluminescence, methods of applying the compounds in thin films, and uses of the compounds of the invention in luminescent probes, electroluminescent displays and the like.

Abstract: Heterocyclic organoaluminum and organoboron coordination complexes that are photoluminescent and electroluminescent, emitting intense blue light. Methods of synthesizing such compounds, methods of producing photoluminescence and electroluminescence, methods of applying the compounds in thin films, and uses of the compounds of the invention in luminescent probes, electroluminescent displays and the like.